Dopamine agonistic potency of two novel prolactin release-inhibiting ergolines.

abstract：:The interaction between endogenous nitric oxide (NO), elicited by administration of Escherichia coli lipopolysaccharide, and cyclooxygenase system, in ethanol-induced injury in rat gastric mucosa, was investigated. Administration of graded doses of lipopolysaccharide reduced the gastric mucosal injury in response to e...

journal_title：European journal of pharmacology

authors： Franco L,Doria D

更新日期：1998-05-08 00:00:00

abstract：:Nitric oxide (NO) is continuously produced in the lung and can be measured in exhaled gas of different species. To investigate a possible neuro-humoral regulation of pulmonary NO production in vivo we injected veratrine, an activator of Na(+) channels known to activate the sympathoadrenal system, in anaesthetized, mec...

journal_title：European journal of pharmacology

authors： Adding LC,Agvald P,Artlich A,Gustafsson LE

更新日期：2001-01-12 00:00:00

abstract：:SQ 20009 and SQ 65396, two new pyrazolopyridines with anxiolytic properties in animals, reversibly increased Na+-independent 3H-GABA binding to rat cerabral cortex membranes in vitro. This modulation was partially chloride dependent and sensitive to Triton-X 100. Kinetic analysis of 3H-muscimol binding revealed an inc...

journal_title：European journal of pharmacology

authors： Placheta P,Karobath M

更新日期：1980-03-21 00:00:00

abstract：:Methoctramine, a selective M2 alpha muscarinic receptor antagonist, was examined for its ability to inhibit carbachol-induced drinking in the rat. Intracerebroventricularly (i.c.v.) administered methoctramine was devoid of activity up to a dose of 100 nmol/rat, whereas higher doses were toxic under our experimental co...

journal_title：European journal of pharmacology

authors： Massi M,Polidori C,Melchiorre C

更新日期：1989-04-25 00:00:00

abstract：:The aim was to determine whether blockade of store-operated Ca(2+) entry, or inhibition of Ca(2+) sensitisation, is the predominant mechanism by which neuronally released nitric oxide mediates relaxation of the mouse anococcygeus. Nitrergic relaxations to field stimulation (10 Hz, 10 s trains) were unaffected by the s...

journal_title：European journal of pharmacology

authors： Gibson A,Wallace P,McFadzean I

更新日期：2003-06-27 00:00:00

abstract：:The in vivo cardiovascular effect and in vitro vasorelaxant effect of harman, one of harmala alkaloids isolated from Peganum harmala, were examined in this study. Harman (1-10 mg/kg, i.v.) dose-dependently produced transient hypotension and long-lasting bradycardia in pentobarbital-anesthetized rats, which were attenu...

journal_title：European journal of pharmacology

authors： Shi CC,Chen SY,Wang GJ,Liao JF,Chen CF

更新日期：2000-03-03 00:00:00

abstract：:Population spikes associated with the paired pulse ratio protocol were used to measure the presynaptic inhibition of corticostriatal transmission caused by mu-opioid receptor activation. A 1 microM of [D-Ala(2), N-MePhe(4), Gly-ol(5)]-enkephalin (DAMGO), a selective mu-opioid receptor agonist, enhanced paired pulse fa...

journal_title：European journal of pharmacology

authors： Barral J,Mendoza E,Galarraga E,Bargas J

更新日期：2003-02-21 00:00:00

abstract：:The present study investigated the changes in NMDA receptor subunit proteins in diazepam-withdrawn rat cerebral cortex, using Western blotting analysis. The protein levels of the NR1 and NR2B, but not NR2A, subunits were significantly increased in diazepam-withdrawn rats compared to those in control rats. Therefore, a...

journal_title：European journal of pharmacology

authors： Tsuda M,Chiba Y,Suzuki T,Misawa M

更新日期：1998-01-12 00:00:00

abstract：:In superfusion experiments with a crude synaptosomal fraction from the nucleus accumbens of rats, lysergic acid diethylamide, mescaline and N,N-dimethyltryptamine (representing different chemical classes of psychotomimetics) produced a concentration-related inhibition of K+-evoked [3H]dopamine release whereas spontane...

journal_title：European journal of pharmacology

authors： Hetey L,Schwitzkowsky R,Oelssner W

更新日期：1983-09-30 00:00:00

abstract：:In this study, we describe the effect of antiepileptic drugs on the production of kynurenic acid in rat cortical slices, and on the activity of kynurenic acid biosynthetic enzymes, kynurenine aminotransferases (KATs I and II) in the brain tissue. Phenobarbital, felbamate, phenytoin and lamotrigine (all at 0.5-3.0 mM) ...

journal_title：European journal of pharmacology

authors： Kocki T,Wielosz M,Turski WA,Urbanska EM

更新日期：2006-07-17 00:00:00

abstract：:The excitatory mechanism of central sympathetic outflow induced by interleukin-1 beta was investigated in urethane-anesthetized rats. Intracerebroventricular administration of interleukin-1 beta induced a gradually developing elevation of plasma noradrenaline levels in a dose-dependent manner (50, 100 and 200 ng/anima...

journal_title：European journal of pharmacology

authors： Murakami Y,Yokotani K,Okuma Y,Osumi Y

更新日期：1996-12-12 00:00:00

abstract：:The present in vivo microdialysis study examined the role of vesicular- and carrier-mediated mechanisms underlying dopamine (DA) release, uptake and metabolism in halothane-anaesthetized rats. Omission of calcium (Ca2+) from the dialysis perfusing medium, thereby reducing the concentration of Ca2+ in the striatal micr...

journal_title：European journal of pharmacology

authors： Hurd YL,Ungerstedt U

更新日期：1989-07-18 00:00:00

abstract：:Fat tissue plays an important role in the regulation of inflammatory processes. Increased visceral fat has been associated with a higher production of cytokines that triggers a low-grade inflammatory response, which eventually may contribute to the development of insulin resistance. In the present study, we investigat...

journal_title：European journal of pharmacology

authors： Alarcon-Aguilar FJ,Almanza-Perez J,Blancas G,Angeles S,Garcia-Macedo R,Roman R,Cruz M

更新日期：2008-12-03 00:00:00

abstract：:A novel compound, FR64822(N-(4-pyridylcarbamoyl)amino 1,2,3,6,-tetrahydropyridine), displays antinociceptive activities in a variety of assays with mice and rats. It has a strong antinociceptive activity in the acetic acid writhing test (ED50 = 1.8 mg/kg p.o.), whereas it has little antinociceptive activity in the tai...

journal_title：European journal of pharmacology

authors： Ohkubo Y,Nomura K,Yamaguchi I

更新日期：1991-11-05 00:00:00

abstract：:The (+)-enantiomer of the dihydropyridine 202-791 produced coronary constrictor and positive inotropic effects in Langendorff-perfused rat hearts whereas (--)-202-791 showed coronary dilator and negative inotropic effects. Both enantiomers showed the vascular effects at lower concentrations than the myocardial effects...

journal_title：European journal of pharmacology

authors： Uematsu T,Cook NS,Hof RP,Vozeh S,Follath F

更新日期：1986-04-29 00:00:00

abstract：:The therapeutic potential of cannabidiol, the major non-psychotropic Cannabis constituent, was investigated in rats exposed to ischemia/reperfusion liver injury. Ischemia was induced by clamping the pedicle of the left hepatic lobe for 30 min, and cannabidiol (5mg/kg, i.v.) was given 1h following the procedure and eve...

journal_title：European journal of pharmacology

authors： Fouad AA,Jresat I

更新日期：2011-11-16 00:00:00

abstract：:The effects of the benzodiazepine receptor antagonist Ro 15-1788, an imidazobenzodiazepine derivative, were studied with respect to three pharmacological activities exerted by diazepam in rats. Two of these, release of shock-induced suppression of drinking and attenuation of non-reward-induced cessation of responding ...

journal_title：European journal of pharmacology

authors： Thiébot MH,Childs M,Soubrié P,Simon P

更新日期：1983-03-18 00:00:00

abstract：:Opiate tolerance is a critical issue in pain management. Previous studies show that activation of Mas-related gene (Mrg) C receptor can modulate the development of morphine tolerance. This study was designed to investigate the underlying mechanism(s). Intrathecal (i.t.) administration of morphine (20µg) increased the ...

journal_title：European journal of pharmacology

authors： Zhang Y,Wang K,Lin M,Li Q,Hong Y

更新日期：2017-11-15 00:00:00

abstract：:The endocannabinoid system appears to have an important role in specific aspects of learning and memory, yet there has been no systematic study of the role of cannabinoid receptors in contextual fear conditioning. The present study examined the effects of cannabinoid CB(1) receptor blockade on the acquisition, consoli...

journal_title：European journal of pharmacology

authors： Arenos JD,Musty RE,Bucci DJ

更新日期：2006-06-13 00:00:00

abstract：:The autoradiographic distribution of putative brain adrenomedullin receptors was investigated using [125I]human adrenomedullin(13-52) as a new radioligand. Specific [125I]human adrenomedullin(13-52) binding sites were very discretely distributed in the rat brain with enrichment seen in the choroid plexus and linings o...

journal_title：European journal of pharmacology

authors： Juaneda C,Dumont Y,Chabot JG,Quirion R

更新日期：2001-06-08 00:00:00

abstract：:Elevated fatty acid levels play a pathogenic role in the development of insulin resistance, associated with type 2 diabetes. Interventions with ability to ameliorate fatty acid-induced insulin resistance might be useful for the management of diabetes. Here, we explored the effect of the diastereomeric mixture of calop...

journal_title：European journal of pharmacology

authors： Jaiswal N,Gunaganti N,Maurya CK,Narender T,Tamrakar AK

更新日期：2015-01-05 00:00:00

abstract：:To determine if the presence of an activator of guanylate cyclase alters the depressor response to a selective inhibitor of low Km cyclic GMP (cGMP) phosphodiesterase (PDE), zaprinast (3-30 mg/kg) was given i.v. to conscious, spontaneously hypertensive rats during a steady state of i.v. infusion of sodium nitroprussid...

journal_title：European journal of pharmacology

authors： Dundore RL,Pratt PF,Hallenbeck WD,Wassey ML,Silver PJ,Buchholz RA

更新日期：1990-08-21 00:00:00

abstract：:In the rat pulmonary artery, phorbol 12,13-dibutyrate induces a contraction due to the activation of the protein kinase C. We investigated the sensitivity of this protein kinase C-mediated contraction to a variety of vascular smooth muscle relaxants. Pretreatment of rat pulmonary artery with relaxant compounds altered...

journal_title：European journal of pharmacology

authors： Savineau JP,Gonzalez De La Fuente P,Marthan R

更新日期：1993-11-09 00:00:00

abstract：:The nature of the inhbitory non-adrenergic non-cholinergic (NANC) neurotransmitter responsible for neurogenic relaxation of rat duodenum was studied with in vitro techniques. Adenosine 5'-triphosphate (ATP)(1 mM), gamma-aminobutyric acid (GABA, 1 mM), dimethylphenylpiperazinium (DMPP, 0.1 mM) and field stimulation (60...

journal_title：European journal of pharmacology

authors： Manzini S,Maggi CA,Meli A

更新日期：1985-07-31 00:00:00

abstract：:Cats were treated once daily for 35 days with flurazepam (FZP). Different groups received 2, 5 or 20 mg/kg per day. A fourth group was started at 20 mg/kg per day, then the dose was increased to 30, and finally 40 mg/kg per day. Muscle relaxation, ataxia, and other measures of neurological impairment were used to meas...

journal_title：European journal of pharmacology

authors： Rosenberg HC,Chiu TH

更新日期：1982-07-16 00:00:00

abstract：:Traditional methods of analyzing the binding of opiates do not accurately establish the affinities of the drugs for the agonist and antagonist states of the opioid receptor. The poor results obtained by the Scatchard procedure may be attributed to the presence of extraneous drug binding sites in the brain-homogenate m...

journal_title：European journal of pharmacology

authors： Cheney BV,Lahti RA,Barsuhn C

更新日期：1982-02-05 00:00:00

abstract：:A substantial barrier to the treatment of Opioid Use Disorder (OUD) is the elevated relapse rates in affected patients, and a significant contributor to these events of relapse is exposure to cues and contexts that are intensely associated with prior drug abuse. The neurotransmitter dopamine plays a key role in reward...

journal_title：European journal of pharmacology

authors： McKendrick G,Sharma S,Sun D,Randall PA,Graziane NM

更新日期：2020-12-15 00:00:00

abstract：:Ten beta-adrenoceptor blocking drugs varying in lipophilicity and beta-adrenoceptor blocking potency were examined for inhibitory effects on synaptosomal [3H]noradrenaline uptake. All compounds produced a concentration-dependent inhibition of noradrenaline uptake, but were at least one order of magnitude less potent t...

journal_title：European journal of pharmacology

authors： Street JA,Walsh A

更新日期：1984-07-13 00:00:00

abstract：:The role of flexibility of the alkyl side chain in the tetrahydrocannabinols to cannabinoid activity has been delineated in previous studies with side chain analogs of Delta(8)-tetrahydrocannabinol with double or triple bonds. This study investigated the site of antinociceptive action for these analogs through analysi...

journal_title：European journal of pharmacology

authors： Wiley JL,Patrick GS,Crocker PC,Saha B,Razdan RK,Martin BR

更新日期：2000-06-02 00:00:00

abstract：:Toll-like receptors (TLRs) play an important role in the recognition of microbial pathogens and induce innate immune responses. The recognition of microbial components by TLRs triggers the activation of myeloid differential factor 88 (MyD88)- and toll-interleukin-1 receptor domain-containing adapter inducing interfero...

journal_title：European journal of pharmacology

authors： Gu GJ,Eom SH,Suh CW,Koh KO,Kim DY,Youn HS

更新日期：2013-12-05 00:00:00