Potent alpha-adrenoceptor action of soterenol on vascular and other smooth muscle.

abstract：:The cardiovascular and biochemical responses during acute oxidative stress induced by D,L-buthionine-(S,R)-sulfoximine (BSO) were investigated in Sprague-Dawley rats. Mean arterial pressure, heart rate and vascular reactivity were measured after subcutaneous injection of BSO (4 mmol/kg). Control rats received saline. ...

journal_title：European journal of pharmacology

authors： Ganafa AA,Socci RR,Eatman D,Silvestrova N,Abukhalaf IK,Bayorh MA

更新日期：2002-11-15 00:00:00

abstract：:Annexin A1 (ANXA1)-formyl peptide receptor (Fpr) system is potent effective mediators in the control of the inflammatory response. In this study, we evaluate the potential involvement of the Fpr family in the protective effect of the mimetic peptide of ANXA1 (ANXA12-26) using an experimental allergic conjunctivitis (A...

journal_title：European journal of pharmacology

authors： Marmorato MP,Gimenes AD,Andrade FEC,Oliani SM,Gil CD

更新日期：2019-01-05 00:00:00

abstract：:A comparison has been made of the abilities of salbutamol, forskolin and prenalterol to relax guinea-pig tracheal rings contracted equivalently with either prostaglandin F2 alpha (PGF2 alpha) or carbachol. In the absence of spontaneous tension, 10(-6) M PGF2 alpha and 4 X 10(-7) M carbachol induced equivalent contract...

journal_title：European journal of pharmacology

authors： Heaslip RJ,Giesa FR,Rimele TJ,Grimes D

更新日期：1986-08-22 00:00:00

abstract：:There is evidence that the septohippocampal cholinergic system is activated in response to stressful stimuli. In addition, prior studies indicate that stimulating the hippocampal cholinergic neurotransmission increases open arm exploration in the elevated plus-maze. This raises the possibility that exposing the rat to...

journal_title：European journal of pharmacology

authors： Degroot A,Wade M,Salhoff C,Davis RJ,Tzavara ET,Nomikos GG

更新日期：2004-06-16 00:00:00

abstract：:Oral pretreatment with E3330, a novel quinone derivative, attenuated liver injury induced with tumor necrosis factor-alpha in galactosamine-sensitized mice. Tumor necrosis factor-alpha is known to induce inflammatory mediators such as leukotrienes and prostanoids. An in vitro study showed that E3330 inhibited the gene...

journal_title：European journal of pharmacology

authors： Nagakawa J,Hishinuma I,Hirota K,Miyamoto K,Yamanaka T,Yamatsu I,Katayama K

更新日期：1992-12-08 00:00:00

abstract：:We recently reported that tumor necrosis factor alpha is able to cause a dose-dependent and persistent reduction in gap junctional intercellular communication between primary human smooth muscle cells. In order to study whether this observed persistent reduction in gap junctional intercellular communication is a uniqu...

journal_title：European journal of pharmacology

authors： Mensink A,Brouwer A,Van den Burg EH,Geurts S,Jongen WM,Lakemond CM,Meijerman I,Van der Wijk T

更新日期：1996-08-22 00:00:00

abstract：:Methotrexate is a disease modifying anti-rheumatic drug that is widely used for the treatment of rheumatoid arthritis. Nimesulide is a non-steroidal anti-inflammatory drug which is frequently used as adjuvant therapy for symptomatic alleviation of rheumatoid arthritis. In this study, we have evaluated the potential in...

journal_title：European journal of pharmacology

authors： Al-Abd AM,Inglis JJ,Nofal SM,Khalifa AE,Williams RO,El-Eraky WI,Abdel-Naim AB

更新日期：2010-10-10 00:00:00

abstract：:Experiments were conducted to explore the effects of Neuropeptide FF acting at spinal and supraspinal sites in models of chronic inflammatory or neuropathic pain and of acute pain. Neuropeptide FF was administered intrathecally (i.t.; 10.0, 25.0 and 50.0 nmol) or intracerebroventricularly (i.c.v.; 10.0, 12.5 and 15.0 ...

journal_title：European journal of pharmacology

authors： Altier N,Dray A,Ménard D,Henry JL

更新日期：2000-11-03 00:00:00

abstract：:Glutamatergic abnormalities are involved in several psychiatric disorders. Clinical evidence demonstrates altered glutamatergic neurotransmission in patients suffering from obsessive-compulsive disorder. MGS0039, (1R,2R,3R,5R,6R)-2-amino-3-(3,4-dichlorobenzyloxy)-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid, is ...

journal_title：European journal of pharmacology

authors： Shimazaki T,Iijima M,Chaki S

更新日期：2004-10-06 00:00:00

abstract：:The characteristics of beta-adrenoceptors on frog and chick erythrocytes have been compared to those present on rat erythrocyte, lung and cerebral cortical membranes. The receptors have been examined using the specific ligand [3H]dihydroalprenolol ([3H]DHA) with conventional filtration techniques. The equilibrium diss...

journal_title：European journal of pharmacology

authors： Dickinson KE,Nahorski SR

更新日期：1981-08-27 00:00:00

abstract：:Cocaine interacts with sigma receptors, suggesting that these sites are important for many of its behavioral effects. Therefore, two novel sigma receptor ligands, BD1008 (N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamine) and BD1063 (1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine), were evaluat...

journal_title：European journal of pharmacology

authors： McCracken KA,Bowen WD,Matsumoto RR

更新日期：1999-01-15 00:00:00

abstract：:Intraperitoneal administration of phencyclidine (PCP, 2.5-20 mg/kg) produced a dose-related inhibition of the increase in serum PRL concentrations produced by alpha-methylparatyrosine (AMPT) or reserpine, but not morphine. Phencyclidine was more potent in antagonizing the PRL-releasing effect of reserpine than that of...

journal_title：European journal of pharmacology

authors： Meltzer HY,Simonovic M,Gudelsky GA

更新日期：1985-03-26 00:00:00

abstract：:Foot shocks applied to the rat on a grid floor caused brain noradrenaline depletion. Hemicholinium-3 injected intracerebroventricularly (i.c.v.) blocked the noradrenaline depletion and this blockade was reversed by choline (i.c.v.). Physostigmine (i.c.v.) had different effects according to the age of the rats: "young"...

journal_title：European journal of pharmacology

authors： Campos HA,Romero E

更新日期：1977-08-01 00:00:00

abstract：:Corticotropin-releasing factor (CRF) has been suggested to play an important role in the development of drug dependence and withdrawal. Based on the recent finding that CRF receptor antagonists inhibit the stress-induced relapse to opiate dependence and attenuate anxiety-like responses related to cocaine withdrawal, t...

journal_title：European journal of pharmacology

authors： Lu L,Liu D,Ceng X

更新日期：2001-03-01 00:00:00

abstract：:We have investigated the effects of antagonists at functional prejunctional alpha 2-adrenoceptors of rat was deferens and rat submandibular gland and compared potencies with affinities for the alpha 2A-, alpha 2B- and putative alpha 2D-ligand binding sites of human platelet, rat kidney, and rat submandibular gland, re...

journal_title：European journal of pharmacology

authors： Smith K,Docherty JR

更新日期：1992-08-25 00:00:00

abstract：:The effect of lithium ion (Li+) on receptor-mediated synthesis of cyclic GMP, a putative second messenger, was examined using intact murine neuroblastoma cells (clone N1E-115). Lithium chloride potently inhibited cyclic GMP formation stimulated by the neuropeptides, neurotensin, angiotensin II and bradykinin in an ide...

journal_title：European journal of pharmacology

authors： Kanba S,Pfenning M,Kanba KS,Richelson E

更新日期：1986-07-15 00:00:00

abstract：:Pregabalin, a ligand of alpha(2)delta subunits of voltage-gated calcium channels, reduces visceral hypersensitivity associated with irritable bowel syndrome. However, effects of pregabalin on bowel function are not well described. We investigated the effects of pregabalin on bowel dysfunction and colonic nociceptive t...

journal_title：European journal of pharmacology

authors： Ohashi-Doi K,Gale JD,Kurebayashi Y

更新日期：2010-09-15 00:00:00

abstract：:Phenylalanine and tyrosine reportedly decrease blood pressure in conscious restrained rats. However, tyrosine has recently been found to increase blood pressure in anesthetized animals, questioning the generality of findings obtained in restrained animals. The present study therefore evaluated the effects of phenylala...

journal_title：European journal of pharmacology

authors： Yourick DL,Tessel RE

更新日期：1989-01-31 00:00:00

abstract：:Effects of protein kinase C inhibitors, staurosporine and 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride and protein tyrosine kinase inhibitors, genistein, tyrphostin and 2,5-dimethylcinnamate on the neutrophil responses stimulated by immunoglobulin G (IgG), complement C5a or platelet-activating factor...

journal_title：European journal of pharmacology

authors： Ahn SK,Shin YK,Kang HJ,Han ES,Lee CS

更新日期：1996-06-13 00:00:00

abstract：:Flavonoids are polyphenols frequently consumed in the diet they have been suggested to exert a number of beneficial actions on human health, including anti-inflammatory activity. This study investigated the immunomodulatory effects of two flavonoids, Chrysin and Hesperetin. The effects of flavonoids on B and T cell pr...

journal_title：European journal of pharmacology

authors： Sassi A,Mokdad Bzéouich I,Mustapha N,Maatouk M,Ghedira K,Chekir-Ghedira L

更新日期：2017-10-05 00:00:00

abstract：:Bone marrow stem cells are able to differentiate into nervous and endothelial cells. In our study, we found that administration of a bone marrow-stimulating factor (granulocyte colony-stimulating factor; G-CSF 50 microg/kg) decrease the brain infarct volume and enhance survival rate in a model of cerebral ischemia. Ta...

journal_title：European journal of pharmacology

authors： Six I,Gasan G,Mura E,Bordet R

更新日期：2003-01-05 00:00:00

abstract：:Little research has been conducted investigating the long-term impact of opioid exposure during adolescence. These experiments were conducted to determine the behavioral effects of morphine exposure during periadolescence (postnatal days 30-32) versus young adulthood (postnatal days 65-67) on subsequent sensitivity to...

journal_title：European journal of pharmacology

authors： White DA,Holtzman SG

更新日期：2005-12-28 00:00:00

abstract：:Acetyl-CoA acetyltransferase (1-O-alkyl-sn-glycero-3-phosphocholine) is a key enzyme in paf-acether biosynthesis. Its immunological activation as related to paf-acether formation was investigated in mast cells derived from mouse bone marrow. The action of ketotifen, a prophylactic anti-asthma drug, on the antigen-indu...

journal_title：European journal of pharmacology

authors： Joly F,Bessou G,Benveniste J,Ninio E

更新日期：1987-12-01 00:00:00

abstract：:The present study examined the effects of histamine on somatostatin-like immunoreactivity levels, binding of 125I-[Tyr11]somatostatin to its specific receptors, somatostatin inhibition of basal and forskolin-stimulated adenylyl cyclase activity and inhibitory guanine-nucleotide binding protein (Gi) function in the rat...

journal_title：European journal of pharmacology

authors： Puebla L,Arilla E

更新日期：1995-04-28 00:00:00

abstract：:The effect of the anti-allergic drug azelastine, 4-(p-chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepine-4-yl)-1-(2H)-phth alazione), on airway hyperresponsiveness induced by immunologically stimulated pulmonary alveolar macrophages was investigated in canine bronchial segments under isometric conditions in vitro. Macroph...

journal_title：European journal of pharmacology

authors： Tamaoki J,Takemura H,Tagaya E,Sakai A,Yamawaki I,Konno K

更新日期：1995-05-15 00:00:00

abstract：:The activation of adenosine A(2B) receptors in human mast cells causes pro-inflammatory responses such as the secretion of interleukin-8. There is evidence for an inhibitory effect of benzodiazepines on mast cell mediated symptoms in patients with systemic mast cell activation disease. Therefore, we investigated the e...

journal_title：European journal of pharmacology

authors： Hoffmann K,Xifró RA,Hartweg JL,Spitzlei P,Meis K,Molderings GJ,von Kügelgen I

更新日期：2013-01-30 00:00:00

abstract：:We investigated the effects of histamine on the motility of isolated segments from canine ureters and characterized pharmacologically the histamine receptors involved. We also evaluated the effects of various autacoids (5-HT, carbachol, noradrenaline, thromboxane, prostaglandin F2alpha) on the motility of canine urete...

journal_title：European journal of pharmacology

authors： Dodel RC,Hafner D,Borchard U

更新日期：1996-12-30 00:00:00

abstract：:A substantial barrier to the treatment of Opioid Use Disorder (OUD) is the elevated relapse rates in affected patients, and a significant contributor to these events of relapse is exposure to cues and contexts that are intensely associated with prior drug abuse. The neurotransmitter dopamine plays a key role in reward...

journal_title：European journal of pharmacology

authors： McKendrick G,Sharma S,Sun D,Randall PA,Graziane NM

更新日期：2020-12-15 00:00:00

abstract：:2-Arachidonylglycerol (2-AG) inhibits the production in vitro of tumor necrosis factor-alpha (TNF-alpha) by mouse macrophages, as well as in mice. It has no effect on the production of nitric oxide (NO). The effect on TNF-alpha is enhanced when 2-AG is administered together with 2-linoleylglycerol (2-Lino-G) and 2-pal...

journal_title：European journal of pharmacology

authors： Gallily R,Breuer A,Mechoulam R

更新日期：2000-10-06 00:00:00

abstract：:The effect of GABA (gamma-aminobutyric acid system) receptor agonists and antagonists on naloxone-induced jumping in morphine-dependent mice was examined. Intraperitoneal (i.p.) or intracerebroventricular (i.c.v.) injection of different doses of the GABA(B) receptor agonist, baclofen (2.5, 5 and 10 mg/kg), reduced nal...

journal_title：European journal of pharmacology

authors： Zarrindast MR,Mousa-Ahmadi E

更新日期：1999-09-24 00:00:00