Abstract：
:(+/-)3,4-Methylenedioxymethamphetamine (MDMA) was administered to rats as a single 40 mg/kg injection s.c. or 40 mg/kg s.c. every second day for 4 injections. Sixteen days following the last injection rats were killed. MDMA produced significant depletions of 5-HT and its metabolite 5-HIAA in the hippocampus and the frontal cortex. 5-HT was depleted to 30% of control value in the hippocampus following a single dose. 5-HT levels were not affected in the hypothalamus, suggesting differential effects on brain 5-HT systems. DA levels in the hypothalamus were significantly increased while NE levels in the frontal cortex were decreased to 73% of control following 4 doses of MDMA. MDMA, therefore, produces long-term depletions in 5-HT which suggests that it may act as a neurotoxin at 5-HT neurons in the brain of rats.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Mokler DJ,Robinson SE,Rosecrans JAdoi
10.1016/0014-2999(87)90441-9subject
Has Abstractpub_date
1987-06-19 00:00:00pages
265-8issue
2eissn
0014-2999issn
1879-0712pii
0014-2999(87)90441-9journal_volume
138pub_type
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