Enhanced vasodilatory responses to bradykinin in stroke-prone spontaneously hypertensive rats.

abstract：:Fructose-2,6-bisphosphate is a potent activator of 6-phosphofructo-1-kinase, a key enzyme in glycolysis. We previously revealed that sulfonylureas stimulate fructose-2,6-bisphosphate production in the rat liver by activating 6-phosphofructo-2-kinase. In the present study, we show that CS-045, a new antidiabetic agent,...

journal_title：European journal of pharmacology

authors： Murano K,Inoue Y,Emoto M,Kaku K,Kaneko T

更新日期：1994-03-21 00:00:00

abstract：:Transient ischemia was produced for 15 min by occlusion of the middle cerebral artery in halothane-anesthetized rats, and changes in the extracellular concentrations of neurotransmitter monoamines and amino acids were examined in the striatum. The occlusion produced marked increases in the extracellular concentrations...

journal_title：European journal of pharmacology

authors： Hamami G,Adachi N,Liu K,Arai T

更新日期：2004-01-26 00:00:00

abstract：:The ontogenesis of kappa-opioid receptors has been studied in the postnatal period from day 5 to day 30 using the highly selective kappa-site ligand [3H]U-69593 in binding studies. Analyses of saturation curves revealed a marked increase in the binding capacities between day 5 and day 10 with no further increment in t...

journal_title：European journal of pharmacology

authors： Kitchen I,Kelly M,Viveros MP

更新日期：1990-01-03 00:00:00

abstract：:The novel CCK antagonist L364,718 was tested on caerulein- and morphine-induced antinociception in rat using the paw pressure test. Caerulein-induced antinociception (ED50 = 30 micrograms/kg) was significantly inhibited by L354,718 (200 micrograms/kg i.p.) which on its own did not affect paw pressure threshold. In con...

journal_title：European journal of pharmacology

authors： Rattray M,Jordan CC,De Belleroche J

更新日期：1988-07-26 00:00:00

abstract：:The aim of this study was to investigate the contribution of the Na(+)/H(+) exchanger to cerebral ischemia using SM-20220 (N-(aminoiminomethyl)-1-methyl-1H-indole-2-carboxamide methanesulfonate), a newly synthesized compound. In in vitro experiments, we evaluated the inhibitory effect of SM-20220 on the Na(+)/H(+) exc...

journal_title：European journal of pharmacology

authors： Kuribayashi Y,Itoh N,Kitano M,Ohashi N

更新日期：1999-10-27 00:00:00

abstract：:In the present study, the emetic effect of the anticancer drug cisplatin, and the protective effects of 5-HT3 receptor antagonists against cisplatin emesis were investigated in the pigeon. The experimental set-up involved the i.v. administration of drugs and subsequent observation of the percentage of vomiting animals...

journal_title：European journal of pharmacology

authors： Preziosi P,D'Amato M,Del Carmine R,Martire M,Pozzoli G,Navarra P

更新日期：1992-10-20 00:00:00

abstract：:Intracellular calcium overload plays a key role in severe acute pancreatitis. Resveratrol can decrease the severity of pancreatitis; however, the mechanism of action of resveratrol has not been determined. The aim of our study was to examine the relationship between calcium overload and the effects of resveratrol in s...

journal_title：European journal of pharmacology

authors： Wang L,Ma Q,Chen X,Sha H,Ma Z

更新日期：2008-02-02 00:00:00

abstract：:Global forebrain ischemia results in damage to the pyramids in the CA1 hippocampal subfield, which is particularly vulnerable to excitotoxic processes. Morphological and functional disintegration of this area leads to a cognitive dysfunction and neuropsychiatric disorders. Treatment with N-methyl-d-aspartate receptor ...

journal_title：European journal of pharmacology

authors： Gellért L,Fuzik J,Göblös A,Sárközi K,Marosi M,Kis Z,Farkas T,Szatmári I,Fülöp F,Vécsei L,Toldi J

更新日期：2011-09-30 00:00:00

abstract：:The breakdown of the relaxation-inducing second messengers cAMP and cGMP is mediated by phosphodiesterases. Inhibitors of functionally present phosphodiesterases can be expected to induce relaxation by increasing the basic amount of cAMP and/or cGMP. In the cat gastric fundus, vinpocetine, which has some selectivity f...

journal_title：European journal of pharmacology

authors： Barbier AJ,Lefebvre RA

更新日期：1995-03-24 00:00:00

abstract：:Since its clinical inception, tamoxifen (TAM) has proved to be a powerful tool in treating estrogen receptor-positive breast cancers while exhibiting manageable side effects. Although TAM was synthesized as an estrogen receptor antagonist, reports have found that a significant fraction of women with estrogen receptor-...

journal_title：European journal of pharmacology

authors： Radin DP,Patel P

更新日期：2016-06-15 00:00:00

abstract：:The Langendorff-perfused rabbit heart preparation has been used to study the interaction of isolated rabbit neutrophils with regionally ischaemic myocardium. Short durations of regional ischaemia (10-60 min) and subsequent reperfusion (30 min) of the hearts with neutrophils resulted in a significant time-dependent acc...

journal_title：European journal of pharmacology

authors： Lad N,Williams TJ,Booth RF

更新日期：1992-11-17 00:00:00

abstract：:The effects of the two enantiomers of the antidepressant nomifensine on catecholamine uptake were investigated using rat brain synaptosomes. According to the results from in vitro and ex vivo/in vitro studies, the inhibitory activity on catecholamine uptake resides entirely in the (+)-form of nomifensine. Further stud...

journal_title：European journal of pharmacology

authors： Schacht U,Leven M

更新日期：1984-02-17 00:00:00

abstract：:The effect of prostacyclin (PGI2, 0.5 nmol . kg-1 . min-1,i.v.) on myocardial metabolism was studied in cats subjected to 5 h of myocardial ischemia (MI) and compared to vehicle-treated MI cats. MI was followed by a 52% decrease in ATP and a concomitant increase (2-3 fold) in lactate and lactate/pyruvate ratio in the ...

journal_title：European journal of pharmacology

authors： Rösen R,Rösen P,Ohlendorf R,Schrör K

更新日期：1981-02-19 00:00:00

abstract：:Cross-tolerance to the respiratory depression induced by i.c.v. [D-Ala2,D-Leu5]enkephalin (DADLE) and by s.c., i.c.v. and i.v. morphine was studied in anesthetized rats that had been rendered tolerant to s.c. sufentanil (4 micrograms/h per 7 days). Tolerance induced by i.c.v. sufentanil was also compared during withdr...

journal_title：European journal of pharmacology

authors： Ayesta FJ,Flórez J

更新日期：1990-01-03 00:00:00

abstract：:We investigated the effects of 1-amino-5-bromouracil on the benzodiazepine-gamma-aminobutyric acid (GABA)A receptor complex to elucidate its central action. 1-Amino-5-bromouracil neither displaced nor enhanced [3H]muscimol, [35S]t-butylbicyclophosphorothionate (TBPS), or [3H]dehydroepiandrosterone sulfate binding to t...

journal_title：European journal of pharmacology

authors： Miyazaki S,Imaizumi M,Machida H

更新日期：1994-12-12 00:00:00

abstract：:The use of antipsychotic medication has consistently been associated with serious side effects including weight gain and metabolic abnormalities. Strategies for mitigating these side effects have been tested, yet effective interventions have not been identified. The current study tested whether two recently identified...

journal_title：European journal of pharmacology

authors： Belanoff JK,Blasey CM,Clark RD,Roe RL

更新日期：2011-03-25 00:00:00

abstract：:Effects of nicotine, and nicotine+vitamin E on glutathione reductase (Glutathione: NADP(+) oxidoreductase, EC 1.8.1.7) activity in the muscle, heart, lungs, testicles, kidney, stomach, brain and liver tissues were investigated in vivo and also in vitro. The groups were: nicotine [0.5 mg/kg/day, intraperitoneal (i.p.)]...

journal_title：European journal of pharmacology

authors： Erat M,Ciftci M,Gumustekin K,Gul M

更新日期：2007-01-12 00:00:00

abstract：:We investigated the effects of three bile acids conjugated with N-acetylglucosamine, ursodeoxycholate N-acetylglucosaminide, tauroursodeoxycholate N-acetylglucosaminide and glycoursodeoxycholate N-acetylglucosaminide, on bile flow and biliary excretion of various markers in comparison with ursodeoxycholic acid, taurou...

journal_title：European journal of pharmacology

authors： Iwaki T,Hirabayashi N,Miyazawa N,Takeuchi Y,Ishizaki K,Sakakura H,Kasai H,Maeda M,Araki T

更新日期：1998-12-11 00:00:00

abstract：:GABA (10-5--10-3 M) had no effect on the spontaneous outflow of previously accumulated 3H-DA or 3H-5HT from rat nigral or striatal slices. However, GABA markedly potentiated the potassium-stimulated release of 3H-DA in both brain regions, while the depolarization-induced output of 3H-5HT was only slightly increased. T...

journal_title：European journal of pharmacology

authors： Starr MS

更新日期：1978-04-01 00:00:00

abstract：:FR 172357, a new non-peptide antagonist of the kinin B(2) receptor was tested in three isolated vessels, the human umbilical vein, the rabbit jugular vein, and the pig coronary artery, to evaluate its antagonistic activities against bradykinin. FR 172357 displaced to the right the concentration-response curves of brad...

journal_title：European journal of pharmacology

authors： Rizzi C,Rizzi A,Calò G,Jorizzo G,Agnello G,Mollica G,Inamura N,Regoli D

更新日期：1999-12-10 00:00:00

abstract：:This study presents a direct comparison of the ligand binding and signaling profiles of a mammalian and non-mammalian mu opioid receptor. Opioid ligand binding and agonist potencies were determined for an amphibian (Rana pipiens) mu opioid receptor (rpMOR) and the human mu opioid receptor (hMOR) in transfected, intact...

journal_title：European journal of pharmacology

authors： Brasel CM,Sawyer GW,Stevens CW

更新日期：2008-12-03 00:00:00

abstract：:In cystic fibrosis respiratory epithelial cells, the absence or dysfunction of the chloride channel CFTR (Cystic Fibrosis Transmembrane conductance Regulator) results in reduced chloride ion transport. In contrast, Ca2+-stimulated Cl- secretion is intact in cystic fibrosis airway epithelia. One possible target for dru...

journal_title：European journal of pharmacology

authors： Norez C,Vandebrouck C,Antigny F,Dannhoffer L,Blondel M,Becq F

更新日期：2008-09-11 00:00:00

abstract：:Previous studies with both intact cells and ram seminal vesicles microsomes have shown that the specific PGHS-2 inhibitors NS-398 (N-[2-(cyclohexyloxy)-4-nitrophenyl]methanesulfonamide) and DuP-697 (5-bromo-2[4-fluorophenyl]-3-[4-methylsulfonylphenyl]-thiophene) attenuate the inhibition of PGHS-1 caused by aspirin and...

journal_title：European journal of pharmacology

authors： Burde T,Rimon G

更新日期：2002-10-25 00:00:00

abstract：:The cyclic peptide urotensin II has recently been cloned from human and reported to potently constrict primate blood vessels. To elucidate the cellular signalling mechanisms of this peptide, we investigated a possible relationship of vasomotor effects of human urotensin II and phosphoinositide turnover in isolated rab...

journal_title：European journal of pharmacology

authors： Saetrum Opgaard O,Nothacker H,Ehlert FJ,Krause DN

更新日期：2000-10-13 00:00:00

abstract：:Oxyntomodulin, a hormone released from jejuno-ileum and composed of the glucagon sequence extended by a C-terminal octapeptide displays original tissue specificity for the gastric mucosa. The aim of this study was to compare the effect of oxyntomodulin on histamine (0.4 mg/kg per h)-stimulated gastric acid secretion i...

journal_title：European journal of pharmacology

authors： Carles-Bonnet C,Jarrousse C,Niel H,Martinez J,Bataille D

更新日期：1991-10-15 00:00:00

abstract：:Learning and memory in the brain likely occur through activity-dependent, long-lasting changes in synaptic transmission. Two opposite activity-dependent synaptic modifications have been identified so far, long-term potentiation and long-term depression. In many brain areas including hippocampal CA1 and neocortex, the ...

journal_title：European journal of pharmacology

authors： Artola A

更新日期：2008-05-06 00:00:00

abstract：:The functions of the 5-HT(4) receptor in the gastrointestinal tract are complex, depending on the species and anatomical regions, and localization of the receptor was not clear. The present study attempted to examine the localization of the 5-HT(4) receptor in the colon of human for comparison with that in guinea pig ...

journal_title：European journal of pharmacology

authors： Sakurai-Yamashita Y,Yamashita K,Kanematsu T,Taniyama K

更新日期：1999-11-03 00:00:00

abstract：:Transfected Chinese hamster ovary cells expressing human alpha2A-, alpha2B- and alpha2C-adrenoceptor subtypes were used to monitor alpha2-adrenoceptor-stimulated GTP hydrolysis. Incubation with 100 microM (-)-adrenaline resulted in stimulation of pertussis toxin-sensitive GTPase by 380% after activation of the alpha2A...

journal_title：European journal of pharmacology

authors： Jansson CC,Pohjanoksa K,Lang J,Wurster S,Savola JM,Scheinin M

更新日期：1999-06-11 00:00:00

abstract：:The inhibition of the tail-flick response induced by beta-endorphin given i.c.v. has been demonstrated to be mediated by the stimulation of epsilon- but not mu-, delta- or kappa-opioid receptors. beta-Endorphin given i.t. also inhibited the tail-flick response. The present studies were designed to determine what types...

journal_title：European journal of pharmacology

authors： Tseng LF,Collins KA

更新日期：1992-04-07 00:00:00

abstract：:Although convulsions due to local anesthetic systemic toxicity are thought to be due to inhibition of GABA(A) receptor-linked currents in the central nervous system, the mechanism of action remains unclear. We therefore examined the effects of local anesthetics on gamma-aminobutyric acid (GABA)-induced currents using ...

journal_title：European journal of pharmacology

authors： Sugimoto M,Uchida I,Fukami S,Takenoshita M,Mashimo T,Yoshiya I

更新日期：2000-08-11 00:00:00