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Central hypertensive action of histamine in conscious normotensive cats.

Abstract：

:In conscious normotensive cats intraventricular (i.c.v.) administration of histamine (2.0-50.0 mug) induced dose-related rises in blood pressure, with no increase in heart rate. The hypertensive response elicited by a sub-maximal dose of histamine (10.0 mu i.c.v.) was significantly antagonised by central pretreatment with the H1-receptor antagonist mepyramine maleate (200 mug i.c.v.) but not by the H2-receptor antagonist metiamide hydrochloride (1.0 mg i.c.v.). Behavioural responses were obtained in response to to histamine (10.0 and 50.0 mug i.c.v.), which were not antagonised by these antihistamine pretreatments.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Finch L,Hicks PE

doi

10.1016/0014-2999(76)90284-3

keywords:

subject

Has Abstract

pub_date

1976-03-01 00:00:00

pages

263-6

issue

1

eissn

0014-2999

issn

1879-0712

pii

0014-2999(76)90284-3

journal_volume

36

pub_type

杂志文章

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