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The anticonvulsant retigabine attenuates nociceptive behaviours in rat models of persistent and neuropathic pain.

Abstract：

:We have tested for anti-nociceptive effects of the anticonvulsant KCNQ channel opener, N-(2-amino-4-(4-fluorobenzylamino)-phenyl)carbamic acid ethyl ester (retigabine), in rat models of experimental pain. In the chronic constriction injury and spared nerve models of neuropathic pain, injection of retigabine (5 and 20 mg/kg, p.o.) significantly attenuated (P<0.05) mechanical hypersensitivity in response to pin prick stimulation of the injured hindpaw. In contrast, retigabine had no effect on mechanical hypersensitivity to von Frey stimulation of the injured hindpaw in either model. Cold sensitivity in response to ethyl chloride was only attenuated (P<0.05) in the chronic constriction injury model. In the formalin test, retigabine (20 mg/kg, p.o.) attenuated flinching behaviour in the second phase compared with vehicle (P<0.05), and this effect was completely reversed by the KCNQ channel blocker 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone (XE-991; 3 mg/kg, i.p.). Neither retigabine nor XE-991 administration affected the latency to respond to noxious thermal stimulation of the tail in control animals. These results suggest that retigabine may prove to be effective in the treatment of neuropathic pain.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Blackburn-Munro G,Jensen BS

doi

10.1016/s0014-2999(02)02924-2

keywords:

subject

Has Abstract

pub_date

2003-01-24 00:00:00

pages

109-16

issue

2-3

eissn

0014-2999

issn

1879-0712

pii

S0014299902029242

journal_volume

460

pub_type

杂志文章

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