Kappa opioid receptor-mediated depression of activity evoked in convergent dorsal horn cells by thermal and non-thermal noxious stimulation.

abstract：:In the mouse tail-flick test, neither the racemate of N-allylnormetazocine (NANM) nor its optical isomers showed antinociceptive activity. However, all three antagonized morphine's tail-flick effects. In the phenylquinone test in mice, the racemate and (-)-isomer of NANM showed agonist activity and antagonized morphin...

journal_title：European journal of pharmacology

authors： Aceto MD,May EL

更新日期：1983-07-22 00:00:00

abstract：:The Role of protein kinase C in the modulatory effect of a mu-opioid receptor agonist, [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]enkephalin (DAMGO), on the glycine-gated Cl(-) current was examined in acutely dissociated rat periaqueductal gray neurons. Using the nystatin-perforated patch-clamp technique, the neurons were voltag...

journal_title：European journal of pharmacology

authors： Jeong HJ,Lee JJ,Hahm ET,Han SH,Min BI,Cho YW

更新日期：2001-11-16 00:00:00

abstract：:The repeated administration of N-methyl-beta-carboline-3-carboxamide (FG 7142) to mice leads to 'chemical kindling', i.e. the development of seizures in response to doses which were initially insufficient to produce convulsive activity. To determine if chemical kindling produced changes in the GABAA receptor/chloride ...

journal_title：European journal of pharmacology

authors： Lewin E,Peris J,Bleck V,Zahniser NR,Harris RA

更新日期：1989-01-24 00:00:00

abstract：:Glial cells express thromboxane A(2) receptor, but its physiological role remains unknown. The present study was performed to examine thromboxane A(2) receptor-mediated morphological change in 1321N1 human astrocytoma cells. Thromboxane A(2) receptor agonists U46619 and STA(2) caused a rapid morphological change to sp...

journal_title：European journal of pharmacology

authors： Honma S,Saika M,Ohkubo S,Kurose H,Nakahata N

更新日期：2006-09-18 00:00:00

abstract：:Several aspects of the role of corticotropin-releasing factor (CRF) in the forced swimming test were investigated in this study by using two different administration schedules. I.c.v. microinjection of CRF produced a dose-dependent increase in swimming activity when the administration schedule originally reported for ...

journal_title：European journal of pharmacology

authors： García-Lecumberri C,Ambrosio E

更新日期：1998-02-05 00:00:00

abstract：:The effect of intrathecal clonidine on thermal nociception and hindlimb flexion was assessed in acute and chronic spinally transected rats. After an acute, 1-day spinalization, there was no change in the antinociceptive dose-response function to clonidine, relative to intact rats. However, there was a significant incr...

journal_title：European journal of pharmacology

authors： Advokat C

更新日期：2002-02-15 00:00:00

abstract：:The location of alpha 2-adrenergic receptors has been investigated in the guinea pig kidney. We used an in vitro labeling autoradiographic technique to examine the distribution of specific [3H]clonidine binding sites with the light microscope. alpha 2-Adrenergic receptors appeared to be located predominantly on the pr...

journal_title：European journal of pharmacology

authors： Young WS 3rd,Kuhar MJ

更新日期：1980-10-31 00:00:00

abstract：:[3H]Neuropeptide Y labelled neuropeptide Y receptors in rat forebrain membranes as a homogenous class of high-affinity sites. Between 80 and 85% of these receptors showed high affinity for Y1-selective antagonists such as (R)-N2-(diphenylacetyl)-N-[(4-hydroxyphenyl)methyl]-D-arginine amide (BIBP3226). While competitiv...

journal_title：European journal of pharmacology

authors： Vanderheyden PM,Van Liefde I,De Backer JP,Vauquelin G

更新日期：1997-07-23 00:00:00

abstract：:Pyrrolidine dithiocarbamate (PDTC) can form a complex with metal ions and then act as a proteasome inhibitor, which leads to tumor cell apoptosis, and could therefore be developed as an anticancer agent. In our efforts to find factors that induce PDTC-mediated apoptosis of tumor cells, the effect of serum concentratio...

journal_title：European journal of pharmacology

authors： Oh DH,Bang JS,Choi HM,Yang HI,Yoo MC,Kim KS

更新日期：2010-12-15 00:00:00

abstract：:Five different muscarinic receptor subtypes can be distinguished by the differences in their amino acid sequence, the coupled signal transduction system, pharmacological binding properties and activation of ionic fluxes. The present study served to characterize the binding profile of muscarinic receptors in human colo...

journal_title：European journal of pharmacology

authors： Kopp R,Lambrecht G,Mutschler E,Moser U,Tacke R,Pfeiffer A

更新日期：1989-10-17 00:00:00

abstract：:The present studies examined the relationship between the blockade of central alpha1-adrenoceptors, as measured by ex vivo binding of [3H]prazosin in the cerebral cortex and the inhibition of behavioral activation to a mildly novel environment (cage change). It was found that intraventricular (i.v.t.) terazosin, a sal...

journal_title：European journal of pharmacology

authors： Stone EA,Rosengarten H,Lin Y,Quartermain D

更新日期：2001-05-25 00:00:00

abstract：:Farrerol, a typical natural flavanone, is the major active component of Rhododendron dauricum L. The objective of this study was to evaluate the attenuation effect of farrerol against the aortic lesions in spontaneously hypertensive rats (SHR) for the first time. Twelve-week-old male SHR were orally administered with ...

journal_title：European journal of pharmacology

authors： Qin X,Hou X,Liang T,Chen L,Lu T,Li Q

更新日期：2015-12-15 00:00:00

abstract：:The administration of morphine and fentanyl by continuous intravenous infusion has been shown to produce analgesic tolerance and physical dependence in human neonates. In animals, daily repeated morphine bolus injections is a common method of inducing neonatal rat tolerance and dependence. Yet this method differs from...

journal_title：European journal of pharmacology

authors： Thornton SR,Wang AF,Smith FL

更新日期：1997-12-11 00:00:00

abstract：:Dantrolene sodium (3 X 10(-4) M) exerted a biphasic effect on the mechanical and electrical activity of the isolated guinea pig left atrium. In the first phase, the drug increased the contractile force by about 200%, and prolonged the action potential duration. This transient positive inotropic effect was antagonized ...

journal_title：European journal of pharmacology

authors： Mészáros J,Kecskeméti V,Szegi J

更新日期：1981-09-11 00:00:00

abstract：:Autophagy is a lysosomal degradation pathway, which is essential for cell survival, proliferation, differentiation and homeostasis. It is well known that beta-amyloid (Aβ) aggregation is one of key characteristics for Alzheimer's disease (AD), which triggers a complex pathological cascade, leading to neurodegeneration...

journal_title：European journal of pharmacology

authors： Wang C,Zhang X,Teng Z,Zhang T,Li Y

更新日期：2014-10-05 00:00:00

abstract：:[3H]BAY U 3405 was used to characterize the effect of acidic and alkaline pH values on the binding of the thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor of human platelet membranes. The specific binding of [3H]BAY U 3405 largely increased upon acidification up to pH 5.8. Saturation binding studies revealed an in...

journal_title：European journal of pharmacology

authors： Theis JG,Dellweg H,Perzborn E,Gross R

更新日期：1992-06-05 00:00:00

abstract：:Herbacetin is an active flavonol (a type of flavonoid) that has various biologic effects such as antioxidant, antitumor, and anti-inflammatory activities. However, one of its novel effects remains to be investigated, that is, the induction of osteoclastogenesis by the receptor activator of nuclear factor-κB ligand (RA...

journal_title：European journal of pharmacology

authors： Li L,Sapkota M,Kim SW,Soh Y

更新日期：2016-04-15 00:00:00

abstract：:The immunosuppressant drug cyclosporine causes nephrotoxicity mainly via alterations of renovascular reactivity. This study investigated whether this effect of cyclosporine is modulated by the male gonadal hormone testosterone. The endothelium-dependent and -independent relaxations evoked by acetylcholine and sodium n...

journal_title：European journal of pharmacology

authors： El-Mas MM,Afify EA,Omar AG,Mohy El-Din MM,Sharabi FM

更新日期：2003-05-16 00:00:00

abstract：:The effects of trichokonin VI (= gliodeliquescin A), a peptaibol isolated from the culture broth of Trichoderma koningii Oudemans, on L-type Ca2+ channel currents in single bullfrog atrial cells were investigated. Our results showed that trichokonin VI is a new potent agonist of L-type Ca2+ channels in cardiac membran...

journal_title：European journal of pharmacology

authors： Huang Q,Tezuka Y,Kikuchi T,Momose Y

更新日期：1994-12-12 00:00:00

abstract：:Intrastriatal injection of kainic acid (5 nmoles) to rats led to severe destruction of nerve cell bodies throughout the caudate-putamen complex and an extensive proliferation of glial cells. Lesioned striata displayed a significant 23% loss of beta-adrenoceptor binding sites 21--24 days after injection of kainic acid....

journal_title：European journal of pharmacology

authors： Nahorski SR,Howlett DR,Redgrave P

更新日期：1979-12-07 00:00:00

abstract：:The decrease in blood flow in response to dopamine (DA) injected intraarterially (i.a.) into the femoral or renal vascular beds was examined in the anaesthetised dog. DA or noradrenaline (NA) were 10 times more potent as vasoconstrictor agents in the femoral than in the renal vasculature. In the femoral bed, the DA in...

journal_title：European journal of pharmacology

authors： Duval N,Hicks PE,Langer SZ

更新日期：1985-02-05 00:00:00

abstract：:In cardiac muscle cells both T-and L-type Ca(2+) channels (TTCCs and LTCCs, respectively) are expressed, and the latter are relevant to a process known as excitation-contraction coupling (ECC). Evidence obtained from docking studies suggests that isoindolines derived from α-amino acids bind to the LTCC CaV1.2. In the ...

journal_title：European journal of pharmacology

authors： Santamaria-Herrera MA,Ríos-Pérez EB,de la Rosa JA,García-Castañeda M,Osornio-Garduño DS,Ramos-Mondragón R,Mancilla-Percino T,Avila G

更新日期：2016-06-15 00:00:00

abstract：:The influence of degradation by peptidases on concentration-response relationships for peptide agonists of the tachykinin and bombesin-like families was investigated. The combined presence of three peptidase inhibitors, phosphoramidon (1 microM), captopril (1 microM) and bestatin (100 microM), had no significant effec...

journal_title：European journal of pharmacology

authors： Hall JM,Fox AJ,Morton IK

更新日期：1990-02-06 00:00:00

abstract：:The characteristics of beta-adrenoceptors on frog and chick erythrocytes have been compared to those present on rat erythrocyte, lung and cerebral cortical membranes. The receptors have been examined using the specific ligand [3H]dihydroalprenolol ([3H]DHA) with conventional filtration techniques. The equilibrium diss...

journal_title：European journal of pharmacology

authors： Dickinson KE,Nahorski SR

更新日期：1981-08-27 00:00:00

abstract：:Chlorogenic acid (CA) is one of the active ingredients in some Chinese herbal injections, which may cause allergic reactions in clinic therapy. However, the criterion of test for allergen had not been employed in current Pharmacopeia of United States, European Pharmacopeia, Japanese Pharmacopeia and British Pharmacope...

journal_title：European journal of pharmacology

authors： Xiao GN,Sun QP,Chen HA

更新日期：2013-01-15 00:00:00

abstract：:Peripheral type benzodiazepine receptors are differentially modified by arachidonate, diethylpyrocarbonate and thiol reagents, as evidenced by the finding that binding of a proposed agonist ([3H]R05-4864) and a proposed antagonist ([3H]PK 11195) to rat kidney mitochondrial membranes can be modified separately. (1) Ara...

journal_title：European journal of pharmacology

authors： Skowroński R,Beaumont K,Fanestil DD

更新日期：1987-11-17 00:00:00

abstract：:Intracellular accumulation of calcium is thought to play an integral role in the progression of ischemic injury and cell death. We infused the calcium entry blocker, nitrendipine (1.5 micrograms/kg per min), into cats in order to investigate the importance of extracellular Ca2+ influx during hemorrhagic shock. Nitrend...

journal_title：European journal of pharmacology

authors： Hock CE,Su JY,Lefer AM

更新日期：1984-01-13 00:00:00

abstract：:The increase of cytoplasmic Ca2+ concentration (Delta[Ca2+]c) in response to antigenic stimulation is a critical step of signals activating immune responses. In addition, the voltage-gated K+ channels (Kv) in T lymphocytes draw attention as an effective target of immune-modulation. Caffeic acid phenethyl ester (CAPE),...

journal_title：European journal of pharmacology

authors： Nam JH,Shin DH,Zheng H,Kang JS,Kim WK,Kim SJ

更新日期：2009-06-10 00:00:00

abstract：:ATP, ADP, adenosine and AMP, but not adenine, inosine, or GMP, caused dose-related intestinal contractions when injected as intra-arterial bolus doses in vascularly perfused isolated segments of dog small bowel. The stimulatory effects of these agents were decreased by receptor densitization during exposure to high co...

journal_title：European journal of pharmacology

authors： Northway MG,Burks TF

更新日期：1980-07-11 00:00:00

abstract：:High fat diet, as an important risk factor, plays a pivotal role in atherosclerotic process. Celastrol is one of the active triterpenoid compounds with antioxidative and anti-inflammatory characters. The aims of this study were to evaluate the effect of celastrol on weight, blood lipid and oxidative injury induced by ...

journal_title：European journal of pharmacology

authors： Wang C,Shi C,Yang X,Yang M,Sun H,Wang C

更新日期：2014-12-05 00:00:00