Effects of acute fluoxetine on extracellular serotonin levels in the raphe: an in vivo microdialysis study.

abstract：:Irisin, the soluble secreted form of fibronectin type III domain containing 5 (FNDC5)-cleaved product, is a recently identified adipo-myokine that has been indicated as a possible link between physical exercise and energetic homeostasis. The co-localization of irisin with neuropeptide Y in hypothalamic sections of par...

journal_title：European journal of pharmacology

authors： Ferrante C,Orlando G,Recinella L,Leone S,Chiavaroli A,Di Nisio C,Shohreh R,Manippa F,Ricciuti A,Vacca M,Brunetti L

更新日期：2016-11-15 00:00:00

abstract：:Nerisopam, an anxiolytic and antipsychotic homophthalazine induces rapid, intense expression of Fos-like immunoreactivity in the rostral, dorsomedial and lateral parts of the striatum in the rat. Fos-positive cells also occurred in the globus pallidus, the olfactory tubercle and in the accumbens nucleus (in the cone a...

journal_title：European journal of pharmacology

authors： Palkovits M,Baffi JS,Berzsenyi P,Horváth EJ

更新日期：1997-07-16 00:00:00

abstract：:Rings of canine bronchi were suspended for isometric tension recording. Contractions produced by exogenously added acetylcholine were inhibited by pirenzepine and pancuronium. The pKB values were 6.76 for pirenzepine (calculated at 10(-6) M) and 5.30 and 5.13 for pancuronium (calculated at 10(-5) and 3 X 10(-5) M, res...

journal_title：European journal of pharmacology

authors： O'Rourke ST,Flavahan NA,Vanhoutte PM

更新日期：1987-08-04 00:00:00

abstract：:Adjuvant-induced arthritis is associated with body weight loss and decreased pituitary growth hormone (GH) and hepatic insulin-like growth factor-I (IGF-I) synthesis. Cytokines as tumor necrosis factor (TNF) mediate wasting associated with chronic inflammation. The aim of this study was to analyse whether the inhibiti...

journal_title：European journal of pharmacology

authors： Granado M,Priego T,Martín AI,Vara E,López-Calderón A,Angeles Villanúa M

更新日期：2006-04-24 00:00:00

abstract：:Alpha(2A)-Adrenoceptors mediate the antinociceptive effects of alpha(2)-adrenoceptor agonists in mice, and analgesic synergism between noradrenergic and opioidergic mechanisms has been reported to be lacking in mice devoid of functional alpha(2A)-adrenoceptors. We investigated whether the antinociceptive actions of op...

journal_title：European journal of pharmacology

authors： Ozdoğan UK,Lähdesmäki J,Scheinin M

更新日期：2006-01-04 00:00:00

abstract：:Cytotrienin A, a member of the triene-ansamycin family, was initially identified to be an inducer of apoptosis and recently shown to be an inhibitor of translation that interferes with eukaryotic elongation factor 1A function. In human lung carcinoma A549 cells, cytotrienin A was found to inhibit more strongly the cel...

journal_title：European journal of pharmacology

authors： Yamada Y,Taketani S,Osada H,Kataoka T

更新日期：2011-09-30 00:00:00

abstract：:Following pretreatment with 6-OH-dopamine, the sympathetic nerve endings of the iris and skeletal muscle of mice and rats were not longer detectable by cytochemistry for noradrenaline. In the same animals, the specific binding of [3H] ouabain to intact soleus muscles was not significantly different from that measured ...

journal_title：European journal of pharmacology

authors： Clausen T,Hansen O,Larsson LI

更新日期：1981-07-10 00:00:00

abstract：:Intracellular recordings were made from myenteric neurons of the guinea-pig duodenum and the responses to local ejection of several substance P (SP) analogs were examined. It was found that senktide (succinyl-[Asp6,Me-Phe8]SP-(6-11)), a selective analog for the NK-3 (SP-N) receptor, was particularly effective in depol...

journal_title：European journal of pharmacology

authors： Hanani M,Chorev M,Gilon C,Selinger Z

更新日期：1988-08-24 00:00:00

abstract：:Protamine is the only agent approved to reverse heparin-induced anticoagulation. Due to the significant adverse effects of protamine there is an important need for an alternative agent with an improved safety profile. The pharmacodynamics of PM102, a novel peptide-based heparin antagonist, was evaluated and compared t...

journal_title：European journal of pharmacology

authors： Cushing DJ,Cooper WD,Cohen ML,McVoy JR,Sobel M,Harris RB

更新日期：2010-06-10 00:00:00

abstract：:The vasodepressor actions of the cyclic endoperoxides PGG2 and PGH2 were compared with those of their products PGD2 and PGE2 using anaesthetised normotensive and genetically hypertensive rats. Given into the aortic arch of normotensives PGE2 was approximately 6 times more potent than PGH2 and 11 times more potent tha...

journal_title：European journal of pharmacology

authors： Armstrong JM,Boura AL,Hamberg M,Samuelsson B

更新日期：1976-10-01 00:00:00

abstract：:The purpose of this study was to examine the influence of ageing on the alterations in binding characteristics of adrenoceptors and membrane phospholipid fatty acids in rat heart following repeated administration of epinephrine. The maximal number of binding sites (Bmax) and dissociation constant (Kd) of [3H]prazosin ...

journal_title：European journal of pharmacology

authors： Benediktsdóttir VE,Skúladóttir GV,Gudbjarnason S

更新日期：1995-05-26 00:00:00

abstract：:The influence of CGS 21680, an adenosine A2A receptor agonist, on striatal glutamate extracellular levels was tested in a microdialysis study in rats. CGS 21680 (10 mu M), infused intrastriatally through the microdialysis probe, greatly enhanced glutamate extracellular levels. These results show that striatal adenosin...

journal_title：European journal of pharmacology

authors： Popoli P,Betto P,Reggio R,Ricciarello G

更新日期：1995-12-12 00:00:00

abstract：:Single myocytes isolated from the guinea-pig ventricle were used under voltage-clamp conditions to study the activity of a newly developed drug, R56865, a benzothiazolamine derivative, against digitalis toxicity. Multicellular Purkinje preparations were used in some experiments. The drug blocked the transient inward c...

journal_title：European journal of pharmacology

authors： Leyssens A,Carmeliet E

更新日期：1991-04-10 00:00:00

abstract：:Approximately 3% of the world׳s population suffers from chronic infections with hepatitis C virus (HCV). Although current treatment regimes are capable of effectively eradicating HCV infection from these patients, the cost of these combinations of direct-acting antivirals are prohibitive. Approximately 80% of untreate...

journal_title：European journal of pharmacology

authors： Douglas DN,Kneteman NM

更新日期：2015-07-15 00:00:00

abstract：:The anorectic effect of CM 57373 in dogs and in rats food-deprived or with experimentally induced hyperphagia (cafeteria-diet hyperphagia and insulin hyperphagia) was compared to the effect of serotoninergic anorectic drug dl-fenfluramine. CM 57373 and dl-fenfluramine administered orally caused a dose-related reductio...

journal_title：European journal of pharmacology

authors： Miranda GF,Poggesi E,Bianchetti A,Unkovic J,Samanin R

更新日期：1988-05-20 00:00:00

abstract：:(-)Piquindone is a new antipsychotic pyrroloisoquinoline derivative that binds to dopamine D2 receptors. We used in vitro quantitative autoradiography to determine the distribution of [3H](-)piquindone binding sites in rat forebrain. [3H](-)Piquindone binding to brain slices was sodium dependent, saturable and of high...

journal_title：European journal of pharmacology

authors： Nock B,Sedvall G,Mcewen BS

更新日期：1986-03-04 00:00:00

abstract：:Schizophrenia is a serious psychiatric disorder that is most frequently treated with the administration of antipsychotics. Although onset of schizophrenia typically occurs in late adolescence, the majority of preclinical research on the behavioral effects of antipsychotics and their mechanism(s) of action has been con...

journal_title：European journal of pharmacology

authors： Wiley JL

更新日期：2008-01-14 00:00:00

abstract：:Deprenyl, used clinically in Parkinson's disease, has multiple pharmacological effects which make it a good candidate to treat neurotoxicity. Thus, we investigated deprenyl's ability to attenuate methamphetamine-induced dopamine neurotoxicity. We also examined deprenyl's effect in changing markers associated with psyc...

journal_title：European journal of pharmacology

authors： Davidson C,Chen Q,Zhang X,Xiong X,Lazarus C,Lee TH,Ellinwood EH

更新日期：2007-11-14 00:00:00

abstract：:UL-FS 49, a chemical congener of AQ-A 39 with structural similarities to verapamil, decreased the rate of spontaneously beating guinea-pig atria at much lower concentrations (effective concentration 30%, EC30 = 0.030 microgram/ml) than it decreased the contractility (2.5 Hz; EC30 = 108 micrograms/ml) and maximal drivi...

journal_title：European journal of pharmacology

authors： Kobinger W,Lillie C

更新日期：1984-09-03 00:00:00

abstract：:Systemic administration of the NMDA receptor antagonist phencyclidine (PCP; 4 mg/kg) produced a profound reduction in prepulse inhibition of the acoustic startle response in rats. Pre-treatment with the selective adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) blocked (0.5 mg/kg) or attenuated (0.1 and 0.2...

journal_title：European journal of pharmacology

authors： Sills TL,Azampanah A,Fletcher PJ

更新日期：1999-03-26 00:00:00

abstract：:We have examined the pharmacology of kainate receptors in cultured hippocampal neurons (6-8 days in vitro (DIV)) from embryonic rats (E17). Cultured neurons were pre-treated with concanavalin A to remove kainate receptor desensitization and whole-cell voltage clamp electrophysiology employed to record inward currents ...

journal_title：European journal of pharmacology

authors： Bleakman D,Ogden AM,Ornstein PL,Hoo K

更新日期：1999-08-13 00:00:00

abstract：:The molecular mechanism underlying the activity of the novel antiepileptic drug retigabine is not yet fully understood. The aim of this study was to investigate whether retigabine interacts directly with the GABA(A) receptor complex (gamma-aminobutyric acid). Receptor-binding assays were conducted using rat brain memb...

journal_title：European journal of pharmacology

authors： van Rijn CM,Willems-van Bree E

更新日期：2003-03-19 00:00:00

abstract：:Observations of sigma (sigma) receptor heterogeneity have prompted interest in identifying ligands for sigma receptor subtypes. Selective ligands for the sigma-2 are unavailable, but [3H]ifenprodil labels sigma-2 sites. Therefore, isomers and analogues of ifenprodil were compared as potential sigma-2 ligands. Threo-if...

journal_title：European journal of pharmacology

authors： Hashimoto K,London ED

更新日期：1995-02-06 00:00:00

abstract：:Alcuronium is known to stabilize allosterically the binding of the muscarinic antagonist N-methylscopolamine to muscarinic M2 receptors and thus to elevate the equilibrium binding of N-methylscopolamine in homogenized cardiac tissue. In order to check for a functional consequence of this effect, the action of alcuroni...

journal_title：European journal of pharmacology

authors： Maass A,Kostenis E,Mohr K

更新日期：1995-01-05 00:00:00

abstract：:Cerebral ischemia results in enhanced expression of smooth muscle cell endothelin and angiotensin receptors in cerebral arteries. We hypothesise that this phenomenon may be detrimental and that acute treatment with a combined non-hypotensive dose of the angiotensin AT(1) receptor inhibitor candesartan and the endothel...

journal_title：European journal of pharmacology

authors： Stenman E,Jamali R,Henriksson M,Maddahi A,Edvinsson L

更新日期：2007-09-10 00:00:00

abstract：:Lipopolysaccharide (LPS) increases inflammatory cytokines of the brain and deregulates the mitochondrial function, thus could increase the seizure susceptibility. Studies have shown that minocycline has neuroprotective and antioxidant properties. In this study, we aimed to evaluate the anticonvulsant properties of min...

journal_title：European journal of pharmacology

authors： Haj-Mirzaian A,Ramezanzadeh K,Tafazolimoghadam A,Kazemi K,Nikbakhsh R,Nikbakhsh R,Amini-Khoei H,Afshari K,Haddadi NS,Shakiba S,Azimirad F,Mousavi SE,Dehpour AR

更新日期：2019-09-05 00:00:00

abstract：:SL 84.0418 (2-(4,5-dihydro-1H-imidazol-2-yl)-1,2,4,5-tetrahydro-2-propyl-pyrrolo[3, 2,1- hi]-indole hydrocholoride) is a novel alpha 2-adrenoceptor antagonist which possesses anti-hyperglycaemic properties in vitro study, we tested its effects on insulin release from isolated mouse islets. In the presence of 15 mM glu...

journal_title：European journal of pharmacology

authors： Jonas JC,Plant TD,Angel I,Langer SZ,Henquin JC

更新日期：1994-03-11 00:00:00

abstract：:Food intake is regulated by various factors such as neuropeptide Y. Neuropeptide Y potently induces an increase in food intake, and simultaneously stimulates arginine-vasopressin (AVP) secretion in the brain. Recently, we reported that V(1A) vasopressin receptor-deficient (V(1A)R(-/-)) mice exhibited altered daily foo...

journal_title：European journal of pharmacology

authors： Aoyagi T,Kusakawa S,Sanbe A,Hiroyama M,Fujiwara Y,Yamauchi J,Tanoue A

更新日期：2009-11-10 00:00:00

abstract：:Aminoguanidine is an inhibitor of inducible nitric oxide synthase (iNOS) and is of potential clinical usefulness. Treatment of mice with anti-Fas antibodies (150 microg/kg, i.v.) induced elevation of plasma alanine aminotransferase activity at 4 h and this elevation was inhibited by pretreatment of mice with aminoguan...

journal_title：European journal of pharmacology

authors： Okamoto T,Okabe S

更新日期：2000-09-08 00:00:00

abstract：:In vivo effects of histidine and carnosine against diabetic deterioration in diabetic Balb/cA mice were studied. Histidine and carnosine at 0.5, 1 g/l were added into drinking water. After 4 weeks intake of these agents, the content of histidine and carnosine in plasma, heart and liver significantly elevated (P < 0.05...

journal_title：European journal of pharmacology

authors： Lee YT,Hsu CC,Lin MH,Liu KS,Yin MC

更新日期：2005-04-18 00:00:00