Organ selectivity of hexahydrosiladifenidol in blocking pre- and postjunctional muscarinic receptors studied in guinea-pig ileum and rat heart.

abstract：:The effects of ICS 205-930 [3 alpha-tropanyl)-1H-indole-3-carboxylic acid ester), an antagonist of 5-HT at neuronal M receptors, were examined in anaesthetised greyhounds subject to acute coronary artery occlusion and reperfusion. Intravenous administration of 0.3 or 2.0 mg kg-1 of ICS 205-930 did not significantly al...

journal_title：European journal of pharmacology

authors： Coker SJ,Dean HG,Kane KA,Parratt JR

更新日期：1986-08-15 00:00:00

abstract：:Purinergic P2Y-receptor agonists amplify glucose-induced insulin secretion from pancreatic beta-cells, thus offering new opportunities for the treatment of type 2 diabetes. However, little is known about which subtypes of purinergic P2Y receptors are expressed in these cells. The INS-1 beta-cell line is used as a mode...

journal_title：European journal of pharmacology

authors： Lugo-Garcia L,Filhol R,Lajoix AD,Gross R,Petit P,Vignon J

更新日期：2007-07-30 00:00:00

abstract：:We have investigated the effect of inhaled HOE 140, a novel bradykinin B2 receptor antagonist, against bradykinin- and vagal stimulation-induced airway microvascular leakage and bronchoconstriction in anesthetized guinea-pigs. Lung resistance was measured for 6 min after challenge, followed by measurement of extravasa...

journal_title：European journal of pharmacology

authors： Sakamoto T,Sun J,Barnes PJ,Chung KF

更新日期：1994-01-14 00:00:00

abstract：:The rat paw edema-inducing, acute inflammatory activity of four snake venom phospholipase A2S (PLA2) (Naja naja, Naja mocambique mocambique, Crotalus atrox and recombinant Naja naja naja) and of recombinant human type II PLA2 (rh-PLA2) found in rheumatoid synovial fluid, were compared after a bolus subplantar injectio...

journal_title：European journal of pharmacology

authors： Morgan DW,Anderson CM,Meyers KP

更新日期：1993-04-22 00:00:00

abstract：:Food intake is regulated by various factors such as neuropeptide Y. Neuropeptide Y potently induces an increase in food intake, and simultaneously stimulates arginine-vasopressin (AVP) secretion in the brain. Recently, we reported that V(1A) vasopressin receptor-deficient (V(1A)R(-/-)) mice exhibited altered daily foo...

journal_title：European journal of pharmacology

authors： Aoyagi T,Kusakawa S,Sanbe A,Hiroyama M,Fujiwara Y,Yamauchi J,Tanoue A

更新日期：2009-11-10 00:00:00

abstract：:Kakkon-to is composed of seven medicinal herbs and exhibited novel antipyretic activity by suppressing interleukin-1alpha production responsive to interferon in a murine intranasal influenza virus infection model. Using this model, antipyretic compounds with such novel biological activities were characterized from the...

journal_title：European journal of pharmacology

authors： Kurokawa M,Kumeda CA,Yamamura J,Kamiyama T,Shiraki K

更新日期：1998-05-01 00:00:00

abstract：:There is some controversy as to whether 5-HT(2C) receptor agonists are anxiogenic or anxiolytic. The effects of the novel 5-HT(2C) receptor agonist, (S)-2-chloro-5-fluoro-indol-1-yl)-1-methyl ethylamine fumarate (RO 60 0175), in three models of anxiety were therefore tested. RO 60 0175 was found to induce hypolocomoti...

journal_title：European journal of pharmacology

authors： Kennett G,Lightowler S,Trail B,Bright F,Bromidge S

更新日期：2000-01-10 00:00:00

abstract：:Recent evidence suggests that polydatin (PD), a resveratrol glucoside, may have beneficial actions on the cardiac hypertrophy. Therefore, the current study focused on the underlying mechanism of the PD anti-hypertrophic effect in cultured cardiomyocytes and in progression from cardiac hypertrophy to heart failure in v...

journal_title：European journal of pharmacology

authors： Dong M,Ding W,Liao Y,Liu Y,Yan D,Zhang Y,Wang R,Zheng N,Liu S,Liu J

更新日期：2015-01-05 00:00:00

abstract：:Foot shocks applied to the rat on a grid floor caused brain noradrenaline depletion. Hemicholinium-3 injected intracerebroventricularly (i.c.v.) blocked the noradrenaline depletion and this blockade was reversed by choline (i.c.v.). Physostigmine (i.c.v.) had different effects according to the age of the rats: "young"...

journal_title：European journal of pharmacology

authors： Campos HA,Romero E

更新日期：1977-08-01 00:00:00

abstract：:We have previously reported that 15-hydroxyeicosatetraenoic acid (15-HETE), a metabolite of arachidonic acid by 15-lipoxygenase, causes pulmonary vasoconstriction via increasing the intracellular Ca(2+) concentration ([Ca(2+)]i). However, the multiple sources of Ca(2+) that contribute to Ca(2+) elevation during and af...

journal_title：European journal of pharmacology

authors： Zheng X,Li Q,Tang X,Liang S,Chen L,Zhang S,Wang Z,Guo L,Zhang R,Zhu D

更新日期：2008-12-28 00:00:00

abstract：:Soluble guanylyl cyclase activity and its stimulation by diethylamineNONOate was measured in aortae from hypertensive TGR(mREN2)27 rats (TGR) and Sprague-Dawley controls. Superoxide dismutase was added in vitro to evaluate the contribution of oxidative breakdown of nitric oxide (NO) by superoxide anions. Expression of...

journal_title：European journal of pharmacology

authors： Jacke K,Witte K,Huser L,Behrends S,Lemmer B

更新日期：2000-09-01 00:00:00

abstract：:The pharmacological profile of YM358, 2,7-diethyl-5-[[2'-(1 H-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]tri azole potassium salt monohydrate, a novel non-peptide angiotensin AT1 receptor antagonist, was studied in vitro and in vivo. YM358 competed with [125I][Sar1, Ile8]angiotensin II for angiotensi...

journal_title：European journal of pharmacology

authors： Shibasaki M,Fujimori A,Takanashi M,Kusayama T,Tokioka T,Satoh Y,Okazaki T,Uchida W,Inagaki O,Yanagisawa I

更新日期：1997-09-24 00:00:00

abstract：:EMD 57445 ((S)-(-)-[4-hydroxy-4-(3,4-benzodioxol-5-yl) -piperidin-1-ylmethyl]-3-(4-methoxyphenyl)-oxazolidin- 2-one) is a new sigma receptor ligand with only marginal affinity for many other (including dopamine) receptors. In the present study, central, particularly neuroleptic-like, effects of this compound were eval...

journal_title：European journal of pharmacology

authors： Maj J,Rogóz Z,Skuza G,Mazela H

更新日期：1996-11-21 00:00:00

abstract：:Mouse myotubes were used to investigate effects of the nondepolarizing neuromuscular blocking drugs pancuronium and atracurium on embryonic-type nicotinic acetylcholine receptor channels. Experiments were performed using patch-clamp techniques in combination with devices for ultra-fast solution exchange at outside--ou...

journal_title：European journal of pharmacology

authors： Löwenick CV,Krampfl K,Schneck H,Kochs E,Bufler J

更新日期：2001-02-09 00:00:00

abstract：:We evaluated the effects of ACEA (selective cannabinoid (CB)1 receptor agonist), WIN 55,212-2 mesylate (WIN; non-selective CB1 and CB2 receptor agonist) and N-palmitoylethanolamine (PEA; an endogenous fatty acid of ethanolamide) in DBA/2 mice, a genetic model of reflex audiogenic epilepsy. PEA, ACEA or WIN intraperito...

journal_title：European journal of pharmacology

authors： Citraro R,Russo E,Leo A,Russo R,Avagliano C,Navarra M,Calignano A,De Sarro G

更新日期：2016-11-15 00:00:00

abstract：:Drugs of abuse and stress are associated with changes in circulating cell populations and reductions in cell-mediated immune responses. The main goal of this study was to determine the influence of repeated and acute d-amphetamine treatments on the foot-shock stress-induced effects on the peripheral lymphocyte subpopu...

journal_title：European journal of pharmacology

authors： Assis MA,Pacchioni AM,Collino C,Paz MC,Sotomayor C,Basso AM,Cancela LM

更新日期：2008-04-28 00:00:00

abstract：:The present studies were carried out to analyze the neurochemical and behavioral effects of peripheral sigma ligand administration in the rat. Based upon previous studies which showed an increase in turning behavior following unilateral intranigral administration of sigma ligands, we determined the effects of two sigm...

journal_title：European journal of pharmacology

authors： Patrick SL,Walker JM,Perkel JM,Lockwood M,Patrick RL

更新日期：1993-02-09 00:00:00

abstract：:The effects of three K+ channel openers on lysozyme output from submucosal gland serous cells and epithelial albumin transport following maintained submaximal stimulation by the secretagogues methacholine and phenylephrine were examined in the ferret trachea in vitro preparation. The K+ channel openers Ro 31-6930, 2-(...

journal_title：European journal of pharmacology

authors： Griffin A

更新日期：1995-07-14 00:00:00

abstract：:Elevated fatty acid levels play a pathogenic role in the development of insulin resistance, associated with type 2 diabetes. Interventions with ability to ameliorate fatty acid-induced insulin resistance might be useful for the management of diabetes. Here, we explored the effect of the diastereomeric mixture of calop...

journal_title：European journal of pharmacology

authors： Jaiswal N,Gunaganti N,Maurya CK,Narender T,Tamrakar AK

更新日期：2015-01-05 00:00:00

abstract：:Transfected Chinese hamster ovary cells expressing human alpha2A-, alpha2B- and alpha2C-adrenoceptor subtypes were used to monitor alpha2-adrenoceptor-stimulated GTP hydrolysis. Incubation with 100 microM (-)-adrenaline resulted in stimulation of pertussis toxin-sensitive GTPase by 380% after activation of the alpha2A...

journal_title：European journal of pharmacology

authors： Jansson CC,Pohjanoksa K,Lang J,Wurster S,Savola JM,Scheinin M

更新日期：1999-06-11 00:00:00

abstract：:The effect of peripheral and intrathecal administration of the bradykinin B2 receptor antagonist HOE140 and the non-steroidal anti-inflammatory drug indomethacin were studied on the response of dorsal horn nociceptive neurones to formalin in the anaesthetized rat. Peripheral pretreatment with HOE140 reduced both phase...

journal_title：European journal of pharmacology

authors： Chapman V,Dickenson AH

更新日期：1992-09-04 00:00:00

abstract：:Effects of N-ethylmaleimide or forskolin on electrically evoked dopamine release were investigated in striatal slices of rats pretreated with methamphetamine. N-Ethylmaleimide and forskolin both enhanced the evoked dopamine release in a concentration-dependent manner. The enhancement by N-ethylmaleimide of spontaneous...

journal_title：European journal of pharmacology

authors： Yamada S,Yokoo H,Nishi S

更新日期：1994-05-23 00:00:00

abstract：:[3H]Rauwolscine binds with high affinity to alpha 2-adrenoceptors (Kd = 4.8 +/- 1.3 nM, Bmax = 79 +/- 26 fmol/mg protein, micromolar affinity for 5-HT) as well as to 5-HT1-like receptors (Kd = 13 +/- 2.7 nM, Bmax = 147 +/- 11.4 fmol/mg protein, nanomolar affinity for 5-HT) in human brain cortex membranes. The Ki value...

journal_title：European journal of pharmacology

authors： Convents A,De Keyser J,De Backer JP,Vauquelin G

更新日期：1989-01-17 00:00:00

abstract：:In anaesthetised guinea-pigs, bronchoconstriction induced by vagal nerve stimulation was potentiated by low doses of the antimuscarinic bronchodilator drug, ipratropium (0.01-1.0 microgram/kg); the maximum effect was obtained with 1.0 microgram/kg which doubled the bronchoconstriction. When the dose was increased abov...

journal_title：European journal of pharmacology

authors： Fryer AD,Maclagan J

更新日期：1987-07-09 00:00:00

abstract：:The binding of [3H]N-(1-[2-thienyl]cyclohexyl)piperidine (TCP) to N-methyl-D-aspartate (NMDA) receptor sites in synaptic membranes prepared from the dorsal hippocampus of the ischaemic gerbil, has been studied. Forebrain ischaemia was induced by 10 min bilateral carotid occlusion and receptor binding determined in the...

journal_title：European journal of pharmacology

authors： Leach MJ,Hollox KJ,O'Donnell RA,Miller AA

更新日期：1988-07-26 00:00:00

abstract：:Emodin is a natural anthraquinone in rhubarb. It has been identified as a prokinetic drug for gastrointestinal motility in Chinese traditional medicine. Emodin contracts smooth muscle by increasing the concentration of intracellular Ca(2+). In many smooth muscles, increasing intracellular Ca(2+) activates Ca(2+)-activ...

journal_title：European journal of pharmacology

authors： Xu L,Ting-Lou,Lv N,Zhu X,Chen Y,Yang J

更新日期：2009-08-01 00:00:00

abstract：:The sulfonylurea compounds glisoxepide and glibenclamide inhibit the uptake of bile acids into isolated rat hepatocytes. The Ki values for the inhibition of cholate uptake was 9 microM with glibenclamide and 200 microM with glisoxepide. The inhibition of cholate uptake by both sulfonylureas was noncompetitive. Uptake ...

journal_title：European journal of pharmacology

authors： Fückel D,Petzinger E

更新日期：1992-03-31 00:00:00

abstract：:The anti-ulcer activity of calcitonin gene-related peptide (CGRP) was inhibited, in a dose-dependent manner, by pretreatment with NG-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthase. Our results suggest that endogenous nitric oxide is involved in the anti-ulcer activity of CGRP. ...

journal_title：European journal of pharmacology

authors： Clementi G,Caruso A,Prato A,De Bernardis E,Fiore CE,Amico-Roxas M

更新日期：1994-04-21 00:00:00

abstract：:Levetiracetam was initially developed as a nootropic drug, although since 2002 it has been used as anticonvulsant for the treatment of partial and generalized epilepsy syndromes. The purpose of the research was to investigate anti-paroxysmal activity of levetiracetam (LEV) on the model of cobalt-induced chronic epilep...

journal_title：European journal of pharmacology

authors： Litvinova Svetlana A,Voroninа Tatyana A,Nerobkova Lubov N,Kutepova Inga S,Avakyan Georgii G,Avakyan Gagik N

更新日期：2019-07-05 00:00:00

abstract：:Omeprazole, besides suppressing gastric acid, causes delayed gastric emptying, which may be associated with aggravated dyspeptic symptoms. Effects of omeprazole on small intestinal transit are unknown. In this study, we evaluated in mice if (a) omeprazole affects transit of a meal through the stomach and small intesti...

journal_title：European journal of pharmacology

authors： Cowan A,Earnest DL,Ligozio G,Rojavin MA

更新日期：2005-07-04 00:00:00