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Regulation of blood pressure by L-arginine-nitric oxide pathway within the superior colliculus of rats.

Abstract：

:Injection into the superior colliculus of anaesthetised rats of the nitric oxide (NO) synthase inhibitor N(omega)-nitro-L-arginine methyl ester (L-NAME; 1 micromol), but not its inactive enantiomer N(omega)-nitro-D-arginine methyl ester (D-NAME; 1 micromol), significantly (P < 0.01) increased the mean arterial blood pressure. Injection to the superior colliculus of L-arginine (L-Arg; 1 micromol), the substrate for NO synthase, significantly (P < 0.01) lessened the pressor effect of L-NAME, while D-arginine (D-Arg; 1 micromol) did not affect it. L-Arg (7.5 micromol), but not D-Arg (7.5 micromol) administered at the peak of the pressor response to L-NAME (1 micromol) also partially reversed this pressor response (P < 0.05). These data would suggest that endogenously produced NO acts within the superior colliculus to modulate the arterial blood pressure.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

D'Amico M,Rossi F,Warner TD

doi

10.1016/s0014-2999(97)83029-4

subject

Has Abstract

pub_date

1997-06-05 00:00:00

pages

65-7

issue

1

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(97)83029-4

journal_volume

328

pub_type

杂志文章

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