alpha 2-Adrenergic receptors are associated with renal proximal tubules.

abstract：:Recently published studies have suggested that behavioral and neurochemical changes induced by selective serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitors are potentiated by coadministration of a 5-HT1A receptor antagonist. The potentiating effect is hypothesized to be due to antagonism of somatodendritic 5-HT...

journal_title：European journal of pharmacology

authors： Sànchez C

更新日期：1997-09-10 00:00:00

abstract：:Thirty percent of osteosarcoma patients die within 5 years. New agents that induce apoptosis of osteosarcoma cells might be therapeutically useful. Here, we characterized the apoptotic mechanism induced by capsaicin in G292 osteosarcoma cells. Our results show that capsaicin induces an increase in the cytosolic Ca(2+)...

journal_title：European journal of pharmacology

authors： Chien CS,Ma KH,Lee HS,Liu PS,Li YH,Huang YS,Chueh SH

更新日期：2013-10-15 00:00:00

abstract：:The Role of protein kinase C in the modulatory effect of a mu-opioid receptor agonist, [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]enkephalin (DAMGO), on the glycine-gated Cl(-) current was examined in acutely dissociated rat periaqueductal gray neurons. Using the nystatin-perforated patch-clamp technique, the neurons were voltag...

journal_title：European journal of pharmacology

authors： Jeong HJ,Lee JJ,Hahm ET,Han SH,Min BI,Cho YW

更新日期：2001-11-16 00:00:00

abstract：:The effect of indomethacin, acetyl salicylic acid and niflumic acid on the chemotaxis and random migration of rat polymorphonuclear leucocytes (PMN) was investigated with a modified Boyden chamber technique under various experimental conditions (two cell sources, administration of drugs in vivo or incubation in vitro,...

journal_title：European journal of pharmacology

authors： Pham Huy D,Roch-Arveiller M,Muntaner O,Giroud JP

更新日期：1985-05-08 00:00:00

abstract：:Alzheimer's disease, an age-related neurodegenerative disorder, is characterized clinically by a progressive loss of memory and cognitive functions. Neuropathologically, Alzheimer's disease is defined by the accumulation of extracellular amyloid protein deposited senile plaques and intracellular neurofibrillary tangle...

journal_title：European journal of pharmacology

authors： Butterfield DA,Perluigi M,Sultana R

更新日期：2006-09-01 00:00:00

abstract：:We investigated the involvement of angiotensin II and vascular smooth muscle sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) function in the impaired NO-induced relaxation seen in established streptozotocin-induced diabetes. Plasma angiotensin II levels, which were elevated in untreated diabetic rats (vs age-matched...

journal_title：European journal of pharmacology

authors： Taguchi K,Kobayashi T,Hayashi Y,Matsumoto T,Kamata K

更新日期：2007-02-05 00:00:00

abstract：:It was previously shown that haloperidol, but not clozapine, induced intense rat catalepsy when co-administered with delta-9-tetrahydrocannabinol. The present study investigated whether similar alterations could be observed on striatal c-Fos immunoreactivity after administration of the same drug combinations. Western ...

journal_title：European journal of pharmacology

authors： Marchese G,Sanna A,Casu G,Casti P,Spada GP,Ruiu S,Pani L

更新日期：2008-11-19 00:00:00

abstract：:Clinical evidence indicates an antiarrhythmic effect of sulfonylureas, which might be blunted by their vascular action. We wanted to investigate the effect of glibenclamide and the new sulfonylthiourea compound 1-[[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]-sulfonyl]-3 -me thylthiourea (HMR1883) on cardiac ele...

journal_title：European journal of pharmacology

authors： Dhein S,Pejman P,Krüsemann K

更新日期：2000-06-16 00:00:00

abstract：:Adenosine has been reported to have beneficial effects against ischemic brain damage, although the mechanisms are not fully clarified. To examine the role of adenosine on the ischemia-evoked release of neurotransmitters, we applied a highly selective agonist for adenosine A1 receptor, 2-chloro-N6-cyclopentyladenosine ...

journal_title：European journal of pharmacology

authors： Goda H,Ooboshi H,Nakane H,Ibayashi S,Sadoshima S,Fujishima M

更新日期：1998-09-18 00:00:00

abstract：:PK20M (Dmt-D-Lys-Phe-Phe-OH) is a novel modified endomorphin-2 (EM-2) peptide producing strong dose- and time-dependent antinociceptive activity. Yet its prototype, endogenous EM-2, has been reported to trigger respiratory and vascular effects such as apnea and hypotension. The purpose of this study was to investigate...

journal_title：European journal of pharmacology

authors： Wojciechowski P,Kleczkowska P,Mollica A,Stefanucci A,Kaczyńska K

更新日期：2020-10-15 00:00:00

abstract：:The antiparkinsonian agent l-deprenyl is metabolized to l-methamphetamine and l-amphetamine and, at higher doses, can facilitate the release and inhibit the reuptake of dopamine. Since l-deprenyl can affect dopamine release and reuptake it was important to evaluate it for cocaine-like discriminative stimulus effects. ...

journal_title：European journal of pharmacology

authors： Yasar S,Schindler CW,Thorndike EB,Goldberg SR

更新日期：1994-07-11 00:00:00

abstract：:The inhibitory actions of the Ca2+ antagonist Cd2+, morphine and noradrenaline (exogenously added + endogenously released) on electrically evoked release of [3H]noradrenaline from superfused rat neocortical slices were strongly reduced when release was enhanced by 4-aminopyridine. In the presence of 4-aminopyridine th...

journal_title：European journal of pharmacology

authors： Schoffelmeer AN,Mulder AH

更新日期：1983-03-04 00:00:00

abstract：:Our aim in performing this study was to analyze in vivo the cell death mechanism induced by toxic doses of digitalis compounds on guinea-pig cardiomyocytes. We analyzed three study groups of five male guinea pigs each. Guinea pigs were intoxicated under anesthesia with ouabain or digoxin (at a 50-60% lethal dose); the...

journal_title：European journal of pharmacology

authors： Ramirez-Ortega M,Zarco G,Maldonado V,Carrillo JF,Ramos P,Ceballos G,Melendez-Zajgla J,Garcia N,Zazueta C,Chanona J,Suarez J,Pastelin G

更新日期：2007-07-02 00:00:00

abstract：:Studies were designed to examine the influence of endothelin type A receptor (ETA) blockade on the hypertensive and renal response to 4 day treatment with the nitric oxide (NO) synthase inhibitor, L-nitroarginine methyl ester (L-NAME), and cyclosporine. In the first series of experiments, male Sprague-Dawley rats main...

journal_title：European journal of pharmacology

authors： Pollock DM,Polakowski JS,Opgenorth TJ,Pollock JS

更新日期：1998-04-03 00:00:00

abstract：:Glutamatergic abnormalities are involved in several psychiatric disorders. Clinical evidence demonstrates altered glutamatergic neurotransmission in patients suffering from obsessive-compulsive disorder. MGS0039, (1R,2R,3R,5R,6R)-2-amino-3-(3,4-dichlorobenzyloxy)-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid, is ...

journal_title：European journal of pharmacology

authors： Shimazaki T,Iijima M,Chaki S

更新日期：2004-10-06 00:00:00

abstract：:The administration of [D-Ala2,Met5]enkephalinamide (D-AME) and [D-Ala2,Leu5]enkephalinamide (D-ALE) into the right atrium of decerebrate rats caused bradycardia, a slight transient biphasic blood pressure response and apnea within 1-2 sec. Apnea was followed by rapid shallow breathing. These effects were dose related ...

journal_title：European journal of pharmacology

authors： Willette RN,Sapru HN

更新日期：1982-02-19 00:00:00

abstract：:Acute administration of an opiate has been suggested to result in the development of supersensitive dopamine receptors. This hypothesis was tested in mice by determining the effect of a single administration of morphine or levorphanol on dopamine agonist-induced stereotypic behaviors and [3H]spiroperidol binding. Admi...

journal_title：European journal of pharmacology

authors： Martin JR,Takemori AE

更新日期：1985-12-10 00:00:00

abstract：:Three carboxyphenylglycine derivatives were examined for their activity on glutamate metabotropic receptors negatively linked to adenylate cyclase. Chinese hamster ovary cells stably expressing mGlu2 and mGlu4 were utilised for this study. A receptor binding analysis was also performed for the main classes of glutamat...

journal_title：European journal of pharmacology

authors： Cavanni P,Pinnola V,Mugnaini M,Trist D,Van Amsterdam FT,Ferraguti F

更新日期：1994-09-15 00:00:00

abstract：:The effects of ZD0947, a novel ATP-sensitive K+ channel (KATP channel) opener, on the activity of reconstituted KATP channels were investigated using cell-attached recordings. KATP channels were studied in HEK 293 cells by co-expression of inwardly rectifying-6 family K+ channel subunits (Kir6.x: Kir6.1 and Kir6.2) wi...

journal_title：European journal of pharmacology

authors： Mori K,Yamashita Y,Teramoto N

更新日期：2016-11-15 00:00:00

abstract：:The arteriovenous fistula model of circulation can produce a high output and low peripheral resistance situation. Here, we have examined the effects of noradrenaline, vasopressin and sodium nitroprusside on cardiac index, mean arterial blood pressure, venous tone, resistance to venous return, arterial resistance, and ...

journal_title：European journal of pharmacology

authors： Guo L,Tabrizchi R

更新日期：2008-05-31 00:00:00

abstract：:Glucocorticoids bind to and activate a cytoplasmic glucocorticoid receptor. The activated glucocorticoid receptor translocates into the nucleus and binds to specific response elements in the promoter regions of anti-inflammatory genes such as lipocortin-1 and secretory leukocyte protease inhibitor (SLPI). However, the...

journal_title：European journal of pharmacology

authors： Hayashi R,Wada H,Ito K,Adcock IM

更新日期：2004-10-01 00:00:00

abstract：:Local administration of amitriptyline into the rat hindpaw produces peripheral antinociception; this is reduced by adenosine receptor antagonists and appears to involve endogenous adenosine. The present study used peripheral microdialysis: (a) to determine whether amitriptyline could enhance extracellular tissue level...

journal_title：European journal of pharmacology

authors： Sawynok J,Reid AR,Liu XJ,Parkinson FE

更新日期：2005-08-22 00:00:00

abstract：:Parenterally administered substance P suppressed stress-induced eating (resulting from mild tail pinch) in a dose-related manner, whereas at similar or higher doses of substance P starvation-induced eating was uneffected. This specific effect of substance P on stress-induced eating is possibly associated with alterati...

journal_title：European journal of pharmacology

authors： Morley JE,Levine AS

更新日期：1980-10-17 00:00:00

abstract：:High temperature requirement A2 (HtrA2)/Omi is a mitochondrial serine protease that is released into the cytosol from mitochondria and in turn promotes caspase activation by proteolyzing inhibitor of apoptosis proteins. Here we asked whether treatment with an HtrA2/Omi inhibitor, 5-[5-(2-nitrophenyl)furfuryliodine]-1,...

journal_title：European journal of pharmacology

authors： Bhuiyan MS,Fukunaga K

更新日期：2007-02-28 00:00:00

abstract：:Blockade of sodium channels located in the sinoatrial node can slow diastolic depolarisation rate, recorded in vitro. The objective was therefore to determine whether these blockers could slow heart rate in vivo. The heart rate was firstly measured in spontaneously beating, isolated rat heart atria in the presence of ...

journal_title：European journal of pharmacology

authors： Létienne R,Vié B,Le Grand B

更新日期：2006-01-20 00:00:00

abstract：:We examined whether danazol has a direct action on ovarian steroid secretion and/or uterine prostaglandin (PG) F2 alpha catabolic activity in immature rats in which the first ovulation was induced and in adult ovariectomized rats. The preovulatory surge of estradiol and progesterone was markedly suppressed together wi...

journal_title：European journal of pharmacology

authors： Kogo H,Takasaki K,Yatabe Y,Nishikawa M,Takeo S,Tamura K

更新日期：1992-01-28 00:00:00

abstract：:The neurochemical control of learning depends on several neurotransmitters, hormones, and neuropeptides. Cortistatin is a neuropeptide with sleep-modulating properties that regulates memory consolidation and evocation. Several reports have suggested that learning processes are expressed under diurnal variations; there...

journal_title：European journal of pharmacology

authors： Méndez-Díaz M,Irwin L,Gómez-Chavarín M,Jiménez-Anguiano A,Cabeza R,Murillo-Rodríguez E,Prospéro-García O

更新日期：2005-01-10 00:00:00

abstract：:AY-22,241 (Actodigin) is a new rapid-acting semisynthetic cardiotonic steroid. In experiments on contractility of cat papillary muscle, Actodigin (2 times 10(-7) to 4 times 10(-6) M) produced a dose-dependent positive inotropic effect, a marked increase in the maximum rate of force development, and no change in restin...

journal_title：European journal of pharmacology

authors： Gliklich JI,Gaffney R,Rosen MR,Hoffman BF

更新日期：1975-05-01 00:00:00

abstract：:The coronavirus disease-19 (COVID-19) outbreak that is caused by a highly contagious severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become a zoonotic pandemic, with approximately 24.5 million positive cases and 8.3 lakhs deaths globally. The lack of effective drugs or vaccine provoked the research fo...

journal_title：European journal of pharmacology

authors： M P,Reddy GJ,Hema K,Dodoala S,Koganti B

更新日期：2021-01-05 00:00:00

abstract：:Fabry disease (FD) is an X-linked metabolic storage disorder arising from the deficiency of lysosomal α-galactosidase A, which leads to the gradual accumulation of glycosphingolipids, mainly globotriaosylceramide (Gb3), throughout the body. Pain in the extremities is an early symptom of FD; however, the underlying pat...

journal_title：European journal of pharmacology

authors： Sugimoto J,Satoyoshi H,Takahata K,Muraoka S

更新日期：2021-01-20 00:00:00