Vagal-dependent stimulation of gastric acid secretion by intracerebroventricularly administered atrial natriuretic peptide in anaesthetized rats.

Abstract:

:The intracerebroventricular (i.c.v.) administration of 10 micrograms of atrial natriuretic peptide (ANP) stimulated spontaneous gastric acid secretion in anaesthetized rats, whereas this dose of ANP was without any effect after i.v. injection. The secretagogue action of i.c.v. administered ANP was totally abolished by truncal vagotomy. The findings indicate that i.c.v. administration of ANP stimulates gastric acid secretion in anaesthetized rats by a central, vagal-dependent mechanism.

journal_name

Eur J Pharmacol

authors

Puurunen J,Ruskoaho H

doi

10.1016/0014-2999(87)90572-3

subject

Has Abstract

pub_date

1987-09-23 00:00:00

pages

493-5

issue

3

eissn

0014-2999

issn

1879-0712

pii

0014-2999(87)90572-3

journal_volume

141

pub_type

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