Antagonism of the ATP component of sympathetic co-transmission in the rat vas deferens by AMP.

Abstract:

:Field stimulation of isolated rat vas deferens preparations caused a twitch contraction followed by a slower phasic contraction. Exogenously applied ATP and noradrenaline caused rapid contractions and slowly developing contractions respectively. Pretreatment with phentolamine antagonised the phasic response to stimulation and the contraction to noradrenaline. Pretreatment with AMP antagonized the twitch response to stimulation and concentrations to ATP. The results support the view that ATP is released as a co-transmitter with noradrenaline in sympathetic nerves.

journal_name

Eur J Pharmacol

authors

Satchell D

doi

10.1016/0014-2999(86)90621-7

subject

Has Abstract

pub_date

1986-12-16 00:00:00

pages

305-8

issue

2-3

eissn

0014-2999

issn

1879-0712

pii

0014-2999(86)90621-7

journal_volume

132

pub_type

杂志文章
  • Morroniside enhances angiogenesis and improves cardiac function following acute myocardial infarction in rats.

    abstract::Angiogenesis is critical for re-establishing blood supply to the ischemic myocardium after acute myocardial infarction (AMI). This study aimed to investigate the effects of morroniside on angiogenesis after AMI and explored associated proangiogenic mechanisms. A rat model of AMI was established by ligation of the left...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2020.172954

    authors: Liu T,Sun F,Cui J,Zheng S,Li Z,Guo D,Tian X,Zhu Z,Zheng W,Wang Y,Wang W

    更新日期:2020-04-05 00:00:00

  • Potent alpha-adrenoceptor action of soterenol on vascular and other smooth muscle.

    abstract::Treatment with soterenol (0.3-300 mug/kg, i.v.) increased the mean arterial blood pressure and decreased heart rate in rabbits. Soterenol caused a dose-dependent contraction of rabbit aorta and portal vein, guinea-pig vas deferens and cat nicitating membrane which was inhibited by phentolamine. Other beta-agonists suc...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(75)90163-6

    authors: Kitagawa H,Yamauchi A,Shibata S

    更新日期:1975-08-01 00:00:00

  • Pharmacological evaluation of the beta-adrenoceptor agonist and thromboxane receptor blocking properties of 1-benzyl substituted trimetoquinol analogues.

    abstract::The beta 1- and beta 2-adrenoceptor agonist and thromboxane A2 (TXA2) antagonist properties of trimetoquinol (TMQ, I) and 1-benzyl substituted TMQ analogues [3'-iodo-4',5'-dimethoxy TMQ, II; 3',5'-diiodo-4'-dimethoxy TMQ, III; 3',4'-dimethoxy-5'-nitro TMQ, IV; 3',4'-dimethoxy-5'-amino TMQ; V; and 3',4'-dimethoxy TMQ, ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(90)90663-q

    authors: Shams G,Romstedt KJ,Gerhardt MA,Harrold MW,Miller DD,Feller DR

    更新日期:1990-08-02 00:00:00

  • Parainfluenza virus type 1 reduces the affinity of agonists for muscarinic receptors in guinea-pig lung and heart.

    abstract::Membrane preparations of guinea-pig lung (containing multiple muscarinic receptor subtypes) and heart (containing M2 receptors only) were incubated with either neuraminidase, parainfluenza virus (which contains neuraminidase), or virus plus 2,3-dehydro-2-deoxy-N-acetylneuraminic acid, a neuraminidase inhibitor. None o...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(90)90244-z

    authors: Fryer AD,el-Fakahany EE,Jacoby DB

    更新日期:1990-05-31 00:00:00

  • Lack of dopamine supersensitivity in rats after chronic administration of blonanserin: Comparison with haloperidol.

    abstract::Long-term treatment with antipsychotic drugs in patients with schizophrenia can lead to dopamine supersensitivity psychosis. It is reported that repeated administration of haloperidol caused dopamine supersensitivity in rats. Blonanserin is an atypical antipsychotic drug with high affinity for dopamine D2, D3 and sero...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2018.04.014

    authors: Hashimoto T,Baba S,Ikeda H,Oda Y,Hashimoto K,Shimizu I

    更新日期:2018-07-05 00:00:00

  • Effect of chronic administration of morphine on the expression of bovine adrenal medulla 22-like immunoreactivity in the spinal cord of rats.

    abstract::The aim of the present study was to investigate the effects of chronic administration of morphine on the expression of an endogenous opioid peptide in the spinal dorsal horn. Bovine adrenal medulla 22-like immunoreactivity (BAM22-IR) was found in the superficial layers of the spinal cord. Intrathecal (i.t.) administra...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2008.06.023

    authors: Chen P,Liu Y,Hong Y

    更新日期:2008-07-28 00:00:00

  • Effect of vascular smooth muscle relaxants on the protein kinase C-mediated contraction in the rat pulmonary artery.

    abstract::In the rat pulmonary artery, phorbol 12,13-dibutyrate induces a contraction due to the activation of the protein kinase C. We investigated the sensitivity of this protein kinase C-mediated contraction to a variety of vascular smooth muscle relaxants. Pretreatment of rat pulmonary artery with relaxant compounds altered...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(93)90432-h

    authors: Savineau JP,Gonzalez De La Fuente P,Marthan R

    更新日期:1993-11-09 00:00:00

  • 12-Deoxyphorbol 13-palmitate mediated cell growth inhibition, G2-M cell cycle arrest and apoptosis in BGC823 cells.

    abstract::The highly toxic monomer 12-deoxyphorbol 13-palmitate (G) was extracted from the roots of Euphorbia fischeriana. Our experimental data confirmed studies showing that 12-deoxyphorbol 13-palmitate had certain antitumor activities. The MTT method, soft agar experiments, and nude mouse tumor experiments proved that 12-deo...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2012.11.015

    authors: Xu HY,Chen ZW,Li H,Zhou L,Liu F,Lv YY,Liu JC

    更新日期:2013-01-30 00:00:00

  • Molecular orbital study on the glutathione-dependent detoxication of ozonides.

    abstract::The present paper describes a theoretical study on the mechanism underlying the reaction of cellular glutathione (GSH) with polyunsaturated fatty acid ozonides. The reaction can be catalyzed by glutathione S-transferases and leads to detoxication of the ozonides. Semi-empirical molecular orbital computer calculations ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0926-6917(92)90031-7

    authors: Hempenius RA,de Vries J,Rietjens IM

    更新日期:1992-12-01 00:00:00

  • Role of glutathione metabolism in the glutamate-induced programmed cell death of neuronal-like PC12 cells.

    abstract::In addition to its well-known interaction with ionotropic and metabotropic receptors, glutamate may, at high concentrations, interfere with a cystine-glutamate antiport designated as Xc- and lead to a significant decrease in cystine uptake and intracellular glutathione level. These effects, in turn, may induce death i...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(97)00155-6

    authors: Froissard P,Monrocq H,Duval D

    更新日期:1997-05-12 00:00:00

  • The adenosine A1 receptor agonist N6-cyclopentyladenosine blocks the disruptive effect of phencyclidine on prepulse inhibition of the acoustic startle response in the rat.

    abstract::Systemic administration of the NMDA receptor antagonist phencyclidine (PCP; 4 mg/kg) produced a profound reduction in prepulse inhibition of the acoustic startle response in rats. Pre-treatment with the selective adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) blocked (0.5 mg/kg) or attenuated (0.1 and 0.2...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(99)00088-6

    authors: Sills TL,Azampanah A,Fletcher PJ

    更新日期:1999-03-26 00:00:00

  • Effects of resveratrol on calcium regulation in rats with severe acute pancreatitis.

    abstract::Intracellular calcium overload plays a key role in severe acute pancreatitis. Resveratrol can decrease the severity of pancreatitis; however, the mechanism of action of resveratrol has not been determined. The aim of our study was to examine the relationship between calcium overload and the effects of resveratrol in s...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2007.10.068

    authors: Wang L,Ma Q,Chen X,Sha H,Ma Z

    更新日期:2008-02-02 00:00:00

  • Endomorphins 1 and 2 induce amnesia via selective modulation of dopamine receptors in mice.

    abstract::The involvement of dopamine receptors in the amnesic effects of the endogenous micro-opioid receptor agonists endomorphins 1 and 2 was investigated by observing step-down type passive avoidance learning in mice. Although the dopamine D1 receptor agonist R(+)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol hydroc...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(02)01760-0

    authors: Ukai M,Lin HP

    更新日期:2002-06-20 00:00:00

  • Myocardial and pulmonary uptake of S-1'-[18F]fluorocarazolol in intact rats reflects radioligand binding to beta-adrenoceptors.

    abstract::The biodistribution of S-(-)-4-(2-hydroxy-3-(1'-[18F]fluoroisopropyl)- aminopropoxy)carbazole ([18F]S-fluorocarazolol, a non-selective beta-adrenoceptor antagonist) was studied in rats (60 min after 18F injection when specific binding in peripheral organs was maximal). 18F uptake in brain, erythrocytes, heart and lung...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(94)00636-l

    authors: Van Waarde A,Elsinga PH,Brodde OE,Visser GM,Vaalburg W

    更新日期:1995-01-16 00:00:00

  • New adenosine A2A receptor antagonists: actions on Parkinson's disease models.

    abstract::The 8-substituted 9-ethyladenine derivatives: 8-bromo-9-ethyladenine (ANR 82), 8-ethoxy- 9-ethyladenine (ANR 94), and 8-furyl-9-ethyladenine (ANR 152) have been characterized in vitro as adenosine receptor antagonists. Adenosine is deeply involved in the control of motor behaviour and substantial evidences indicate th...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2005.01.057

    authors: Pinna A,Volpini R,Cristalli G,Morelli M

    更新日期:2005-04-11 00:00:00

  • Dopaminergic receptors in cat brain. Action of triton X-100 on [3H]spiroperidol binding and localization in relation to the synaptic region.

    abstract::[3H]Spiroperidol binding was used to assay dopaminergic receptors in synaptosomal membranes isolated from basal ganglia of cat brain. In addition to the usual filtration, a special centrifugation technique was developed which has some advantages for ligands with high non-specific binding. The specific binding to contr...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(82)90568-4

    authors: Jimenez Aguilar C,De Robertis E

    更新日期:1982-04-08 00:00:00

  • Serotonergic effects of dotarizine in coronary artery and in oocytes expressing 5-HT2 receptors.

    abstract::In strips of pig coronary arteries incubated in oxygenated Krebs-bicarbonate solution at 37 degrees C, dotarizine blocked the phasic contractions evoked by 5-HT (0.5 microM) or K+ depolarization (35 mM K+) with an IC50 of 0.22 and 3.7 microM, respectively. Flunarizine inhibited both types of contractions with IC50 val...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(97)01073-x

    authors: Montiel C,Herrero CJ,García-Palomero E,Renart J,García AG,Lomax RB

    更新日期:1997-08-06 00:00:00

  • Role of endothelin ET(A) receptors in the hypertension produced by 4-day L-nitroarginine methyl ester and cyclosporine treatment.

    abstract::Studies were designed to examine the influence of endothelin type A receptor (ETA) blockade on the hypertensive and renal response to 4 day treatment with the nitric oxide (NO) synthase inhibitor, L-nitroarginine methyl ester (L-NAME), and cyclosporine. In the first series of experiments, male Sprague-Dawley rats main...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(98)00043-0

    authors: Pollock DM,Polakowski JS,Opgenorth TJ,Pollock JS

    更新日期:1998-04-03 00:00:00

  • Psychological co-morbidities in COPD: Targeting systemic inflammation, a benefit for both?

    abstract::COPD is a chronic lung disease characterized by persistent respiratory symptoms and airflow limitation due to airway and/or alveolar abnormalities. Furthermore, COPD is often characterized by extrapulmonary manifestations and comorbidities worsening COPD progression and quality of life. A neglected comorbidity in COPD...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ejphar.2018.10.001

    authors: Pelgrim CE,Peterson JD,Gosker HR,Schols AMWJ,van Helvoort A,Garssen J,Folkerts G,Kraneveld AD

    更新日期:2019-01-05 00:00:00

  • Effects of endothelin ETA receptor antagonism with PD 156707 on hemodynamics and renal vascular resistance in rabbits.

    abstract::The objective of this study was to determine the in vivo effectiveness of the selective endothelin ETA receptor antagonist PD 156707 (sodium 2-benzo[1,3]dioxol-5-yl-4-(4-methoxy-phenyl)-4-oxo-3-(3,4,5-trimet hoxy- benzyl)-but-2-enoate). Effectiveness was defined by the ability of the compound to block increases in ren...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(96)00954-5

    authors: Ignasiak DP,McClanahan TB,Saganek LJ,Potoczak RE,Hallak H,Gallagher KP

    更新日期:1997-03-05 00:00:00

  • Troglitazone prevents insulin dependent diabetes in the non-obese diabetic mouse.

    abstract::Troglitazone has recently been introduced in the treatment of Type 2 diabetes. In addition to its anti-diabetic effects it acts as a perixosome proliferator activated receptor-gamma (PPAR-gamma) agonist and has anti-inflammatory properties by inhibiting macrophage tumour necrosis factor-alpha (TNF-alpha) secretion. It...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(98)00574-3

    authors: Beales PE,Liddi R,Giorgini AE,Signore A,Procaccini E,Batchelor K,Pozzilli P

    更新日期:1998-09-18 00:00:00

  • Role of Cl(-) channels in alpha-adrenoceptor-mediated vasoconstriction in the anesthetized rat.

    abstract::In vitro studies have provided evidence that Cl(-) ion currents are important for activation of vascular smooth muscle contraction. The stilbene, 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS), disrupts Cl(-) metabolism by blocking Cl(-) channels and by inhibiting Cl(-) bicarbonate exchange. The aims of thi...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(00)00471-4

    authors: Lamb FS,Kooy NW,Lewis SJ

    更新日期:2000-08-11 00:00:00

  • Effects of a dual L/N-type Ca(2+) channel blocker cilnidipine on neurally mediated chronotropic response in anesthetized dogs.

    abstract::We investigated the effects of an L-type and N-type Ca(2+) channel blocker, cilnidipine, on neurally mediated chronotropic responses to clarify the anti-autonomic profile of cilnidipine in anesthetized dogs. Pretreatment with cilnidipine (0.3, 1.0 and 3.0 microg/kg, i.v.), which decreased mean blood pressure by 5 to 3...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(01)00738-5

    authors: Konda T,Takahara A,Maeda K,Dohmoto H,Yoshimoto R

    更新日期:2001-02-09 00:00:00

  • Discrepancies in characterization of sigma sites in the mouse central nervous system.

    abstract::The characteristics of [3H](+)-pentazocine and [3H]1,3-di(2-tolyl) guanidine (DTG) binding to mouse whole brain, cortex, cerebellum and spinal cord membranes were investigated in radioreceptor assays. [3H](+)-Pentazocine bound to a single, high affinity site (Kd = 1.2-1.6 nM) with increasing density along the neuraxis...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(95)00383-v

    authors: Kovács KJ,Larson AA

    更新日期:1995-10-16 00:00:00

  • Agonists and protein kinase C-activation induce phosphorylation and internalization of FFA1 receptors.

    abstract::FFA1 (previously known as GPR40) is a free fatty acid receptor involved in the regulation of inflammatory processes and insulin secretion. The cellular actions resulting from FFA1 activation have received considerable attention. However, little is known on the regulation of the receptor function. In the present work, ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2015.10.038

    authors: Sosa-Alvarado C,Hernández-Méndez A,Romero-Ávila MT,Sánchez-Reyes OB,Takei Y,Tsujimoto G,Hirasawa A,García-Sáinz JA

    更新日期:2015-12-05 00:00:00

  • Regulatory role of the dopamine and norepinephrine transporters in pentylenetetrazol-kindled mice: association with effect of antidepressants.

    abstract::In clinical practice, patients with epilepsy are frequently associated with psychiatric disorders, including cognitive impairment, depression, and attention deficit hyperactivity disorder. In fact, patients with epilepsy often take centrally acting drugs, such as antidepressants and anxiolytics; however, it remains un...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2011.10.017

    authors: Takechi K,Suemaru K,Kawasaki H,Araki H

    更新日期:2011-12-30 00:00:00

  • Factors affecting the transition of acute kidney injury to chronic kidney disease: Potential mechanisms and future perspectives.

    abstract::Acute kidney injury (AKI) is defined as a rapid loss of kidney function characterised by inflammation and cell death, ultimately leading to further functional and structural renal alterations. Based on experimental and epidemiological pieces of evidence, AKI may progress to chronic kidney disease (CKD) even after a re...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ejphar.2019.172711

    authors: Ogbadu J,Singh G,Aggarwal D

    更新日期:2019-12-15 00:00:00

  • Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats.

    abstract::In neuropathic rats sensitive to phentolamine (alpha-adrenoreceptor antagonist, 2 mg/kg, i.p.), prazosin (alpha1-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) significantly attenuated cold allodynia whereas yohimbine (alpha2-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) had no significant effect. In neuropathic rats insen...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2005.08.030

    authors: Kim SK,Min BI,Kim JH,Hwang BG,Yoo GY,Park DS,Na HS

    更新日期:2005-10-31 00:00:00

  • Characterization of the cloned guinea pig leukotriene B4 receptor: comparison to its human orthologue.

    abstract::A cDNA clone coding for the guinea pig leukotriene B4 (BLT) receptor has been isolated from a lung cDNA library. The guinea pig BLT receptor has an open reading frame corresponding to 348 amino acids and shares 73% and 70% identity with human and mouse BLT receptors, respectively. Scatchard analysis of membranes prepa...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(99)00514-2

    authors: Boie Y,Stocco R,Sawyer N,Greig GM,Kargman S,Slipetz DM,O'Neill GP,Shimizu T,Yokomizo T,Metters KM,Abramovitz M

    更新日期:1999-09-10 00:00:00

  • AMPA-induced Ca(2+) influx in cultured rat cortical nonpyramidal neurones: pharmacological characterization using fura-2 microfluorimetry.

    abstract::Immunocytochemical and Co(2+) uptake studies revealed that in primary cultures of rat cortical neurones, the majority of neurones are gamma-aminobutyric acid (GABA) immunopositive and can express Ca(2+)-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors. By fura-2 microfluorimetry, it...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(02)01296-7

    authors: Fischer W,Franke H,Scheibler P,Allgaier C,Illes P

    更新日期:2002-03-01 00:00:00