当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PHARMACOLOGY期刊下所有文献 > Various GABA-mimetic drugs differently affect cocaine-evoked hyperlocomotion and sensitization.

Various GABA-mimetic drugs differently affect cocaine-evoked hyperlocomotion and sensitization.

Abstract：

:To substantiate the notion that cocaine behavioral effects may be influenced by gamma-aminobutyric acid (GABA) neurotransmission male Wistar rats were injected with gabapentin (a cyclic GABA analogue), tiagabine (a GABA reuptake inhibitor), or vigabatrin (a GABA transaminase inhibitor) before acute or repeated treatment with cocaine evoking either locomotor hyperactivation or sensitization. Gabapentin (1-30 mg/kg), tiagabine (2.5-10 mg/kg) or vigabatrin (75-250 mg/kg) attenuated the cocaine (10 mg/kg)-induced hyperactivation and in the highest doses they also decreased basal locomotor activation. Vigabatrin (75-250 mg/kg) dose-dependently reduced the development of cocaine sensitization in rats treated repeatedly (days 1-5) with cocaine (10 mg/kg) and then challenged with cocaine (10 mg/kg) following 5-day withdrawal; the remaining drugs were ineffective. When injected acutely with a cocaine challenge dose, gabapentin (3-10 mg/kg) or vigabatrin (150 mg/kg), but not tiagabine, significantly attenuated the expression of cocaine sensitization. The present results show that enhanced GABA-ergic neurotransmission exerted inhibitory actions on acute responses to cocaine, however, only in a case of vigabatrin the inhibition seems to be unrelated to the inhibitory effect of the drugs on basal locomotor activity. The finding that vigabatrin protected against the development and the expression of cocaine sensitization further supports its therapeutic potential in the treatment of cocaine dependence.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Filip M,Frankowska M,Gołda A,Zaniewska M,Vetulani J,Przegaliński E

doi

10.1016/j.ejphar.2006.05.011

subject

Has Abstract

pub_date

2006-07-17 00:00:00

pages

163-70

issue

3

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(06)00497-3

journal_volume

541

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF PHARMACOLOGY文献大全
  • Neurotoxicity of the meperidine analogue N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on brain catecholamine neurons in the mouse.

    abstract：:The effect of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (NMPTP) on central monoamine neurons in mice was investigated using histo- and biochemical techniques. NMPTP (2 X 10 mg/kg i.v.) produced a rapid and long-lasting reduction (-30%) of striatal dopamine, while the dopamine levels were only transiently reduced in...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(84)90521-1

    authors： Hallman H,Olson L,Jonsson G

    更新日期：1984-01-13 00:00:00

  • Recovery of the muscarinic cholinergic receptor from its down-regulation in cultured smooth muscle.

    abstract：:The recovery of the muscarinic cholinergic receptor (mAChR) from its down-regulation by long-term exposure to ACh was investigated. This was done to obtain information about regulation of the mAChR. Exposure of guinea-pig vas deferens to 30 microM ACh for 24 h decreased the amount of mAChR to 30% of the initial level,...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(85)90417-0

    authors： Higuchi H,Uchida S,Yoshida H

    更新日期：1985-02-26 00:00:00

  • Cardiovascular characterization of UL-FS 49, 1,3,4,5-tetrahydro-7,8-dimethoxy-3-[3-][2-(3,4-dimethoxyphenyl)ethyl] methylimino]propyl]-2H-3-benzazepin-2-on hydrochloride, a new "specific bradycardic agent".

    abstract：:UL-FS 49, a chemical congener of AQ-A 39 with structural similarities to verapamil, decreased the rate of spontaneously beating guinea-pig atria at much lower concentrations (effective concentration 30%, EC30 = 0.030 microgram/ml) than it decreased the contractility (2.5 Hz; EC30 = 108 micrograms/ml) and maximal drivi...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(84)90363-7

    authors： Kobinger W,Lillie C

    更新日期：1984-09-03 00:00:00

  • Rodent models of treatment-resistant depression.

    abstract：:Major depression is a prevalent and debilitating disorder and a substantial proportion of patients fail to reach remission following standard antidepressant pharmacological treatment. Limited efficacy with currently available antidepressant drugs highlights the need to develop more effective medications for treatment-...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejphar.2014.10.063

    authors： Caldarone BJ,Zachariou V,King SL

    更新日期：2015-04-15 00:00:00

  • The effect of O-1602, a GPR55 agonist, on the cyclophosphamide-induced rat hemorrhagic cystitis.

    abstract：:The goal of our study was to determine whether GPR55 agonists, O-1602, could reverse the cyclophosphamide (CYP)-induced changes in cystometric and inflammatory parameters, indicative of the development of bladder inflammation and overactivity. If confirmed, the stimulation of novel cannabinoid receptor - GPR55, could ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2020.173321

    authors： Wróbel A,Zapała Ł,Zapała P,Piecha T,Radziszewski P

    更新日期：2020-09-05 00:00:00

  • Targets and pathways involved in the antitumor activity of citral and its stereo-isomers.

    abstract：:This review provides a comprehensive analysis of the anticancer potential of the natural product citral (CIT) found in many plants and essential oils, and extensively used in the food and cosmetic industry. CIT is composed of two stereoisomers, the trans-isomer geranial being a more potent anticancer compound than the...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejphar.2020.172945

    authors： Bailly C

    更新日期：2020-03-15 00:00:00

  • Chronic MAO A and MAO B inhibition decreases the 5-HT1A receptor-mediated inhibition of forskolin-stimulated adenylate cyclase.

    abstract：:The effect of chronic administration of various monoamine oxidase (MAO) inhibitors on the ability of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) to inhibit forskolin-stimulated adenylate cyclase activity was studied. Groups of 12 rats were given either saline, (E)-beta-fluoromethylene-m-tyrosine (MDL 72394 0.25...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(88)90199-9

    authors： Sleight AJ,Marsden CA,Palfreyman MG,Mir AK,Lovenberg W

    更新日期：1988-09-23 00:00:00

  • Stability of the vasopressin V2 receptor-adenylyl cyclase system in rat kidney.

    abstract：:In the Brattleboro rat with diabetes insipidus vasopressin V2 receptor mRNA and the mRNA of various adenylyl cyclase (AC) isoforms are moderately reduced compared with those of normal rats. In the present study renal vasopressin V2 receptor mRNA was modestly higher (by 34%), as was expression of AC 5, 6 and 9 mRNAs (u...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(97)01461-1

    authors： Shen T,Laycock J,Suzuki Y,Defer N,Hanoune J

    更新日期：1998-01-02 00:00:00

  • Carvedilol abrogates hypoxia-induced oxidative stress and neuroinflammation in microglial BV2 cells.

    abstract：:Microglia initially undergo rapid activation in response to injury and stressful stimuli, such as hypoxia. Oxidative stress and the inflammatory response play critical roles in hypoxic-ischemic brain injury. Carvedilol is a β-blocker used to treat high blood pressure and heart failure. In this study, we investigated w...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2017.08.013

    authors： Gao X,Wu B,Fu Z,Zhang Z,Xu G

    更新日期：2017-11-05 00:00:00

  • Increased grooming behaviour is induced by apomorphine in mice treated with discriminant benzamide derivatives.

    abstract：:Grooming behaviour in mice was dose dependently increased by SK&F 38393 (1.87-30 mg/kg), whereas it was dose dependently decreased by RU 24926 (2.5-10 mg/kg) or LY 171555 (0.4-1.6 mg/kg) alone or combined with SK&F 38393 or apomorphine (0.39-6 mg/kg). The inhibitory effect of 0.75 mg/kg apomorphine on grooming behavio...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(88)90141-0

    authors： Vasse M,Protais P

    更新日期：1988-10-26 00:00:00

  • MK-886, an inhibitor of the 5-lipoxygenase-activating protein, inhibits cyclooxygenase-1 activity and suppresses platelet aggregation.

    abstract：:MK-886, an inhibitor of the 5-lipoxygenase-activating protein (FLAP), potently suppresses leukotriene biosynthesis in intact cells and is frequently used to define a role of the 5-lipoxygenase (EC 1.13.11.34) pathway in cellular or animal models of inflammation, allergy, cancer, and cardiovascular disease. Here we sho...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2009.02.023

    authors： Koeberle A,Siemoneit U,Northoff H,Hofmann B,Schneider G,Werz O

    更新日期：2009-04-17 00:00:00

  • MC70 potentiates doxorubicin efficacy in colon and breast cancer in vitro treatment.

    abstract：:A major limitation of cancer treatment is the ability of cancer cells to develop resistance to chemotherapeutic drugs, by the establishment of multidrug resistance. Here, we characterize MC70 as ABC transporters inhibitor and anticancer agent, alone or with chemotherapy. MC70 was analyzed for its interaction with ABCB...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2011.08.025

    authors： Azzariti A,Quatrale AE,Porcelli L,Colabufo NA,Cantore M,Cassano G,Gasparre G,Iannelli G,Tommasi S,Panaro MA,Paradiso A

    更新日期：2011-11-16 00:00:00

  • Differentiation-inducing factor-1-induced growth arrest of K562 leukemia cells involves the reduction of ERK1/2 activity.

    abstract：:The differentiation-inducing factor-1 (DIF-1) is a signal molecule that induces stalk cell differentiation in the cellular slime mold Dictyostelium discoideum. In addition, DIF-1 is a potent antileukemic agent that induces growth arrest in K562 cells. In this study, we investigated the mechanism of action of DIF-1 in ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2003.11.041

    authors： Akaishi E,Narita T,Kawai S,Miwa Y,Sasaguri T,Hosaka K,Kubohara Y

    更新日期：2004-02-06 00:00:00

  • Acetylsalicylic acid inhibits α,β-meATP-induced facilitation of neck muscle nociception in mice--implications for acute treatment of tension-type headache.

    abstract：:Infusion of α,β-methylene ATP (α,β-meATP) into murine neck muscle facilitates brainstem nociception. This animal experimental model is suggested to be appropriate for investigating pathophysiological mechanisms in tension-type headache. It was hypothesized that d-lysine acetylsalicylic acid (ASA, aspirin®) reverses th...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2011.10.008

    authors： Ristic D,Spangenberg P,Ellrich J

    更新日期：2011-12-30 00:00:00

  • Beta-endorphin differentially affects inflammation in two inbred rat strains.

    abstract：:It has been shown that inflammation of rat paws elicits accumulation of opioid peptide beta-endorphin-containing immune cells in the inflamed subcutaneous tissue, contributing to immunocyte-produced pain suppression. However, the possible mechanisms involved in the pharmacological application of beta-endorphin in rat ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2006.08.012

    authors： Stanojević S,Mitić K,Vujić V,Kovacević-Jovanović V,Dimitrijević M

    更新日期：2006-11-07 00:00:00

  • Nimesulide improves the disease modifying anti-rheumatic profile of methotrexate in mice with collagen-induced arthritis.

    abstract：:Methotrexate is a disease modifying anti-rheumatic drug that is widely used for the treatment of rheumatoid arthritis. Nimesulide is a non-steroidal anti-inflammatory drug which is frequently used as adjuvant therapy for symptomatic alleviation of rheumatoid arthritis. In this study, we have evaluated the potential in...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2010.07.006

    authors： Al-Abd AM,Inglis JJ,Nofal SM,Khalifa AE,Williams RO,El-Eraky WI,Abdel-Naim AB

    更新日期：2010-10-10 00:00:00

  • Effects of FK409, a nitric oxide donor, on renal responses to renal nerve stimulation in anesthetized dogs.

    abstract：:We examined the effects of (+/-)-(E)-4-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide (FK409), a nitric oxide (NO) donor, on renal actions and norepinephrine overflow induced by renal nerve stimulation in anesthetized dogs, with or without N(G)-nitro-L-arginine (NOARG), a NO synthase inhibitor. Renal nerve stimulatio...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(97)01424-6

    authors： Tadano K,Matsuo G,Hashimoto T,Matsumura Y

    更新日期：1998-01-12 00:00:00

  • The relationship between morphine, aspartic acid and L-asparaginase in rats.

    abstract：:Morphine and aspartic acid were administered separately and in combination to 80 rats divided into 8 groups. Ten and 20 min following the injections, brain, liver and kidney L-asparaginase activity was determined. Morphine decreased brain and liver L-asparaginase activity and increased that of kidney. Aspartic acid co...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(79)90244-9

    authors： Koyuncuoğlu H,Keyer-Uysal M,Berkman K,Güngör M,Genç EM

    更新日期：1979-12-20 00:00:00

  • Functional evidence for an apical ANP receptor in LLC-PK1 kidney epithelial cells.

    abstract：:The localization of natriuretic peptide receptors was studied in LLC-PK1 cell monolayers grown on a micro-porous membrane filter. The addition of alpha-human atrial natriuretic peptide (alpha-hANP) to the apical side of the cells produced a concentration-dependent increase in cyclic GMP (cGMP) formation, the extent of...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0922-4106(94)90071-x

    authors： Hashimoto Y,Ozaki J,Yasuhara M,Hori R,Suga S,Itoh H,Nakao K,Inui K

    更新日期：1994-08-16 00:00:00

  • MMPT as a reactive oxygen species generator induces apoptosis via the depletion of intracellular GSH contents in A549 cells.

    abstract：:MMPT, (5-[(4-methylphenyl)methylene]-2-(phenylamino)-4(5H)-thiazolone), a thiazolidin compound, was identified in our laboratory as a novel antineoplastic agent with a broad spectrum of antitumor activity against many human cancer cells. A previous study showed that MMPT inhibited cell growth, and induced apoptosis in...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2012.05.003

    authors： Zhao YF,Zhang C,Suo YR

    更新日期：2012-08-05 00:00:00

  • Effects of second-generation histamine H1 receptor antagonists on the sleep-wakefulness cycle in rats.

    abstract：:The present study was performed to examine the sedative effects of second-generation histamine H(1) receptor antagonist using power spectrum analysis in the rat. Similar to ketotifen, olopatadine caused a decrease in sleep latency at a dose of 50 mg/kg, while epinastine and cetirizine showed no significant effect even...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2004.05.010

    authors： Shigemoto Y,Shinomiya K,Mio M,Azuma N,Kamei C

    更新日期：2004-06-28 00:00:00

  • Inhibition of aftercontractions and phasic calcium release by yohimbine in ferret papillary muscle.

    abstract：:Phasic release of calcium from the sarcoplasmic reticulum occurs in all mammalian cardiac preparations when the intracellular calcium concentration is sufficiently high. The phasic calcium release is often sufficient to trigger electrophysiological responses and aftercontractions. These can be detrimental to normal ca...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(89)90551-7

    authors： Briggs GM,Morgan JP,Gwathmey JK

    更新日期：1989-11-07 00:00:00

  • Ischaemia-reperfusion injury in mouse skeletal muscle is reduced by N omega-nitro-L-arginine methyl ester and dexamethasone.

    abstract：:We have developed a model of ischaemia-reperfusion injury in C57BL/6 mice involving ischaemia for 0.5 to 2.5 h with an elastic tourniquet on one hind limb and reperfusion for 24 h, analogous to a well-established model of ischaemia-reperfusion injury in the rat. Viability was assessed in tissue homogenates of the gast...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(97)01101-1

    authors： Knight KR,Zhang B,Morrison WA,Stewart AG

    更新日期：1997-08-13 00:00:00

  • Effects of tachykinin NK1 or PAF receptor blockade on the lung injury induced by scorpion venom in rats.

    abstract：:In cases of severe human scorpion envenoming, lung injury is a common finding and frequently the cause of death. In the rat, two distinct mechanisms account for oedema following the intravenous injection of the venom -- acute left ventricular failure resulting from a massive release of catecholamines and an increase i...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(99)00382-9

    authors： Matos IM,Souza DG,Seabra DG,Freire-Maia L,Teixeira MM

    更新日期：1999-07-09 00:00:00

  • Insulin-induced relaxation of rat mesenteric artery is mediated by Ca(2+)-activated K(+) channels.

    abstract：:We tested the hypothesis that relaxation of the rat mesenteric artery in response to insulin is mediated by K(+) channels. Two concentrations of insulin (10 and 100 mU/ml) induced relaxation of the artery by 6+/-1%, 24+/-3% (mean+/-S.E.M.). Denudation of the endothelium or precontraction by KCl (30 mM), clotrimazole (...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(00)00892-x

    authors： Iida S,Taguchi H,Watanabe N,Kushiro T,Kanmatsuse K

    更新日期：2001-01-05 00:00:00

  • Lack of evidence for cross-competition between vasoactive intestinal peptide and somatostatin at their respective receptors.

    abstract：:A possible cross-competition between vasoactive intestinal peptide (VIP) and somatostatin (somatotropin release inhibiting factor; SRIF) and their respective receptors, was investigated at native or recombinant SRIF and VIP/pituitary adenylate cyclase-activating polypeptide (PACAP) receptors. The activity of VIP was e...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(01)01223-7

    authors： Hannon JP,Langenegger D,Waser B,Hoyer D,Reubi JC

    更新日期：2001-08-31 00:00:00

  • Prostacyclin prevents ischemia-induced increase of lactate and cyclic AMP in ischemic myocardium.

    abstract：:The effect of prostacyclin (PGI2, 0.5 nmol . kg-1 . min-1,i.v.) on myocardial metabolism was studied in cats subjected to 5 h of myocardial ischemia (MI) and compared to vehicle-treated MI cats. MI was followed by a 52% decrease in ATP and a concomitant increase (2-3 fold) in lactate and lactate/pyruvate ratio in the ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(81)90454-4

    authors： Rösen R,Rösen P,Ohlendorf R,Schrör K

    更新日期：1981-02-19 00:00:00

  • Magnetic bead-based proteomic technology to study paricalcitol effect in kidney transplant recipients.

    abstract：:Secondary hyperparathyroidism is a common complication in patients with chronic kidney disease and frequently persists after kidney transplantation. Paricalcitol, a selective vitamin D receptor activator, is indicated in the management of this disorder and recent evidences have suggested that this drug has other benef...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ejphar.2013.03.040

    authors： Pérez V,Sánchez-Escuredo A,Lauzurica R,Bayés B,Navarro-Muñoz M,Pastor MC,Cañas L,Bonet J,Romero R

    更新日期：2013-06-05 00:00:00

  • Exogenous SO2 donor treatment impairs reconsolidation of drug reward memory in mice.

    abstract：:Substance-related and addictive disorders (SRADs) are characterized by compulsive drug use and recurrent relapse. The persistence of pathological drug-related memories indisputably contributes to a high propensity to relapse. Hence, strategies to disrupt reconsolidation of drug reward memory are currently being pursue...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2021.173911

    authors： Rulan D,Zhenbang Y,Yipu Z,Yuan G,Galaj E,Xiaorui S,Wenshuya L,Jiaqi L,Yan Z,Chang Y,Xi Y,Li S,Yixiao L,Haishui S

    更新日期：2021-01-24 00:00:00

  • Lack of intrinsic activity and significant subtype selectivity of SR 95639A at muscarinic receptors.

    abstract：:We assessed the intrinsic activity of the purported selective muscarinic M1 receptor agonist SR 95639A (morpholinoethylamino-3-benzocyclohepta-(5,6-c)-pyridazine) in inducing several receptor-mediated signals. Our results indicate that SR 95639A lacks the ability to activate phosphoinositide hydrolysis in rat cerebral...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0922-4106(92)90126-g

    authors： Mohamed AS,Forray C,Aly MH,el-Fakahany EE

    更新日期：1992-10-01 00:00:00