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In vitro modulation by SQ 20009 and SQ 65396 of GABA receptor binding in rat CNS membranes.

Abstract：

:SQ 20009 and SQ 65396, two new pyrazolopyridines with anxiolytic properties in animals, reversibly increased Na+-independent 3H-GABA binding to rat cerabral cortex membranes in vitro. This modulation was partially chloride dependent and sensitive to Triton-X 100. Kinetic analysis of 3H-muscimol binding revealed an increase of the apparent number of binding sites. The results are compatible with a functional association between Na+-independent GABA binding sites and the GABA/benzodiazepine receptor complex.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Placheta P,Karobath M

doi

10.1016/0014-2999(80)90281-2

subject

Has Abstract

pub_date

1980-03-21 00:00:00

pages

225-8

issue

2-3

eissn

0014-2999

issn

1879-0712

pii

0014-2999(80)90281-2

journal_volume

62

pub_type

杂志文章

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