Effects of acute fluoxetine on extracellular serotonin levels in the raphe: an in vivo microdialysis study.

Abstract:

:Acute administration of fluoxetine (1, 10 and 20 mg/kg i.p.) increased extracellular levels of serotonin (5-hydroxytryptamine, 5-HT) in the frontal cortex, ventral hippocampus and raphe nuclei as measured by in vivo microdialysis in anaesthetized rats. In the frontal cortex, fluoxetine showed a marked dose-response effect whereas in the ventral hippocampus and raphe nuclei the fluoxetine-induced effect was maximum at 10 mg/kg. However, the maximal increase in 5-HT was observed in the cell body-containing area, the raphe nuclei. The order of changes in extracellular 5-HT was raphe nuclei > ventral hippocampus > frontal cortex. Our results add further arguments in favour of the key role played by raphe nuclei in the mechanism of action of serotoninergic antidepressant drugs.

journal_name

Eur J Pharmacol

authors

Malagié I,Trillat AC,Jacquot C,Gardier AM

doi

10.1016/0014-2999(95)00573-4

subject

Has Abstract

pub_date

1995-11-14 00:00:00

pages

213-7

issue

2

eissn

0014-2999

issn

1879-0712

pii

0014-2999(95)00573-4

journal_volume

286

pub_type

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