Abstract:
:Hepatocellular carcinoma (HCC), as the commonest type in liver cancer, is in urgent need for better treatment target due to its high mortality and poor prognosis. The involvement of angiogenesis in HCC has been identified by multiple studies, but the underlying mechanism remains unclear. Long non-coding RNAs (LncRNAs) have been reported to regulate numerous cancers, including HCC. LncRNA-OR3A4 has been reported to exert oncogenic and angiogenetic functions in gastric cancer, but its role in HCC hasn't been elucidated. Present study aimed to uncover the biological role of OR3A4 in tumor progression and angiogenesis in HCC. The upregulation of OR3A4 in HCC tissues and cell lines and its prognostic significance were first identified. Loss-of-function assays, including CCK-8, transwell and tube formation assay, validated OR3A4 as a promoter for HCC progression and angiogenesis. The association of OR3A4 and AGGF1 with HCC and poor prognosis was identified by qRT-PCR and Kaplan-Meier analysis. Western blotting and spearman's correlation curve verified the effect of OR3A4 on AGGF1 level and their positive association. Rescue assays revealed that OR3A4 promoted cancer progression and angiogenesis in HCC via AGGF1/akt/mTOR. Together, present study revealed OR3A4 as a novel prognostic target for HCC, which regulated tumor progression and angiogenesis through AGGF1/akt/mTOR pathway.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Li W,Fu Q,Man W,Guo H,Yang Pdoi
10.1016/j.ejphar.2019.01.049subject
Has Abstractpub_date
2019-04-15 00:00:00pages
106-114eissn
0014-2999issn
1879-0712pii
S0014-2999(19)30072-Xjournal_volume
849pub_type
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journal_title:European journal of pharmacology
pub_type: 杂志文章
doi:10.1016/0014-2999(81)90368-x
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journal_title:European journal of pharmacology
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doi:10.1016/j.ejphar.2015.05.047
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doi:10.1016/j.ejphar.2005.12.043
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journal_title:European journal of pharmacology
pub_type: 杂志文章
doi:10.1016/s0014-2999(01)01396-6
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abstract::The binding affinity of olanzapine, clozapine and atropine for muscarinic receptor subtypes in clonal Chinese hamster ovary (CHO) cell lines was compared in intact cells in physiological media to disrupted cells in hypotonic buffer. The affinity of olanzapine and clozapine, but not atropine, for muscarinic receptor su...
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pub_type: 杂志文章
doi:10.1016/s0014-2999(00)00037-6
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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abstract::A single dose of methamphetamine (25 mg/kg i.p.) was administered to young adult gerbils (Meriones unguiculatus) aged 90 days and the number of spices was determined along 40-microns segments of basal, lateral and apical dendrites of pyramidal cells in layers III and V of the prefrontal cortex, after 1.5, 7, 20 and 30...
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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pub_type: 杂志文章
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journal_title:European journal of pharmacology
pub_type: 杂志文章,评审
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journal_title:European journal of pharmacology
pub_type: 杂志文章
doi:10.1016/0014-2999(81)90087-x
更新日期:1981-07-17 00:00:00