Abstract：
:The testicular capsules of different mammalian species exhibit spontaneous motor activity. In addition, contractions can be mediated by neuronal stimulation or exogenous drug administration. However, the physiological role of testicular capsule motor activity is still not well understood. Nevertheless, there is evidence for putative roles in spermatozoa transport from the testis to the caput epididymis, control of interstitial/intratesticular pressure and testicular blood flow. In this review, we have collated information about the agents that regulate testicular capsule motor activity, their receptors and second messengers as well as the impact of altered testicular capsule function on the male reproductive system. Furthermore, we highlight the knowledge gaps in the physiology and pharmacology of the testicular capsule as indicators of future research directions that may lead to a better understanding of the physiological role of testicular capsule motor activity and its importance in male fertility.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Jurkiewicz NH,Jurkiewicz A,da Silva Júnior EDdoi
10.1016/j.ejphar.2020.173345subject
Has Abstractpub_date
2020-09-15 00:00:00pages
173345eissn
0014-2999issn
1879-0712pii
S0014-2999(20)30437-4journal_volume
883pub_type
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