Abstract:
:The intracerebroventricular (i.c.v.) administration of 10 micrograms of atrial natriuretic peptide (ANP) stimulated spontaneous gastric acid secretion in anaesthetized rats, whereas this dose of ANP was without any effect after i.v. injection. The secretagogue action of i.c.v. administered ANP was totally abolished by truncal vagotomy. The findings indicate that i.c.v. administration of ANP stimulates gastric acid secretion in anaesthetized rats by a central, vagal-dependent mechanism.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Puurunen J,Ruskoaho Hdoi
10.1016/0014-2999(87)90572-3subject
Has Abstractpub_date
1987-09-23 00:00:00pages
493-5issue
3eissn
0014-2999issn
1879-0712pii
0014-2999(87)90572-3journal_volume
141pub_type
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