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Effects of histamine H(1) receptor antagonists on hippocampal theta rhythm during spatial memory performance in rats.

Abstract：

:The effects of histamine H(1) receptor antagonists (promethazine, diphenhydramine, chlorphenilamine and triprolidine) on hippocampal theta rhythm during eight-arm radial maze performance were investigated using rats. Promethazine showed a significant increase in the number of total errors and working memory errors at doses of 10 and 20 mg/kg, and a significant increase was also observed in reference memory errors at a dose of 20 mg/kg. Diphenhydramine and chlorphenilamine at a dose of 20 mg/kg and triprolidine at a dose of 35 mg/kg also caused significant increases in the number of total, reference memory and working memory errors. Promethazine, diphenhydramine and chlorphenilamine, having potent anti-muscarinic receptor properties, increased hippocampal theta power during radial maze performance at a dose of 20 mg/kg. On the other hand, triprolidine, which has weak anti-muscarinic receptor properties compared with other histamine H(1) receptor antagonists, decreased theta power at a dose of 35 mg/kg. These results suggest that anti-muscarinic receptor properties rather than anti-histamine H(1) receptor properties may affect hippocampal theta power during spatial memory deficit induced by promethazine, diphenhydramine and chlorphenilamine.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Masuoka T,Mikami A,Yasuda M,Shinomiya K,Kamei C

doi

10.1016/j.ejphar.2007.08.020

subject

Has Abstract

pub_date

2007-12-08 00:00:00

pages

77-82

issue

1-3

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(07)00928-4

journal_volume

576

pub_type

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