Abstract：
:The stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W.1419), which was promising in inflammatory bowel disease (PL-10, PLD-116, PL-14736, Pliva) trials, protects against both acute and chronic alcohol-induced lesions in stomach and liver, but also, given peripherally, affects various centrally mediated disturbances. Now, in male NMRI mice BPC 157 (10 pg intraperitoneally, 10 ng and 10 microg, intraperitoneally or intragastrically) (i) strongly opposed acute alcohol (4 g/kg intraperitoneally) intoxication (i.e., quickly produced and sustained anesthesia, hypothermia, increased ethanol blood values, 25% fatality, 90-min assessment period) given before or after ethanol, and (ii) when given after abrupt cessation of ethanol (at 0 or 3 or 7 h withdrawal time), attenuated withdrawal (assessed through 24 hours) after 20%-alcohol drinking (7.6 g/kg) through 13 days, with provocation on the 14th day.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Blagaic AB,Blagaic V,Romic Z,Sikiric Pdoi
10.1016/j.ejphar.2004.07.112keywords:
subject
Has Abstractpub_date
2004-09-24 00:00:00pages
285-90issue
3eissn
0014-2999issn
1879-0712pii
S0014-2999(04)00907-0journal_volume
499pub_type
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