当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PHARMACOLOGY期刊下所有文献 > Role of lipoxygenase metabolites in platelet-activating factor- and antigen-induced bronchial hyperresponsiveness and eosinophil infiltration.

Role of lipoxygenase metabolites in platelet-activating factor- and antigen-induced bronchial hyperresponsiveness and eosinophil infiltration.

Abstract：

:The effect of a novel leuktriene B4 receptor antagonist N-[5[[8-(1-hydroxy-2- phenyl)ethyl]dibenzofuran-2yl]5-hydroxypentanoyl]pyrrolidine (PF 10042) has been evaluated in comparison with 2-[3(1-hydroxyhexyl)phenoxymethyl]quinoline hydrochloride (PF 5901), a specific inhibitor of the 5-lipoxygenase pathway of arachidonic acid metabolism, against platelet activating factor (PAF) and allergen induced bronchial hyperresponsiveness and pulmonary eosinophil infiltration in the guinea pig. PF 10042 significantly displaced radiolabelled [3H]leukotriene B4 from binding sites on human neutrophils with an EC50 of 3 muM. PF 10042 (100 mg/kg, i.p.) significantly inhibited PAF and allergen induced bronchial hyperresponsiveness without reducing the concomitant eosinophil infiltration, whereas PF 5901 (100 mg/kg, p.o.) significantly inhibited both PAF and allergen induced bronchial hyperresponsiveness and eosinophil infiltration. We suggest from these results that PAF and allergen induced bronchial hyperresponsiveness may be secondary to the release of leukotriene B4, but this lipoxygenase metabolite does not contribute significantly to the observed eosinophil infiltration.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Seeds EA,Kilfeather S,Okiji S,Schoupe TS,Donigi-Gale D,Page CP

doi

10.1016/0926-6917(95)90057-8

subject

Has Abstract

pub_date

1995-12-07 00:00:00

pages

369-76

issue

4

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(95)80095-6

journal_volume

293

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF PHARMACOLOGY文献大全
  • Vasorelaxant mechanism of the new vasodilator, FK409.

    abstract：:To define the vasorelaxation mechanism of FK409, we examined the effect of the compound on vascular tension and cyclic nucleotide levels in isolated rat thoracic aorta contracted with norepinephrine, and on activities of guanylate cyclase and cyclic GMP phosphodiesterase prepared from rat or rabbit thoracic aorta. FK4...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0922-4106(93)90032-5

    authors： Isono T,Koibuchi Y,Sato N,Furuichi A,Nishii M,Yamamoto T,Mori J,Kohsaka M,Ohtsuka M

    更新日期：1993-08-15 00:00:00

  • Effect of almitrine on upper airway muscle contraction in young and old rats.

    abstract：:The effects of almitrine on the contractile properties of isolated geniohyoid and sternohyoid muscles were determined in physiological salt solution at 30 degrees C in young and old rats. In young rats, almitrine had no effect on twitch or tetanic tension, twitch:tetanic tension ratio, contractile kinetics, active or ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(01)00721-x

    authors： Cantillon D,Bradford A

    更新日期：2001-01-26 00:00:00

  • Drug-induced alterations in the efflux of 5-hydroxytryptamine and of 5-hydroxyindoleacetic acid into superfusates of the rat spinal cord.

    abstract：:The effect of dl-p-chloroamphetamine, fluoxetine and probenecid on the efflux of endogenous 5-hydroxytryptamine (5HT) and 5-hydroxyindoleacetic acid (5HIAA) into superfusates of the spinal cord of anesthetized rats was examined. Mean basal efflux of 5HT and 5HIAA was 0.27 and 15.56 ng/ml superfusate, respectively. The...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(83)90083-3

    authors： Hammond DL,Tyce GM,Yaksh TL

    更新日期：1983-03-04 00:00:00

  • Inhibitors of 1,2-diacylglycerol kinase potentiate the TRH-induced stimulation of Ca2+-activated K+ current.

    abstract：:Transient activation of the outward K+ current caused by a rise in the cytosolic free Ca2+ concentration, [Ca2+]i was the predominant change in plasma membrane ion flux during the first phase of thyrotropin-releasing hormone (TRH) action on pituitary cells. Following the intracellular application of inhibitors of 1,2-...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0922-4106(89)90046-1

    authors： Mollard P,Vacher P,Dufy B,Winiger BP,Schlegel W

    更新日期：1989-03-07 00:00:00

  • Magnetic bead-based proteomic technology to study paricalcitol effect in kidney transplant recipients.

    abstract：:Secondary hyperparathyroidism is a common complication in patients with chronic kidney disease and frequently persists after kidney transplantation. Paricalcitol, a selective vitamin D receptor activator, is indicated in the management of this disorder and recent evidences have suggested that this drug has other benef...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ejphar.2013.03.040

    authors： Pérez V,Sánchez-Escuredo A,Lauzurica R,Bayés B,Navarro-Muñoz M,Pastor MC,Cañas L,Bonet J,Romero R

    更新日期：2013-06-05 00:00:00

  • Rosuvastatin enhanced functional recovery after sciatic nerve injury in the rat.

    abstract：:Posttraumatic nerve recovery remains a challenge in regenerative medicine. As such, there is a need for agents that limit nerve damage and enhance nerve regeneration. Here we investigate rosuvastatin, a 3-hydroxy-3-methylglutaryl coenzyme (HMG-CoA) reductase inhibitor, with anti-inflammatory and antioxidant properties...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2020.173260

    authors： Abdolmaleki A,Zahri S,Bayrami A

    更新日期：2020-09-05 00:00:00

  • Protective and preventive effects of teprenone on gastric mucosal lesions in rats.

    abstract：:We have reported that neutrophil infiltration into gastric mucosa is closely related to gastric mucosal lesion development in rats with water immersion restraint stress. In this study, we examined the effect of teprenone, which is known to prevent gastric mucosal injury through stimulation of gastric mucus synthesis a...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(98)00430-0

    authors： Nishida K,Ohta Y,Ishiguro I

    更新日期：1998-07-31 00:00:00

  • Structural requirements of mastoparan for activation of membrane-bound guanylate cyclase.

    abstract：:Mastoparan activated membrane-bound guanylate cyclase and potentiated the effect of atrial natriuretic factor (ANF) and ATP on guanylate cyclase activity in rat lung membranes. Mastoparan is a cationic, amphiphilic tetradecapeptide with an amidated carboxyl terminus. It takes the alpha-helical conformation upon intera...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0922-4106(93)90196-g

    authors： Song DL,Chang GD,Ho CL,Chang CH

    更新日期：1993-11-15 00:00:00

  • Effect of catecholamines on oedema induced by inflammatory agents in the rat.

    abstract：:The effect of intracutaneous adrenaline and noradrenaline (5 X 10(-12) and 5 X 10(-11) mol) was examined on the oedema (Evans blue dye leakage) response of rats to several inflammatory agents. The catecholamines reduced the oedema response to all agents tested except prostaglandin E1 (PGE1) which was significantly pot...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(79)90500-4

    authors： O'Duffy G,Chahl LA

    更新日期：1979-08-15 00:00:00

  • Azaphenylalanine-based serine protease inhibitors induce caspase-mediated apoptosis.

    abstract：:Molecules regulating cell death constitute prominent therapeutic targets. The pro-apoptotic role of serine protease inhibitors prompted us to search for novel modulators of this process. We have tested some recently synthesized antithrombotic compounds for their potential to induce apoptotic cell death. Cell based ana...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2008.11.008

    authors： Celhar T,Batista Napotnik T,Obreza A,Zega A,Anderluh PS,Kikelj D,Mlinaric-Rascan I

    更新日期：2009-01-05 00:00:00

  • Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory and analgesic effects of the natural marine compound lemnalol from Formosan soft coral Lemnalia cervicorni.

    abstract：:Lemnalol (8-isopropyl-5-methyl-4-methylene-decahydro-1,5-cyclo-naphthalen-3-ol) is a natural compound isolated from the marine soft coral Lemnalia cervicorni. In the present study, the anti-inflammatory and anti-nociceptive properties of lemnalol were investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2007.08.048

    authors： Jean YH,Chen WF,Duh CY,Huang SY,Hsu CH,Lin CS,Sung CS,Chen IM,Wen ZH

    更新日期：2008-01-14 00:00:00

  • Bufotalin from Venenum Bufonis inhibits growth of multidrug resistant HepG2 cells through G2/M cell cycle arrest and apoptosis.

    abstract：:Venenum Bufonis, a traditional Chinese medicine, is widely used in the treatment of liver cancer in modern Chinese medical practices. In our search for anti-hepatoma constituents in Venenum Bufonis, bufotalin, bufalin, telocinobufagin and cinobufagin were obtained. Bufotalin was the most potent active compound among t...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2012.06.045

    authors： Zhang DM,Liu JS,Tang MK,Yiu A,Cao HH,Jiang L,Chan JY,Tian HY,Fung KP,Ye WC

    更新日期：2012-10-05 00:00:00

  • Vascular effects of capsaicin in isolated perfused rat mesenteric bed.

    abstract：:The effects of intra- and extraluminal capsaicin administration were evaluated in isolated perfused rat mesenteric bed. Capsaicin (10 nM-1 microM) produced a potent concentration-dependent relaxation of the tonic vasoconstriction induced by norepinephrine (1 microM) but not by high-K+ (60 mM). The capsaicin-induced re...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(88)90559-6

    authors： Manzini S,Perretti F

    更新日期：1988-03-29 00:00:00

  • Potent alpha-adrenoceptor action of soterenol on vascular and other smooth muscle.

    abstract：:Treatment with soterenol (0.3-300 mug/kg, i.v.) increased the mean arterial blood pressure and decreased heart rate in rabbits. Soterenol caused a dose-dependent contraction of rabbit aorta and portal vein, guinea-pig vas deferens and cat nicitating membrane which was inhibited by phentolamine. Other beta-agonists suc...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(75)90163-6

    authors： Kitagawa H,Yamauchi A,Shibata S

    更新日期：1975-08-01 00:00:00

  • Effect of cetiedil analogs on acetylcholine and choline fluxes in synaptosomes and vesicles.

    abstract：:Cetiedil is a potent blocker of acetylcholine and choline fluxes. Several analogs of this compound have been synthesized and their effect on acetylcholine (ACh) and choline fluxes in synaptosomes and on ACh uptake in synaptic vesicles have been studied. The effects of these analogs were compared to those of other drug...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(89)90355-5

    authors： Gaudry-Talarmain YM,Diebler MF,Robba M,Lancelot JC,Lesbats B,Israël M

    更新日期：1989-08-03 00:00:00

  • Tacrine and physostigmine block nicotinic receptors in Xenopus oocytes injected with Torpedo electroplaque membranes.

    abstract：:Tacrine and physostigmine were tested for direct nicotinic actions on Xenopus oocytes microinjected with Torpedo electroplaque membranes. In this preparation, responses to acetylcholine arise 6-8 h after microinjection, due to the incorporation of nicotinic receptors into the plasma membrane by a process not involving...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(98)00793-6

    authors： Cantí C,Bodas E,Marsal J,Solsona C

    更新日期：1998-12-18 00:00:00

  • Human saphenous vein contains both endothelin ETA and ETB contractile receptors.

    abstract：:We have investigated the endothelin receptor subtypes mediating contraction in isolated preparations of human saphenous vein. Endothelin-1 (EC50: 17.8 nM), endothelin-3 (EC50: 82.3 nM) and the endothelin ETB receptor-selective agonists, [Ala1,3,11,15]endothelin-1 (EC50: 63 nM) and sarafotoxin S6c (EC50: 0.75 nM) all p...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(94)90144-9

    authors： White DG,Garratt H,Mundin JW,Sumner MJ,Vallance PJ,Watts IS

    更新日期：1994-05-23 00:00:00

  • Neuroprotection with a new kynurenic acid analog in the four-vessel occlusion model of ischemia.

    abstract：:Global forebrain ischemia results in damage to the pyramids in the CA1 hippocampal subfield, which is particularly vulnerable to excitotoxic processes. Morphological and functional disintegration of this area leads to a cognitive dysfunction and neuropsychiatric disorders. Treatment with N-methyl-d-aspartate receptor ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2011.05.069

    authors： Gellért L,Fuzik J,Göblös A,Sárközi K,Marosi M,Kis Z,Farkas T,Szatmári I,Fülöp F,Vécsei L,Toldi J

    更新日期：2011-09-30 00:00:00

  • Discrimination of (+)-3-PPP sites from DTG sites by FH-510, a novel potent sigma ligand, in rat brain.

    abstract：:The effect of 5,8-dimethyl-4-(2-di-n-propylaminoethyl)carbazol monohydrochloride (FH-510) on the binding of sigma ligands such as [3H](+)-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine ([3H](+)-3-PPP) and [3H]1,3-di-o-tolylguanidine ([3H]DTG) to rat brain membranes was studied. The inhibitory effect of FH-510 on [3H](+)-3...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(93)90638-x

    authors： Chaki S,Tanaka M,Muramatsu M,Otomo S

    更新日期：1993-11-30 00:00:00

  • Inhibition of superoxide anion generation by CHS-111 via blockade of the p21-activated kinase, protein kinase B/Akt and protein kinase C signaling pathways in rat neutrophils.

    abstract：:In formyl-Met-Leu-Phe (fMLP)-stimulated rat neutrophils, 2-benzyl-3-(4-hydroxymethylphenyl)indazole (CHS-111) inhibited superoxide anion (O(2)(-)) generation, which was not mediated by scavenging the generated O(2)(-) or by a cytotoxic effect, and attenuated migration. CHS-111 had no effect on the arachidonic acid-ind...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2009.04.050

    authors： Chang LC,Lin RH,Huang LJ,Chang CS,Kuo SC,Wang JP

    更新日期：2009-08-01 00:00:00

  • Binding characteristics of levetiracetam to synaptic vesicle protein 2A (SV2A) in human brain and in CHO cells expressing the human recombinant protein.

    abstract：:A specific binding site for the antiepileptic drug levetiracetam (2S-(oxo-1-pyrrolidinyl)butanamide, Keppra) in rat brain, referred to as the levetiracetam binding site, was discovered several years ago. More recently, this binding site has been identified as the synaptic vesicle protein 2A (SV2A), a protein present i...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2006.02.022

    authors： Gillard M,Chatelain P,Fuks B

    更新日期：2006-04-24 00:00:00

  • Influence of acute treatment with sibutramine on the sympathetic neurotransmission of the young rat vas deferens.

    abstract：:The effects of acute treatment with sibutramine on the peripheral sympathetic neurotransmission in vas deferens of young rats were still not evaluated. Therefore, we carried out this study in order to verify the effects of acute sibutramine treatment on the neuronal- and exogenous agonist-induced contractions of the y...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2014.05.035

    authors： de Souza BP,da Silva ED Jr,Jurkiewicz A,Jurkiewicz NH

    更新日期：2014-09-05 00:00:00

  • Role of triptolide in cell proliferation, cell cycle arrest, apoptosis and histone methylation in multiple myeloma U266 cells.

    abstract：:Multiple myeloma is an incurable hematological malignancy. Different studies demonstrated the occurrence of genetic and epigenetic alterations in multiple myeloma. Histone lysine methylation has emerged as a central epigenetic change in the organization of eukaryotic chromatin with far-reaching implications for the re...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2010.05.034

    authors： Zhao F,Chen Y,Zeng L,Li R,Zeng R,Wen L,Liu Y,Zhang C

    更新日期：2010-11-10 00:00:00

  • Various GABA-mimetic drugs differently affect cocaine-evoked hyperlocomotion and sensitization.

    abstract：:To substantiate the notion that cocaine behavioral effects may be influenced by gamma-aminobutyric acid (GABA) neurotransmission male Wistar rats were injected with gabapentin (a cyclic GABA analogue), tiagabine (a GABA reuptake inhibitor), or vigabatrin (a GABA transaminase inhibitor) before acute or repeated treatme...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2006.05.011

    authors： Filip M,Frankowska M,Gołda A,Zaniewska M,Vetulani J,Przegaliński E

    更新日期：2006-07-17 00:00:00

  • Evidence for low brain penetration by the H1-receptor antagonist temelastine (SK&F 93944).

    abstract：:Competition by the potent selective H1-receptor antagonist temelastine (SK & F 93944) with [3H]mepyramine binding to mouse cortex H1-receptors has been measured in vitro and vivo. The data were compared with that obtained using the classical H1-receptor antagonists mepyramine and promethazine and indicated that temela...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(87)90206-8

    authors： Calcutt CR,Ganellin CR,Jackson B,Leigh BK,Owen DA,Smith IR

    更新日期：1987-01-06 00:00:00

  • Pharmacological and histochemical evidence for P2X receptors in human umbilical vessels.

    abstract：:The presence of P2X purinoceptors in human umbilical vessels were studied with organ bath recording, radioligand binding assays, autoradiography, and immunohistochemistry. In isolated umbilical arteries and veins from normal term pregnancy, both ATP and alpha,beta-methylene ATP caused concentration-dependent contracti...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(98)00383-5

    authors： Bo X,Sexton A,Xiang Z,Nori SL,Burnstock G

    更新日期：1998-07-17 00:00:00

  • Activation of epithelial sodium channel in human middle ear epithelial cells by dexamethasone.

    abstract：:The middle ear epithelium functions to maintain a fluid-free middle ear cavity. Dysfunction of the middle ear epithelial ion and fluid transport is implicated in the pathogenesis of fluid collection in the middle ear cavity, characteristic of otitis media with effusion. The efficacy of steroid therapy for the treatmen...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2008.11.012

    authors： Son EJ,Kim SH,Park HY,Kim SJ,Yoon JH,Chung HP,Choi JY

    更新日期：2009-01-14 00:00:00

  • Multiple agonist binding sites of muscarinic acetylcholine receptors and their relation to the negative inotropic action of agonists in guinea-pig heart.

    abstract：:The Kd values of the multiple agonist binding sites in cardiac muscarinic receptors (mAChR) and pD2 values for negative inotropic actions were determined independently and their relation was examined. The guinea-pig cardiac mAChR is known to have three agonist binding sites (super-high (SH), high (H) and low (L) affin...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(85)90293-6

    authors： Mizushima A,Uchida S,Matsumoto K,Osugi T,Kagiya T,Zhou XM,Higuchi H,Yoshida H

    更新日期：1985-12-17 00:00:00

  • Ethyl beta-carboline-3-carboxylate reverses the diazepam effect on cerebellar cyclic GMP.

    abstract：:The administration of ethyl beta-carboline-3-carboxylate (beta-CCE), a ligand for benzodiazepine receptors, did not affect the cerebellar cyclic GMP level in mice, but giving beta-CCE together with diazepam significantly inhibited the diazepam-induced decrease in cyclic GMP. The fact that no antagonism was observed wh...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(82)90065-6

    authors： Fujimoto M,Kawasaki K,Matsushita A,Okabayashi T

    更新日期：1982-05-21 00:00:00

  • Modulatory role of endogenous androgens on airway smooth muscle tone in isolated guinea-pig and bovine trachea; involvement of beta2-adrenoceptors, the polyamine system and external calcium.

    abstract：:Androgens relax several smooth muscles, including the airways. They also contract ileum and myocardium via nongenomic mechanisms. To find out whether androgens modulate airway smooth muscles in different species and further assess their mechanism of action, regarding the role of beta-adrenoceptors, polyamines and extr...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2008.10.039

    authors： Bordallo J,de Boto MJ,Meana C,Velasco L,Bordallo C,Suárez L,Cantabrana B,Sánchez M

    更新日期：2008-12-28 00:00:00