Abstract:
:We investigated the influence of inhibition of nitric oxide (NO) synthase, using NG-nitro-L-arginine (L-NNA) or NG-mono-methyl-L-arginine (L-NMMA), and the effects of exogenous donor of NO, such as glyceryl trinitrate (GTN), on the healing of chronic gastric ulcers induced by acetic acid, on gastric blood flow around the ulcer and on the number of capillaries in the granulation tissue at the ulcer bed. The inhibition of NO synthase resulted in a delay in ulcer healing and in a reduction in blood flow at the ulcer margin and in the number of capillaries in the granulation tissue at the ulcer bed. These effects of inhibition of NO synthase were antagonized, in part, by the administration of GTN or L-arginine but not D-arginine. We conclude that endogenous NO plays an important role in the maintenance of blood flow around the ulcer, in the angiogenesis in the granulation tissue and, thus, in the healing of gastric ulcers.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Konturek SJ,Brzozowski T,Majka J,Pytko-Polonczyk J,Stachura Jdoi
10.1016/0014-2999(93)90997-vsubject
Has Abstractpub_date
1993-08-03 00:00:00pages
215-7issue
1-3eissn
0014-2999issn
1879-0712pii
0014-2999(93)90997-Vjournal_volume
239pub_type
杂志文章abstract::Pretreatment of rats with intraventricular 6-hydroxydopamine produced considerable destruction of noradrenergic and dopaminergic nerve terminals as indicated by depletions in synaptosomal catecholamine contents. However, 6-hydroxydopamine pretreatment did not result in diminished release of ATP during depolarization o...
journal_title:European journal of pharmacology
pub_type: 杂志文章
doi:10.1016/0014-2999(82)90191-1
更新日期:1982-05-07 00:00:00
abstract::Metastasis in breast cancer is a leading cause of mortality among women in many countries. This study investigated the anti-cancer role of benzoimidazoquinazoline and benzimidazotriazin; two novel compounds that were designed, synthesized, structurally elucidated, and biologically evaluated as potent anti-angiogenic a...
journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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更新日期:1985-08-27 00:00:00
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journal_title:European journal of pharmacology
pub_type: 杂志文章
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更新日期:1992-08-14 00:00:00
abstract::The lack of specific receptors (and antagonists) has hampered the research on the neural mechanism of action of adrenocorticotropic hormone (ACTH)- and melanocyte-stimulating hormone (MSH)-like peptides. Yet the original observations in the 1970s already pointed to cAMP as a possible mediator of ACTH/MSH effects in ne...
journal_title:European journal of pharmacology
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abstract::Tissue neutrophils, human salivary neutrophils donated from healthy subjects and synovial fluid neutrophils collected from patients with rheumatoid arthritis were compared with circulating blood neutrophils. Concomitant treatment of circulating blood neutrophils with tumor necrosis factor-alpha (TNF-alpha) and cyclohe...
journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
pub_type: 杂志文章
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
pub_type: 杂志文章
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更新日期:1995-09-05 00:00:00
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journal_title:European journal of pharmacology
pub_type: 杂志文章
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
pub_type: 杂志文章
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更新日期:1987-01-06 00:00:00
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journal_title:European journal of pharmacology
pub_type: 杂志文章
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更新日期:2002-10-18 00:00:00
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
pub_type: 杂志文章
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journal_title:European journal of pharmacology
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pub_type: 杂志文章,评审
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更新日期:2019-01-05 00:00:00
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
pub_type: 杂志文章
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更新日期:1996-11-07 00:00:00
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journal_title:European journal of pharmacology
pub_type: 杂志文章
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journal_title:European journal of pharmacology
pub_type: 杂志文章
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更新日期:1979-12-07 00:00:00
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journal_title:European journal of pharmacology
pub_type: 杂志文章
doi:10.1016/j.ejphar.2014.06.050
更新日期:2014-10-05 00:00:00
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journal_title:European journal of pharmacology
pub_type: 杂志文章
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更新日期:1995-01-05 00:00:00
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journal_title:European journal of pharmacology
pub_type: 杂志文章
doi:10.1016/0014-2999(84)90645-9
更新日期:1984-10-01 00:00:00
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journal_title:European journal of pharmacology
pub_type: 杂志文章
doi:10.1016/s0014-2999(97)01142-4
更新日期:1997-09-03 00:00:00