Alpha 2-adrenoceptors not imidazole receptors mediate depression of a sacral spinal reflex in the cat.

abstract：:Inhibition of the thromboxane A2-synthesizing enzyme (DP-1904: [+/-]-6-[1-imidazolylmethyl]-5,6,7,8-tetrahydronaphthalene-2-carbo xylic acid hydrochloride hemihydrate) reportedly suppresses intercellular adhesion molecule-1 (ICAM-1) expression on the surface of stimulated vascular endothelial cells (Ishizuka et al., 1...

journal_title：European journal of pharmacology

authors： Ishizuka T,Suzuki K,Kawakami M,Hidaka T,Matsuki Y,Nakamura H

更新日期：1996-10-03 00:00:00

abstract：:A substantial proportion of depressed patients do not respond to current antidepressant drug therapies. So far, antidepressant drugs have been developed based on the "monoaminergic hypothesis" of depression, which considers a synaptic deficiency in 5-hydroxytryptamine (5-HT; serotonin) or noradrenaline as main cause. ...

journal_title：European journal of pharmacology

authors： Leggio GM,Salomone S,Bucolo C,Platania C,Micale V,Caraci F,Drago F

更新日期：2013-11-05 00:00:00

abstract：:Achondroplasia, results from a mutation in the FGF receptor type 3, leading to receptor hyperactivation and subsequent amplification of FGF receptor type 3 signals. We have tested the ability of pyridoxal-5'-phosphate-6-azophenyl-2', 4'-disulfonate (PPADS) to decrease the overactivation and signalling of FGF receptor ...

journal_title：European journal of pharmacology

authors： Guzmán-Aránguez A,Crooke A,Yayon A,Pintor J

更新日期：2008-04-14 00:00:00

abstract：:BAY 38-7271 [(-)-(R)-3-(2-hydroxymethylindanyl-4-oxy)phenyl-4,4,4-trifluoro-1-sulfonate] is a novel, highly potent and selective cannabinoid CB(1)/CB(2) receptor agonist with neuroprotective properties. It was the aim of the present study to further confirm its cannabinoid CB(1) receptor agonist properties in a highly...

journal_title：European journal of pharmacology

authors： De Vry J,Rüdiger Jentzsch K

更新日期：2002-12-20 00:00:00

abstract：:Plants are a natural source of bioactive compounds such as secondary metabolites. These molecules, also called phytochemicals, are fundamental for plant survival and often show therapeutic properties used for the treatment of human diseases. Asperuloside is a secondary metabolite which belongs to iridoid glycosides an...

journal_title：European journal of pharmacology

authors： Manzione MG,Martorell M,Sharopov F,Bhat NG,Kumar NVA,Fokou PVT,Pezzani R

更新日期：2020-09-15 00:00:00

abstract：:Nonalcoholic steatohepatitis (NASH) is one of the most common liver diseases involving chronic accumulation of fat and inflammation, often leading to advanced fibrosis, cirrhosis and carcinoma. However, the pathological mechanism for this is unknown. GPR120/FFAR4 has been recognized as a functional fatty acid receptor...

journal_title：European journal of pharmacology

authors： Nakamoto K,Shimada K,Harada S,Morimoto Y,Hirasawa A,Tokuyama S

更新日期：2018-02-05 00:00:00

abstract：:The anticonvulsant effects produced by mixtures of oxcarbazepine and gabapentin (two second-generation antiepileptic drugs) in numerous fixed-ratio combinations of 1:1, 1:2, 1:5, 1:10, 1:15, and 1:20 were examined isobolographically in the mouse maximal electroshock seizure model. Results displayed that mixtures of bo...

journal_title：European journal of pharmacology

authors： Luszczki JJ,Andres MM,Czuczwar SJ

更新日期：2005-05-16 00:00:00

abstract：:Desensitization of serotonin 5-HT2 receptor-mediated enhancement of the N-methyl-D-aspartate (NMDA) depolarization was studied in rat cortical neurons. Serotonin and (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) induced long term desensitization. Staurosporine, a nonspecific protein kinase C inhibitor, pot...

journal_title：European journal of pharmacology

authors： Rahman S,Neuman RS

更新日期：1993-07-20 00:00:00

abstract：:In the present investigation, we used standard patch clamp techniques to test whether nitric oxide (NO) generation has any role to play with either activation or inhibition of ATP-sensitive (KATP) channels in guinea-pig urinary bladder. We found that NO generation leads to activation of KATP channels through a cyclic ...

journal_title：European journal of pharmacology

authors： Deka DK,Brading AF

更新日期：2004-05-10 00:00:00

abstract：:Cocaine is eliminated and detoxified principally through the metabolism of nonspecific plasma and tissue esterases. Microsomal oxidative metabolism is of importance in cocaine N-demethylation, this being a principal pathway of cocaine bioactivation and hepatotoxicity. The contribution of different cytochrome P450 (CYP...

journal_title：European journal of pharmacology

authors： Pellinen P,Honkakoski P,Stenbäck F,Niemitz M,Alhava E,Pelkonen O,Lang MA,Pasanen M

更新日期：1994-01-03 00:00:00

abstract：:Acute noise stress decreased [3H]5-hydroxytryptamine ([3H]5-HT) uptake in synaptosomes from rat hypothalamus, hippocampus and cerebral cortex. The decrease was due to the maximum rate of [3H]5-HT uptake, which peaked 30 min after stress and partly returned to resting values within 4 h, with no changes in affinity (Km ...

journal_title：European journal of pharmacology

authors： Mennini T,Taddei C,Codegoni A,Gobbi M,Garattini S

更新日期：1993-09-14 00:00:00

abstract：:In Parkinson disease the degeneration of dopaminergic neurones is believed to lead to a disinhibition of the subthalamic nucleus thus increasing the firing rate of the glutamatergic excitatory projections to the substantia nigra. In consequence, excessive glutamatergic activity will cause excitotoxicity and oxidative ...

journal_title：European journal of pharmacology

authors： Oster S,Radad K,Scheller D,Hesse M,Balanzew W,Reichmann H,Gille G

更新日期：2014-02-05 00:00:00

abstract：:It is known that low-dose aspirin is effective in coronary artery therapy, although it has not yet been clarified how it exerts its action. Here, we report that treatment of coronary artery patients with 100 mg/day of aspirin does not attenuate thrombin generation, but reduces free thrombin by favouring the formation ...

journal_title：European journal of pharmacology

authors： Di Micco B,Colonna G,Di Micco P,Di Micco G,Russo BM,Macalello MA,Ragone R

更新日期：2003-01-26 00:00:00

abstract：:In this study, the elevated zero-maze model of anxiety was used to investigate CCK receptor antagonist effects on the behaviour of male Lister-hooded rats and to demonstrate, by administering antagonists in the presence or absence of selective 5-hydroxytryptamine (5-HT) re-uptake inhibitors, the involvement of 5-HT in...

journal_title：European journal of pharmacology

authors： Bickerdike MJ,Marsden CA,Dourish CT,Fletcher A

更新日期：1994-12-27 00:00:00

abstract：:alpha 2-adrenoceptor-mediated contractions of the rabbit saphenous vein were previously found to be inhibited by wortmannin, a protein kinase inhibitor which blocks receptor-dependent phospholipase D activation. Since other studies have indicated that receptor-dependent phospholipase D activation required activity of ...

journal_title：European journal of pharmacology

authors： Jinsi A,Deth RC

更新日期：1995-04-13 00:00:00

abstract：:Toll-like receptors (TLRs) play an important role in the recognition of microbial pathogens and induce innate immune responses. The recognition of microbial components by TLRs triggers the activation of myeloid differential factor 88 (MyD88)- and toll-interleukin-1 receptor domain-containing adapter inducing interfero...

journal_title：European journal of pharmacology

authors： Gu GJ,Eom SH,Suh CW,Koh KO,Kim DY,Youn HS

更新日期：2013-12-05 00:00:00

abstract：:The purpose of our study was to determine whether a toxic arrhythmogenic dose of digitalis administered to an in vivo preparation would affect the neuronal uptake of norepinephrine, serotonin and dopamine in brain tissue and norepinephrine in cardiac tissue. This was investigated by intoxicating anesthetized cats with...

journal_title：European journal of pharmacology

authors： Helke CJ,Kellar KJ,Gillis RA

更新日期：1978-11-01 00:00:00

abstract：:Curcumol is one of the major components of the essential oil of Rhizoma Curcumae, a common traditional Chinese medicine with anti-inflammatory properties. However, the anti-inflammatory activity and the underlying molecular mechanisms of this compound remain unclear. In the present study, the anti-inflammation effect ...

journal_title：European journal of pharmacology

authors： Chen X,Zong C,Gao Y,Cai R,Fang L,Lu J,Liu F,Qi Y

更新日期：2014-01-15 00:00:00

abstract：:Specific binding of [3H]imipramine to its recognition sites in frontal cortex and levels of serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and norepinephrine (NE) as well as uptake of serotonin by crude synaptosomal (P2) fraction were determined in a group of rats chronically (for 21 days) treated with differen...

journal_title：European journal of pharmacology

authors： Hrdina PD

更新日期：1987-06-19 00:00:00

abstract：:Age-related changes in the modulatory action of nitric oxide (NO) on cyclic GMP levels and Na(+),K(+)-ATPase activity in the proximal rat trachea were investigated using sodium nitroprusside, 8-bromo-cyclic GMP and okadaic acid. At 24 months, both control activities of Na(+), K(+)-ATPase and Mg(2+)-ATPase were decreas...

journal_title：European journal of pharmacology

authors： Scavone C,Glezer I,Demarchi Munhoz C,de Sena Bernardes C,Pekelmann Markus R

更新日期：2000-01-24 00:00:00

abstract：:The beta-carboline FG 7142 was studied alone and in combination with Ro 15-1788, CGS 8216 and lorazepam in squirrel monkeys trained to respond under a fixed-interval (FI) schedule of food presentation. FG 7142 (0.3-5.6 mg/kg i.v.) produced dose-related decreases in the rate of FI responding, effects opposite to those ...

journal_title：European journal of pharmacology

authors： Wettstein JG

更新日期：1989-04-25 00:00:00

abstract：:Transient outward K+ current, Ito, contributes to cardiac action potential generation and is primarily carried by Kv4.3 (KCND3) channels. Two Kv4.3 isoforms are expressed in human ventricle and show differential remodeling in heart failure (HF). Lidocaine and mexiletine may be applied in selected patients to suppress ...

journal_title：European journal of pharmacology

authors： Rahm AK,Müller ME,Gramlich D,Lugenbiel P,Uludag E,Rivinius R,Ullrich ND,Schmack B,Ruhparwar A,Heimberger T,Weis T,Karck M,Katus HA,Thomas D

更新日期：2020-08-05 00:00:00

abstract：:Thirty percent of osteosarcoma patients die within 5 years. New agents that induce apoptosis of osteosarcoma cells might be therapeutically useful. Here, we characterized the apoptotic mechanism induced by capsaicin in G292 osteosarcoma cells. Our results show that capsaicin induces an increase in the cytosolic Ca(2+)...

journal_title：European journal of pharmacology

authors： Chien CS,Ma KH,Lee HS,Liu PS,Li YH,Huang YS,Chueh SH

更新日期：2013-10-15 00:00:00

abstract：:Cerebral ischemia/reperfusion (I/R) is a lethal and disabling disease. Studies have suggested that hyperglycemia is a risk factor for cerebral I/R. Baicalin is a natural bioactive flavonoid extracted from Scutellaria baicalensis Georgi with neuroprotective activity. In the present study, we investigated the effects of...

journal_title：European journal of pharmacology

authors： Li S,Sun X,Xu L,Sun R,Ma Z,Deng X,Liu B,Fu Q,Qu R,Ma S

更新日期：2017-11-15 00:00:00

abstract：:Notoginsenoside R1, a unique constituent from the root of Panax notoginseng, exerts anti-inflammatory, anti-oxidative and anti-apoptotic properties. The purpose of this study was to assess the contribution of the anti-inflammatory effects of R1 to the amelioration of isoproterenol (ISO)-induced hypertrophied hearts of...

journal_title：European journal of pharmacology

authors： Xiao J,Zhu T,Yin YZ,Sun B

更新日期：2018-08-15 00:00:00

abstract：:Interleukin-6 (IL-6) is a key proinflammatory cytokine which plays a central role in the pathogenesis of periodontal disease. Host modulatory agents targeting at inhibiting IL-6, therefore, appear to be beneficial in slowing the progression of periodontal disease and potentially reducing destructive aspects of the hos...

journal_title：European journal of pharmacology

authors： Choi EY,Jin JY,Choi JI,Choi IS,Kim SJ

更新日期：2014-04-15 00:00:00

abstract：:We have examined the motor responses to the dopamine D(3) receptor-preferring agonist, S(+)-(4aR,10bR)-3,4,4a, 10b-tetrahydro-4-propyl-2H,5H-1-benzopyranol[4,3-b]-1,4-oxazin+ ++-9-ol ((+)-PD128,907), by non-habituated male rats during postnatal development. (+)-PD128,907 (0.025 and 0.1 mg/kg) increased motor activity ...

journal_title：European journal of pharmacology

authors： Heijtz RD,Ogren SO,Fuxe K

更新日期：2000-03-24 00:00:00

abstract：:AMN082 is a selective metabotropic glutamate mGlu7 receptor agonist reported to exhibit antidepressant activity. Considering that excessive glutamate release is involved in the pathogenesis of depression, the effect of N,N'-dibenzyhydryl-ethane-1,2-diamine dihydrochloride (AMN082) on glutamate release in rat cerebroco...

journal_title：European journal of pharmacology

authors： Wang CC,Kuo JR,Huang SK,Wang SJ

更新日期：2018-03-15 00:00:00

abstract：:Despite ample in vitro evidence that myofilament Ca(2+)-responsiveness of stunned myocardium is decreased, in vivo data are inconclusive. Conversely, while Ca(2+)-sensitizing agents increase myofilament Ca(2+)-responsiveness in vitro, it has been questioned whether this also occurs in vivo. We therefore tested in open...

journal_title：European journal of pharmacology

authors： de Zeeuw S,Trines SA,Krams R,Duncker DJ,Verdouw PD

更新日期：2000-09-01 00:00:00

abstract：:The inhibitory effect of forskolin-stimulated 3',5'-cyclic monophosphate (c-AMP) synthesis in isolated rat adipocytes has been measured for eight typical adenosine receptor agonists. The percent inhibition was evaluated using concentrations of each compound corresponding to 100 times their Ki, inhibitory binding const...

journal_title：European journal of pharmacology

authors： Borea PA,Varani K,Dalpiaz A,Capuzzo A,Fabbri E,IJzerman AP

更新日期：1994-03-15 00:00:00