Effects of acute fluoxetine on extracellular serotonin levels in the raphe: an in vivo microdialysis study.


:Acute administration of fluoxetine (1, 10 and 20 mg/kg i.p.) increased extracellular levels of serotonin (5-hydroxytryptamine, 5-HT) in the frontal cortex, ventral hippocampus and raphe nuclei as measured by in vivo microdialysis in anaesthetized rats. In the frontal cortex, fluoxetine showed a marked dose-response effect whereas in the ventral hippocampus and raphe nuclei the fluoxetine-induced effect was maximum at 10 mg/kg. However, the maximal increase in 5-HT was observed in the cell body-containing area, the raphe nuclei. The order of changes in extracellular 5-HT was raphe nuclei > ventral hippocampus > frontal cortex. Our results add further arguments in favour of the key role played by raphe nuclei in the mechanism of action of serotoninergic antidepressant drugs.


Eur J Pharmacol


Malagié I,Trillat AC,Jacquot C,Gardier AM




Has Abstract


1995-11-14 00:00:00














  • In vivo pharmacological profile of S 38093, a novel histamine H3 receptor inverse agonist.

    abstract::S 38093, a novel histamine H3 receptor inverse agonist, was tested in a series of neurochemical and behavioral paradigms designed to evaluate its procognitive and arousal properties. In intracerebral microdialysis studies performed in rats, S 38093 dose-dependently increased histamine extracellular levels in the prefr...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Panayi F,Sors A,Bert L,Martin B,Rollin-Jego G,Billiras R,Carrié I,Albinet K,Danober L,Rogez N,Thomas JY,Pira L,Bertaina-Anglade V,Lestage P

    更新日期:2017-05-15 00:00:00

  • Argatroban, specific thrombin inhibitor, induced phenotype change of cultured rabbit vascular smooth muscle cells.

    abstract::To investigate whether argatroban ((2R,4R)-4-methyl-1-[N(2)-((RS)-3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L-arginyl]-2-piperidinecarboxylic acid hydrate, a selective thrombin inhibitor, exerts a direct action on phenotype conversion of vascular smooth muscle cells, cultured rabbit aortic vascular smooth muscl...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Yoshinaga M,Sunagawa M,Shimada S,Nakamura M,Murayama S,Kosugi T

    更新日期:2003-02-07 00:00:00

  • Reduction of renal tubular injury with a RAGE inhibitor FPS-ZM1, valsartan and their combination in streptozotocin-induced diabetes in the rat.

    abstract::Receptor for advanced glycation end-products (RAGE) is involved in the pathogenesis of diabetic nephropathy. FPS-ZM1, a selective RAGE inhibitor, in combination with valsartan were investigated for their protective potentials on the renal markers of tubular injury in streptozotocin-induced diabetic rats. Rats were ass...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Sanajou D,Ghorbani Haghjo A,Argani H,Roshangar L,Rashtchizadeh N,Ahmad SNS,Ashrafi-Jigheh Z,Bahrambeigi S,Asiaee F,Rashedi J,Aslani S

    更新日期:2019-01-05 00:00:00

  • Dopamine D1 receptor stimulation increases striatal acetylcholine release in the rat.

    abstract::The effect of selective D1 receptor agonists on acetylcholine (ACh) release in the striatum was investigated using in vivo microdialysis. Administration of the reactive enantiomer, (+)-SKF 38393 (2, 10 mg/kg s.c.), doses which elevate grooming and sniffing behaviour, increased ACh release by 40 and 75%, respectively. ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Damsma G,Tham CS,Robertson GS,Fibiger HC

    更新日期:1990-09-21 00:00:00

  • Antiplatelet and antithrombogenic effects of suloctidil.

    abstract::Platelet aggregation induced in mice or rats by i.v. ADP can be antagonized by oral administration of suloctidil. This effect on platelet behaviour appears to be sufficient to reduce the rate of thrombotic occlusion of the femoral artery in the dog and to protect the rat against occurrence of thrombophlebitis. ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Roba J,Claeys M,Lambelin G

    更新日期:1976-06-01 00:00:00

  • Adiponectin, ghrelin, and leptin differentially influence human platelet and human vascular endothelial cell functions: implication in obesity-associated cardiovascular diseases.

    abstract::A very strong epidemiological link exists between obesity, the metabolic syndrome, diabetes and diabetes-associated cardiovascular pathologies. For this reason the peripheral effects of the centrally-acting satiety adipokines, adiponectin and leptin, and of non-adipose-derived hormones with similar effects, like ghrel...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Elbatarny HS,Netherton SJ,Ovens JD,Ferguson AV,Maurice DH

    更新日期:2007-03-08 00:00:00

  • Anxiolytic activity on locus coeruleus-mediated suppression of muricidal aggression.

    abstract::The evidence suggests that stimulation of brain noradrenergic neurons plays an inhibitory role in rat mouse-killing (muricidal) aggression. Anxiolytic benzodiazepines inhibit locus coeruleus activity and previous data showed that chlordiazepoxide was capable of antagonizing the locus coeruleus-mediated suppression of ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Kozak W,Valzelli L,Garattini S

    更新日期:1984-10-15 00:00:00

  • Effects of imipramine or GABA(B) receptor ligands on the immobility, swimming and climbing in the forced swim test in rats following discontinuation of cocaine self-administration.

    abstract::We tested if discontinuation of cocaine self-administration can lead to the development of depressive-like symptoms in the forced swim test expressed as changes in immobility, swimming and climbing behaviors in rats. A "yoked" procedure in which rats were run simultaneously in groups of three, with two rats received t...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Frankowska M,Gołda A,Wydra K,Gruca P,Papp M,Filip M

    更新日期:2010-02-10 00:00:00

  • Prevention of cyclosporine A-induced renal vasoconstriction by the endothelin receptor antagonist SB 209670.

    abstract::Administration of endothelin to inactin-anesthetized rats resulted in a significant renal vasoconstriction as evidenced by a reduction in both renal plasma flow and glomerular filtration rate. Infusion of the novel nonpeptide endothelin ETA/ETB receptor antagonist, (+/-)-SB 209670, [(1RS-2SR,3RS)-3-(2-carboxymethoxy-4...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Brooks DP,Contino LC

    更新日期:1995-12-29 00:00:00

  • Loss of amitriptyline analgesia in alpha 2A-adrenoceptor deficient mice.

    abstract::Tricyclic antidepressants have analgesic and sedative effects in addition to their antidepressive properties. We tested the acute analgesic and locomotor inhibitory effects of the tricyclic antidepressant amitriptyline and the alpha(2)-adrenoceptor agonist clonidine in wild-type control and in alpha(2A)-adrenoceptor k...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Ozdoğan UK,Lähdesmäki J,Mansikka H,Scheinin M

    更新日期:2004-02-06 00:00:00

  • Stereoselectivity of the enantiomers of trihexyphenidyl and its methiodide at muscarinic receptor subtypes.

    abstract::High stereoselectivity was observed for the enantiomers of trihexyphenidyl and trihexyphenidyl methiodide at muscarinic M1-receptors in field-stimulated rabbit vas deferens and at M2 alpha- and M2 beta-receptors in guinea-pig atrium and ileum, respectively. Considerably higher affinities (up to 1700-fold) were found f...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Lambrecht G,Feifel R,Moser U,Aasen AJ,Waelbroeck M,Christophe J,Mutschler E

    更新日期:1988-10-11 00:00:00

  • Inhibitory activity of kinetin on free radical formation of activated platelets in vitro and on thrombus formation in vivo.

    abstract::Kinetin has been shown to have anti-aging effects on several different systems, including plants and human cells. Recently, we demonstrated that kinetin markedly inhibited platelet aggregation in washed human platelets. In the present study, an electron spin resonance (ESR) method was used to further evaluate the scav...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Hsiao G,Shen MY,Lin KH,Chou CY,Tzu NH,Lin CH,Chou DS,Chen TF,Sheu JR

    更新日期:2003-04-04 00:00:00

  • Oral administration of quercetin inhibits bone loss in rat model of diabetic osteopenia.

    abstract::Diabetic osteopenia can result in an increased incidence of bone fracture and a delay in fracture healing. Quercetin, one of the most widely distributed flavonoids in plants, possesses antioxidant property and beneficial effect on osteoporosis in ovariectomized mice. All these properties make quercetin a potential can...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Liang W,Luo Z,Ge S,Li M,Du J,Yang M,Yan M,Ye Z,Luo Z

    更新日期:2011-11-16 00:00:00

  • Enhancement of bone morphogenetic protein-2 expression and bone formation by coumarin derivatives via p38 and ERK-dependent pathway in osteoblasts.

    abstract::Osteoporosis is a reduction in skeletal mass due to an imbalance between bone resorption and bone formation. Bone morphogenetic protein (BMP) plays important roles in osteoblastic differentiation and bone formation. Therefore, components involved in BMP activation are good targets for the development of anti-osteoporo...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Tang CH,Yang RS,Chien MY,Chen CC,Fu WM

    更新日期:2008-01-28 00:00:00

  • Ca2+ dependence of the amphetamine, nomifensine, and Lu 19-005 effect on in vivo dopamine transmission.

    abstract::The present in vivo microdialysis study examined the role of vesicular- and carrier-mediated mechanisms underlying dopamine (DA) release, uptake and metabolism in halothane-anaesthetized rats. Omission of calcium (Ca2+) from the dialysis perfusing medium, thereby reducing the concentration of Ca2+ in the striatal micr...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Hurd YL,Ungerstedt U

    更新日期:1989-07-18 00:00:00

  • Pentobarbital-induced changes in vagal tone and reflex vagal activity in rabbits.

    abstract::The effects of pentobarbital on heart rate, reflexly mediated vagal activity and the automaticity (intrinsic rate) of the sinoatrial (SA) node were investigated in rabbits. When administered in three cumulative doses (10 mg/kg i.v. each) at 15 min intervals, each dose produced transient hypotension which was not modif...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Murthy VS,Zagar ME,Vollmer RR,Schmidt DH

    更新日期:1982-10-15 00:00:00

  • Short-term prophylaxis with deoxyspergualin prevents testicular autoimmunity in mice.

    abstract::The effects of the treatment with the immunosuppressant deoxyspergualin on the development of experimental autoimmune orchitis were studied. The results showed that C3H/He mice immunized with testicular germ cells and treated daily with either 0.3 or 3 mg/kg body weight deoxyspergualin during days 15-20 post-immunizat...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Ablake M,Itoh M,Kaneko T,Iimura A,Nakamura Y,Meroni P,Nicoletti F

    更新日期:2002-08-23 00:00:00

  • C(5) modified uracil derivatives showing antiproliferative and erythroid differentiation inducing activities on human chronic myelogenous leukemia K562 cells.

    abstract::The K562 cell line has been proposed as a useful experimental system to identify anti-tumor compounds acting by inducing terminal erythroid differentiation. K562 cells exhibit a low proportion of hemoglobin-synthesizing cells under standard cell growth conditions, but are able to undergo terminal erythroid differentia...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Brognara E,Lampronti I,Breveglieri G,Accetta A,Corradini R,Manicardi A,Borgatti M,Canella A,Multineddu C,Marchelli R,Gambari R

    更新日期:2011-12-15 00:00:00

  • Differentiation between rat brain and mouse vas deferens delta opioid receptors.

    abstract::Certain enkephalin analogues, including those which contain the conformationally restricted amino acid E-(2R,3S)-cyclopropylphenylalanine [2R,3S)-delta E Phe), have been shown to have high affinity for brain delta opioid receptors but are much less active in mouse vas deferens bioassays. To investigate whether there a...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Vaughn LK,Wire WS,Davis P,Shimohigashi Y,Toth G,Knapp RJ,Hruby VJ,Burks TF,Yamamura HI

    更新日期:1990-02-20 00:00:00

  • Changes in naloxone and haloperidol effects during the development of captivity-induced jumping stereotypy in bank voles.

    abstract::Captivity-induced stereotypies in bank voles (Clethrionomys glareolus) were inhibited at the age of 1, 2, 4, 6, 8 and 10 months by 0.2 mg/kg haloperidol s.c., while 35 mg/kg naloxone s.c. only inhibited them at the age of 4-6 months. Other activities were not significantly inhibited. The change in the naloxone effect ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Kennes D,Odberg FO,Bouquet Y,De Rycke PH

    更新日期:1988-08-09 00:00:00

  • Organ selectivity of hexahydrosiladifenidol in blocking pre- and postjunctional muscarinic receptors studied in guinea-pig ileum and rat heart.

    abstract::Pre- and postjunctional pA2 values of the muscarinic antagonist hexahydrosiladifenidol were determined with guinea-pig ileum and rat heart. Hexahydrosiladifenidol did not discriminate between pre- and postjunctional receptors within the same organ but was more potent on the ileum (20-80 times) than on the heart. It is...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Fuder H,Kilbinger H,Müller H

    更新日期:1985-07-11 00:00:00

  • Aggression behaviour induced by oral administration of the Janus-kinase inhibitor tofacitinib, but not oclacitinib, under stressful conditions.

    abstract::Janus kinase (JAK) inhibitors have recently been developed for allergic diseases. We focused on the 2 different JAK inhibitors, tofacitinib (selective for JAK3) and oclacitinib (selective for JAK1 and 2), to clarify the mechanism of anti-inflammatory and anti-itching potency of these drugs. In the process of detecting...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Fukuyama T,Tschernig T,Qi Y,Volmer DA,Bäumer W

    更新日期:2015-10-05 00:00:00

  • (+)-Cyclazosin, a selective alpha1B-adrenoceptor antagonist: functional evaluation in rat and rabbit tissues.

    abstract::To shed light on the discrepancy between reported binding and functional affinity and selectivity at alpha(1b/B)-adrenoceptors, the antagonist (+)-cyclazosin was reinvestigated in rat and rabbit tissues. It displayed a competitive antagonism at alpha(1A) and alpha(1D)-adrenoceptors of rat prostatic vas deferens and ao...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Marucci G,Angeli P,Buccioni M,Gulini U,Melchiorre C,Sagratini G,Testa R,Giardinà D

    更新日期:2005-10-17 00:00:00

  • A novel hypothesis on metal dyshomeostasis and mitochondrial dysfunction in amyotrophic lateral sclerosis: Potential pathogenetic mechanism and therapeutic implications.

    abstract::Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by motor dysfunctions resulting from the loss of upper (UMNs) and lower (LMNs) motor neurons. While ALS symptoms are coincidental with pathological changes in LMNs and UMNs, the causal relationship between the two is unclear....

    journal_title:European journal of pharmacology

    pub_type: 杂志文章,评审


    authors: Nakagawa Y,Yamada S

    更新日期:2021-02-05 00:00:00

  • Effects of serotonin 5-HT1B receptor ligands on the cocaine- and food-maintained self-administration in rats.

    abstract::In order to substantiate the concept that cocaine behavioral effects may be influenced by serotonin (5-HT)1B receptors, male Wistar rats were trained to self-administer cocaine intravenously (0.5 mg/kg/injection), and were systemically pretreated with the selective 5-HT1B receptor antagonist N-[3-[3-(dimethylamine)eth...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Przegaliński E,Gołda A,Frankowska M,Zaniewska M,Filip M

    更新日期:2007-03-22 00:00:00

  • Mast cells, brain inflammation and autism.

    abstract::Increasing evidence indicates that brain inflammation is involved in the pathogenesis of neuropsychiatric diseases. Mast cells (MCs) are located perivascularly close to neurons and microglia, primarily in the leptomeninges, thalamus, hypothalamus and especially the median eminence. Corticotropin-releasing factor (CRF)...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章,评审


    authors: Theoharides TC,Stewart JM,Panagiotidou S,Melamed I

    更新日期:2016-05-05 00:00:00

  • Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum.

    abstract::Ginger (rhizomes of Zingiber officinale) has been shown to exert potent anti-emetic properties, but its mode of action has not yet been elucidated. Among its active constituents, [6]-, [8]- and [10]-gingerol as well as [6]-shogaol were shown in different in vivo studies to be at least partly responsible for the drug's...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Abdel-Aziz H,Windeck T,Ploch M,Verspohl EJ

    更新日期:2006-01-13 00:00:00

  • Carvedilol abrogates hypoxia-induced oxidative stress and neuroinflammation in microglial BV2 cells.

    abstract::Microglia initially undergo rapid activation in response to injury and stressful stimuli, such as hypoxia. Oxidative stress and the inflammatory response play critical roles in hypoxic-ischemic brain injury. Carvedilol is a β-blocker used to treat high blood pressure and heart failure. In this study, we investigated w...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Gao X,Wu B,Fu Z,Zhang Z,Xu G

    更新日期:2017-11-05 00:00:00

  • Hexahydrobenzo[a]phenanthridines: novel dopamine D3 receptor ligands.

    abstract::We report that certain substituted hexahydrobenzo[a]phenanthridines are novel high affinity ligands selective for the dopamine D3 receptor. These data demonstrate that substitutions on the heterocyclic nitrogen and the pendant phenyl ring of this nucleus cause a marked increase in both affinity and selectivity for dop...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Watts VJ,Lawler CP,Knoerzer T,Mayleben MA,Neve KA,Nichols DE,Mailman RB

    更新日期:1993-08-03 00:00:00

  • Further evidence for involvement of adenosine-5'-triphosphate in non-adrenergic non-cholinergic relaxation of the isolated rat duodenum.

    abstract::The nature of the inhbitory non-adrenergic non-cholinergic (NANC) neurotransmitter responsible for neurogenic relaxation of rat duodenum was studied with in vitro techniques. Adenosine 5'-triphosphate (ATP)(1 mM), gamma-aminobutyric acid (GABA, 1 mM), dimethylphenylpiperazinium (DMPP, 0.1 mM) and field stimulation (60...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Manzini S,Maggi CA,Meli A

    更新日期:1985-07-31 00:00:00