Inhibition of nitric oxide synthase delays healing of chronic gastric ulcers.

Abstract:

:We investigated the influence of inhibition of nitric oxide (NO) synthase, using NG-nitro-L-arginine (L-NNA) or NG-mono-methyl-L-arginine (L-NMMA), and the effects of exogenous donor of NO, such as glyceryl trinitrate (GTN), on the healing of chronic gastric ulcers induced by acetic acid, on gastric blood flow around the ulcer and on the number of capillaries in the granulation tissue at the ulcer bed. The inhibition of NO synthase resulted in a delay in ulcer healing and in a reduction in blood flow at the ulcer margin and in the number of capillaries in the granulation tissue at the ulcer bed. These effects of inhibition of NO synthase were antagonized, in part, by the administration of GTN or L-arginine but not D-arginine. We conclude that endogenous NO plays an important role in the maintenance of blood flow around the ulcer, in the angiogenesis in the granulation tissue and, thus, in the healing of gastric ulcers.

journal_name

Eur J Pharmacol

authors

Konturek SJ,Brzozowski T,Majka J,Pytko-Polonczyk J,Stachura J

doi

10.1016/0014-2999(93)90997-v

subject

Has Abstract

pub_date

1993-08-03 00:00:00

pages

215-7

issue

1-3

eissn

0014-2999

issn

1879-0712

pii

0014-2999(93)90997-V

journal_volume

239

pub_type

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