A role for nitric oxide in the anti-ulcer activity of calcitonin gene-related peptide.

abstract：:The purpose of this study was to investigate whether the selective angiotensin AT2 receptor ligands, CGP 42112B (Nic-Tyr-(N alpha-benzoyloxycarbonyl-Arg)Lys-His-Pro-Ile-OH) and PD 123319 ((s)-1-[[4-(dimethylamino)-3-methyl-phenyl]methyl]-5-(diphenylacetyl+ ++)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]-pyridine-6-carboxylic...

journal_title：European journal of pharmacology

authors： Macari D,Whitebread S,Cumin F,De Gasparo M,Levens N

更新日期：1994-06-23 00:00:00

abstract：:Isolated rat diaphragms were treated with the oxime HI-6, 25 min after the start of soman exposure for 5, 15, 20 or 25 min. Recovery of neuromuscular transmission (NMT) was smaller and the subsequent spontaneous failure of NMT greater when soman exposure was longer. Diaphragms taken from anaesthetized atropinized soma...

journal_title：European journal of pharmacology

authors： Van Helden HP,Wolthuis OL

更新日期：1983-05-06 00:00:00

abstract：:The role beta-adrenoceptors in the control of venous tone is not clear. This study examines the dose-response effects of isoprenaline, a non-selective beta-adrenoceptor agonist, on mean circulatory filling pressure (MCFP), an index of body venous tone, in conscious and unrestrained rats. Dose-response curves of isopre...

journal_title：European journal of pharmacology

authors： Abdelrahman A,Pang CC

更新日期：1990-11-13 00:00:00

abstract：:Gamma globin induction remains a promising pharmacological therapeutic treatment mode for sickle cell anemia and beta thalassemia, however Hydroxyurea remains the only FDA approved drug which works via this mechanism. In this regard, we assayed the γ-globin inducing capacity of Cis-vaccenic acid (CVA). CVA induced dif...

journal_title：European journal of pharmacology

authors： Aimola IA,Inuwa HM,Nok AJ,Mamman AI,Bieker JJ

更新日期：2016-04-05 00:00:00

abstract：:(5R,6R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3 .2.1]octane (PTAC) is a potent muscarinic receptor ligand with high affinity for central muscarinic receptors and no or substantially less affinity for a large number of other receptors or binding sites including dopamine receptors. The ligand exhibits parti...

journal_title：European journal of pharmacology

authors： Bymaster FP,Shannon HE,Rasmussen K,Delapp NW,Mitch CH,Ward JS,Calligaro DO,Ludvigsen TS,Sheardown MJ,Olesen PH,Swedberg MD,Sauerberg P,Fink-Jensen A

更新日期：1998-09-04 00:00:00

abstract：:Cutaneous arteries show enhanced contraction in response to cooling, which is suggested to be mediated via α2C-adrenoceptors. We have previously shown that α1-adrenoceptors are also involved in the enhanced contraction in cooling conditions. In the present study, we aimed to identify the α1-adrenoceptor subtype involv...

journal_title：European journal of pharmacology

authors： Ishida H,Saito SY,Ishikawa T

更新日期：2018-11-05 00:00:00

abstract：:The vasodilatory role of calcitonin gene-related peptide in activating K+ channels was examined in isolated, suffused human uterine arteries. Calcitonin gene-related peptide produced a concentration-dependent relaxation of norepinephrine (1 microM)-induced contractions. Calcitonin gene-related peptide was antagonized ...

journal_title：European journal of pharmacology

authors： Nelson SH,Suresh MS,Dehring DJ,Johnson RL

更新日期：1993-10-05 00:00:00

abstract：:Ifoxetine (CGP 15210 G; (+/-)-bis-[cis-3-hydroxy-4-(2,3-dimethyl-phenoxy)]-piperidine sulfate) prevented the depletion of serotonin (5-HT) induced by H 75/12 and p-chloromethamphetamine in the rat brain, and that caused by endogenously released dopamine after the combined administration of haloperidol and amfonelic ac...

journal_title：European journal of pharmacology

authors： Waldmeier PC,Maître L,Baumann PA,Hauser K,Bischoff S,Bittiger H,Paioni R

更新日期：1986-10-14 00:00:00

abstract：:The kappa-opioid receptor agonist, U50,488H (trans-(+-)-3,4-dichloro-N-methyl-[2-(1-pyrrolidinyl)-cyclohexyl]- benzeneacetamide), has recently been reported to induce dystonia after s.c. administration of 5-10 mg/kg in guinea pigs. The dystonic movements observed in response to U50,488H resembled those previously repo...

journal_title：European journal of pharmacology

authors： Richter A,Löscher W

更新日期：1993-05-19 00:00:00

abstract：:Emerging evidences indicated that the dysbiosis of microbiota was related to the onset of systemic lupus erythematosus (SLE). Bacteroides fragilis (B. fragilis) ATCC 25285, a human commensal, was discovered to improve inflammatory diseases. However, whether B. fragilis (ATCC 25285) has the beneficial effects on the tr...

journal_title：European journal of pharmacology

authors： Li D,Pan Y,Xia X,Liang J,Liu F,Dou H,Hou Y

更新日期：2020-10-05 00:00:00

abstract：:In the present study, the interaction of nitric oxide synthase (NOS) inhibitors, L-NAME (N(G)-nitro-L-arginine methyl ester HCl) and L-NA (N(omega)-nitro-L-arginine), and its precursor, L-arginine (2-(S)-2-amino-5-[(aminoiminomethyl)amino] pentatonic acid), with theophylline on mouse body temperature was studied. Intr...

journal_title：European journal of pharmacology

authors： Zarrindast MR,Adl M,Sharifzadeh M,Bahreini T

更新日期：2002-09-06 00:00:00

abstract：:The release of [3H]5-hydroxytryptamine ([3H]5-HT) evoked by 15 mM KCl in superfused rat cerebellum synaptosomes was inhibited by 5-HT (pEC30 = 8.73). Methiothepin antagonized 5-HT (pA2 = 9.28); ketanserin, methysergide, cinanserin and spiperone were ineffective. The receptors involved were activated (pEC30 = 8.90) by ...

journal_title：European journal of pharmacology

authors： Bonanno G,Maura G,Raiteri M

更新日期：1986-07-31 00:00:00

abstract：:The increase in blood clotting factor VIII (antihaemophilic factor, F-VIII) and fibrinolytic activity induced by the administration of neurohypophyseal hormone analogues, was assayed in sheep. Peptides with high selectivity for vasopressin V1, V2 or myometrial oxytocin receptors in the dose range of 0.1-10 micrograms/...

journal_title：European journal of pharmacology

authors： Neuenschwander S,Pliska V

更新日期：1997-04-04 00:00:00

abstract：:The object of the present paper was to investigate the in vivo pharmacological profile of the dihydropyridine neuropeptide Y Y(1) receptor antagonist 1,4-Dihydro-4-[3-[[[[3-[spiro(indene-4,1'-piperidin-1-yl)]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-pyridine dicarboxylic acid, dimethylester (H 394/84). The ...

journal_title：European journal of pharmacology

authors： Malmström RE,Balmér KC,Weilitz J,Nordlander M,Sjölander M

更新日期：2001-04-20 00:00:00

abstract：:The influence of inflammatory cells on airway reactivity was investigated on arachidonic acid-induced relaxations of guinea-pig trachea and on arachidonic acid metabolism in guinea-pig tracheal epithelial cells. The presence of either eosinophils or neutrophils (1.0 x 10(7) cells/ml), from bronchoalveolar lavage, decr...

journal_title：European journal of pharmacology

authors： Prié S,Conroy DM,Gleich GJ,Sirois P

更新日期：1996-12-19 00:00:00

abstract：:Ro5-4864, diazepam and chlordiazepoxide inhibited the concanavalin A-induced [14C]serotonin release from rat mast cells dose dependently with IC30 values 38, 115 and 160 microM, respectively. They also inhibited concanavalin A-induced 45Ca uptake, with IC50 values 180, 860 and 1800 microM, respectively. Clonazepam sli...

journal_title：European journal of pharmacology

authors： Suzuki-Nishimura T,Sano T,Uchida MK

更新日期：1989-08-11 00:00:00

abstract：:3H-Glycine was released by 50 mM K+ in a calcium-dependent manner from rat substantia nigra slices. This release was abolished by GABA (0.1-1 mM) and muscimol (0.1 mM). Taurine and beta-alanine were without effect on evoked 3H-glycine release. The effect of GABA (0.5 mM) was reversed picrotoxin (50 micro M). These res...

journal_title：European journal of pharmacology

authors： Kerwin R,Pycock C

更新日期：1980-06-13 00:00:00

abstract：:Corticotropin-releasing factor (CRF) has been suggested to play an important role in the development of drug dependence and withdrawal. Based on the recent finding that CRF receptor antagonists inhibit the stress-induced relapse to opiate dependence and attenuate anxiety-like responses related to cocaine withdrawal, t...

journal_title：European journal of pharmacology

authors： Lu L,Liu D,Ceng X

更新日期：2001-03-01 00:00:00

abstract：:We used two experimental models to prove that resveratrol (trans-3,4',5-trihydroxystilbene) reduces cardiac ischemic-reperfusion injury by means of a nitric oxide- and adenosine-dependent mechanism. (1). ACUTE EX VIVO: resveratrol (10 microM, 10 min) infusion in Langendorff-perfused normoxic rat hearts significantly i...

journal_title：European journal of pharmacology

authors： Bradamante S,Barenghi L,Piccinini F,Bertelli AA,De Jonge R,Beemster P,De Jong JW

更新日期：2003-03-28 00:00:00

abstract：:The effects of a serotonin (5-HT) releasing drug, p-chloroamphetamine, on plasma glucose levels were investigated in rats. p-Chloroamphetamine elicited a significant hyperglycemia. The hyperglycemic effects of p-chloroamphetamine were completely prevented by the 5-HT synthesis inhibitor, p-chlorophenylalanine. Prior a...

journal_title：European journal of pharmacology

authors： Yamada J,Sugimoto Y,Yoshikawa T

更新日期：1998-10-23 00:00:00

abstract：:The effects of inhibitors of Ca(2+)-dependent endopeptidases (antipain and leupeptin) on morphine analgesia, reinforcing properties of morphine and on the development of opiate physical dependence were studied. Male Wistar rats were used. The analgesic action of morphine in the tail-immersion test was increased signif...

journal_title：European journal of pharmacology

authors： Lyupina YV,Sudakov SK,Yarygin VN

更新日期：1996-05-23 00:00:00

abstract：:The decrease in blood flow in response to dopamine (DA) injected intraarterially (i.a.) into the femoral or renal vascular beds was examined in the anaesthetised dog. DA or noradrenaline (NA) were 10 times more potent as vasoconstrictor agents in the femoral than in the renal vasculature. In the femoral bed, the DA in...

journal_title：European journal of pharmacology

authors： Duval N,Hicks PE,Langer SZ

更新日期：1985-02-05 00:00:00

abstract：:Effects of protein kinase C inhibitors, staurosporine and 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride and protein tyrosine kinase inhibitors, genistein, tyrphostin and 2,5-dimethylcinnamate on the neutrophil responses stimulated by immunoglobulin G (IgG), complement C5a or platelet-activating factor...

journal_title：European journal of pharmacology

authors： Ahn SK,Shin YK,Kang HJ,Han ES,Lee CS

更新日期：1996-06-13 00:00:00

abstract：:Since orally administered K+ channel openers may have cardiovascular side effects, it is possible that inhaled administration would be preferred for the treatment of asthma. We have investigated whether inhaled levcromakalim and HOE 234 inhibit histamine-induced bronchoconstriction and airway plasma exudation in anaes...

journal_title：European journal of pharmacology

authors： Kidney JC,Lotvall JO,Lei Y,Chung KF,Barnes PJ

更新日期：1996-01-18 00:00:00

abstract：:The effect of a novel leuktriene B4 receptor antagonist N-[5[[8-(1-hydroxy-2- phenyl)ethyl]dibenzofuran-2yl]5-hydroxypentanoyl]pyrrolidine (PF 10042) has been evaluated in comparison with 2-[3(1-hydroxyhexyl)phenoxymethyl]quinoline hydrochloride (PF 5901), a specific inhibitor of the 5-lipoxygenase pathway of arachido...

journal_title：European journal of pharmacology

authors： Seeds EA,Kilfeather S,Okiji S,Schoupe TS,Donigi-Gale D,Page CP

更新日期：1995-12-07 00:00:00

abstract：:The anticonvulsant effects produced by mixtures of oxcarbazepine and gabapentin (two second-generation antiepileptic drugs) in numerous fixed-ratio combinations of 1:1, 1:2, 1:5, 1:10, 1:15, and 1:20 were examined isobolographically in the mouse maximal electroshock seizure model. Results displayed that mixtures of bo...

journal_title：European journal of pharmacology

authors： Luszczki JJ,Andres MM,Czuczwar SJ

更新日期：2005-05-16 00:00:00

abstract：:The effects of the alpha-agonists clonidine and guanfacine on rat cortical norepinephrine turnover during morphine withdrawal were assessed. Cortical norepinephrine levels were measured, after administration of alpha-methyl-p-tyrosine, by fluorometric assay. Chronic treatment with morphine did not affect norepinephrin...

journal_title：European journal of pharmacology

authors： Zigun JR,Bannon MJ,Roth RH

更新日期：1981-04-09 00:00:00

abstract：:The effects of phencyclidine [1-(1-phenylcyclohexyl)-piperidine; PCP] on cardiac action potential duration (APD) were compared to those of some of its derivatives, in strips of isolated frog ventricular muscle perfused with normal Ringer solution. We studied compounds with PCP-like behavioral actions (N-ethyl-1-phenyl...

journal_title：European journal of pharmacology

authors： D'Amico GA,Kline RP,Maayani S,Weinstein H,Kupersmith J

更新日期：1983-04-08 00:00:00

abstract：:The effect of xanthone on smooth muscle was studied in thoracic aorta isolated from rats. Xanthone relaxed the norepinephrine-induced contraction of rat thoracic aorta. This relaxing effect of xanthone persisted in endothelium-denuded aorta suggesting that the relaxation induced by xanthone is endothelium-independent....

journal_title：European journal of pharmacology

authors： Cheng YW,Kang JJ

更新日期：1997-10-01 00:00:00

abstract：:Perfused rabbit hearts removed 3H-5-hydroxytryptamine (3H-5-HT) from a perfusion solution containing 2.6 ng/ml and a tissue-to-medium ratio of about 10 was achieved after a 55 min perfusion period. 12.4 +/- 1.0% of the cardiac total radioactivity consisted of metabolites and metabolites appeared in the venous effluent...

journal_title：European journal of pharmacology

authors： Fozard JR,Berry JL

更新日期：1975-06-01 00:00:00