Compared effects of indapamide, hydrochlorothiazide and chlorthalidone on electrical and mechanical activities in vascular smooth muscle.

abstract：:Eating disorders constitute major medical health problems in the western world. Even though little is known about the mechanisms behind abnormal eating behavior, it has become clear that the central nervous system (CNS), particularly the hypothalamus, plays a significant role. The anorexic anx/anx mouse is a unique mo...

journal_title：European journal of pharmacology

authors： Johansen JE,Fetissov S,Fischer H,Arvidsson S,Hökfelt T,Schalling M

更新日期：2003-11-07 00:00:00

abstract：:Endothelial dysfunction is associated with a reduced bioavailability of nitric oxide (NO). In this study, the effects of 17β-estradiol supplement on endothelial function were examined in ovariectomized (OVX) rats following long-term inhibition of NO synthases with L-NAME. Female Sprague Dawley rats were ovariectomized...

journal_title：European journal of pharmacology

authors： Shi Y,Leung SWS

更新日期：2020-09-05 00:00:00

abstract：:Endogenous cannabinoid ligands and cannabinoid CB(1) receptor agonists have been shown to exert potent anticonvulsant effects in various experimental models of epilepsy. The purpose of this study was to determine the effects of arachidonyl-2'-chloroethylamide (ACEA; N-(2-chloroethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide, ...

journal_title：European journal of pharmacology

authors： Luszczki JJ,Czuczwar P,Cioczek-Czuczwar A,Czuczwar SJ

更新日期：2006-10-10 00:00:00

abstract：:The present study was to investigate the neuroprotective efficacy and mechanism of Forsythoside B. Male Sprague-Dawley rats were subjected to middle cerebral artery occlusion for 1 h followed by reperfusion for 23 h. Rats received an intravenous bolus injection of Forsythoside B at 15 min after reperfusion. The result...

journal_title：European journal of pharmacology

authors： Jiang WL,Tian JW,Fu FH,Zhu HB,Hou J

更新日期：2010-08-25 00:00:00

abstract：:Mitiglinide (KAD-1229), a new anti-diabetic drug, is thought to stimulate insulin secretion by closing the ATP-sensitive K+ (K(ATP)) channels in pancreatic beta-cells. However, its selectivity for the various K(ATP) channels is not known. In this study, we examined the effects of mitiglinide on various cloned K(ATP) c...

journal_title：European journal of pharmacology

authors： Sunaga Y,Gonoi T,Shibasaki T,Ichikawa K,Kusama H,Yano H,Seino S

更新日期：2001-11-09 00:00:00

abstract：:The aim of the present study was to investigate the effects of chronic administration of morphine on the expression of an endogenous opioid peptide in the spinal dorsal horn. Bovine adrenal medulla 22-like immunoreactivity (BAM22-IR) was found in the superficial layers of the spinal cord. Intrathecal (i.t.) administra...

journal_title：European journal of pharmacology

authors： Chen P,Liu Y,Hong Y

更新日期：2008-07-28 00:00:00

abstract：:Oral methylnalorphine ( methylnalorphinium ) caused a dose-dependent selective inhibition of inflammatory hyperalgesia (measured in the rat by a modified version of the Randall- Selitto test) without affecting the oedema. When subcutaneously injected, repeated doses of morphine for 5 days caused progressive analgesic ...

journal_title：European journal of pharmacology

authors： Ferreira SH,Lorenzetti BB,Rae GA

更新日期：1984-03-16 00:00:00

abstract：:Eleutheroside E (EE), a principal component of Eleutherococcus senticosus, has been reported to have anti-inflammatory and protective effects in ischemia heart etc. However, whether it can mitigate behavioral alterations induced by sleep deprivation, has not yet been elucidated. Numerous studies have demonstrated that...

journal_title：European journal of pharmacology

authors： Huang LZ,Wei L,Zhao HF,Huang BK,Rahman K,Qin LP

更新日期：2011-05-11 00:00:00

abstract：:Acid sensing ion channels (ASICs) are implicated in various brain functions including learning and memory and are involved in a number of neurological disorders such as pain, ischemic stroke, depression, and multiple sclerosis. We have recently defined ASICs as one of receptor targets of aromatic diamidines in neurons...

journal_title：European journal of pharmacology

authors： Chen X,Orser BA,MacDonald JF

更新日期：2010-12-01 00:00:00

abstract：:In the rat substantia nigra Type II benzodiazepine recognition sites (measured as the portion of [3H]flunitrazepam binding which remain after the addition of 2 X 10(-7) M Cl 218872) represent 50% of the total benzodiazepine recognition sites. The density of Type II sites was increased by 35% following the degeneration...

journal_title：European journal of pharmacology

authors： Porceddu ML,Corda MG,Sanna E,Biggio G

更新日期：1985-06-07 00:00:00

abstract：:Chronic Obstructive Pulmonary Disease (COPD) is a major incurable global health burden and is the 4th leading cause of death worldwide. It is believed that an exaggerated inflammatory response to cigarette smoke causes progressive airflow limitation. This inflammation, where macrophages, neutrophils and T lymphocytes ...

journal_title：European journal of pharmacology

authors： Vlahos R,Bozinovski S

更新日期：2015-07-15 00:00:00

abstract：:Spinorphin has been isolated from the bovine spinal cord as an endogenous inhibitor of enkephalin-degrading enzymes (aminopeptidase, dipeptidyl aminopeptidase III, angiotensin-converting enzyme and enkephalinase), and tynorphin has been synthesized as a more potent inhibitor of dipeptidyl aminopeptidase III. In this s...

journal_title：European journal of pharmacology

authors： Yamazaki T,Honda M,Yamamoto Y,Hazato T,Ono H

更新日期：2001-02-16 00:00:00

abstract：:Due to the limited results achieved in the clinical treatment of heart failure, a new inotropic strategy of myosin motor activation has been developed. The lead molecule of myosin activator agents is omecamtiv mecarbil, which binds directly to the heavy chain of the cardiac β-myosin and enhances cardiac contractility ...

journal_title：European journal of pharmacology

authors： Nánási P Jr,Gaburjakova M,Gaburjakova J,Almássy J

更新日期：2017-08-15 00:00:00

abstract：:A novel growth hormone secretagogues type 1a (GHS1a) receptors antagonist (2R)-N'-[3,5- bis(trifluoromethyl)phenyl]-2-[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-(3- pyridinyl)ethanohydrazide (GSK1614343) was functionally characterised in rat pituitary adenoma cell line, RC-4B/C endogenously expressing GHS1a rec...

journal_title：European journal of pharmacology

authors： Perdonà E,Faggioni F,Buson A,Sabbatini FM,Corti C,Corsi M

更新日期：2011-01-10 00:00:00

abstract：:The effects of acute or repeated treatment of male albino BKW mice with caerulein, a cholecystokinin octapeptide (CCK-8) agonist, and with devazepide (MK-329) and L-365,260, antagonists at CCKA ('peripheral') and CCKB ('central') receptors respectively, on motor activity and [propionyl-3H]propionylated-CCK-8 ([3H]pCCK...

journal_title：European journal of pharmacology

authors： Vasar E,Stephenson JD,Meldrum BS

更新日期：1991-09-24 00:00:00

abstract：:A sensitive high pressure liquid chromatography (HPLC) method was used to measure acetylcholine release from canine bronchial tissue in response to electrical stimulation. Indomethacin enhanced the efflux of acetylcholine, an effect that was reversed by the addition of prostaglandin E2 (PGE2). Prostaglandin D2 (PGD2) ...

journal_title：European journal of pharmacology

authors： Deckers IA,Rampart M,Bult H,Herman AG

更新日期：1989-08-29 00:00:00

abstract：:Effects of local anesthetics and structurally related drugs on the glibenclamide-sensitive K+ currents evoked by Y-26763 (a K+ channel opener) were investigated in native Xenopus oocytes. The K+ current induced by Y-26763 (100 microM) was reversibly suppressed by all six local anesthetics tested in a concentration-dep...

journal_title：European journal of pharmacology

authors： Yoneda I,Sakuta H,Okamoto K,Watanabe Y

更新日期：1993-11-15 00:00:00

abstract：:A single electroconvulsive shock produced analgesia (expressed as prolongation of hot-plate latency) in Wistar rats 45 min after the shock. The analgesic action was prevented by administration of nifedipine, 5 mg/kg i.p., 15 min before the electroconvulsive shock, while nifedipine injection after electroconvulsive sho...

journal_title：European journal of pharmacology

authors： Antkiewicz-Michaluk L,Michaluk J,Vetulani J

更新日期：1994-03-11 00:00:00

abstract：:The cerebrovascular actions of bosentan, a novel endothelin antagonist with effects at endothelin ETA and ETB receptors, have been examined in individual pial arterioles on the cortical surface of chloralose-anaesthetised cats. Subarachnoid perivascular microapplication of bosentan (0.3-300 microM) had minimal effect ...

journal_title：European journal of pharmacology

authors： Patel TR,McAuley MA,McCulloch J

更新日期：1994-07-21 00:00:00

abstract：:Ischemia/reperfusion injury ends up in the cascade of excitotoxic stimulation of superoxide and nitric oxide formation leading to the generation of highly reactive products, including peroxinitrite and hydroxyl radical, which are capable of damaging lipids, proteins and DNA. Several polyphenolic compounds scavenge the...

journal_title：European journal of pharmacology

authors： ArunaDevi R,Lata S,Bhadoria BK,Ramteke VD,Kumar S,Sankar P,Kumar D,Tandan SK

更新日期：2010-01-25 00:00:00

abstract：:An intricate surveillance network consisting of enteroendocrine cells, immune cells and sensory nerve fibres monitors the luminal and interstitial environment in the alimentary canal. Functional bowel disorders are characterized by persistent alterations in digestive regulation and gastrointestinal discomfort and pain...

journal_title：European journal of pharmacology

authors： Holzer P

更新日期：2001-10-19 00:00:00

abstract：:A bicarbonate-dependent organic cation transporter, unique from rOCT1 and rOCT2, primarily mediates amantadine uptake into renal proximal tubules. We examined whether intracellular pH regulates bicarbonate-dependent amantadine transporter function in these tubules. NH(4)Cl treatment resulted in immediate intracellular...

journal_title：European journal of pharmacology

authors： Goralski KB,Bose R,Sitar DS

更新日期：2006-07-10 00:00:00

abstract：:Multiple methamphetamine administrations rapidly decrease rat striatal dopamine transporter activity. To determine the species specificity of this phenomenon, the present studies examined effects of this stimulant on the dopamine transporter in mice. As in rats, multiple methamphetamine injections rapidly reduced stri...

journal_title：European journal of pharmacology

authors： Sandoval V,Hanson GR,Fleckenstein AE

更新日期：2000-12-15 00:00:00

abstract：:The influence of increasing concentrations of histamine (0.1 microM-1 mM) was studied on proximal and distal ring segments of left anterior descendens coronary arteries isolated from rats. Addition of histamine to prostaglandin F2 alpha (10 microM)-precontracted proximal segments elicited a further contraction. This e...

journal_title：European journal of pharmacology

authors： Van de Voorde J,Brochez V,Vanheel B

更新日期：1994-12-12 00:00:00

abstract：:This study examined the mechanism of action of neurotensin on intraluminal pressure in rat proximal colon. The direct and indirect contractile response to neurotensin (100 nM) was abolished in Ca(2+)-free solution, and was antagonized by nifedipine (1-5-10 nM) and potentiated by Bay K 8644 (methyl 1,4-dihydro-2,6-dime...

journal_title：European journal of pharmacology

authors： Mulè F,Serio R

更新日期：1997-01-29 00:00:00

abstract：:In male Swiss mice, muscimol produced myoclonic jerks. A 3 mg/kg (i.p.) dose induced this response in all of the mice tested and the peak response of 73 jerks per min was observed between 27 and 45 min. Increasing the brain serotonin levels by the administration of 5-hydroxytryptophan (80-160 mg/kg) in combination wit...

journal_title：European journal of pharmacology

authors： Menon MK,Vivonia CA

更新日期：1981-07-17 00:00:00

abstract：:In vitro effects of d,l-methadone and morphine on [3H]serotonin (3H-5-HT) uptake in rat periaqueductal gray (PAG) slices were investigated. Only methadone had a significant inhibitory effect on 3H-5-HT uptake which was significantly enhanced by naloxone. The systemic administration of methadone did not affect 3H-5-HT ...

journal_title：European journal of pharmacology

authors： Donzanti BA,Warwick RO

更新日期：1979-10-26 00:00:00

abstract：:Interactions between cannabinoid CB(1) and GABA receptors and ligands were investigated in the myenteric plexus-longitudinal muscle of the guinea pig ileum. Electrically evoked contractions of the myenteric plexus-longitudinal muscle were inhibited by the cannabinoid receptor agonist CP55,940 ((-)-cis-3-[2-Hydroxy-4-(...

journal_title：European journal of pharmacology

authors： Begg M,Molleman A,Parsons M

更新日期：2002-01-02 00:00:00

abstract：:Numerous studies have demonstrated the stimulatory effect of 5-HT1A receptor agonists, such as 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), on plasma corticotrophin (ACTH) levels in the rat. However, until recently the lack of a selective 5-HT1A receptor antagonist has hampered mechanistic studies in this area....

journal_title：European journal of pharmacology

authors： Critchley DJ,Childs KJ,Middlefell VC,Dourish CT

更新日期：1994-10-13 00:00:00

abstract：:PK20M (Dmt-D-Lys-Phe-Phe-OH) is a novel modified endomorphin-2 (EM-2) peptide producing strong dose- and time-dependent antinociceptive activity. Yet its prototype, endogenous EM-2, has been reported to trigger respiratory and vascular effects such as apnea and hypotension. The purpose of this study was to investigate...

journal_title：European journal of pharmacology

authors： Wojciechowski P,Kleczkowska P,Mollica A,Stefanucci A,Kaczyńska K

更新日期：2020-10-15 00:00:00