Antagonism of the ATP component of sympathetic co-transmission in the rat vas deferens by AMP.

abstract：:The present study was performed to clarify the mechanism of change in intraocular pressure by 2-(1-hexyn-1-yl)adenosine (2-H-Ado), a selective adenosine A2 receptor agonist, in rabbits. 2-H-Ado (0.1%, 50 microl)-induced ocular hypertension (E(max): 7.7 mm Hg) was inhibited by an adenosine A2A receptor antagonist 1,3,7...

journal_title：European journal of pharmacology

authors： Konno T,Uchibori T,Nagai A,Kogi K,Nakahata N

更新日期：2005-08-22 00:00:00

abstract：:D,L-Propranolol given in single doses by gavage or s.c. injection to awake rats, always slowed the heart without affecting blood pressure. Doses of 0.2 mg/100 g injected twice daily lowered systolic pressure after 3 days in DOCA hypertensive but not in normotensive or spontaneously hypertensive rats. When chronic trea...

journal_title：European journal of pharmacology

authors： Buñag RD

更新日期：1977-06-15 00:00:00

abstract：:We investigated the involvement of p160ROCK (a Rho-associated coiled coil-forming protein kinase), one of Rho kinases on superoxide anion production (O(2)(-) production), aggregation and adhesion of human polymorphonuclear leukocytes under physiological condition, using a selective p160ROCK inhibitor, (+)-(R)-trans-4-...

journal_title：European journal of pharmacology

authors： Kawaguchi A,Ohmori M,Harada K,Tsuruoka S,Sugimoto K,Fujimura A

更新日期：2000-09-08 00:00:00

abstract：:The effects of the enantiomers of clenbuterol were compared in four psychopharmacological tests in which beta-adrenergic agonists are known to be active. In mice (+/-)-clenbuterol 0.06 mg/kg decreased motor activity and antagonized the hypothermia induced by 16 mg/kg of apomorphine; at 0.5 mg/kg it increased head-twit...

journal_title：European journal of pharmacology

authors： Martin P,Puech AJ,Brochet D,Soubrié P,Simon P

更新日期：1985-10-29 00:00:00

abstract：:Apomorphine-induced locomotor stimulation was investigated in the developing rat following injection with 6-hydroxydopa at birth. Treatment with 6-hydroxydopa potentiated locomotor responsiveness to apomorphine in the 20-day-old rat. The 6-hydroxydopa-treated animal at 30 days, however, was less sensitive to the drug ...

journal_title：European journal of pharmacology

authors： Nomura Y,Segawa T

更新日期：1978-07-15 00:00:00

abstract：:The relationship between morphine tolerance and pituitary-adrenocortical activity was examined. In rats made tolerant to morphine by implantation of morphine-containing pellets, there was a significant reduction in plasma levels of beta-endorphin-like immunoreactivity (beta-END-LI), whereas no significant changes in c...

journal_title：European journal of pharmacology

authors： Antonio Martínez J,Vargas ML,Fuente T,Del Rio Garcia J,Milanés MV

更新日期：1990-06-21 00:00:00

abstract：:A novel compound, FR64822(N-(4-pyridylcarbamoyl)amino 1,2,3,6,-tetrahydropyridine), displays antinociceptive activities in a variety of assays with mice and rats. It has a strong antinociceptive activity in the acetic acid writhing test (ED50 = 1.8 mg/kg p.o.), whereas it has little antinociceptive activity in the tai...

journal_title：European journal of pharmacology

authors： Ohkubo Y,Nomura K,Yamaguchi I

更新日期：1991-11-05 00:00:00

abstract：:We have confirmed our earlier finding that most red wines are able to bring about 5-hydroxytryptamine (5-HT, serotonin) release from platelets in vitro. Platelets from individual subjects manifested varying degrees of releasing ability but responded to different wines with a similar rank ordering. There was a high cor...

journal_title：European journal of pharmacology

authors： Pattichis K,Louca LL,Jarman J,Sandler M,Glover V

更新日期：1995-01-13 00:00:00

abstract：:Helicobacter pylori (H. pylori) and nonsteroidal anti-inflammatory drugs (NSAID) are the most common pathogens in the gastroduodenal mucosa in animals and humans, but their relationship in ulcerogenesis has been little studied. According to some authors, H. pylori infection in humans does not act synergistically with ...

journal_title：European journal of pharmacology

authors： Pawlik T,Konturek PC,Konturek JW,Konturek SJ,Brzozowski T,Cześnikiewicz M,Plonka M,Bielanski W,Areny H

更新日期：2002-08-02 00:00:00

abstract：:This review focuses on alpha(1)-adrenoceptor phosphorylation and function. Most of what is currently known is based on studies on the hamster alpha(1B)-adrenoceptor. It is known that agonist stimulation leads to homologous desensitization of these receptors and current evidence indicates that such decrease in receptor...

journal_title：European journal of pharmacology

authors： García-Sáinz JA,Vázquez-Prado J,del Carmen Medina L

更新日期：2000-02-11 00:00:00

abstract：:Gastric vascular responses to histamine and its selective H1- and H2-agonists in vitro were investigated in the isolated vascular-perfused stomach of rabbit and rat. In the rabbit stomach under resting conditions bolus injection of histamine (5-80 nmol) caused a small increase in perfusion pressure (PP). However, duri...

journal_title：European journal of pharmacology

authors： Salvati P,Whittle BJ

更新日期：1983-04-22 00:00:00

abstract：:Partial bladder outlet obstruction of the pig is considered as a valuable preclinical model for evaluating the profile of compounds for the treatment of bladder overactivity. In this study, we characterized the pharmacological properties of isolated bladder smooth muscle from pigs following partial outlet obstruction ...

journal_title：European journal of pharmacology

authors： Milicic I,Buckner SA,Daza A,Coghlan M,Fey TA,Brune ME,Gopalakrishnan M

更新日期：2006-02-17 00:00:00

abstract：:Inhibition of local cortisol regeneration from circulating cortisone by blocking 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) has been shown to ameliorate the risk factors associated with the metabolic syndrome. Chronic modulation of glucocorticoid homeostasis may result in hypothalamic-pituitary-adrenal (HPA) axis s...

journal_title：European journal of pharmacology

authors： Hamilton BS,Schoelch C,Schuler-Metz A,Krosky P,Lala DS,Claremon DA,McGeehan GM

更新日期：2016-10-15 00:00:00

abstract：:Using a batch method for incubation of hippocampal slices, we have examined the effects of 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (RU24969) and (m-trifluoromethylphenyl)piperazine (TFMPP) on release of endogenous 5-hydroxytryotamine (5-HT). Release of 5-HT from slices was enhanced by RU24969 and TFMPP ...

journal_title：European journal of pharmacology

authors： Auerbach SB,Kamalakannan N,Rutter JJ

更新日期：1990-11-06 00:00:00

abstract：:The effects of intraperitoneal injections of two opioid antagonists on plasma corticosterone levels in stressed mice was investigated. The effects of the mu-opioid receptor antagonist naloxone was dependent on the dose used. Low doses (0.5 and 1 mg/kg) potentiated the elevation of plasma corticosterone observed in sal...

journal_title：European journal of pharmacology

authors： Kitchen I,Rowan KM

更新日期：1984-05-18 00:00:00

abstract：:The effect of the non-selective antagonist of excitatory amino acid receptors kynurenic acid (50, 100 and 150 mg/kg, i.p.) on morphine-derived reward was studied in rats. Kynurenic acid dose dependently blocked the acquisition of morphine conditioned place preference when injected before conditioning. The expression o...

journal_title：European journal of pharmacology

authors： Bespalov A,Dumpis M,Piotrovsky L,Zvartau E

更新日期：1994-11-03 00:00:00

abstract：:Platelet serotonin (5HT) uptake was measured in 18 subjects administered physostigmine salicylate in a double-blind, placebo crossover design. In comparison to placebo, the drug caused a significant transient depression in mood, as measured by self- and observer-rated depression scores. In addition, physostigmine sign...

journal_title：European journal of pharmacology

authors： Rausch JL,Janowsky DS,Risch SC,Huey LY

更新日期：1985-02-12 00:00:00

abstract：:The effects of endothelin, a potent endogenous vasoconstrictor peptide, were examined in a range of vascular and non-vascular tissues. At concentrations that cause vasoconstriction in portal vein and aorta, the peptide strongly contracted rat uterus, trachea and vas deferens, but not guinea pig ileum. Nifedipine, a di...

journal_title：European journal of pharmacology

authors： Borges R,Von Grafenstein H,Knight DE

更新日期：1989-06-20 00:00:00

abstract：:Clinical and experimental data indicate that the cerebral cortex plays an important role in pain perception and endogenous antinociceptive system function. Moreover, the enhancement of descending inhibitory cortical control may be involved in the mechanisms of analgetic effect of some agents. The present study was des...

journal_title：European journal of pharmacology

authors： Kharkevich DA,Churukanov VV

更新日期：1999-06-30 00:00:00

abstract：:Recent studies have shown that many organophosphates can bind competitively and noncompetitively to membrane muscarinic receptors. The present study investigated the responses of the rat aortic rings to diisopropyl-flurophosphate (DFP), an organophsophorus cholinesterase inhibitor, and the possible involvement of musc...

journal_title：European journal of pharmacology

authors： Lim SL,Sim MK,Loke WK

更新日期：2000-09-22 00:00:00

abstract：:Several studies have recently suggested a principal role of adenosine in the pathogenesis of radiocontrast media-induced nephropathy. In the present experiments, we therefore investigated the renal protective effects of 8-(noradamantan-3-yl)-1,3-dipropylxanthine (KW-3902), a potent and selective adenosine A1 receptor ...

journal_title：European journal of pharmacology

authors： Yao K,Heyne N,Erley CM,Risler T,Osswald H

更新日期：2001-02-23 00:00:00

abstract：:The effects of trichokonin VI (= gliodeliquescin A), a peptaibol isolated from the culture broth of Trichoderma koningii Oudemans, on L-type Ca2+ channel currents in single bullfrog atrial cells were investigated. Our results showed that trichokonin VI is a new potent agonist of L-type Ca2+ channels in cardiac membran...

journal_title：European journal of pharmacology

authors： Huang Q,Tezuka Y,Kikuchi T,Momose Y

更新日期：1994-12-12 00:00:00

abstract：:Astrocytes have been shown to release factors that affect various aspects of neuronal development. We have previously shown that the acetylcholine analog carbachol, by activating muscarinic M(3) receptors in rat astrocytes, increases their ability to promote neuritogenesis in hippocampal neurons. This effect was media...

journal_title：European journal of pharmacology

authors： Guizzetti M,Moore NH,VanDeMark KL,Giordano G,Costa LG

更新日期：2011-06-01 00:00:00

abstract：:Cachexia is the main cause of mortality in advanced cancer patients. We investigated the effects of insulin (INS) and glutamine dipeptide (GDP), isolated or associated, on cachexia and metabolic changes induced by Walker 256 tumor in rats. INS (NPH, 40 UI/kg, sc) or GDP (1.5g/kg, oral gavage) was once-daily administer...

journal_title：European journal of pharmacology

authors： de Morais H,de Fatima Silva F,da Silva FG,Silva MO,Graciano MFR,Martins MIL,Carpinelli ÂR,Mazucco TL,Bazotte RB,de Souza HM

更新日期：2017-07-05 00:00:00

abstract：:Previous studies have demonstrated that Fos-like immunoreactivity is increased in spinal dorsal horn neurons in several pain models, and have suggested that Fos-like immunoreactivity could be used as a marker of neurons activated by painful stimulation. In the present study, we evaluated nociceptive behaviors and spin...

journal_title：European journal of pharmacology

authors： Zhu CZ,Nikkel AL,Martino B,Bitner RS,Decker MW,Honore P

更新日期：2006-02-15 00:00:00

abstract：:Intravenous administration of E. coli lipopolysaccharide (LPS) inhibited the migration of neutrophils into the pleural cavity that occurs following challenge with intrapleural carrageenin. Treatment of animals with levamisole (10 mg/kg i.p.) 30 min after the intravenous administration of LPS almost restored carrageeni...

journal_title：European journal of pharmacology

authors： Rocha NP,Ferreira SH

更新日期：1986-03-11 00:00:00

abstract：:The functions of the 5-HT(4) receptor in the gastrointestinal tract are complex, depending on the species and anatomical regions, and localization of the receptor was not clear. The present study attempted to examine the localization of the 5-HT(4) receptor in the colon of human for comparison with that in guinea pig ...

journal_title：European journal of pharmacology

authors： Sakurai-Yamashita Y,Yamashita K,Kanematsu T,Taniyama K

更新日期：1999-11-03 00:00:00

abstract：:The effects of protein kinase C (PKC) activators on gamma-aminoburyric acid (GABA) rho 1 receptor function were studied in rho 1 -expressing Xenopus oocytes. The PKC activator phorbol 12-myristate 13-acetate (PMA) but not the inactive analog phorbol 12-mono-myristate inhibited the GABA-gated chloride currents. Mezerei...

journal_title：European journal of pharmacology

authors： Kusama T,Sakurai M,Kizawa Y,Uhl GR,Murakami H

更新日期：1995-11-30 00:00:00

abstract：:Cyclosporin A is shown to attenuate antinociceptive effects of morphine, development and expression of morphine-induced tolerance and dependency via nitric oxide (NO) pathway. In the present study, the effect of systemic cyclosporin A on morphine-induced conditioned place preference (CPP) and the probable involvement ...

journal_title：European journal of pharmacology

authors： Motiei Langroudi R,Khoshnoodi MA,Abadi NY,Tahsili Fahadan P,Ghahremani MH,Dehpour AR

更新日期：2005-01-10 00:00:00

abstract：:Electrically stimulated release of [3H]dopamine [( 3H]DA) in slices of rat striatum was dose dependently inhibited by apomorphine (67% maximal inhibition) with an EC50 of 17 nM. DA receptor inactivation with N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ; 0.5 and 2 mg/kg) dose dependently shifted the ED50 for ap...

journal_title：European journal of pharmacology

authors： Yokoo H,Goldstein M,Meller E

更新日期：1988-10-18 00:00:00