Prostacyclin prevents ischemia-induced increase of lactate and cyclic AMP in ischemic myocardium.

abstract：:The corticotropin releasing factor (CRF) family includes CRF and urocortin. The effects of urocortin and CRF (0.3, 1, 3 and 10 nmol/kg, i.v.) relative to those of vehicle (0.9% NaCl) on mean arterial pressure and mean circulatory filling pressure (index of venous tone) were examined in conscious, unrestrained rats tha...

journal_title：European journal of pharmacology

authors： Abdelrahman AM,Lin Lim S,Pang CC

更新日期：2005-03-07 00:00:00

abstract：:The purpose of this study was to investigate whether the selective angiotensin AT2 receptor ligands, CGP 42112B (Nic-Tyr-(N alpha-benzoyloxycarbonyl-Arg)Lys-His-Pro-Ile-OH) and PD 123319 ((s)-1-[[4-(dimethylamino)-3-methyl-phenyl]methyl]-5-(diphenylacetyl+ ++)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]-pyridine-6-carboxylic...

journal_title：European journal of pharmacology

authors： Macari D,Whitebread S,Cumin F,De Gasparo M,Levens N

更新日期：1994-06-23 00:00:00

abstract：:Hepatocellular carcinoma (HCC), as the commonest type in liver cancer, is in urgent need for better treatment target due to its high mortality and poor prognosis. The involvement of angiogenesis in HCC has been identified by multiple studies, but the underlying mechanism remains unclear. Long non-coding RNAs (LncRNAs)...

journal_title：European journal of pharmacology

authors： Li W,Fu Q,Man W,Guo H,Yang P

更新日期：2019-04-15 00:00:00

abstract：:It has been suggested that morphine-6-glucuronide, a major metabolite of the opioid analgesic morphine, is more potent as an analgesic than the parent drug. This finding appears not to be due to differences in affinity for opioid receptors. Therefore, in the present study the opioid receptor mediated effects of morphi...

journal_title：European journal of pharmacology

authors： Schmidt N,Brune K,Geisslinger G

更新日期：1994-04-01 00:00:00

abstract：:DSP-4 (N-(2-chloroethyl)-ethyl-2-bromobenzylamine) a novel neurotoxin which destroys central noradrenaline neurones after peripheral injection was administered to rats (50 mg/kg X 2). This procedure did not alter activity responses to quipazine (7.5 mg/kg) or apomorphine (0.2 mg/kg) but prevented their enhancement by ...

journal_title：European journal of pharmacology

authors： Heal DJ,Davies CL,Goodwin GM

更新日期：1985-09-10 00:00:00

abstract：:Nitric oxide (NO) has been described to exert various anti-atherogenic actions. However, NO, in some cases, has been shown to stimulate the oxidation of low-density lipoprotein (LDL), which constitute an important triggering event in atherosclerosis. Thus, some NO donors, despite their advantages, might also induce ox...

journal_title：European journal of pharmacology

authors： Jaworski K,Kinard F,Goldstein D,Holvoet P,Trouet A,Schneider YJ,Remacle C

更新日期：2001-08-03 00:00:00

abstract：:The effects of 1 mM L-cysteine on sodium nitrite-, 3-morpholinosydnonimine (SIN-1)- and acetylcholine-induced relaxation and cyclic GMP accumulation were studied in isolated noradrenaline-precontracted rat mesenteric arterial rings. L-Cysteine augmented the relaxation and cyclic GMP increase induced by sodium nitrate ...

journal_title：European journal of pharmacology

authors： Arvola P,Pörsti I,Vuorinen P,Huhtala H,Metsä-Ketelä T,Vapaatalo H

更新日期：1992-04-22 00:00:00

abstract：:The excitatory mechanism of central sympathetic outflow induced by interleukin-1 beta was investigated in urethane-anesthetized rats. Intracerebroventricular administration of interleukin-1 beta induced a gradually developing elevation of plasma noradrenaline levels in a dose-dependent manner (50, 100 and 200 ng/anima...

journal_title：European journal of pharmacology

authors： Murakami Y,Yokotani K,Okuma Y,Osumi Y

更新日期：1996-12-12 00:00:00

abstract：:We have recently demonstrated that hyperthermia induced by 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and m-chlorophenylpiperazine (m-CPP) are separately mediated by selective stimulation of 5-HT2A and 5-HT2C receptors, respectively in Wistar rats. Furthermore, hyperthermia induced by either DOI or m-CPP was ...

journal_title：European journal of pharmacology

authors： Aulakh CS,Mazzola-Pomietto P,Murphy DL

更新日期：1995-08-25 00:00:00

abstract：:Dihydralazine (0.1 mg/kg), injected intravenously into male Sprague-Dawley rats, caused a decrease in mean arterial blood pressure and an increase in renal plasma flow, while urine volume remained unchanged. Dihydralazine had no effect on kallikrein excretion in the urine and on kallikrein activity in the renal cortex...

journal_title：European journal of pharmacology

authors： Bönner G,Beck D,Deeg M,Marin-Grez M,Gross F

更新日期：1982-02-26 00:00:00

abstract：:Acetylcholine releases a non-prostanoid endothelium-derived hyperpolarizing factor (EDHF) and nitric oxide from physiological salt solution perfused rat mesenteric arteries. This study reports an impairment in EDHF-mediated vasodilation in deoxycorticosterone acetate (DOCA)-salt hypertensive versus control normotensiv...

journal_title：European journal of pharmacology

authors： Adeagbo AS,Joshua IG,Falkner C,Matheson PJ

更新日期：2003-11-14 00:00:00

abstract：:The physiological role of NPFF/FMRFa family of peptides appears to be complex and exact mechanism of action of these peptides is not yet completely understood. In same line of scrutiny, another analog of YGGFMKKKFMRFamide (YFa), a chimeric peptide of met-enkephalin and FMRFamide, was rationally designed and synthesize...

journal_title：European journal of pharmacology

authors： Vats ID,Chaudhary S,Sharma A,Nath M,Pasha S

更新日期：2010-07-25 00:00:00

abstract：:The localization of natriuretic peptide receptors was studied in LLC-PK1 cell monolayers grown on a micro-porous membrane filter. The addition of alpha-human atrial natriuretic peptide (alpha-hANP) to the apical side of the cells produced a concentration-dependent increase in cyclic GMP (cGMP) formation, the extent of...

journal_title：European journal of pharmacology

authors： Hashimoto Y,Ozaki J,Yasuhara M,Hori R,Suga S,Itoh H,Nakao K,Inui K

更新日期：1994-08-16 00:00:00

abstract：:The present study was designed to evaluate the preventive effects of p-coumaric acid on lysosomal dysfunction and myocardial infarct size in isoproterenol induced myocardial infarcted rats. Male albino Wistar rats were pretreated with p-coumaric acid (8 mg/kg body weight) daily for a period of 7 days after which isopr...

journal_title：European journal of pharmacology

authors： Jyoti Roy A,Stanely Mainzen Prince P

更新日期：2013-01-15 00:00:00

abstract：:This study investigated the antinociceptive action of p-chloro-selenosteroid (PCS), administered by intragastric route (i.g.) to mice against acute models. The contribution of adenosinergic, dopaminergic, serotonergic, nitric oxide and opioid systems was investigated. It was evaluated if the administration of PCS trig...

journal_title：European journal of pharmacology

authors： Marcondes Sari MH,Guerra Souza AC,Gonçalves Rosa S,Souza D,Dorneles Rodrigues OE,Wayne Nogueira C

更新日期：2014-02-15 00:00:00

abstract：:In Parkinson disease the degeneration of dopaminergic neurones is believed to lead to a disinhibition of the subthalamic nucleus thus increasing the firing rate of the glutamatergic excitatory projections to the substantia nigra. In consequence, excessive glutamatergic activity will cause excitotoxicity and oxidative ...

journal_title：European journal of pharmacology

authors： Oster S,Radad K,Scheller D,Hesse M,Balanzew W,Reichmann H,Gille G

更新日期：2014-02-05 00:00:00

abstract：:We isolated a novel peptide, calcitonin receptor-stimulating peptide-1 (CRSP-1), from porcine brain and found that the administration of this peptide into rats induced a transient decrease in plasma calcium concentration. Therefore, we investigated the effects of CRSP-1 on osteoclastogenesis. Osteoclast-like cells wer...

journal_title：European journal of pharmacology

authors： Notoya M,Arai R,Katafuchi T,Minamino N,Hagiwara H

更新日期：2007-04-10 00:00:00

abstract：:We have investigated, by using the whole-cell patch-clamp technique, the Ca2+ channel antagonist properties of eliprodil in cultured cerebellar granule cells which are known to express L-, N-, P- as well as Q- and R-type Ca2+ channels. Eliprodil maximally antagonized 50% of the voltage-dependent Ba2+ current with an I...

journal_title：European journal of pharmacology

authors： Biton B,Godet D,Granger P,Avenet P

更新日期：1997-04-04 00:00:00

abstract：:Morphine produced a dose-dependent increase in the activity of dopamine-containing neurons in the substantia nigra and ventral tegmental area recorded from mouse brain slices in vitro. The response was not changed in a low calcium/high magnesium incubation medium, indicating that the observed effects are the result of...

journal_title：European journal of pharmacology

authors： Trulson ME,Arasteh K

更新日期：1985-08-07 00:00:00

abstract：:Rats were treated with ethanol in the drinking fluid 2 X 1 h daily for 83 weeks. [3H]Muscimol, [3H]quinuclidinyl benzilate ( [3H]QNB) and [3H]nicotine binding was measured in selected brain areas 7, 14 and 21 days after withdrawal of ethanol. A significant increase (P less than 0.05) when compared to controls was foun...

journal_title：European journal of pharmacology

authors： Nordberg A,Wahlström G,Eriksson B

更新日期：1985-09-24 00:00:00

abstract：:Three carboxyphenylglycine derivatives were examined for their activity on glutamate metabotropic receptors negatively linked to adenylate cyclase. Chinese hamster ovary cells stably expressing mGlu2 and mGlu4 were utilised for this study. A receptor binding analysis was also performed for the main classes of glutamat...

journal_title：European journal of pharmacology

authors： Cavanni P,Pinnola V,Mugnaini M,Trist D,Van Amsterdam FT,Ferraguti F

更新日期：1994-09-15 00:00:00

abstract：:Galantamine is a reversible inhibitor of acetylcholinesterase and an allosteric-potentiating ligand of the nicotinic acetylcholine receptors. It is used for treating mild-to-moderate Alzheimer's disease. Interestingly, QT interval prolongation on the electrocardiogram (ECG), malignant ventricular arrhythmias and synco...

journal_title：European journal of pharmacology

authors： Vigneault P,Bourgault S,Kaddar N,Caillier B,Pilote S,Patoine D,Simard C,Drolet B

更新日期：2012-04-15 00:00:00

abstract：:Somatostatin and gamma-aminobutyric acid (GABA) concentrations were evaluated in the brain of kindled rats treated chronically with carbamazepine and valproic acid. Kindled seizures were almost completely blocked by treatment with carbamazepine, whereas the effect of valproic acid was partial, suppressing only general...

journal_title：European journal of pharmacology

authors： Higuchi T,Yamazaki O,Takazawa A,Kato N,Watanabe N,Minatogawa Y,Yamazaki J,Ohshima H,Nagaki S,Igarashi Y

更新日期：1986-06-17 00:00:00

abstract：:Previous studies show that naringenin promotes insulin sensitivity in fructose-fed rats. This study investigates whether naringenin prevents oxidative events and apoptotic changes triggered in the rat liver by a high fructose diet. Male Wistar rats of body weight 150-180 g were fed either diet containing starch (60% c...

journal_title：European journal of pharmacology

authors： Kannappan S,Palanisamy N,Anuradha CV

更新日期：2010-10-25 00:00:00

abstract：:Myocardial pH was measured continuously with a micro pH electrode inserted into the left ventricular wall in dogs. Anterior descending coronary flow was reduced to about 1/3 of the original flow by partial occlusion of the coronary artery. Myocardial pH decreased from 7.50--7.60 to 7.06--7.24 after partial occlusion. ...

journal_title：European journal of pharmacology

authors： Abiko Y,Sakai K

更新日期：1980-06-27 00:00:00

abstract：:Oxidative stress is proved to be harmful to the vascular endothelial cells which are important in preventing the formation and progression of atheromatous plaque. This study was designed to investigate the protective effect and potential mechanisms of dihydrotestosterone (DHT) against H(2)O(2)-induced apoptosis of hum...

journal_title：European journal of pharmacology

authors： Xu ZR,Hu L,Cheng LF,Qian Y,Yang YM

更新日期：2010-09-25 00:00:00

abstract：:In order to provide further support for a role of central nitric oxide as a mediator of penile erection and yawning, the nitric oxide donors sodium nitroprusside, hydroxylamine, isoamyl nitrite and S-nitroso-N-acetyl-penicillamine were injected into the lateral ventricles (i.c.v.) or into the paraventricular nucleus o...

journal_title：European journal of pharmacology

authors： Melis MR,Argiolas A

更新日期：1995-12-27 00:00:00

abstract：:Anorexia and muscle wasting are frequently observed in cancer patients and influence their clinical outcome. The better understanding of the mechanisms underlying behavioral changes and altered metabolism yielded to the development of specialized nutritional support, which enhances utilization of provided calories and...

journal_title：European journal of pharmacology

authors： Laviano A,Seelaender M,Sanchez-Lara K,Gioulbasanis I,Molfino A,Rossi Fanelli F

更新日期：2011-09-01 00:00:00

abstract：:The stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W.1419), which was promising in inflammatory bowel disease (PL-10, PLD-116, PL-14736, Pliva) trials, protects against both acute and chronic alcohol-induced lesions in stomach and liver, but also, given peripherally, affects various centrally mediated dis...

journal_title：European journal of pharmacology

authors： Blagaic AB,Blagaic V,Romic Z,Sikiric P

更新日期：2004-09-24 00:00:00

abstract：:Previous studies from this laboratory have shown that administration of nitric oxide (NO) donors reduces the early phase (which peaks at 4 h) of carrageenan-induced paw oedema. The aim of this study was to investigate the influence of NO donors on the delayed phase of the mouse paw oedema, which peaks 48 h after carra...

journal_title：European journal of pharmacology

authors： Fernandes D,Assreuy J

更新日期：2004-10-06 00:00:00