当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PHARMACOLOGY期刊下所有文献 > The sigma receptor ligand rimcazole alters secretion of prolactin and alpha-melanocyte stimulating hormone by dopaminergic and non-dopaminergic mechanisms.

The sigma receptor ligand rimcazole alters secretion of prolactin and alpha-melanocyte stimulating hormone by dopaminergic and non-dopaminergic mechanisms.

Abstract：

:The role of tuberoinfundibular and periventricular-hypophysial dopaminergic neurons in mediating rimcazole-induced decreases in plasma concentrations of prolactin and alpha-melanocyte stimulating hormone was assessed. Dopaminergic neuronal activity was estimated by measuring concentrations of 3,4-dihydroxyphenylacetic acid (DOPAC) in the median eminence and intermediate lobe of the pituitary which contain terminals of tuberoinfundibular and periventricular-hypophysial dopaminergic neurons, respectively. Rimcazole decreased plasma concentrations of both prolactin and alpha-melanocyte stimulating hormone, increased the concentration of DOPAC in median eminence, but did not alter DOPAC concentrations in the intermediate lobe of the pituitary. Pretreatment with a 'putative' sigma receptor agonist, pentazocine, prevented the rimcazole-induced increase of the concentration of DOPAC in the median eminence, but did not block the ability of rimcazole to decrease plasma concentrations of prolactin. The results of this study reveal that the ability of rimcazole to decrease alpha-melanocyte stimulating hormone secretion is not mediated by a dopaminergic mechanism, whereas the ability of rimcazole to decrease prolactin secretion appears to be mediated by both dopaminergic and non-dopaminergic mechanisms.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Eaton MJ,Lookingland KJ,Moore KE

doi

10.1016/0014-2999(95)00841-1

subject

Has Abstract

pub_date

1996-03-28 00:00:00

pages

171-7

issue

1-3

eissn

0014-2999

issn

1879-0712

pii

0014-2999(95)00841-1

journal_volume

299

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF PHARMACOLOGY文献大全
  • Animal models of rheumatoid arthritis: How informative are they?

    abstract：:Animal models of arthritis are widely used to de-convolute disease pathways and to identify novel drug targets and therapeutic approaches. However, the high attrition rates of drugs in Phase II/III rates means that a relatively small number of drugs reach the market, despite showing efficacy in pre-clinical models. Th...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejphar.2015.03.047

    authors： McNamee K,Williams R,Seed M

    更新日期：2015-07-15 00:00:00

  • Comparison of some biological properties of neurotensin and its natural analogue LANT-6.

    abstract：:The biological properties of neurotensin (NT) and the chicken peptide [Lys8,Asn9]neurotensin-(8-13) (LANT-6) were compared in 3 in vitro assays: (1) competitive inhibition of [3H]NT binding to rat brain synaptic membranes, (2) relaxation of the rat ileum, and (3) contraction of the guinea-pig ileum. The data show that...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(84)90147-x

    authors： Kitabgi P,Checler F,Vincent JP

    更新日期：1984-04-06 00:00:00

  • Drug affinities for the agonist and antagonist states of the opioid receptor.

    abstract：:Traditional methods of analyzing the binding of opiates do not accurately establish the affinities of the drugs for the agonist and antagonist states of the opioid receptor. The poor results obtained by the Scatchard procedure may be attributed to the presence of extraneous drug binding sites in the brain-homogenate m...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(82)90127-3

    authors： Cheney BV,Lahti RA,Barsuhn C

    更新日期：1982-02-05 00:00:00

  • α1D-adrenoceptor involves the relaxation effect of farrerol in rat aortic vascular smooth muscle cells.

    abstract：:The aim of this study was to investigate the relaxation effect of farrerol on rat aortic vascular smooth muscle cells (VSMCs) and its underlying mechanism. VSMCs were cultured primarily and were used to examine the relaxation effect of farrerol. Cells surface and length were measured by dynamic observation, or by rhod...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2019.02.012

    authors： Qin X,Hou X,Zhang K,Li Q

    更新日期：2019-06-15 00:00:00

  • Antagonism of beta-adrenoceptor-mediated relaxations of human bronchial smooth muscle by carbachol.

    abstract：:Activation of muscarinic M2 receptors has been suggested to account, in part, for the reduced relaxant potency of beta-adrenoceptor agonists in canine and guinea-pig tracheal smooth muscle pre-contracted with muscarinic agonists as compared to histamine. The aim of the present study was to determine whether the potenc...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(95)00048-p

    authors： Watson N,Magnussen H,Rabe KF

    更新日期：1995-03-14 00:00:00

  • Mitomycin C induces fibroblasts apoptosis and reduces epidural fibrosis by regulating miR-200b and its targeting of RhoE.

    abstract：:Mitomycin C (MMC) is known to reduce epidural fibrosis, but the underlying mechanisms have not yet been elucidated. Aberrant miR-200b expressions have been reported in multiple types of fibrotic tissues from many diseases. The aim of this study was to clarify the mechanism by which MMC induces fibroblasts apoptosis an...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2015.08.002

    authors： Sun Y,Ge Y,Fu Y,Yan L,Cai J,Shi K,Cao X,Lu C

    更新日期：2015-10-15 00:00:00

  • Oxidation by trace Cu2+ ions underlies the ability of ascorbate to induce vascular dysfunction in the rat perfused mesentery.

    abstract：:Ascorbate has both antioxidant and pro-oxidant activities. We have previously shown that plasma levels of ascorbate induce constriction and blockade of dilatation mediated by endothelium-derived hyperpolarizing factor (EDHF). In this study we sought to determine if these detrimental actions were mediated by a prooxida...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2009.04.033

    authors： Nelli S,Craig J,Martin W

    更新日期：2009-07-01 00:00:00

  • Naltrindole, a selective delta-opioid receptor antagonist, potentiates the lethal effects of cocaine by a central mechanism of action.

    abstract：:The potentiation of the toxic and lethal effects of cocaine by the selective delta-opioid receptor antagonist naltrindole was explored in unrestrained, unanesthetized rats that received a continuous intravenous infusion of cocaine until death. The lethal dose of cocaine was lowered dose dependently in animals administ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(97)01090-x

    authors： Patterson AB,Gordon FJ,Holtzman SG

    更新日期：1997-08-20 00:00:00

  • Discovery of a novel neuroprotective compound, AS1219164, by high-throughput chemical screening of a newly identified apoptotic gene marker.

    abstract：:We have reported that tacrolimus (FK506), an immunosuppressive drug, and diclofenac, a non-steroidal anti-inflammatory drug, possess different modes of neuroprotective action. FK506 suppresses only thapsigargin-induced apoptosis in neuroblastoma SH-SY5Y cells while diclofenac reverses tunicamycin-induced as well as th...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2011.07.027

    authors： Yamazaki T,Muramoto M,Okitsu O,Morikawa N,Kita Y

    更新日期：2011-11-01 00:00:00

  • External ATP antagonizes the effect of potassium channel openers in guinea-pig ventricular papillary muscle.

    abstract：:Right ventricular papillary muscles of the guinea-pig heart were electrically stimulated. Cromakalim 10-100 microM and Ro 31-6930 3 microM depressed the contractile force and shortened the duration of action potentials. Glibenclamide 0.3-3 microM, ATP 100 microM and alpha, beta-methylene ATP (alpha, beta-meATP) 30 mic...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(92)90244-x

    authors： Bott A,Eltze M,Illes P

    更新日期：1992-03-17 00:00:00

  • Characterization of scratching behavior induced by intradermal administration of morphine and fentanyl in mice.

    abstract：:Itching is known as a commonly side effect of opioid administration. However, the relationship of opioid receptors to itching is unclear. In this study, we examined the effect of intradermal injection of morphine and fentanyl on the itching sensation. When injected intradermally into the rostral back of mice, morphine...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2009.10.066

    authors： Yamamoto A,Kuyama S,Kamei C,Sugimoto Y

    更新日期：2010-02-10 00:00:00

  • Effect of vagotomy on airway hyperreactivity to endogenously released neurotransmitters at 18-24 h after inhaled antigen.

    abstract：:Airway reactivity was examined in anaesthetized guinea-pigs 18-24 h after inhalation challenge of ovalbumin-sensitized animals with ovalbumin. Bronchoconstrictor responses were measured from the increases in pulmonary inflation pressure. The study was undertaken to examine whether ovalbumin challenge induced airway hy...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(98)00215-5

    authors： Johnson A,Broadley KJ

    更新日期：1998-05-22 00:00:00

  • Mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease.

    abstract：:The past decade has witnessed a number of exciting developments in the field of mitochondrial dynamics - a phenomenon in which changes in mitochondrial shape and movement impact on cellular physiology and pathology. By undergoing fusion and fission, mitochondria are able to change their morphology between elongated in...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejphar.2015.04.056

    authors： Ong SB,Kalkhoran SB,Cabrera-Fuentes HA,Hausenloy DJ

    更新日期：2015-09-15 00:00:00

  • Amelioration of brain damage after focal ischemia in the rat by a novel inhibitor of lipid peroxidation.

    abstract：:We studied the effects of 2-(allyl-1-piperazinyl)-4-n-amyloxyquinazoline fumarate (KB-5666) on brain edema and histological neuronal damage in rats with focal ischemia and on lipid peroxidation in brain homogenates and brain mitochondria in vitro. KB-5666 (3-100 microM) inhibited lipid peroxidation in brain homogenate...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(91)90367-y

    authors： Hara H,Kogure K,Kato H,Ozaki A,Sukamoto T

    更新日期：1991-05-02 00:00:00

  • Deltorphin II enhances extracellular levels of dopamine in the nucleus accumbens via opioid receptor-independent mechanisms.

    abstract：:The effects of the delta2-opioid receptor agonist, deltorphin II, on extracellular levels of dopamine in the rat nucleus accumbens were investigated in awake animals by in vivo brain microdialysis. In agreement with previous studies, perfusion of deltorphin II (50.0 nmol) into the nucleus accumbens significantly incre...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2004.03.028

    authors： Murakawa K,Hirose N,Takada K,Suzuki T,Nagase H,Cools AR,Koshikawa N

    更新日期：2004-04-26 00:00:00

  • Effect of diazepam on cerebral 5-hydroxytryptamine synthesis.

    abstract：:In the brains of normal and reserpinized rats both diazepam and amino-oxyacetic acid (AOAA) decreased the 5-hydroxytryptophan (5HTP) accumulation induced by the decarboxylase inhibitor 3-hydroxybenzylhydrazine (NSD 1015). In reserpinized animals, the action of diazepam was antagonized by picrotoxin and bicuculline in ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(79)90200-0

    authors： Saner A,Pletscher A

    更新日期：1979-05-01 00:00:00

  • NMDA receptor antagonists to characterize rat renal organic cation transporter function.

    abstract：:We hypothesized that uncompetitive NMDA glutamate receptor antagonists memantine (2,5-dimethyl-1-adamantanamine), and amino-alkyl-cyclohexane compounds: MRZ 2/579 (1-amino-1,3,3,5,5-pentamethylcyclohexane HCl), MRZ 2/600 (1-amino-1-ethyl-3,3,5,5-tetramethylcyclohexane HCl), and MRZ 2/615 (1-amino-1,3,5,5-tetramethyl-3...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(02)02121-0

    authors： Fourie J,Escobar MR,Sitar DS

    更新日期：2002-09-27 00:00:00

  • Allosteric interactions of three muscarine antagonists at bovine tracheal smooth muscle and cardiac M2 receptors.

    abstract：:The kinetics of [3H]dexetimide dissociation from muscarine receptors in bovine cardiac left ventricular and tracheal smooth muscle membranes were studied in the absence and presence of three muscarine antagonists. It was found that [3H]dexetimide dissociation from cardiac muscarine receptors was monophasic and very fa...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0922-4106(89)90045-x

    authors： Roffel AF,Elzinga CR,Meurs H,Zaagsma J

    更新日期：1989-03-07 00:00:00

  • Effects of N-methyl-D-aspartate antagonists on the cough reflex.

    abstract：:The effects of antagonists of N-methyl-D-aspartate (NMDA) on the capsaicin-induced cough reflex in rats were studied. Intracisternal (i. cist.) injection of MK-801, a non-competitive antagonist of NMDA, significantly decreased the number of coughs in a dose-dependent manner. The competitive antagonists of NMDA, 2-DL-a...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(89)90560-8

    authors： Kamei J,Tanihara H,Igarashi H,Kasuya Y

    更新日期：1989-09-13 00:00:00

  • Cardiovascular and endocrine effects of naloxone compared in normotensive and hypertensive patients.

    abstract：:Naloxone, a competitive antagonist of opioid receptors, and placebo (dextrose 5% in water (D5W) were administered on separate days to healthy normotensive (NT) male volunteers and to male patients with essential hypertension (HT). A single-blind, placebo-controlled, cross-over design was employed. Increasing doses of ...

    journal_title：European journal of pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1016/0014-2999(86)90048-8

    authors： Fuenmayor N,Cubeddu L

    更新日期：1986-07-31 00:00:00

  • Ubiquinol rescues simvastatin-suppression of mitochondrial content, function and metabolism: implications for statin-induced rhabdomyolysis.

    abstract：:Statin medications diminish cholesterol biosynthesis and are commonly prescribed to reduce cardiovascular disease. Statins also reduce production of ubiquinol, a vital component of mitochondrial energy production; ubiquinol reduction may contribute to rhabdomyolysis. Human rhabdomyosarcoma cells were treated with eith...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2013.04.009

    authors： Vaughan RA,Garcia-Smith R,Bisoffi M,Conn CA,Trujillo KA

    更新日期：2013-07-05 00:00:00

  • Dopamine D-1 and D-2 receptor agonists and antagonists and neuropeptide-induced excessive grooming.

    abstract：:The administration of the dopamine D-1 receptor antagonist, SCH 23390, but not of the dopamine D-2 receptor antagonist, sulpiride, suppressed the excessive grooming induced by a new environment or by various neuropeptides. In addition, administration of the dopamine D-1 agonist, SK & F 38393, induced excessive groomin...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(89)90527-x

    authors： Van Wimersma Greidanus TB,Maigret C,Torn M,Ronner E,Van der Kracht S,Van der Wee NJ,Versteeg DH

    更新日期：1989-12-07 00:00:00

  • Pharmacological studies on the NOP and opioid receptor agonist PWT2-[Dmt1]N/OFQ(1-13).

    abstract：:An innovative chemical strategy named peptide welding technology (PWT) has been developed for the facile synthesis of tetrabranched peptides. [Dmt1]N/OFQ(1-13)-NH2 acts as a universal agonist for nociceptin/orphanin FQ (N/OFQ) and classical opioid receptors. The present study investigated the pharmacological profile o...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2016.11.026

    authors： Cerlesi MC,Ding H,Bird MF,Kiguchi N,Ferrari F,Malfacini D,Rizzi A,Ruzza C,Lambert DG,Ko MC,Calo G,Guerrini R

    更新日期：2017-01-05 00:00:00

  • Compound action potential inhibition produced by various antidepressants in the frog sciatic nerve.

    abstract：:Although an inhibition of action potential conduction in nerve fibers possibly contributes to at least a part of antinociception produced by analgesics and the adjuvants, it has not been fully examined yet how the conduction inhibition differs in extent among their drugs. We investigated the effects of various antidep...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2017.11.047

    authors： Hirao R,Fujita T,Sakai A,Kumamoto E

    更新日期：2018-01-15 00:00:00

  • Pericardial mesothelial cells produce endothelin-1 and possess functional endothelin ETB receptors.

    abstract：:We investigated the endothelin production and endothelin receptor activity of pericardial mesothelial cells obtained from spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats. The pericardial mesothelial cells were maintained in vitro and the production of endothelin-1 by these cells was evaluated by usin...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(98)00110-1

    authors： Kuwahara M,Kuwahara M

    更新日期：1998-04-24 00:00:00

  • The effects of nitroglycerin during cardiopulmonary resuscitation.

    abstract：:The outcome for both in-hospital and out-of hospital cardiac arrest remains dismal. Vasopressors are used to increase coronary perfusion pressure and thus facilitate return of spontaneous circulation during cardiopulmonary resuscitation. However, they are associated with a number of potential adverse effects and may d...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejphar.2014.04.002

    authors： Stefaniotou A,Varvarousi G,Varvarousis DP,Xanthos T

    更新日期：2014-07-05 00:00:00

  • Resveratrol attenuates high fat diet-induced mouse cardiomyopathy through upregulation of estrogen related receptor-α.

    abstract：:Resveratrol reportedly promotes the improvement of cardiac dysfunction and other cardiovascular diseases. Studies demonstrate resveratrol exhibits a set of benefits, including anti-oxidative property, anti-apoptosis and anti-inflammation. However, the molecular mediators of resveratrol-induced cardiac benefits are sti...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2018.10.018

    authors： Lu Y,Lu X,Wang L,Yang W

    更新日期：2019-01-15 00:00:00

  • High affinity [3H]zolpidem binding in the rat brain: an imidazopyridine with agonist properties at central benzodiazepine receptors.

    abstract：:[3H]Zolpidem, a novel hypnotic drug possessing a chemical structure unrelated to that of benzodiazepine (BZD) was employed as a new ligand to determine its binding characteristics to membrane preparations of rat cerebral cortex and cerebellum. In both structures, the imidazopyridine [3H]zolpidem bound with high affini...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(86)90276-1

    authors： Arbilla S,Allen J,Wick A,Langer SZ

    更新日期：1986-11-04 00:00:00

  • Effect of Ca2+ entry blockers on myosin light-chain kinase and protein kinase C.

    abstract：:Thirteen Ca2+ entry blockers were compared with respect to their inhibitory effects on the activity of smooth muscle myosin light-chain kinase and smooth muscle protein kinase C, and the Ca2+-induced contraction of basilar artery rings. Comparison of the IC50 values obtained for these compounds, suggests that with the...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(89)90410-x

    authors： Schächtele C,Wagner B,Rudolph C

    更新日期：1989-04-12 00:00:00

  • The putative imidazoline receptor agonist, harmane, promotes intracellular calcium mobilisation in pancreatic beta-cells.

    abstract：:beta-Carbolines (including harmane and pinoline) stimulate insulin secretion by a mechanism that may involve interaction with imidazoline I(3)-receptors but which also appears to be mediated by actions that are additional to imidazoline receptor agonism. Using the MIN6 beta-cell line, we now show that both the imidazo...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2004.08.018

    authors： Squires PE,Hills CE,Rogers GJ,Garland P,Farley SR,Morgan NG

    更新日期：2004-10-06 00:00:00