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Identity of the putative delta1-opioid receptor as a delta-kappa heteromer in the mouse spinal cord.

Abstract：

:In view of the co-localization of spinal delta- and kappa-opioid receptors, we have investigated the interaction of selective opioid receptor agonists and antagonists in the spinal cord of mice in order to determine if these receptors are organized as heteromers. The finding that norbinaltorphimine (kappa) antagonized [D-Pen(2,5)]enkephalin (delta(1)), but not deltorphin II (delta(2)), strongly suggests that the putative delta(1)-subtype is a delta-kappa heteromer. Studies with selective opioid receptor (ant)agonists support this conclusion.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Portoghese PS,Lunzer MM

doi

10.1016/s0014-2999(03)01599-1

keywords:

subject

Has Abstract

pub_date

2003-04-25 00:00:00

pages

233-4

issue

1-3

eissn

0014-2999

issn

1879-0712

pii

S0014299903015991

journal_volume

467

pub_type

杂志文章

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