Norbinaltorphimine: antagonist profile at kappa opioid receptors.

abstract：:The role beta-adrenoceptors in the control of venous tone is not clear. This study examines the dose-response effects of isoprenaline, a non-selective beta-adrenoceptor agonist, on mean circulatory filling pressure (MCFP), an index of body venous tone, in conscious and unrestrained rats. Dose-response curves of isopre...

journal_title：European journal of pharmacology

authors： Abdelrahman A,Pang CC

更新日期：1990-11-13 00:00:00

abstract：:Recent data show that corticolimbic expression of the effector immediate early gene Arc is up-regulated by standard antidepressant drugs. Here, we tested the effect upon Arc expression of a novel antidepressant and selective 5-hydroxytryptamine/noradrenaline reuptake inhibitor (SNRI), (-)1-(1-dimethylaminomethyl) 5-me...

journal_title：European journal of pharmacology

authors： Pei Q,Sprakes M,Millan MJ,Rochat C,Sharp T

更新日期：2004-04-12 00:00:00

abstract：:Denudatin B is an antiplatelet agent isolated from the flower buds of Magnolia fargesii. We studied the effects of denudatin B on the vasoconstriction of rat thoracic aorta induced by high potassium (K+) solution, norepinephrine (NE) and caffeine, and to elucidate its mode of action. The contraction of rat aorta cause...

journal_title：European journal of pharmacology

authors： Yu SM,Chen CC,Huang YL,Tsai CW,Lin CH,Huang TF,Teng CM

更新日期：1990-10-02 00:00:00

abstract：:In a medium containing 100 mM NaCl and 10 mM MgCl2, the binding of antagonists to rat myocardial muscarinic receptors is well described by the simple Langmuir isotherm. However, in low ionic strength media, while a small proportion of the sites (23%) display a small (2-3 fold) increase in antagonist affinity, the majo...

journal_title：European journal of pharmacology

authors： Hulme EC,Berrie CP,Birdsall NJ,Burgen AS

更新日期：1981-07-17 00:00:00

abstract：:Substance P (SP) caused an immediate and vigorous contraction of the longitudinal smooth muscle layer of the guinea-pig ileum. The contractile response to SP, unlike that to acetylcholine or histamine was not maintained but faded to baseline levels in about 6 min. When 0.3-1.0 nM SP was added the fading time was short...

journal_title：European journal of pharmacology

authors： Huidobro-Toro JP,Chelala CA,Bahouth S,Nodar R,Musacchio JM

更新日期：1982-06-16 00:00:00

abstract：:Low doses of BHT 920, LY 171555 and (+)3PPP, three dopamine agonists selective for D-2 receptors, induced yawning in rats. This effect was reduced by the selective D-1 antagonist SCH 23390 but the antagonism did not exceed a 50% reduction from the control values. In contrast, the selective D-2 antagonist (-)sulpiride ...

journal_title：European journal of pharmacology

authors： Longoni R,Spina L,Di Chiara G

更新日期：1987-02-10 00:00:00

abstract：:The novel antiepileptic and neuroprotective drug felbamate (1 mM) caused a marked inhibition of voltage-dependent Na+ currents expressed in Xenopus oocytes upon injection of the cRNA encoding alpha-subunits from rat and human brain. This inhibition was present only if felbamate was perfused on the intracellular side o...

journal_title：European journal of pharmacology

authors： Taglialatela M,Ongini E,Brown AM,Di Renzo G,Annunziato L

更新日期：1996-12-05 00:00:00

abstract：:Microdialysis of the substantia nigra pars reticulata in freely moving rats disclosed a steady release of dopamine and its metabolites which was greatly reduced after reserpine (4 mg/kg s.c.) and alpha-methyl-p-tyrosine (200 mg/kg i.p.) pretreatments. Local infusion of high K+ (100 mM) or L-3,4-dihydroxyphenylalanine ...

journal_title：European journal of pharmacology

authors： Biggs CS,Fowler LJ,Whitton PS,Starr MS

更新日期：1996-03-28 00:00:00

abstract：:The actions of carbachol were studied on the firing response of neostriatal neurons recorded intracellularly from in vitro slice preparations of the rat brain. Carbachol (1-10 microM) reversibly reduced the afterhyperpolarization in neostriatal neurons. This effect was accompanied by an increase in both firing frequen...

journal_title：European journal of pharmacology

authors： Pineda JC,Bargas J,Flores-Hernández J,Galarraga E

更新日期：1995-08-15 00:00:00

abstract：:The effects of nimodipine on the amphetamine- and methamphetamine-induced decrease in central tryptophan hydroxylase activity was examined. Rats were administered 4 or 5 injections of amphetamine or methamphetamine at 6-h intervals with or without nimodipine (1 mg/kg), and killed 1 or 18 h after the last drug administ...

journal_title：European journal of pharmacology

authors： Elkins KW,Gibb JW,Hanson GR,Wilkins DG,Johnson M

更新日期：1993-12-21 00:00:00

abstract：:Mouse gastric fundus strips were relaxed by ultraviolet light (UV) irradiation, exogenous nitric oxide (NO), isoproterenol, S-nitrosoglutathione, S-nitroso-L-cysteine and S-nitroso-N-acetyl-penicillamine. Glutathione did not affect relaxations in response to UV irradiation, exogenous NO and isoproterenol while inhibit...

journal_title：European journal of pharmacology

authors： Ogülener N,Ergün Y

更新日期：2002-08-30 00:00:00

abstract：:Insulin resistance in skeletal muscle is a major risk factor for the development of type 2 diabetes (T2D). In this study, we investigated the effect of icariin on insulin resistance in C2C12 mouse skeletal muscle cells. C2C12 myoblasts were differentiated into myotubes for five days, then treated with icariin (50 and ...

journal_title：European journal of pharmacology

authors： Han Y,Jung HW,Park YK

更新日期：2015-07-05 00:00:00

abstract：:The breakdown of the relaxation-inducing second messengers cAMP and cGMP is mediated by phosphodiesterases. Inhibitors of functionally present phosphodiesterases can be expected to induce relaxation by increasing the basic amount of cAMP and/or cGMP. In the cat gastric fundus, vinpocetine, which has some selectivity f...

journal_title：European journal of pharmacology

authors： Barbier AJ,Lefebvre RA

更新日期：1995-03-24 00:00:00

abstract：:Cyclophosphamide (CPA) is a chemotherapeutic drug widely used in the treatment of breast cancer or leukemia in clinic. However, CPA was reported to have hepatotoxicity. This study aims to observe the engaged mechanism of CPA-induced liver injury in mice and the protection of liquiritin (LQ) and liquiritigenin (LG). Li...

journal_title：European journal of pharmacology

authors： Chen M,Zhang C,Zhang J,Kai G,Lu B,Huang Z,Ji L

更新日期：2019-08-05 00:00:00

abstract：:The effect of dl-p-chloroamphetamine, fluoxetine and probenecid on the efflux of endogenous 5-hydroxytryptamine (5HT) and 5-hydroxyindoleacetic acid (5HIAA) into superfusates of the spinal cord of anesthetized rats was examined. Mean basal efflux of 5HT and 5HIAA was 0.27 and 15.56 ng/ml superfusate, respectively. The...

journal_title：European journal of pharmacology

authors： Hammond DL,Tyce GM,Yaksh TL

更新日期：1983-03-04 00:00:00

abstract：:Voltage-gated potassium (Kv) channels are the largest superfamily of potassium (K) channels. A variety of Kv channels are expressed in the vascular smooth muscle cells (SMC). Studies have shown that gestational diabetes mellitus (GDM) and pregnancy-induced hypertension (PIH) cause various changes in the human umbilica...

journal_title：European journal of pharmacology

authors： Djokic V,Jankovic S,Labudovic-Borovic M,Rakocevic J,Stanisic J,Rajkovic J,Novakovic R,Kostic M,Djuric M,Gostimirovic M,Gojkovic-Bukarica L

更新日期：2020-09-05 00:00:00

abstract：:The effects of indapamide, hydrochlorothiazide and chlorthalidone were studied on isometric contractions, calcium contractures (in depolarized preparations) and membrane potentials in isolated longitudinal strips from rat portal veins. Indapamide inhibited all three responses more potently than did current diuretics. ...

journal_title：European journal of pharmacology

authors： Mironneau J,Savineau JP,Mironneau C

更新日期：1981-10-22 00:00:00

abstract：:Clinical evidence indicates an antiarrhythmic effect of sulfonylureas, which might be blunted by their vascular action. We wanted to investigate the effect of glibenclamide and the new sulfonylthiourea compound 1-[[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]-sulfonyl]-3 -me thylthiourea (HMR1883) on cardiac ele...

journal_title：European journal of pharmacology

authors： Dhein S,Pejman P,Krüsemann K

更新日期：2000-06-16 00:00:00

abstract：:Induction of lower lip retraction after local infusion of the selective 5-HT1A receptor agonist (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in the dorsal and median raphe nuclei was measured. Infusion of 8-OH-DPAT (2.5, 5 and 10 micrograms/rat) into the median raphe nucleus caused an immediate and dose-de...

journal_title：European journal of pharmacology

authors： Berendsen HH,Bourgondien FG,Broekkamp CL

更新日期：1994-10-03 00:00:00

abstract：:The present study investigated the effect of morphine sensitization on the impairment of spatial memory retrieval induced by acute morphine in adult male rats. Spatial memory was assessed by 2-day Morris water maze task which included training and test day. On the training day, rats were trained by a single training s...

journal_title：European journal of pharmacology

authors： Farahmandfar M,Naghdi N,Karimian SM,Kadivar M,Zarrindast MR

更新日期：2012-05-15 00:00:00

abstract：:To investigate the long-term functional change in the 5-HT(2A) receptor after acute stress, we examined the effect of single footshock on head shake behavior induced by the 5-HT(2A) receptor agent (+/-)-2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI) in rats. Head shakes were evoked in a dose-dependent manner by 0...

journal_title：European journal of pharmacology

authors： Izumi T,Suzuki K,Inoue T,Li XB,Maki Y,Muraki I,Kitaichi Y,Hashimoto S,Koyama T

更新日期：2002-10-04 00:00:00

abstract：:The effects of protein kinase C (PKC) activators on gamma-aminoburyric acid (GABA) rho 1 receptor function were studied in rho 1 -expressing Xenopus oocytes. The PKC activator phorbol 12-myristate 13-acetate (PMA) but not the inactive analog phorbol 12-mono-myristate inhibited the GABA-gated chloride currents. Mezerei...

journal_title：European journal of pharmacology

authors： Kusama T,Sakurai M,Kizawa Y,Uhl GR,Murakami H

更新日期：1995-11-30 00:00:00

abstract：:RES-701-1 (cyclic (Gly1-Asp9)(Gly-Asn-Trp-His-Gly-Thr-Ala-Pro-Asp-Trp-Phe- Phe-Asn-Tyr-Tyr-Trp)), a peptide isolated from Streptomyces sp., has been reported to inhibit the endothelin ETB receptor. We examined the effects of this peptide on the blood vessels and the small intestine. In isolated rat aorta without endot...

journal_title：European journal of pharmacology

authors： Karaki H,Sudjarwo SA,Hori M,Tanaka T,Matsuda Y

更新日期：1994-09-12 00:00:00

abstract：:We have investigated whether the histamine H3-receptors influence nonadrenergic noncholinergic (NANC) bronchoconstriction in guinea-pig in vivo. Atropine, propranolol, mepyramine and cimetidine were administered to block the effects of beta-adrenoceptor-, acetylcholine, H1- and H2-receptor-mediated responses, respecti...

journal_title：European journal of pharmacology

authors： Ichinose M,Barnes PJ

更新日期：1989-12-12 00:00:00

abstract：:The effect of diethyldithiocarbamate (DETC, 10(-3) M) on the vasorelaxant activity of acetylcholine, nitric oxide (NO), nitrite, glyceryl trinitrate or dinitrosyl iron cysteine complexes was studied in isolated rat aortic rings contracted with norepinephrine. Pretreatment of these segments with DETC attenuated the vas...

journal_title：European journal of pharmacology

authors： Vedernikov YP,Mordvintcev PI,Malenkova IV,Vanin AF

更新日期：1992-02-25 00:00:00

abstract：:It has been documented cardiac fibroblasts as the predominant cell population undergoing senescence in heart. Calcitonin gene-related peptide (CGRP) exhibits a wide range of cardiovascular protective effects. Whether CGRP protects against cardiac fibroblasts senescence in cardiac fibrosis remains unknown. Here, we det...

journal_title：European journal of pharmacology

authors： Li WQ,Tan SL,Li XH,Sun TL,Li D,Du J,Wei SS,Li YJ,Zhang BK

更新日期：2019-01-15 00:00:00

abstract：:Accumulating evidence indicates the role of microglial activation and sustained neuroinflammation in the pathogenesis of cognitive dysfunction, a common feature associated with depressive disorders. It also indicates the role of Wnt/β-catenin pathway in regulation of microglia-mediated neuroinflammation. Amisulpride e...

journal_title：European journal of pharmacology

authors： Mohamed AM,Habib MZ,Ebeid MA,Abdelraouf SM,El Faramawy Y,Aboul-Fotouh S,Magdy Y

更新日期：2020-10-15 00:00:00

abstract：:The effects of the treatment with the immunosuppressant deoxyspergualin on the development of experimental autoimmune orchitis were studied. The results showed that C3H/He mice immunized with testicular germ cells and treated daily with either 0.3 or 3 mg/kg body weight deoxyspergualin during days 15-20 post-immunizat...

journal_title：European journal of pharmacology

authors： Ablake M,Itoh M,Kaneko T,Iimura A,Nakamura Y,Meroni P,Nicoletti F

更新日期：2002-08-23 00:00:00

abstract：:We investigated the therapeutic effects of OK432 (picibanil; CAS39325-1-4), an immunomodulator that is derived from the Su strain of Streptococcus pyogenes. This agent was administered alone or combined with human interferon-alpha in a murine model of insulin-dependent diabetes mellitus. Interferon-alpha inhibits vira...

journal_title：European journal of pharmacology

authors： Kanda T,Kogure S,Nara M,Tsukui S,Utsugi T,Tomono S,Kawazu S,Nagai R,Kobayashi I

更新日期：1998-01-26 00:00:00

abstract：:The displacement of [3H]flunitrazepam by unlabelled flunitrazepam or zolpidem was used to assess the affinity and density of sub-types of GABA(A) receptors in the superior frontal and primary motor cortices of ten alcoholic, seven alcoholic-cirrhotic and ten matched control cases. The binding was best fitted by a mode...

journal_title：European journal of pharmacology

authors： Lewohl JM,Crane DI,Dodd PR

更新日期：1997-05-20 00:00:00