Effects of local anesthetics and related drugs on endogenous glibenclamide-sensitive K+ channels in Xenopus oocytes.

abstract：:YM992 ((S)-2-[[(7-fluoro-4-indanyl)oxy]methyl]morpholine monohydrochloride) is a novel compound that has selective serotonin (5-hydroxytryptamine, 5-HT) re-uptake inhibition and 5-HT2A receptor antagonistic activity in vivo. YM992, fluoxetine and citalopram showed 5-HT uptake inhibition activity in l-5-hydroxy-tryptop...

journal_title：European journal of pharmacology

authors： Takeuchi H,Yatsugi S,Hatanaka K,Nakato K,Hattori H,Sonoda R,Koshiya K,Fujii M,Yamaguchi T

更新日期：1997-06-18 00:00:00

abstract：:The present study was designed to characterize the vasopressin receptor subtype involved in the vasopressin-induced activation of the central sympatho-adrenomedullary outflow using urethane-anesthetized rats. Intracerebroventricularly (i.c.v.) administered vasopressin (0.1, 0.2 and 0.5 nmol/animal) dose-dependently el...

journal_title：European journal of pharmacology

authors： Okada S,Murakami Y,Nakamura K,Yokotani K

更新日期：2002-12-13 00:00:00

abstract：:This study investigates the relationship between the rate of phorbol ester-induced contraction of intact rat aorta and protein kinase C activation, as assessed by the translocation of protein kinase C from the cytosolic to the particulate fraction. Aorta was exposed to Ca(2+)-free physiologic salt solution prior to ph...

journal_title：European journal of pharmacology

authors： Bazan E,Campbell AK,Rapoport RM

更新日期：1995-08-15 00:00:00

abstract：:The effects of (S)-nafenodone, a new antidepressant, were studied on contraction and 45Ca2+ fluxes in rat vascular smooth muscle. In isolated rat aorta (S)-nafenodone, 10(-7) - 10(-4) M, inhibited the contractions induced by 80 mM KCl (IC50 = 1.4 +/- 0.4 x 10(-5) M) and 10(-5) M noradrenaline (IC50 = 1.2 +/- 0.2 x 10(...

journal_title：European journal of pharmacology

authors： Pérez-Vizcaíno F,Carrón R,Delpón E,Duarte J,Tamargo J

更新日期：1993-02-23 00:00:00

abstract：:Corticotropin-releasing factor (CRF) regulates the hypothalamic-pituitary-adrenal axis, coordinates the mammalian stress response, and acting primarily via the CRF(1) receptor, has been strongly implicated in the pathophysiology of depression and anxiety. Furthermore, the behavioral and autonomic activation that occur...

journal_title：European journal of pharmacology

authors： Skelton KH,Oren D,Gutman DA,Easterling K,Holtzman SG,Nemeroff CB,Owens MJ

更新日期：2007-09-24 00:00:00

abstract：:We studied the interaction of S-methylisothiourea (a selective inducible nitric oxide synthase inhibitor) with rofecoxib (a selective cyclooxygenase-2 inhibitor) and mefenamic acid (a non-selective cyclooxygenase inhibitor) in adjuvant-induced arthritis in female albino Wistar rats, applying the isobolographic analysi...

journal_title：European journal of pharmacology

authors： Bhat AS,Tandan SK,Kumar D,Krishna V,Prakash VR

更新日期：2007-02-05 00:00:00

abstract：:Epristeride, a 5alpha-reductase inhibitor, decreases prostate size and improves symptoms in men with benign prostatic hyperplasia. However, little is known about the histopathology of the prostate after treatment with epristeride. To study the relationship between apoptosis and the mechanism of epristeride in the trea...

journal_title：European journal of pharmacology

authors： Sun ZY,Wu HY,Wang MY,Tu ZH

更新日期：1999-04-29 00:00:00

abstract：:A single dose of 50 mg chlorimipramine was followed by a rapid and pronounced decrease in [3H]imipramine binding to platelet membranes. Incubation of human platelets or platelet membranes with 25 nM chlorimipramine similarly reduced [3H]imipramine binding. Imipramine, desmethylchlorimipramine, chlorpromazine and some ...

journal_title：European journal of pharmacology

authors： Mellerup ET,Plenge P

更新日期：1986-07-15 00:00:00

abstract：:Cocaine and a cocaine analog, WIN 36,065-2, were administered daily for 3 or 4 days. Both compounds developed sensitization to their locomotor stimulatory effects, with similarly shaped dose-response curves. Dosages giving optimal sensitization were 25 mg/kg per day for cocaine and 3 mg/kg for WIN 35,065-2. At 40 mg/k...

journal_title：European journal of pharmacology

authors： Reith ME

更新日期：1986-10-14 00:00:00

abstract：:Administration of endothelin to inactin-anesthetized rats resulted in a significant renal vasoconstriction as evidenced by a reduction in both renal plasma flow and glomerular filtration rate. Infusion of the novel nonpeptide endothelin ETA/ETB receptor antagonist, (+/-)-SB 209670, [(1RS-2SR,3RS)-3-(2-carboxymethoxy-4...

journal_title：European journal of pharmacology

authors： Brooks DP,Contino LC

更新日期：1995-12-29 00:00:00

abstract：:The efficacy of a combinational prophylactic regimen on the lethality, convulsions, and loss of morphological and functional integrities of the brain induced by an organophosphate soman was investigated in rats. The rats were implanted subcutaneously with osmotic minipumps containing the combinational prophylactic reg...

journal_title：European journal of pharmacology

authors： Choi EK,Park D,Yon JM,Hur GH,Ha YC,Che JH,Kim J,Shin S,Jang JY,Hwang SY,Seong YH,Kim DJ,Kim JC,Kim YB

更新日期：2004-11-28 00:00:00

abstract：:Insulin resistance is a major pathophysiological feature in the development of type 2 diabetes. The liver is an important organ responsible for the development of insulin resistance, and exploring liver glucose metabolism is important to study insulin resistance. We first established the model of insulin resistance in...

journal_title：European journal of pharmacology

authors： Fan X,Tao J,Zhou Y,Hou Y,Wang Y,Gu D,Su Y,Jang Y,Li S

更新日期：2019-01-15 00:00:00

abstract：:Fabry disease (FD) is an X-linked metabolic storage disorder arising from the deficiency of lysosomal α-galactosidase A, which leads to the gradual accumulation of glycosphingolipids, mainly globotriaosylceramide (Gb3), throughout the body. Pain in the extremities is an early symptom of FD; however, the underlying pat...

journal_title：European journal of pharmacology

authors： Sugimoto J,Satoyoshi H,Takahata K,Muraoka S

更新日期：2021-01-20 00:00:00

abstract：:The aim of the present study was to determine whether U50,488H (a selective kappa-opioid receptor agonist) inhibits cardiac hypertrophy and fibrosis induced by beta-adrenoceptor stimulation in a rat model. Cardiac hypertrophy and fibrosis were developed by intraperitoneal administration of isoprenaline (ip. 3.0 mg/kg/...

journal_title：European journal of pharmacology

authors： Yin W,Zhang P,Huang JH,Zhang QY,Fan R,Li J,Zhou JJ,Hu YZ,Guo HT,Zhang SM,Wang YM,Kaye AD,Gu CH,Liu JC,Cheng L,Cui Q,Yi DH,Pei JM

更新日期：2009-04-01 00:00:00

abstract：:Previous studies have shown that repeated injections of acidic saline, given into the lateral gastrocnemius muscle of rats, results in a bilateral reduction in withdrawal threshold to tactile stimulation of the hindpaws. We have now characterised this model of muscoskeletal pain pharmacologically, by evaluating the an...

journal_title：European journal of pharmacology

authors： Nielsen AN,Mathiesen C,Blackburn-Munro G

更新日期：2004-03-08 00:00:00

abstract：:Platycodi Radix is the root of Platycodon grandiflorum and it is widely used in the traditional Oriental medicine as an expectorant for pulmonary diseases and a remedy for respiratory disorders. Platycodin D is the major constituent of triterpene saponins in the root. This study investigates apoptosis by platycodin D ...

journal_title：European journal of pharmacology

authors： Ahn KS,Hahn BS,Kwack K,Lee EB,Kim YS

更新日期：2006-05-10 00:00:00

abstract：:N(G)-(Nitro-L-arginine (L-NOARG), an inhibitor of nitric oxide synthase, induces catalepsy in mice. The objective of the present work was to investigate if serotonergic drugs are able to modulate this effect. Results showed that the cataleptogenic effect of L-NOARG (40 mg/kg) in male albino-Swiss mice was enhanced by ...

journal_title：European journal of pharmacology

authors： Nucci-da-Silva LP,Guimarães FS,Del Bel EA

更新日期：1999-08-20 00:00:00

abstract：:Neuropathic pain has been suggested to be resistant to treatment with opiates. Such perceived lack of opioid responsiveness may be due to the dose-range over which specific opioid compounds have been studied as well as the efficacy of these compounds. Dihydroetorphine is a novel opiate that demonstrates significantly ...

journal_title：European journal of pharmacology

authors： Martin TJ,Hairston CT,Lutz PO,Harris LS,Porreca F

更新日期：1998-09-11 00:00:00

abstract：:The effects of (-)-N(1)phenethyl-norcymserine (PEC, 5 mk/kg, i.p.) on acetylcholine release and cholinesterase activity in the rat cerebral cortex were compared with those of donepezil (1 mg/kg, i.p.), a selective acetylcholinesterase inhibitor, and rivastigmine (0.6 mg/kg, i.p.), an inhibitor of acetylcholinesterase ...

journal_title：European journal of pharmacology

authors： Cerbai F,Giovannini MG,Melani C,Enz A,Pepeu G

更新日期：2007-10-31 00:00:00

abstract：:The effects of histamine H(1) receptor antagonists (promethazine, diphenhydramine, chlorphenilamine and triprolidine) on hippocampal theta rhythm during eight-arm radial maze performance were investigated using rats. Promethazine showed a significant increase in the number of total errors and working memory errors at ...

journal_title：European journal of pharmacology

authors： Masuoka T,Mikami A,Yasuda M,Shinomiya K,Kamei C

更新日期：2007-12-08 00:00:00

abstract：:Tamsulosin (10(-10)-10(-9) M) or prazosin (10(-9)-10(-8) M) concentration dependently blocked the tension responses to electrical field stimulation (0.3 ms duration, 80 V and 20 Hz) in human hyperplastic prostate with lC50 values of (1.93 +/- 0.26) x 10(-10) M and (2.11 +/- 0.21) x 10(-9) M, respectively. The relative...

journal_title：European journal of pharmacology

authors： Chueh SC,Guh JH,Chen J,Lai MK,Ko FN,Teng CM

更新日期：1996-06-03 00:00:00

abstract：:Chloranolol (5 mg/kg i.p.) retarded the disappearance of noradrenaline induced by the dopamine-beta-hydroxylase (DBH) inhibitor FLA 63, in the hypothalamus, nucleus of the solitary tract (A-2/C-2 area), and lateral reticular nucleus (A-1/C-1 area) regions, while propranolol (20 mg/kg i.p.) was effective only in the hy...

journal_title：European journal of pharmacology

authors： Simonyi A,Kanyicska B,Szentendrei T,Fekete MI

更新日期：1984-02-17 00:00:00

abstract：:The anticancer drugs camptothecin (CPT) and topotecan (TPT) are known DNA topoisomerase I inhibitors which cause DNA damage and lead to cell death. In this study we provide evidence that CPT and TPT also interfere with the elements of cytoskeleton - microtubules and actin filaments which could be partly responsible fo...

journal_title：European journal of pharmacology

authors： Wang X,Tanaka M,Krstin S,Peixoto HS,Moura CCM,Wink M

更新日期：2016-10-15 00:00:00

abstract：:Ibogaine, a naturally occurring alkaloid, has been claimed to be effective in treating addition to opiate and stimulant drugs. As a preclinical test of this claim, the present study sought to determine if ibogaine would reduce the intravenous self-administration of morphine in rats. Ibogaine dose dependently (2.5-80 m...

journal_title：European journal of pharmacology

authors： Glick SD,Rossman K,Steindorf S,Maisonneuve IM,Carlson JN

更新日期：1991-04-03 00:00:00

abstract：:WEB 2086, a novel specific platelet activating factor (PAF) antagonist derived from triazolodiazepines, inhibited in a dose-related manner the hypotensive and lethal effect of PAF as well as of E. coli endotoxin in the rat. The hypotension induced by endotoxin (15 mg/kg i.v.) or PAF (30 ng/(kg X min) i.v.) in anaesthe...

journal_title：European journal of pharmacology

authors： Casals-Stenzel J

更新日期：1987-03-17 00:00:00

abstract：:FR 172357, a new non-peptide antagonist of the kinin B(2) receptor was tested in three isolated vessels, the human umbilical vein, the rabbit jugular vein, and the pig coronary artery, to evaluate its antagonistic activities against bradykinin. FR 172357 displaced to the right the concentration-response curves of brad...

journal_title：European journal of pharmacology

authors： Rizzi C,Rizzi A,Calò G,Jorizzo G,Agnello G,Mollica G,Inamura N,Regoli D

更新日期：1999-12-10 00:00:00

abstract：:Nitric oxide (NO) and prostacyclin (PGI(2)) are two of the most important vasodilators produced by endothelial cells, the regulation of NO on PGI(2) production has not been fully clear yet. Polyaspartoyl.L-arginine (PDR) is an L-arginine residue-rich compound with inhibitory effects of platelet aggregation and thrombo...

journal_title：European journal of pharmacology

authors： Tang Z,Yang J,Liu X,Wang Y,Peng S

更新日期：2008-12-28 00:00:00

abstract：:In this study the effect of purified rat anti-mouse IL-5 monoclonal antibody on aeroallergen-induced infiltration of eosinophils in the bronchoalveolar lavage fluid of guinea pigs was studied. The i.p. injection of anti-IL-5 antibody 4 h after aeroallergen challenge inhibited eosinophil infiltration in a dose-dependen...

journal_title：European journal of pharmacology

authors： Chand N,Harrison JE,Rooney S,Pillar J,Jakubicki R,Nolan K,Diamantis W,Sofia RD

更新日期：1992-01-28 00:00:00

abstract：:Eating disorders constitute major medical health problems in the western world. Even though little is known about the mechanisms behind abnormal eating behavior, it has become clear that the central nervous system (CNS), particularly the hypothalamus, plays a significant role. The anorexic anx/anx mouse is a unique mo...

journal_title：European journal of pharmacology

authors： Johansen JE,Fetissov S,Fischer H,Arvidsson S,Hökfelt T,Schalling M

更新日期：2003-11-07 00:00:00

abstract：:The potencies for in vivo inhibition of substantia nigra pars compacta dopamine single cell firing were determined for apomorphine, BHT 920, N-0923, (+/-)-7-hydroxy-dipropylaminotetralin (7-OH-DPAT), (+)-3-(3-hydroxyphenyl)-N-propylpiperidine (3-PPP), pramipexole, quinelorane, quinpirole, RU 24926, U-86170, and U-9135...

journal_title：European journal of pharmacology

authors： Kreiss DS,Bergstrom DA,Gonzalez AM,Huang KX,Sibley DR,Walters JR

更新日期：1995-04-24 00:00:00