Caprolactam-barbiturate interaction at the GABAA receptor complex in the guinea-pig intestine.

abstract：:The aim was to find whether the chloride channel blocker, picrotoxin, at subconvulsant doses could affect the activity of imipramine or desipramine in the 'forced swimming' test with rats. It was found that picrotoxin enhanced the anti-immobility effects of imipramine and desipramine whereas open field activity remain...

journal_title：European journal of pharmacology

authors： Fernández-Teruel A,Escorihuela RM,Boix F,Tobeña A

更新日期：1990-05-31 00:00:00

abstract：:Oxidative stress is usually considered as an important factor to the pathogenesis of various diseases. Peroxynitrite (ONOO(-)) and hypochlorite (OCl(-)) are formed in immune cells as a part of the innate host defense system, but excessive reactive oxygen species generation can cause progressive inflammation and tissue...

journal_title：European journal of pharmacology

authors： Ren X,Ding Y,Lu N

更新日期：2016-03-15 00:00:00

abstract：:Treatment of rat reticulocytes with tetradecanoyl phorbol acetate (TPA), a tumor-promoting phorbol ester which activates protein kinase C, resulted in an about 50% decrease in the stimulation of adenylate cyclase activity by a subsequent challenge with a beta-adrenoceptor agonist. This phenomenon mimics agonist-induce...

journal_title：European journal of pharmacology

authors： Yamashita A,Kurokawa T,Une Y,Ishibashi S

更新日期：1988-07-07 00:00:00

abstract：:We have reported that tacrolimus (FK506), an immunosuppressive drug, and diclofenac, a non-steroidal anti-inflammatory drug, possess different modes of neuroprotective action. FK506 suppresses only thapsigargin-induced apoptosis in neuroblastoma SH-SY5Y cells while diclofenac reverses tunicamycin-induced as well as th...

journal_title：European journal of pharmacology

authors： Yamazaki T,Muramoto M,Okitsu O,Morikawa N,Kita Y

更新日期：2011-11-01 00:00:00

abstract：:The vasoactive properties of the neurokinins (substance P (SP), neurokinin A (NKA), neurokinin B (NKB)) and some selective analogues were assessed in the arterial and venous mesenteric beds of the rat. Although both sides of the mesenteric vasculature displayed endothelium-dependent relaxation in response to acetylcho...

journal_title：European journal of pharmacology

authors： D'Orléans-Juste P,Claing A,Télémaque S,Warner TD,Regoli D

更新日期：1991-11-12 00:00:00

abstract：:Galantamine is a drug in clinical use for the treatment of Alzheimer's disease, but its mechanism(s) of action remains controversial. Here we addressed the question whether galantamine could potentiate neurotransmitter release by inhibiting small conductance Ca2+ -activated K+ channels (KCa2). Galantamine potentiated ...

journal_title：European journal of pharmacology

authors： Alés E,Gullo F,Arias E,Olivares R,García AG,Wanke E,López MG

更新日期：2006-10-24 00:00:00

abstract：:Retinal ATP-dependent calcium ion uptake is stimulated by a number of agents, but none are previously reported to be as potent as taurine. We have evaluated the effects of 2-aminoethylmethyl-sulfone (AEMS), thiomorpholine-1,1-dioxide (TMS), and N-methyl-thiomorpholine-1,1-dioxide (M-TMS) on calcium ion uptake. AEMS is...

journal_title：European journal of pharmacology

authors： Liebowitz SM,Lombardini JB,Allen CI

更新日期：1986-01-14 00:00:00

abstract：:The effects of 2-methylthio ATP, an ATP analogue that is more specific for the P2Y receptor, were investigated on insulin secretion in the anesthetized dog in vivo. 2-Methylthio ATP was infused directly into the pancreaticoduodenal artery for 15 min. The infusion was performed so as to obtain a pancreaticoduodenal art...

journal_title：European journal of pharmacology

authors： Ribes G,Bertrand G,Petit P,Loubatières-Mariani MM

更新日期：1988-10-11 00:00:00

abstract：:Ellagic acid, a natural phenol compound found in numerous fruits and vegetables, causes various physiological effects in different cell models. However, the effect of this compound on Ca(2+) homeostasis in liver cells is unknown. This study examined the effect of ellagic acid on intracellular Ca(2+) concentration ([Ca...

journal_title：European journal of pharmacology

authors： Liang WZ,Chou CT,Cheng JS,Wang JL,Chang HT,Chen IS,Lu T,Yeh JH,Kuo DH,Shieh P,Chen FA,Kuo CC,Jan CR

更新日期：2016-06-05 00:00:00

abstract：:Anandamide is an endogenous ligand at both the inhibitory cannabinoid CB(1) receptor and the excitatory vanilloid receptor 1 (VR1). The CB(1) receptor and vanilloid VR1 receptor are expressed in about 50% and 40% of dorsal root ganglion neurons, respectively. While all vanilloid VR1 receptor-expressing cells belong to...

journal_title：European journal of pharmacology

authors： Morisset V,Ahluwalia J,Nagy I,Urban L

更新日期：2001-10-19 00:00:00

abstract：:Recombinant human tumor necrosis factor alpha (TNF alpha) decreases social exploration and induces weight loss in mice in a dose- and time-dependent manner (2.5-40 micrograms/mouse). To assess the role of interleukin-1 (IL-1) in these effects, mice pretreated with IL-1 receptor antagonist (IL-1ra, 500 micrograms/mouse...

journal_title：European journal of pharmacology

authors： Bluthé RM,Dantzer R,Kelley KW

更新日期：1991-12-17 00:00:00

abstract：:Electrical stimulation produced a contraction in the isolated guinea-pig vas deferens. This response was blocked by tetrodotoxin, guanethidine and bretylium but not by atropine. The magnitude of the contractile response to electrical stimulation depended on the concentration of the external calcium. Sulfur-containing ...

journal_title：European journal of pharmacology

authors： Morishita H,Sugiyama M,Furukawa T

更新日期：1983-11-11 00:00:00

abstract：:A major challenge in translational research is to reduce the currently high proportion of new candidate treatment agents for neuroinflammatory disease, which fail to reproduce promising effects observed in animal models when tested in patients. This disturbing situation has raised criticism against the currently used ...

journal_title：European journal of pharmacology

authors： 't Hart BA

更新日期：2015-07-15 00:00:00

abstract：:Population spikes associated with the paired pulse ratio protocol were used to measure the presynaptic inhibition of corticostriatal transmission caused by mu-opioid receptor activation. A 1 microM of [D-Ala(2), N-MePhe(4), Gly-ol(5)]-enkephalin (DAMGO), a selective mu-opioid receptor agonist, enhanced paired pulse fa...

journal_title：European journal of pharmacology

authors： Barral J,Mendoza E,Galarraga E,Bargas J

更新日期：2003-02-21 00:00:00

abstract：:Experiments were performed on 39 male albino rats anaesthetized with pentobarbitone sodium and paralyzed with gallamine triethiodide. Facial motoneurones consistently showed a progressive alteration of spike shape and decrease in spike firing frequency during the continuous microelectrophoretic application of the exci...

journal_title：European journal of pharmacology

authors： Martin MR,Lodge D,Headley PM,Biscoe TJ

更新日期：1977-04-07 00:00:00

abstract：:Blockade of sodium channels located in the sinoatrial node can slow diastolic depolarisation rate, recorded in vitro. The objective was therefore to determine whether these blockers could slow heart rate in vivo. The heart rate was firstly measured in spontaneously beating, isolated rat heart atria in the presence of ...

journal_title：European journal of pharmacology

authors： Létienne R,Vié B,Le Grand B

更新日期：2006-01-20 00:00:00

abstract：:We examined the effect of HSR-81 ((-)-(R)-alpha-[(tert-butylamino)methyl]-2-chloro-4-hydroxybenzyl alcohol L-tartrate), a newly developed, potent and selective beta 2-adrenoceptor agonist, as well as ritodrine and isoproterenol, on the spontaneous rhythmic contraction in uteri isolated from late pregnant, middle pregn...

journal_title：European journal of pharmacology

authors： Ohashi T,Hashimoto S,Morikawa K,Kato H,Ito Y,Asano M,Azuma H

更新日期：1996-07-04 00:00:00

abstract：:Currently, little is known about mechanisms underlying passive sensitization-induced nonspecific airway hyperresponsiveness. We sought to determine whether the nonspecific airway hyperresponsiveness observed after passive sensitization involves an increased role of Rho-kinase in airway smooth muscle contraction. In ad...

journal_title：European journal of pharmacology

authors： Schaafsma D,Zuidhof AB,Nelemans SA,Zaagsma J,Meurs H

更新日期：2006-02-15 00:00:00

abstract：:LK 204-545 ((+/-)-1-(2-(3-(2-cyano-4-(2-cyclopropyl-methoxy-ethoxy)phenoxy)-2-hydro xy-propyl-amino)-ethyl)-3-(4-hydrxy-phenyl) urea), an antagonist that possesses high beta1-/beta2-selectivity in the rat, and a range of cardio-selective and non-selective beta-adrenoceptor antagonists were examined to compare their ra...

journal_title：European journal of pharmacology

authors： Louis SN,Nero TL,Iakovidis D,Jackman GP,Louis WJ

更新日期：1999-02-19 00:00:00

abstract：:We have studied the effects of selective and non-selective adenosine receptor agonists and antagonists in audiogenic-seizure-sensitive DBA/2 mice, an animal model of generalized reflex epilepsy. With the exception of the adenosine A3 receptor agonist, N6-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine (IB-MECA), all th...

journal_title：European journal of pharmacology

authors： De Sarro G,De Sarro A,Di Paola ED,Bertorelli R

更新日期：1999-04-29 00:00:00

abstract：:The 235-1 pituitary tumor clone was utilized to study prolactin secretion after perturbing cyclic AMP and calcium metabolism. Cellular cyclic AMP levels were elevated after treatment with PGE1, cholera toxin, forskolin, isobutylmethylxanthine as well as dibutryl cyclic AMP; these cyclic AMP responses were associated w...

journal_title：European journal of pharmacology

authors： Schettini G,Rogol AD,MacLeod RM,Yasumoto T,Cronin MJ

更新日期：1985-03-12 00:00:00

abstract：:We have demonstrated that activation of ATP-sensitive potassium (K(ATP)) channels can attenuate sympathetic hyperinnervation. Sildenafil, a phosphodiesterase-5 inhibitor, has been shown to provide a preconditioning-like cardioprotective effect via opening of K(ATP) channels. The aim of this study was to investigate wh...

journal_title：European journal of pharmacology

authors： Lee TM,Chen CC,Chung TH,Chang NC

更新日期：2012-09-05 00:00:00

abstract：:Na+-H+ exchange inhibitors may reduce myocardial damage after reperfusion. However, their effects on microvascular deterioration are not known. We examined the potency of a novel Na+-H+ exchange inhibitor, SM-20550 [ N-(Aminoiminomethyl)-1,4-dimethyl-1H-indole-2-carboxamide methanesulfonate], and its effects on microv...

journal_title：European journal of pharmacology

authors： Ito Y,Imai S,Ui G,Nakano M,Imai K,Kamiyama H,Naganuma F,Matsui K,Ohashi N,Nagai R

更新日期：1999-06-25 00:00:00

abstract：:In the brain, various neurotransmitters such as noradrenaline and GABA regulate peripheral sympathetic functions. Previously, it has been reported that both β-adrenoceptor activation and GABAB receptor activation in the brain are involved in the elevation of plasma noradrenaline levels. However, it is unknown whether ...

journal_title：European journal of pharmacology

authors： Yamaguchi N,Mimura K,Okada S

更新日期：2019-04-05 00:00:00

abstract：:We have previously demonstrated that treatment with L-cis diltiazem reduced cardiac infarct size in vivo. To examine the effect of L-cis diltiazem on Ca(2+) overload induced by ischemia/reperfusion, we used a model for Ca(2+) overload produced by metabolic inhibition in isolated guinea pig myocytes. Intracellular Ca(2...

journal_title：European journal of pharmacology

authors： Nishida M,Urushidani T,Sakamoto K,Nagao T

更新日期：1999-12-03 00:00:00

abstract：:Previous results provided evidence for an inhibitory GABAergic influence on the dopamine neurons of the rat retina, without proving that endogenous GABA physiologically regulates the activity of these cells. We injected picrotoxinin intraocularly to dark-adapted rats and measured retinal dopamine turnover. Dopamine wa...

journal_title：European journal of pharmacology

authors： Kamp CW,Morgan WW

更新日期：1981-01-29 00:00:00

abstract：:The effects of 4-aminopyridine (4-AP) on basal and glucose-induced insulin secretion and on plasma glucose concentrations were investigated in vivo in intact mice and in mice subjected to surgical adrenalectomy plus chemical sympathectomy induced by 6-hydroxydopamine. In normal intact mice, an i.v. injection of 4-AP, ...

journal_title：European journal of pharmacology

authors： Ahrén B,Leander S,Lundquist I

更新日期：1981-09-11 00:00:00

abstract：:The effects of dopamine (DA) and of two selective DA DA1 agonists (SKF 38393 and SKF 82526) on adenylate cyclase activity were studied with human kidney cortex membrane preparations. DA elicited a dose-related stimulation of adenylate cyclase activity with an EC50 of 60 microM. The selective DA DA1 antagonist SCH 2339...

journal_title：European journal of pharmacology

authors： Baldi E,Pupilli C,Amenta F,Mannelli M

更新日期：1988-05-10 00:00:00

abstract：:Injection into the superior colliculus of anaesthetised rats of the nitric oxide (NO) synthase inhibitor N(omega)-nitro-L-arginine methyl ester (L-NAME; 1 micromol), but not its inactive enantiomer N(omega)-nitro-D-arginine methyl ester (D-NAME; 1 micromol), significantly (P < 0.01) increased the mean arterial blood p...

journal_title：European journal of pharmacology

authors： D'Amico M,Rossi F,Warner TD

更新日期：1997-06-05 00:00:00

abstract：:Isolated rat mast cells were used to study whether ionophore A23187 could induce histamine release by mobilizing cellular calcium. The histamine release was a slow process which was completed after about 20 min incubation with A23187. The A23187-induced histamine release was inhibited after incubation of the cells wit...

journal_title：European journal of pharmacology

authors： Johansen T

更新日期：1980-04-04 00:00:00