[3H]rauwolscine labels alpha 2-adrenoceptors and 5-HT1A receptors in human cerebral cortex.

abstract：:This study examined the potential of the selective extra-synaptic α5-GABAA receptor inhibitor S44819 (Egis-13529) to improve cognitive performance in preclinical models of vascular cognitive impairment (VCI). Chronic hypoperfusion of the brain in mice was induced by permanent occlusion of the right common carotid arte...

journal_title：European journal of pharmacology

authors： Gacsályi I,Móricz K,Gigler G,Megyeri K,Machado P,Antoni FA

更新日期：2018-09-05 00:00:00

abstract：:Serotonergic and dopaminergic involvement in hyperthermia induced by a serotonin (5-hydroxytryptamine, 5-HT)-releasing drug, p-chloroamphetamine, was investigated in mice. Neither the 5-HT transporter inhibitor fluoxetine nor the 5-HT depleter p-chlorophenylalanine affected p-chloroamphetamine-induced hyperthermia. Th...

journal_title：European journal of pharmacology

authors： Sugimoto Y,Ohkura M,Inoue K,Yamada J

更新日期：2001-11-02 00:00:00

abstract：:Pyrethroid insecticides have been reported to increase transmembrane sodium influx and inhibit ion-dependent ATPases in insect, squid, and toad nerve tissues. Since changes in sarcolemmal ion fluxes and inhibition of membrane-bound ATPases can alter myocardial contractility, the effects of a potent synthetic pyrethroi...

journal_title：European journal of pharmacology

authors： Berlin JR,Akera T,Brody TM,Matsumura F

更新日期：1984-03-02 00:00:00

abstract：:The effects of acute chronic administration of tricyclic antidepressants on the pituitary-adrenal axis were studied in adult male rats. Acute administration of desipramine, imipramine and chlorimipramine activated the pituitary-adrenal axis. The effect of imipramine was found to be of short duration with a significant...

journal_title：European journal of pharmacology

authors： Armario A,García-Marquez C

更新日期：1987-08-11 00:00:00

abstract：:The inhibitors of advanced glycation endproduct and oxidative stress, as well as N-methyl-d-aspartate (NMDA) receptor antagonists have received considerable interest because of their close association with renoprotective effects. The therapeutic potential of 20(S)-ginsenoside Rg(3) (20(S)-Rg(3)), isolated from Panax g...

journal_title：European journal of pharmacology

authors： Kang KS,Yamabe N,Kim HY,Park JH,Yokozawa T

更新日期：2008-09-04 00:00:00

abstract：:The existence of neurogenic mediator candidates apart from noradrenaline and acetylcholine involved in the control of vascular tone has attracted enormous attention during the past few decades. One such mediator is neuropeptide Y (NPY), which is co-localized with noradrenaline in sympathetic perivascular nerves. Stimu...

journal_title：European journal of pharmacology

authors： Franco-Cereceda A,Liska J

更新日期：1998-05-15 00:00:00

abstract：:In myopathic BIO 8262-hamsters beta1-adrenergic stimulation of cardiac adenylyl cyclase has been found to be markedly reduced compared to that of healthy controls. In order to test the hypothesis that the functional uncoupling of beta1-adrenoceptors in diseased hamster hearts is due to agonist-dependent desensitizatio...

journal_title：European journal of pharmacology

authors： Witte K,Kinzler N,Schnecko A,Olbrich HG,Lemmer B

更新日期：1997-09-10 00:00:00

abstract：:The impairment of arterial baroreceptor and vasodilator functions are two major contributors to the hypertensive action of cyclosporine (CSA). In this study, in vivo and in vitro pharmacological studies were performed to investigate whether these effects of CSA are differentially modulated by endothelin and thromboxan...

journal_title：European journal of pharmacology

authors： Nasser SA,Elmallah AI,Sabra R,Khedr MM,El-Din MM,El-Mas MM

更新日期：2014-03-15 00:00:00

abstract：:The present study investigated the effect of acidosis (reduction in pH of the Krebs' solution from 7.4 to 6.9) on responses to vasoconstrictors and vasodilators, with a focus on purines, in the rat isolated perfused mesenteric arterial bed. alpha,beta-Methylene ATP (alpha,beta-meATP) (10 microM), a selective P2X recep...

journal_title：European journal of pharmacology

authors： Ralevic V

更新日期：2000-10-06 00:00:00

abstract：:Membrane currents in response to the application of alpha, beta-methylene ATP (alpha,beta-meATP) were recorded by the whole-cell patch-clamp technique in human embryonic kidney 293 cells transfected with the human P2X3 receptor (HEK 293-hP2X3 cells). Trichloroethanol, the biologically active metabolite of chloral hydr...

journal_title：European journal of pharmacology

authors： Köles L,Wirkner K,Fürst S,Wnendt S,Illes P

更新日期：2000-12-15 00:00:00

abstract：:The present study was to investigate the neuroprotective efficacy and mechanism of Forsythoside B. Male Sprague-Dawley rats were subjected to middle cerebral artery occlusion for 1 h followed by reperfusion for 23 h. Rats received an intravenous bolus injection of Forsythoside B at 15 min after reperfusion. The result...

journal_title：European journal of pharmacology

authors： Jiang WL,Tian JW,Fu FH,Zhu HB,Hou J

更新日期：2010-08-25 00:00:00

abstract：:We employed an ex vivo [(3)H]rolipram binding experiment to elucidate the mechanism of emetic activity of phosphodiesterase 4 inhibitors. In Suncus murinus (an insectivore used for evaluation of emesis), emetic potential as well as ability to occupy the high-affinity rolipram binding site in brain membrane fraction in...

journal_title：European journal of pharmacology

authors： Hirose R,Manabe H,Nonaka H,Yanagawa K,Akuta K,Sato S,Ohshima E,Ichimura M

更新日期：2007-11-14 00:00:00

abstract：:We used in vitro autoradiography to identify the endothelin-1 receptor subtype(s) in the superficial gray layer of the superior colliculus of rats. These studies showed dense binding of (3-[125I]iodotyrosyl13)-[Ala11,15]Ac-endothelin-1-(6-2 1) (BQ3020) (for endothelin ETB receptors), while tissues incubated with [125I...

journal_title：European journal of pharmacology

authors： D'Amico M,Di Filippo C,Rossi F

更新日期：1998-04-17 00:00:00

abstract：:Iron-mediated oxidative stress has been recognized as one of the leading causes of chronic kidney injury. The effect of L-type calcium channel (LTCC) blocker on iron overload has been shown in cardiomyocytes, liver cells, and nerve cells. So far, few studies have examined whether blockers improve kidney iron-mediated ...

journal_title：European journal of pharmacology

authors： Sun L,Lin X,Pornprasert S,Lü X,Ran B,Lin Y

更新日期：2020-11-05 00:00:00

abstract：:A number of neurosteroids exert antiseizure and/or neuroprotective properties. The aim of this study was to evaluate the effect of the neurosteroid alphaxalone on the protective action of conventional antiepileptics in four seizure tests. Alphaxalone (up to 5 mg/kg) did not exert a significant action against amygdala-...

journal_title：European journal of pharmacology

authors： Borowicz KK,Zadrozniak M,Swiader M,Kowalska A,Kleinrok Z,Czuczwar SJ

更新日期：2002-08-02 00:00:00

abstract：:Several major antiepileptic drugs, including carbamazepine, phenytoin and phenobarbital, induce xenobiotic metabolizing enzymes via activation of nuclear receptors, including pregnane X receptor (NR1I2) and constitutive androstane receptor (NR1I3). Via activation of these xenobiotic sensors, antiepileptic drugs may al...

journal_title：European journal of pharmacology

authors： Ambroziak K,Kuteykin-Teplyakov K,Luna-Tórtos C,Al-Falah M,Fedrowitz M,Löscher W

更新日期：2010-02-25 00:00:00

abstract：:4,6,6-Trimethylcaprolactam antagonised GABAA receptor-mediated contractile responses in guinea-pig isolated ileum, displacing the GABA dose-response curve to the right in a non-parallel manner, and causing a depression of the maximum response. Pentobarbitone not only potentiated the GABAA receptor-mediated contraction...

journal_title：European journal of pharmacology

authors： Kerr DI,Ong J,Prager RH,Ward DA

更新日期：1986-05-13 00:00:00

abstract：:The present paper describes a theoretical study on the mechanism underlying the reaction of cellular glutathione (GSH) with polyunsaturated fatty acid ozonides. The reaction can be catalyzed by glutathione S-transferases and leads to detoxication of the ozonides. Semi-empirical molecular orbital computer calculations ...

journal_title：European journal of pharmacology

authors： Hempenius RA,de Vries J,Rietjens IM

更新日期：1992-12-01 00:00:00

abstract：:Allosterism between gamma-aminobutyric acid (GABA), benzodiazepine and picrotoxinin recognition sites on the GABAA receptor was studied in primary cultures of cerebellar granule cells. The increase in [3H]flunitrazepam binding induced by GABA was inhibited by bicuculline and picrotoxinin and the decrease in [35S]t-but...

journal_title：European journal of pharmacology

authors： Vale C,Pomés A,Rodríguez-Farré E,Suñol C

更新日期：1997-01-29 00:00:00

abstract：:We investigated the effects of L-arginine and NG-nitro-L-arginine methyl ester (L-NAME) on macromolecule extravasation in the microcirculation of awake hamsters by computer-assisted image analysis of the distribution of FITC (fluorescein isothiocyanate)-dextran fluorescence in dorsal fold skin preparations. This analy...

journal_title：European journal of pharmacology

authors： Gimeno G,Carpentier PH,Desquand-Billiald S,Hanf R,Finet M

更新日期：1998-04-10 00:00:00

abstract：:Cetiedil is a potent blocker of acetylcholine and choline fluxes. Several analogs of this compound have been synthesized and their effect on acetylcholine (ACh) and choline fluxes in synaptosomes and on ACh uptake in synaptic vesicles have been studied. The effects of these analogs were compared to those of other drug...

journal_title：European journal of pharmacology

authors： Gaudry-Talarmain YM,Diebler MF,Robba M,Lancelot JC,Lesbats B,Israël M

更新日期：1989-08-03 00:00:00

abstract：:H89 (N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide) is a compound characterized in vitro as a potent and selective inhibitor of protein kinase A (PKA). In this study, we found that H89 reduced the phosphorylation of the myosin regulatory light chain (MRLC) at Thr-18/Ser-19 and induced disassembly of stre...

journal_title：European journal of pharmacology

authors： Umeda D,Yamada K,Tachibana H

更新日期：2008-08-20 00:00:00

abstract：:Schedule-induced polydipsia occurs when food-deprived rats are exposed to a fixed-interval feeding schedule (FI = 60 s) for 1 h every day. Amperozide, a novel antipsychotic drug with a strong affinity for the 5-HT2 receptor, was injected i.p. after completion of the requisite training sessions. The experimental ration...

journal_title：European journal of pharmacology

authors： Tung CS,Wu WH,Tseng CJ,Yin TH

更新日期：1994-04-21 00:00:00

abstract：:The present study investigated the role of histamine H(3) and H(4) receptors in gastric mucosal defense, by the use of selective ligands. Firstly, the affinities of several histaminergic agonists for the rat histamine H(3) and H(4) receptors were checked in HEK 293T cells transfected with either receptor subtype. Next...

journal_title：European journal of pharmacology

authors： Coruzzi G,Adami M,Pozzoli C,de Esch IJ,Smits R,Leurs R

更新日期：2011-11-01 00:00:00

abstract：:The inhibitory effects of a hypotensive agent, cadralazine and its metabolite, ISF-2405, on the level of cytosolic Ca2+ ([Ca2+]cyt) and on contractions were examined in isolated vascular smooth muscle. Cadralazine slightly inhibited the transient norepinephrine-induced contraction in rabbit aorta and canine femoral, r...

journal_title：European journal of pharmacology

authors： Mitsui M,Nakao K,Inukai T,Karaki H

更新日期：1990-03-20 00:00:00

abstract：:Cordycepin, (3'-deoxyadenosine), a bioactive compound of Cordyceps militaris, has been shown to exhibit many pharmacological actions, such as anti-inflammatory, antioxidative and anticancer activities. Little is known about the neuroprotective action of cordycepin as well as its molecular mechanisms. In this study, co...

journal_title：European journal of pharmacology

authors： Cheng Z,He W,Zhou X,Lv Q,Xu X,Yang S,Zhao C,Guo L

更新日期：2011-08-16 00:00:00

abstract：:Corticotropin-releasing factor (CRF) regulates the hypothalamic-pituitary-adrenal axis, coordinates the mammalian stress response, and acting primarily via the CRF(1) receptor, has been strongly implicated in the pathophysiology of depression and anxiety. Furthermore, the behavioral and autonomic activation that occur...

journal_title：European journal of pharmacology

authors： Skelton KH,Oren D,Gutman DA,Easterling K,Holtzman SG,Nemeroff CB,Owens MJ

更新日期：2007-09-24 00:00:00

abstract：:B cell antigen presentation, cytokine production, and antibody production are targets of pharmacological intervention in inflammatory and infectious diseases. Here we review recent pre-clinical evidence demonstrating that pharmacologically relevant levels of n-3 polyunsaturated fatty acids (PUFA) derived from marine f...

journal_title：European journal of pharmacology

authors： Whelan J,Gowdy KM,Shaikh SR

更新日期：2016-08-15 00:00:00

abstract：:Apoptosis or programmed cell death has been suggested as an important mode of neurodegeneration in Alzheimer's disease pathogenesis. The present study explored the neuroprotective effect of 2-ethoxy-4,5-diphenyl-1,3-oxazine-6-one (EDPOO) against H(2)O(2)-induced cell death in rat pheochromocytoma (PC12) cells. We foun...

journal_title：European journal of pharmacology

authors： Ansari N,Khodagholi F,Amini M

更新日期：2011-05-11 00:00:00

abstract：:The present study describes the effects of halothane on morphine activity in the isolated left atria of the rat. Concentration-response curves were obtained for the negative inotropic effects of morphine on electrically stimulated left atria. Morphine significantly decreased the contractile force, with an inhibitory c...

journal_title：European journal of pharmacology

authors： Laorden ML,Hernandez J,Carceles MD,Miralles FS,Puig MM

更新日期：1990-01-17 00:00:00