Dopamine D-1 and D-2 receptor agonists and antagonists and neuropeptide-induced excessive grooming.

abstract：:Although muscarinic M(2) and M(3) receptors are known to be important for regulation of gastric and small intestinal motility, muscarinic receptor subtypes regulating colonic function remain to be investigated. The aim of this study was to characterize muscarinic receptors involved in regulation of colonic contractili...

journal_title：European journal of pharmacology

authors： Kondo T,Nakajima M,Teraoka H,Unno T,Komori S,Yamada M,Kitazawa T

更新日期：2011-11-16 00:00:00

abstract：:We investigated the effect of sevoflurane (fluoromethyl-2,2,2-trifluoro-1-(trifluoromethyl) ethylether) on intracellular calcium concentration ([Ca2+]i) and nitric oxide (NO) release from cultured porcine aortic endothelial cells using fura-2 fluorometry, and direct (ESR spectrometry with NO-trapping by 2-(4-carboxyph...

journal_title：European journal of pharmacology

authors： Az-ma T,Fujii K,Yuge O

更新日期：1995-03-15 00:00:00

abstract：:A series of 26 drugs was tested for in vitro binding to opiate receptors in the presence and absence of 0.1 M NaCl. The results were correlated with assays for in vivo pharmacological potency. Highly significant correlation was found between binding in the presence and absence of sodium ions and analgesic potency. For...

journal_title：European journal of pharmacology

authors： Stahl KD,van Bever W,Janssen P,Simon EJ

更新日期：1977-12-01 00:00:00

abstract：:High stereoselectivity was observed for the enantiomers of trihexyphenidyl and trihexyphenidyl methiodide at muscarinic M1-receptors in field-stimulated rabbit vas deferens and at M2 alpha- and M2 beta-receptors in guinea-pig atrium and ileum, respectively. Considerably higher affinities (up to 1700-fold) were found f...

journal_title：European journal of pharmacology

authors： Lambrecht G,Feifel R,Moser U,Aasen AJ,Waelbroeck M,Christophe J,Mutschler E

更新日期：1988-10-11 00:00:00

abstract：:PCA 50941 is a novel 1,4-dihydropyridine derivative. Its vasoconstricting effects prompted a systematic comparison with the prototypic Ca2+ channel activator, Bay K 8644. The two compounds exhibit marked analogies and differences in their cardiovascular profiles. PCA 50941 exhibits a pronounced vascular over cardiac s...

journal_title：European journal of pharmacology

authors： Priego J,González-Morales MA,Cillero FJ,Villarroya M,Sunkel C,de Casa-Juana MF,López MG,Artalejo CR,de Pascual R,García AG

更新日期：1993-10-12 00:00:00

abstract：:Nitric oxide (NO) and prostacyclin (PGI(2)) are two of the most important vasodilators produced by endothelial cells, the regulation of NO on PGI(2) production has not been fully clear yet. Polyaspartoyl.L-arginine (PDR) is an L-arginine residue-rich compound with inhibitory effects of platelet aggregation and thrombo...

journal_title：European journal of pharmacology

authors： Tang Z,Yang J,Liu X,Wang Y,Peng S

更新日期：2008-12-28 00:00:00

abstract：:When injected directly into the tail, U50,488H is a potent analgesic in the tailflick assay (ED50 3.1 micrograms). The analgesic activity is lost if the radiant heat is focused 1 cm away from the site of injection. The kappa 1-opioid receptor antagonist nor-binaltorphimine given systemically reverses the local analges...

journal_title：European journal of pharmacology

authors： Kolesnikov Y,Jain S,Wilson R,Pasternak GW

更新日期：1996-08-29 00:00:00

abstract：:The effect of genistein, a tyrosine kinase inhibitor, on nitroglycerin-induced relaxation was examined in rat aortic rings contracted by phenylephrine. In rat aortic rings, genistein (10(-5) M and 3x10(-5) M), a tyrosine kinase inhibitor, but not daidzein, an analogue of genistein, increased relaxation induced by nitr...

journal_title：European journal of pharmacology

authors： Satake N,Imanishi M,Shibata S

更新日期：1999-07-21 00:00:00

abstract：:The effects of riluzole, an anticonvulsant and neuroprotective compound, on excitatory amino acid-evoked currents were studied in Xenopus laevis oocytes injected with mRNA from rat whole brain or cortex. Responses to kainic acid were blocked by riluzole (IC50 = 167 microM) as well as by the quinoxalinedione antagonist...

journal_title：European journal of pharmacology

authors： Debono MW,Le Guern J,Canton T,Doble A,Pradier L

更新日期：1993-04-28 00:00:00

abstract：:We used two experimental models to prove that resveratrol (trans-3,4',5-trihydroxystilbene) reduces cardiac ischemic-reperfusion injury by means of a nitric oxide- and adenosine-dependent mechanism. (1). ACUTE EX VIVO: resveratrol (10 microM, 10 min) infusion in Langendorff-perfused normoxic rat hearts significantly i...

journal_title：European journal of pharmacology

authors： Bradamante S,Barenghi L,Piccinini F,Bertelli AA,De Jonge R,Beemster P,De Jong JW

更新日期：2003-03-28 00:00:00

abstract：:HgCl2 and mersalyl increased and later decreased both the spontaneous and evoked transmitter liberation at the frog neuromuscular junction. Lower concentration of HgCl2 exhibited only an inhibitory effect on transmitter release. These mercurials inhibited calcium transport of mitochondria and synaptosomal vesicles. Lo...

journal_title：European journal of pharmacology

authors： Binah O,Meiri U,Rahamimoff H

更新日期：1978-10-15 00:00:00

abstract：:The present study was undertaken to evaluate the effects of an adenylate cyclase activator N,N-dimethyl-beta-alanine[3R-(3alpha, 4alphabeta, 5beta, 6beta, 6aalpha, 10alpha, 10abeta, 10balpha)]-5(acetyloxy)-3-ethenyldodecahydro-10, 10b-dihydroxy-3, 4a, 7, 7, 10a-pentamethyl-1-oxo-1H-naphtho [2,1-b] pyran-6-yl ester hyd...

journal_title：European journal of pharmacology

authors： Tanahashi M,Hara S,Yoshida M,Suzuki-Kusaba M,Yokoyama H,Hosono M,Hisa H,Satoh S

更新日期：1999-05-21 00:00:00

abstract：:The ability of SCH 23390 as compared to haloperidol to produce catalepsy in rats was evaluated in three tests for catalepsy. SCH 23390 produced catalepsy in all three tests with ED50 (mg/kg s.c.) of 0.017 on the vertical grid, 0.023 on the horizontal bar and 0.038 on the 'four corks'. Haloperidol produced catalepsy wi...

journal_title：European journal of pharmacology

authors： Morelli M,Di Chiara G

更新日期：1985-11-05 00:00:00

abstract：:Effects of protein kinase C inhibitors, staurosporine and 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride and protein tyrosine kinase inhibitors, genistein, tyrphostin and 2,5-dimethylcinnamate on the neutrophil responses stimulated by immunoglobulin G (IgG), complement C5a or platelet-activating factor...

journal_title：European journal of pharmacology

authors： Ahn SK,Shin YK,Kang HJ,Han ES,Lee CS

更新日期：1996-06-13 00:00:00

abstract：:The pharmacological activity of N-methyl-actinodaphnine, isolated from Illigera luzonensis, was determined by functional and binding experiments with peripheral tissues. In a functional study, N-methyl-actinodaphnine was a simple competitive antagonist of contractions elicited by phenylephrine (pA2 = 7.11) in rat thor...

journal_title：European journal of pharmacology

authors： Guh JH,Ko FN,Yu SM,Wu YC,Teng CM

更新日期：1995-06-06 00:00:00

abstract：:In this study we aimed to test central administration of CDP-choline on serum ghrelin, leptin, glucose and corticosterone levels in rats. Intracerebroventricular (i.c.v.) 0.5, 1.0 and 2.0 µmol CDP-choline and saline were administered to male Wistar-Albino rats. For the measurement of serum leptin and ghrelin levels, b...

journal_title：European journal of pharmacology

authors： Kiyici S,Basaran NF,Cavun S,Savci V

更新日期：2015-10-05 00:00:00

abstract：:The potential of resiniferatoxin and capsaicin to modulate emesis and genital grooming was investigated in Suncus murinus. Resinifertoxin (3-30 nmol, i.c.v.), E-capsaicin (10-100 nmol, i.c.v.) and Z-capsaicin (100 nmol, i.c.v.) induced emesis (P<0.05) and subsequently antagonised the emetic response induced by intraga...

journal_title：European journal of pharmacology

authors： Rudd JA,Wai MK

更新日期：2001-06-22 00:00:00

abstract：:Microdialysis of the substantia nigra pars reticulata in freely moving rats disclosed a steady release of dopamine and its metabolites which was greatly reduced after reserpine (4 mg/kg s.c.) and alpha-methyl-p-tyrosine (200 mg/kg i.p.) pretreatments. Local infusion of high K+ (100 mM) or L-3,4-dihydroxyphenylalanine ...

journal_title：European journal of pharmacology

authors： Biggs CS,Fowler LJ,Whitton PS,Starr MS

更新日期：1996-03-28 00:00:00

abstract：:Cutaneous arteries show enhanced contraction in response to cooling, which is suggested to be mediated via α2C-adrenoceptors. We have previously shown that α1-adrenoceptors are also involved in the enhanced contraction in cooling conditions. In the present study, we aimed to identify the α1-adrenoceptor subtype involv...

journal_title：European journal of pharmacology

authors： Ishida H,Saito SY,Ishikawa T

更新日期：2018-11-05 00:00:00

abstract：:Notoginsenoside R1, a unique constituent from the root of Panax notoginseng, exerts anti-inflammatory, anti-oxidative and anti-apoptotic properties. The purpose of this study was to assess the contribution of the anti-inflammatory effects of R1 to the amelioration of isoproterenol (ISO)-induced hypertrophied hearts of...

journal_title：European journal of pharmacology

authors： Xiao J,Zhu T,Yin YZ,Sun B

更新日期：2018-08-15 00:00:00

abstract：:Several reports suggest that enteric cholinergic neurons are subject to a tonic inhibitory modulation, whereas few studies are available concerning the role of facilitatory pathways. Glutamate, the main excitatory neurotransmitter in the central nervous system (CNS), has recently been described as an excitatory neurot...

journal_title：European journal of pharmacology

authors： Giaroni C,Zanetti E,Chiaravalli AM,Albarello L,Dominioni L,Capella C,Lecchini S,Frigo G

更新日期：2003-08-22 00:00:00

abstract：:The biodistribution of S-(-)-4-(2-hydroxy-3-(1'-[18F]fluoroisopropyl)- aminopropoxy)carbazole ([18F]S-fluorocarazolol, a non-selective beta-adrenoceptor antagonist) was studied in rats (60 min after 18F injection when specific binding in peripheral organs was maximal). 18F uptake in brain, erythrocytes, heart and lung...

journal_title：European journal of pharmacology

authors： Van Waarde A,Elsinga PH,Brodde OE,Visser GM,Vaalburg W

更新日期：1995-01-16 00:00:00

abstract：:In chloralose-anaesthesized cats, clonidine, an alpha 2-adrenoceptor agonist with an imidazole ring, depressed pudendal nerve reflex activity. Clonidine's inhibitory action on this compound action potential response was mimicked by guanabenz, a non-imidazole alpha 2-adrenoceptor agonist, and was reversed by SK & F 864...

journal_title：European journal of pharmacology

authors： Downie JW,Espey MJ,Gajewski JB

更新日期：1991-03-26 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) is a key enzyme that catalyzes the biosynthesis of prostaglandins from arachidonic acid and plays a critical role in some pathologies including inflammation, neurodegenerative diseases and cancer. Cryptotanshinone is a major constituent of tanshinones, which are extracted from the medicinal he...

journal_title：European journal of pharmacology

authors： Jin DZ,Yin LL,Ji XQ,Zhu XZ

更新日期：2006-11-07 00:00:00

abstract：:Recently, stable gastric pentadecapeptide BPC 157 reversed the high MDA- and NO-tissue values to the healthy levels. Thereby, BPC 157 therapy cured rats with bile duct ligation (BDL) (sacrifice at 2, 4, 6, 8 week). BPC 157-medication (10 μg/kg, 10 ng/kg) was continuously in drinking water (0.16 μg/ml, 0.16 ng/ml, 12 m...

journal_title：European journal of pharmacology

authors： Sever AZ,Sever M,Vidovic T,Lojo N,Kolenc D,Vuletic LB,Drmic D,Kokot A,Zoricic I,Coric M,Vlainic J,Poljak L,Seiwerth S,Sikiric P

更新日期：2019-03-15 00:00:00

abstract：:Four analogues of Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2, a mammalian FMRFamide-like peptide with antiopiate properties, were synthesized with N-terminus modifications and were shown to have high affinity for F8Famide binding sites. The degradation rate of these analogues in mouse brain slices was 3 times lower than that...

journal_title：European journal of pharmacology

authors： Gicquel S,Mazarguil H,Allard M,Simonnet G,Zajac JM

更新日期：1992-11-03 00:00:00

abstract：:Lergotrile and apomorphine, two direct-acting dopamine agonists, caused marked hyperglycemia in fasted rats, while compounds which release endogenous dopamine (amphetamine, methylphenidate) or inhibit dopamine reuptake (LR5182), failed to elevate blood glucose. The effect of lergotrile was dose dependent, causing bloo...

journal_title：European journal of pharmacology

authors： Schmidt MJ

更新日期：1979-10-26 00:00:00

abstract：:Animal models of arthritis are widely used to de-convolute disease pathways and to identify novel drug targets and therapeutic approaches. However, the high attrition rates of drugs in Phase II/III rates means that a relatively small number of drugs reach the market, despite showing efficacy in pre-clinical models. Th...

journal_title：European journal of pharmacology

authors： McNamee K,Williams R,Seed M

更新日期：2015-07-15 00:00:00

abstract：:Five different muscarinic receptor subtypes can be distinguished by the differences in their amino acid sequence, the coupled signal transduction system, pharmacological binding properties and activation of ionic fluxes. The present study served to characterize the binding profile of muscarinic receptors in human colo...

journal_title：European journal of pharmacology

authors： Kopp R,Lambrecht G,Mutschler E,Moser U,Tacke R,Pfeiffer A

更新日期：1989-10-17 00:00:00

abstract：:The testicular capsules of different mammalian species exhibit spontaneous motor activity. In addition, contractions can be mediated by neuronal stimulation or exogenous drug administration. However, the physiological role of testicular capsule motor activity is still not well understood. Nevertheless, there is eviden...

journal_title：European journal of pharmacology

authors： Jurkiewicz NH,Jurkiewicz A,da Silva Júnior ED

更新日期：2020-09-15 00:00:00