Loss of beta-adrenoceptor binding sites in rat striatum following kainic acid lesions.

abstract：:Insulin resistance in skeletal muscle is a major risk factor for the development of type 2 diabetes (T2D). In this study, we investigated the effect of icariin on insulin resistance in C2C12 mouse skeletal muscle cells. C2C12 myoblasts were differentiated into myotubes for five days, then treated with icariin (50 and ...

journal_title：European journal of pharmacology

authors： Han Y,Jung HW,Park YK

更新日期：2015-07-05 00:00:00

abstract：:The role beta-adrenoceptors in the control of venous tone is not clear. This study examines the dose-response effects of isoprenaline, a non-selective beta-adrenoceptor agonist, on mean circulatory filling pressure (MCFP), an index of body venous tone, in conscious and unrestrained rats. Dose-response curves of isopre...

journal_title：European journal of pharmacology

authors： Abdelrahman A,Pang CC

更新日期：1990-11-13 00:00:00

abstract：:In this study we have investigated the functional activity of GR127935 (2-methyl-1,2,4 oxadiazol-3-yl)-biphenyl-[4-carboxylic acid 4-methoxy-3-(4-methyl-piperazine-1-yl]-amide) at human 5-HT1D alpha and 5-HT1D beta receptors which have been expressed in a Chinese Hamster Ovary (CHO) cell line. Using [35S] GTP gamma S ...

journal_title：European journal of pharmacology

authors： Watson JM,Burton MJ,Price GW,Jones BJ,Middlemiss DN

更新日期：1996-10-31 00:00:00

abstract：:Recent data show that corticolimbic expression of the effector immediate early gene Arc is up-regulated by standard antidepressant drugs. Here, we tested the effect upon Arc expression of a novel antidepressant and selective 5-hydroxytryptamine/noradrenaline reuptake inhibitor (SNRI), (-)1-(1-dimethylaminomethyl) 5-me...

journal_title：European journal of pharmacology

authors： Pei Q,Sprakes M,Millan MJ,Rochat C,Sharp T

更新日期：2004-04-12 00:00:00

abstract：:Endogenous opioid and nociceptin systems are widely distributed in the gastrointestinal tract where they seem to play a crucial role in maintaining the intestinal homeostasis. The aim of our study was to assess whether activation of nociceptin (NOP) and µ-opioid (MOP) receptors by a mixed NOP/MOP receptor agonist, BU0...

journal_title：European journal of pharmacology

authors： Zielińska M,Ben Haddou T,Cami-Kobeci G,Sałaga M,Jarmuż A,Padysz M,Kordek R,Spetea M,Husbands SM,Fichna J

更新日期：2015-10-15 00:00:00

abstract：:Intrinsic drug resistance occurs in many renal carcinomas and is associated with increased expression of multidrug resistant proteins, which inhibits intracellular drug accumulation. Multidrug resistant protein 1, also known as P-glycoprotein, is a membrane drug efflux pump belonging to the ATP-binding cassette (ABC) ...

journal_title：European journal of pharmacology

authors： Sato H,Siddig S,Uzu M,Suzuki S,Nomura Y,Kashiba T,Gushimiyagi K,Sekine Y,Uehara T,Arano Y,Yamaura K,Ueno K

更新日期：2015-01-05 00:00:00

abstract：:Inflammation, closely associated with obesity, is emerging as an important risk factor for the pathophysiological development of atherosclerosis and diabetes mellitus. Fat balance is critical in the aetiology of obesity. Lipoprotein lipase is an important enzyme in lipid metabolism. The aim of this study was to invest...

journal_title：European journal of pharmacology

authors： Cai M,Yin W,Li Q,Liao D,Tsutsumi K,Hou H,Liu Y,Zhang C,Li J,Wang Z,Xiao J

更新日期：2006-07-01 00:00:00

abstract：:Levodopa is the standard-of-care for Parkinson's disease, but continued loss of dopamine neurons with disease progression decreases its bioconversion to dopamine, leading to increased side effects and decreased efficacy. In theory, dopamine agonists could equal levodopa, but no approved oral "dopamine agonist" matches...

journal_title：European journal of pharmacology

authors： Mailman RB,Yang Y,Huang X

更新日期：2021-02-05 00:00:00

abstract：:St. John's wort (Hypericum perforatum L.) is widely used for the treatment of mild to moderately severe depression. However, the nature of its active principles and the exact mode of antidepressant action are still unknown. It has been suggested repeatedly in preclinical and clinical studies that the content of the ac...

journal_title：European journal of pharmacology

authors： Simmen U,Bobirnac I,Ullmer C,Lübbert H,Berger Büter K,Schaffner W,Schoeffter P

更新日期：2003-01-05 00:00:00

abstract：:We have characterized a specific binding site for angiotensin IV on bovine aortic endothelial cell membranes. Pseudo-equilibrium studies at 37 degrees C for 2 h have shown that this binding site recognizes angiotensin IV with a high affinity (Kd = 0.71; average of two experiments that yielded values of 0.71 and 0.72 n...

journal_title：European journal of pharmacology

authors： Bernier SG,Servant G,Boudreau M,Fournier A,Guillemette G

更新日期：1995-10-15 00:00:00

abstract：:27-O-Caffeoyl myricerone (50-235) is a nonpeptide endothelin receptor antagonist which is highly selective for the endothelin ETA receptor subtype. In order to determine which functional groups in 50-235 are essential for its activity, we examined the potencies of 50-235 and its derivatives to inhibit [125I]endothelin...

journal_title：European journal of pharmacology

authors： Mihara S,Sakurai K,Nakamura M,Konoike T,Fujimoto M

更新日期：1993-10-15 00:00:00

abstract：:The maximal pressor effect induced by DOI in the pithed rat was smaller than that induced by 5-HT, suggesting partial agonistic properties of DOI. DOI shifted the dose-pressor response curve of 5-HT to the right. It is concluded that, in addition to its 5-HT2 agonistic properties, DOI also possesses 5-HT2 antagonistic...

journal_title：European journal of pharmacology

authors： Dabiré H,Chaouche-Teyara K,Cherqui C,Fournier B,Schmitt H

更新日期：1989-10-24 00:00:00

abstract：:In conscious normotensive cats intraventricular (i.c.v.) administration of histamine (2.0-50.0 mug) induced dose-related rises in blood pressure, with no increase in heart rate. The hypertensive response elicited by a sub-maximal dose of histamine (10.0 mu i.c.v.) was significantly antagonised by central pretreatment ...

journal_title：European journal of pharmacology

authors： Finch L,Hicks PE

更新日期：1976-03-01 00:00:00

abstract：:Basic fibroblast growth factor (bFGF) is a heparin-binding polypeptide with potent trophic and protective effects on brain neurons, glia and endothelia. In previous studies, we showed that intravenously administered bFGF reduced the volume of cerebral infarcts following permanent occlusion of the middle cerebral arter...

journal_title：European journal of pharmacology

authors： Ren JM,Finklestein SP

更新日期：1997-05-26 00:00:00

abstract：:The inhibition of the tail-flick response induced by beta-endorphin given i.c.v. has been demonstrated to be mediated by the stimulation of epsilon- but not mu-, delta- or kappa-opioid receptors. beta-Endorphin given i.t. also inhibited the tail-flick response. The present studies were designed to determine what types...

journal_title：European journal of pharmacology

authors： Tseng LF,Collins KA

更新日期：1992-04-07 00:00:00

abstract：:2-Arachidonylglycerol (2-AG) inhibits the production in vitro of tumor necrosis factor-alpha (TNF-alpha) by mouse macrophages, as well as in mice. It has no effect on the production of nitric oxide (NO). The effect on TNF-alpha is enhanced when 2-AG is administered together with 2-linoleylglycerol (2-Lino-G) and 2-pal...

journal_title：European journal of pharmacology

authors： Gallily R,Breuer A,Mechoulam R

更新日期：2000-10-06 00:00:00

abstract：:Age-related changes in the modulatory action of nitric oxide (NO) on cyclic GMP levels and Na(+),K(+)-ATPase activity in the proximal rat trachea were investigated using sodium nitroprusside, 8-bromo-cyclic GMP and okadaic acid. At 24 months, both control activities of Na(+), K(+)-ATPase and Mg(2+)-ATPase were decreas...

journal_title：European journal of pharmacology

authors： Scavone C,Glezer I,Demarchi Munhoz C,de Sena Bernardes C,Pekelmann Markus R

更新日期：2000-01-24 00:00:00

abstract：:Using the radioactive microsphere technique in anaesthetized pigs, we studied the systemic and carotid haemodynamic effects of intracarotid infusions (0.3, 1, 3 and 10 micrograms/kg.min) of 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole succinate (RU 24969), a drug with high affinity for 5-HT1A and 5-HT1B reco...

journal_title：European journal of pharmacology

authors： Bom AH,Villalón CM,Verdouw PD,Saxena PR

更新日期：1989-11-14 00:00:00

abstract：:GABAA and GABAB receptor agonists and antagonists were administered locally in the striatum of intact and kainic acid lesioned rats. (+/-)-Baclofen, a GABAB receptor agonist, significantly decreased the level of extracellular dopamine in the striatum of intact rats. (+/-)-Phaclofen, a GABAB receptor antagonist, increa...

journal_title：European journal of pharmacology

authors： Smolders I,De Klippel N,Sarre S,Ebinger G,Michotte Y

更新日期：1995-09-15 00:00:00

abstract：:This paper examines the biochemical and behaviour changes induced by an acute stress (five 10-s, 1-mA foot-shocks) in three groups of rats: (1) never stressed, (2) subjected to chronic variate stress for 20 days, (3) subjected to the same chronic stress and treated with 5 mg/kg per day amitriptyline. After 15 min, acu...

journal_title：European journal of pharmacology

authors： Ferretti C,Blengio M,Gamalero SR,Ghi P

更新日期：1995-06-23 00:00:00

abstract：:The zero-trans influx of uridine in human erythrocytes is inhibited by lidoflazine and analogs thereof. The concentrations required for inhibition of nucleoside transport were higher when the compounds were simultaneously added with uridine than upon preincubation of the inhibitors with the erythrocytes. R70380 proved...

journal_title：European journal of pharmacology

authors： Pirovano IM,Van Belle H,Ijzerman AP

更新日期：1990-12-15 00:00:00

abstract：:Previous studies showed that whereas the potent 5-HT3 receptor antagonist (S)-[3H]zacopride only labels 5-HT3 receptor binding sites, the (R)-enantiomer, (R)-[3H]zacopride, labels these receptors and another class of high-affinity binding sites, named the R sites, in membranes from the rat cerebral cortex and NG 108-1...

journal_title：European journal of pharmacology

authors： Kidd FJ,Levy JC,Nielsen M,Hamon M,Gozlan H

更新日期：1993-09-15 00:00:00

abstract：:The main aim of the study was to examine analgesic effects of the topical opioids and non-steroidal anti-inflammatory drugs (NSAIDs) in a radiant heat tail-flick nociception model. Also, we have tested whether the addition of lauric acid to propylene glycol improves skin permeation for the opioids and NSAIDs. We found...

journal_title：European journal of pharmacology

authors： Kolesnikov Y,Sõritsa D

更新日期：2008-01-28 00:00:00

abstract：:Deferoxamine has shown cutaneous wound healing potential by increased neovascularization. We hypothesized that topically applied deferoxamine facilitates wound healing in diabetic rats by modulating important cytokines and growth factors that take part in healing processes in a time-dependent manner. Diabetes was indu...

journal_title：European journal of pharmacology

authors： Ram M,Singh V,Kumawat S,Kumar D,Lingaraju MC,Uttam Singh T,Rahal A,Kumar Tandan S,Kumar D

更新日期：2015-10-05 00:00:00

abstract：:The study investigated the effects of dopamine D1-like receptor stimulation on the autonomic nervous system. Fenoldopam (20 microg/kg) was injected i.v. in conscious sinoaortic denervated dogs, that is, surgically deprived of baroreflex pathways. In barodenervated dogs, fenoldopam (20 microg/kg) induced arterial hypot...

journal_title：European journal of pharmacology

authors： Vernejoul F,Damase-Michel C,Montastruc JL,Tran MA

更新日期：2002-05-31 00:00:00

abstract：:Substituted benzamides such as metoclopramide, cisapride, zacopride, renzapride or BRL 20627, stimulate intestinal motility in various species. As they are antagonists at 5-HT3 and agonists at 5-HT4 receptors and as both mechanisms could potentially contribute to their gastrointestinal prokinetic effect, the underlyin...

journal_title：European journal of pharmacology

authors： Buchheit KH,Buhl T

更新日期：1991-11-26 00:00:00

abstract：:Peripheral type benzodiazepine receptors are differentially modified by arachidonate, diethylpyrocarbonate and thiol reagents, as evidenced by the finding that binding of a proposed agonist ([3H]R05-4864) and a proposed antagonist ([3H]PK 11195) to rat kidney mitochondrial membranes can be modified separately. (1) Ara...

journal_title：European journal of pharmacology

authors： Skowroński R,Beaumont K,Fanestil DD

更新日期：1987-11-17 00:00:00

abstract：:The effects of brief actinomycin D treatment (0.1 microgram/ml, 0.5 h) on inhibition of cell growth and colony formation were studied in synchronized HeLa cells. Cells in late S and G2 phases were found to be maximally sensitive to inhibition of cell growth and colony formation after short exposure to actinomycin D. C...

journal_title：European journal of pharmacology

authors： Wu MH,Yung BY

更新日期：1994-04-04 00:00:00

abstract：:Morphine and aspartic acid were administered separately and in combination to 80 rats divided into 8 groups. Ten and 20 min following the injections, brain, liver and kidney L-asparaginase activity was determined. Morphine decreased brain and liver L-asparaginase activity and increased that of kidney. Aspartic acid co...

journal_title：European journal of pharmacology

authors： Koyuncuoğlu H,Keyer-Uysal M,Berkman K,Güngör M,Genç EM

更新日期：1979-12-20 00:00:00

abstract：:The neuroprotective effects of catalpol, an iridoid glycoside present in the roots of Rehmannia glutinosa, on 1-methyl-4-phenylpyridinium (MPP(+))-induced oxidative stress in cultured mesencephalic neurons, especially dopaminergic neurons, were investigated. Exposure of mesencephalic neurons to 10microM MPP(+) induced...

journal_title：European journal of pharmacology

authors： Tian YY,Jiang B,An LJ,Bao YM

更新日期：2007-07-30 00:00:00