当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PHARMACOLOGY期刊下所有文献 > Time window of infarct reduction by intravenous basic fibroblast growth factor in focal cerebral ischemia.

Time window of infarct reduction by intravenous basic fibroblast growth factor in focal cerebral ischemia.

Abstract：

:Basic fibroblast growth factor (bFGF) is a heparin-binding polypeptide with potent trophic and protective effects on brain neurons, glia and endothelia. In previous studies, we showed that intravenously administered bFGF reduced the volume of cerebral infarcts following permanent occlusion of the middle cerebral artery in rats. In the current study, we examined the time dependence of bFGF infusion on infarct reduction, and the effect of co-infusion of bFGF with heparin. We found a significant reduction in infarct volume when the bFGF infusion (50 microg/kg per h for 3 h) was begun up to 3 h, but not 4 h after the onset of ischemia. The infarct reducing effects of bFGF were not altered by co-infusion of heparin. These results are potentially important in light of the ongoing clinical trials of intravenous bFGF in acute stroke.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Ren JM,Finklestein SP

doi

10.1016/s0014-2999(97)89672-0

subject

Has Abstract

pub_date

1997-05-26 00:00:00

pages

11-6

issue

1

eissn

0014-2999

issn

1879-0712

pii

S0014299997896720

journal_volume

327

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF PHARMACOLOGY文献大全
  • GABA potentiates potassium-stimulated 3H-dopamine release from slices of rat substantia nigra and corpus striatum.

    abstract：:GABA (10-5--10-3 M) had no effect on the spontaneous outflow of previously accumulated 3H-DA or 3H-5HT from rat nigral or striatal slices. However, GABA markedly potentiated the potassium-stimulated release of 3H-DA in both brain regions, while the depolarization-induced output of 3H-5HT was only slightly increased. T...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(78)90091-2

    authors： Starr MS

    更新日期：1978-04-01 00:00:00

  • Depolarization preconditioning produces cytoprotection against veratridine-induced chromaffin cell death.

    abstract：:The hypothesis that K(+) channels and cell depolarization are involved in neuronal death and neuroprotection was tested in bovine chromaffin cells subjected to two treatment periods: the first period (preconditioning period) lasted 6 to 48 h and consisted of treatment with high K(+) solutions or with tetraethylammoniu...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2006.08.084

    authors： Orozco C,García-de-Diego AM,Arias E,Hernández-Guijo JM,García AG,Villarroya M,López MG

    更新日期：2006-12-28 00:00:00

  • Reduction of cisplatin hepatotoxicity by procainamide hydrochloride in rats.

    abstract：:In preceding papers, we proposed that procainamide hydrochloride, a class I antiarrhythmic agent, was able to protect mice and rats from cisplatin-induced nephrotoxicity and that it could exert its action through accumulation in kidneys followed by coordination with cisplatin (or its hydrolysis metabolites) and format...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(02)01537-6

    authors： Zicca A,Cafaggi S,Mariggiò MA,Vannozzi MO,Ottone M,Bocchini V,Caviglioli G,Viale M

    更新日期：2002-05-10 00:00:00

  • Targets and pathways involved in the antitumor activity of citral and its stereo-isomers.

    abstract：:This review provides a comprehensive analysis of the anticancer potential of the natural product citral (CIT) found in many plants and essential oils, and extensively used in the food and cosmetic industry. CIT is composed of two stereoisomers, the trans-isomer geranial being a more potent anticancer compound than the...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejphar.2020.172945

    authors： Bailly C

    更新日期：2020-03-15 00:00:00

  • The effects of adenosine triphosphate and related purines on arterial resistance vessels in vitro and in vivo.

    abstract：:The distribution of P2-purinoceptors in pre-capillary resistance vessels was studied in vitro, using Krebs perfused rabbit ears and in vivo, in autoperfused hindquarters, intestinal and renal vasculatures of pentobarbitone anaesthetised cats. ATP (10(-10)-10(-6) mol i.a.) caused dose-dependent vasodilatation which, in...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(89)90834-0

    authors： Taylor EM,Parsons ME,Wright PW,Pipkin MA,Howson W

    更新日期：1989-02-28 00:00:00

  • Effects of 4-aminopyridine on cat blood pressure in relation to the sympathetic nervous system.

    abstract：:The pressor effect of 4-aminopyridine (4-AP) was studied in anesthetized cats and in isolated cat aortic ring preparations. A significant increase in blood pressure (38.9 +/- 11.4 mmHg) was observed following intravenous administration of 4-AP (0.3 mg/kg). The elevated blood pressure lasted for 1.3 h and returned to t...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(85)90343-7

    authors： Yen MH,Lee SH,Ho ST

    更新日期：1985-07-11 00:00:00

  • Synergistic affective analgesic interaction between delta-9-tetrahydrocannabinol and morphine.

    abstract：:Evidence for an analgesic interaction between delta-9-tetrahydrocannabinol (Delta(9)-THC) and morphine was sought using an experimental pain model applied to normal volunteers. The study incorporated a double blinded, four treatment, four period, four sequence, crossover design. Subjects received Delta(9)-THC 5 mg ora...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2005.11.036

    authors： Roberts JD,Gennings C,Shih M

    更新日期：2006-01-13 00:00:00

  • The effect of local and systemic application of dopaminergic agents on tail flick latency in the rat.

    abstract：:Dopamine (DA) is thought to have a neurotransmitter role in the spinal cord of the rat. Intrathecal administration of the DA receptor agonist apomorphine has previously been shown to reduce nocifensive responses. The present experiments investigated the site of action of apomorphine, and the mechanisms by which DA ago...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(85)90001-9

    authors： Barasi S,Duggal KN

    更新日期：1985-11-19 00:00:00

  • Effect of 3-acetylpyridine on serotonin uptake and release from rat cerebellar slices.

    abstract：:The cerebellum receives indolaminergic fibers influencing Purkinje cell discharges. Data from our laboratories have demonstrated an endogenous release of serotonin (5-HT) and a Na(+)-dependent uptake and Ca(2+)-dependent release of [3H]5-HT from slices, homogenates and synaptosomal fractions of the rat cerebellar mole...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(91)90555-5

    authors： Beas-Zárate C,Morales-Villagran A,Tapia-Arizmendi G,Feria-Velasco A

    更新日期：1991-05-30 00:00:00

  • The ablation of the Ca(v)2.3/E-type voltage-gated Ca2+ channel causes a mild phenotype despite an altered glucose induced glucagon response in isolated islets of Langerhans.

    abstract：:Glucagon release upon hypoglycemia is an important homeostatic mechanism utilized by vertebrates to restore blood glucose to normal. Glucagon secretion itself is triggered by Ca2+ influx through voltage-gated ion channels, and the gene inactivation of R-type Ca2+ channels, with Ca(v)2.3 as the ion conducting subunit, ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2005.01.044

    authors： Pereverzev A,Salehi A,Mikhna M,Renström E,Hescheler J,Weiergräber M,Smyth N,Schneider T

    更新日期：2005-03-21 00:00:00

  • Neuroprotection of taurine against reactive oxygen species is associated with inhibiting NADPH oxidases.

    abstract：:It is well established that taurine shows potent protection against glutamate-induced injury to neurons in stroke. The neuroprotection may result from multiple mechanisms. Increasing evidences suggest that NADPH oxidases (Nox), the primary source of superoxide induced by N-methyl-d-aspartate (NMDA) receptor activation...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2016.03.006

    authors： Han Z,Gao LY,Lin YH,Chang L,Wu HY,Luo CX,Zhu DY

    更新日期：2016-04-15 00:00:00

  • Effect of DL-propranolol on nitric oxide production in perfused rat hindquarters.

    abstract：:The effect of DL-propranolol on NO release in perfused rat hindquarters was studied by using oxyhemoglobin as a capture system to allow the quantitative assay of NO production. In some experiments the stable prostacyclin metabolite 6-keto-PGF1 alpha (6-keto) was simultaneously assayed. We observed that: (1) DL-propran...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(92)90686-x

    authors： Mota-Filipe H,Castro M,Gião-T-Rico JM

    更新日期：1992-03-24 00:00:00

  • Inhibitory effect of spinal mGlu(5) receptor antisense oligonucleotide on the up-regulated expression of spinal G protein associated with chronic morphine treatment.

    abstract：:Knockdown of spinal metabotropic glutamate 5 (mGlu5) receptor was shown to inhibit the development of intrathecal morphine antinociceptive tolerance. The present work was designed to evaluate the expression of spinal G-protein during morphine tolerance and knockdown of spinal mGlu5 receptor with antisense oligonucleot...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2013.11.024

    authors： Chen M,Zhang X,Xu H,Ma X,Jiang W,Xu T

    更新日期：2014-01-15 00:00:00

  • Discrepancy between routine and expert pathologists' assessment of non-palpable breast cancer and its impact on locoregional and systemic treatment.

    abstract：:Histopathological parameters are essential for deciding on adjuvant treatment following breast cancer surgery. We assessed the impact of inter-observer variability on treatment strategy in patients operated for clinically node negative, non-palpable breast carcinomas. In the context of a multicenter randomised control...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ejphar.2012.12.033

    authors： Postma EL,Verkooijen HM,van Diest PJ,Willems SM,van den Bosch MA,van Hillegersberg R

    更新日期：2013-10-05 00:00:00

  • Yawning produced by dopamine agonists in rhesus monkeys.

    abstract：:Yawning was recorded from five rhesus monkeys restrained in a chair after i.m. injection of dopaminergic compounds: apomorphine (0.03 mg/kg), quinpirole (0.01 mg/kg), and (-)-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine (1 mg/kg). SKF 38393 or physostigmine produced no yawning. Yawning from apomorphine was blocked by ch...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(91)90351-p

    authors： Code RA,Tang AH

    更新日期：1991-08-29 00:00:00

  • Some effects of ORG GC 94, a potential anti-migraine drug, on human platelets.

    abstract：:Some effects of Org GC 94 (1,3,4,14b-tetrahydro-2,7-dimethyl-2H-dibenzo[b,f]pyrazino[1,2-d][1,4]oxazepine maleate) on human platelets have been investigated. Without pretreatment with ADP, 5-HT-induced aggregation of humam platets was completely inhibited by 2.5 x 10(-8) M of Org GC 94. Aggregation triggered by noradr...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(77)90290-4

    authors： Bhargava N,Matthijsen R,Schönbaum E

    更新日期：1977-04-07 00:00:00

  • Celastrol suppresses obesity process via increasing antioxidant capacity and improving lipid metabolism.

    abstract：:High fat diet, as an important risk factor, plays a pivotal role in atherosclerotic process. Celastrol is one of the active triterpenoid compounds with antioxidative and anti-inflammatory characters. The aims of this study were to evaluate the effect of celastrol on weight, blood lipid and oxidative injury induced by ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2014.09.043

    authors： Wang C,Shi C,Yang X,Yang M,Sun H,Wang C

    更新日期：2014-12-05 00:00:00

  • Rat vena cava alpha 1B-adrenoceptors: characterization by [3H]prazosin binding and contraction experiments.

    abstract：:We examined which subtypes of alpha 1-adrenoceptors are expressed in rat vena cava by using both functional and [3H]prazosin binding experiments. Pretreatment with chloroethylclonidine inactivated about 80% of the specific [3H]prazosin binding sites and reduced the maximal noradrenaline-induced contraction to the same...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0922-4106(93)90042-8

    authors： Sayet I,Neuilly G,Rakotoarisoa L,Mironneau J,Mironneau C

    更新日期：1993-08-15 00:00:00

  • The anticonvulsant retigabine attenuates nociceptive behaviours in rat models of persistent and neuropathic pain.

    abstract：:We have tested for anti-nociceptive effects of the anticonvulsant KCNQ channel opener, N-(2-amino-4-(4-fluorobenzylamino)-phenyl)carbamic acid ethyl ester (retigabine), in rat models of experimental pain. In the chronic constriction injury and spared nerve models of neuropathic pain, injection of retigabine (5 and 20 ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(02)02924-2

    authors： Blackburn-Munro G,Jensen BS

    更新日期：2003-01-24 00:00:00

  • Isolated human bladder: evidence for an adenine dinucleotide acting on P2X-purinoceptors and for purinergic transmission.

    abstract：:In isolated strips of human urinary bladder detrusor muscle, ATP, alpha, beta-methylene ATP and P1,P6-diadenosine hexaphosphate caused concentration-dependent contractions. ATP was less potent than the two synthetic purine compounds and gave smaller maximum responses. Responses to ATP, P1,P6-diadenosine hexaphosphate ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(89)90881-9

    authors： Hoyle CH,Chapple C,Burnstock G

    更新日期：1989-12-12 00:00:00

  • The inducible nitric oxide synthase inhibitor ONO-1714 blunts dextran sulfate sodium colitis in mice.

    abstract：:In mice with acute dextran sulfate sodium colitis, we examined the effect of inducible nitric oxide synthase inhibition by (1S,5S,6R,7R)-7chloro-3-amino-5methyl-2-azabicyclo[4.1.0]heptane hydrochloride (ONO-1714) on colonic biochemistry, injury, and inflammation. Colonic luminal nitrate and nitrite were measured by th...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(00)00926-2

    authors： Naito Y,Takagi T,Ishikawa T,Handa O,Matsumoto N,Yagi N,Matsuyama K,Yoshida N,Yoshikawa T

    更新日期：2001-01-19 00:00:00

  • Modulation of calcium uptake and D-aspartate release by GABAB receptors in cultured cerebellar granule cells.

    abstract：:(-)Baclofen, a GABAB receptor agonist, and GABA attenuated by 60% the high K+-evoked 45Ca2+ uptake into cultured cerebellar granule cells with an EC50 of 110 +/- 18 nM and 2.4 +/- 0.2 microM, respectively. The attenuation by baclofen of 45Ca2+ uptake was stereospecific and the effect of GABA was unaffected by bicucull...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(87)90557-7

    authors： Zhu XZ,Chuang DM

    更新日期：1987-09-23 00:00:00

  • The sigma receptor ligand rimcazole alters secretion of prolactin and alpha-melanocyte stimulating hormone by dopaminergic and non-dopaminergic mechanisms.

    abstract：:The role of tuberoinfundibular and periventricular-hypophysial dopaminergic neurons in mediating rimcazole-induced decreases in plasma concentrations of prolactin and alpha-melanocyte stimulating hormone was assessed. Dopaminergic neuronal activity was estimated by measuring concentrations of 3,4-dihydroxyphenylacetic...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(95)00841-1

    authors： Eaton MJ,Lookingland KJ,Moore KE

    更新日期：1996-03-28 00:00:00

  • 1-Methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine (2'-CH3-MPTP) is a more potent dopaminergic neurotoxin than MPTP in mice.

    abstract：:The administration to mice of 1-methyl-4-(2'-methylphenyl)-1,2,3, 6-tetrahydropyridine (2'-CH3-MPTP), a substituted analog of the dopaminergic neurotoxin MPTP caused even more dopaminergic toxicity than MPTP itself. Under conditions in which MPTP was relatively ineffective (i.e. two injections per day of 0.113 mmol/kg...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(86)90115-9

    authors： Youngster SK,Duvoisin RC,Hess A,Sonsalla PK,Kindt MV,Heikkila RE

    更新日期：1986-03-18 00:00:00

  • Genetic susceptibility factors for Alzheimer's disease.

    abstract：:Alzheimer's disease is the most frequent cause of dementia. Family and twin studies have suggested that genetic factors play a role in Alzheimer's disease development. Some Alzheimer's disease cases show an autosomal dominant inheritance pattern and thus allow the discovery of major disease genes. However, most Alzhei...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/s0014-2999(00)00903-1

    authors： Richard F,Amouyel P

    更新日期：2001-01-19 00:00:00

  • The mu opiate receptor is responsible for descending pain inhibition originating in the periaqueductal gray region of the rat brain.

    abstract：:Opiate agonists exhibiting selectivity for mu, kappa, sigma, and delta opiate receptors were microinjected into the periaqueductal gray region (PAG) of the brain of rats to determine the receptor subtype(s) associated with the initiation of descending pain inhibition. The spinally organized, heat nociceptive tail-flic...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(88)90145-8

    authors： Smith DJ,Perrotti JM,Crisp T,Cabral ME,Long JT,Scalzitti JM

    更新日期：1988-10-26 00:00:00

  • Biphasic action of ethanol on contraction of skeletal muscle.

    abstract：:Ethanol (160-640 mM) produces a biphasic action on the indirectly stimulated rat phrenic nerve--diaphragm preparation. This consists of a potentiation followed by a blockade of muscle contraction. Concomitant with the increase in the force of contraction was the appearance of multiple neural action potentials recorded...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(75)90044-8

    authors： Cooper SA,Dretchen KL

    更新日期：1975-04-01 00:00:00

  • d-LSD-induced c-Fos expression occurs in a population of oligodendrocytes in rat prefrontal cortex.

    abstract：:Induction of mRNA or protein for immediate-early genes, such as c-fos, is used to identify brain areas, specific cell types, and neuronal circuits that become activated in response to various stimuli including psychoactive drugs. The objective of the present study was to identify the cell types in the prefrontal corte...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2007.12.031

    authors： Reissig CJ,Rabin RA,Winter JC,Dlugos CA

    更新日期：2008-03-31 00:00:00

  • Role of nitric oxide in systemic effect of theophylline on mouse body temperature.

    abstract：:In the present study, the interaction of nitric oxide synthase (NOS) inhibitors, L-NAME (N(G)-nitro-L-arginine methyl ester HCl) and L-NA (N(omega)-nitro-L-arginine), and its precursor, L-arginine (2-(S)-2-amino-5-[(aminoiminomethyl)amino] pentatonic acid), with theophylline on mouse body temperature was studied. Intr...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(02)02159-3

    authors： Zarrindast MR,Adl M,Sharifzadeh M,Bahreini T

    更新日期：2002-09-06 00:00:00

  • The phytoestrogen genistein enhances endothelium-independent relaxation in the porcine coronary artery.

    abstract：:Genistein, a phytoestrogen, possesses cardioprotective effects. Responses to genistein (0.1-100 microM) were assessed in 9,11-dideoxy-9 alpha, 11 alpha-methanoepoxy prostaglandin F(2 alpha) (U46619)-contracted porcine coronary arterial rings, with significant relaxations at high concentrations. At concentrations with ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2003.09.028

    authors： Lee MY,Man RY

    更新日期：2003-11-28 00:00:00