Effects of acute fluoxetine on extracellular serotonin levels in the raphe: an in vivo microdialysis study.


:Acute administration of fluoxetine (1, 10 and 20 mg/kg i.p.) increased extracellular levels of serotonin (5-hydroxytryptamine, 5-HT) in the frontal cortex, ventral hippocampus and raphe nuclei as measured by in vivo microdialysis in anaesthetized rats. In the frontal cortex, fluoxetine showed a marked dose-response effect whereas in the ventral hippocampus and raphe nuclei the fluoxetine-induced effect was maximum at 10 mg/kg. However, the maximal increase in 5-HT was observed in the cell body-containing area, the raphe nuclei. The order of changes in extracellular 5-HT was raphe nuclei > ventral hippocampus > frontal cortex. Our results add further arguments in favour of the key role played by raphe nuclei in the mechanism of action of serotoninergic antidepressant drugs.


Eur J Pharmacol


Malagié I,Trillat AC,Jacquot C,Gardier AM




Has Abstract


1995-11-14 00:00:00














  • The antinociceptive effect of amisulpride in mice is mediated through opioid mechanisms.

    abstract::Antinociceptive effects of various neuroleptics in animal acute pain-models have been described, mediated trough different pathways including the opioid system. In this study, we assessed the antinociceptive effects of the atypical neuroleptic drug amisulpride, which acts as a selective blocker of dopamine D2 and D3 r...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Weizman T,Pick CG,Backer MM,Rigai T,Bloch M,Schreiber S

    更新日期:2003-10-08 00:00:00

  • Nicotine suppresses gastric wound repair via the inhibition of polyamine and K(+) channel expression.

    abstract::Nicotine is one of the most representative components in cigarette smoke leading to gastric ulceration. Both ornithine decarboxylase and potassium ion (K(+)) channels are essential for cell growth and wound repair. The aim of the present study is to elucidate the causative relationship of these two factors during woun...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Shin VY,Liu ES,Koo MW,Luo JC,So WH,Cho CH

    更新日期:2002-05-24 00:00:00

  • Corticotropin-releasing factor 1 and 2 receptors in the dorsal raphé differentially affect serotonin release in the nucleus accumbens.

    abstract::Corticotropin-releasing factor (CRF) is a neurohormone that mediates stress, anxiety, and affects serotonergic activity. Studies have shown that CRF has dose-dependent opposing effects on serotonergic activity. This effect has been hypothesized to be differentially mediated by CRF(1) and CRF(2) receptors in the dorsal...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Lukkes JL,Forster GL,Renner KJ,Summers CH

    更新日期:2008-01-14 00:00:00

  • Characterization of angiotensin II antagonism displayed by Ib, a novel nonpeptide angiotensin AT(1) receptor antagonist.

    abstract::The pharmacologic profile of Ib, 5-n-butyl-4-{4-[2-(1H-tetrazole-5-yl)-1H-pyrrol-1-yl]phenylmethyl}-2,4-dihydro-2-(2,6-dichloridephenyl)-3H-1,2,4-triazol-3-one, a novel nonpeptide angiotensin AT(1) receptor antagonist, was investigated by receptor-binding studies, functional in vitro assays with rabbit and rat aorta, ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Wu J,Wang Q,Guo J,Hu Z,Yin Z,Xu J,Wu X

    更新日期:2008-07-28 00:00:00

  • Pharmacological characterization of urinary bladder smooth muscle contractility following partial bladder outlet obstruction in pigs.

    abstract::Partial bladder outlet obstruction of the pig is considered as a valuable preclinical model for evaluating the profile of compounds for the treatment of bladder overactivity. In this study, we characterized the pharmacological properties of isolated bladder smooth muscle from pigs following partial outlet obstruction ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Milicic I,Buckner SA,Daza A,Coghlan M,Fey TA,Brune ME,Gopalakrishnan M

    更新日期:2006-02-17 00:00:00

  • Antinociceptive effects induced through the stimulation of spinal cannabinoid type 2 receptors in chronically inflamed mice.

    abstract::The stimulation of spinal cannabinoid type 2 (CB(2)) receptors is a suitable strategy for the alleviation of experimental pain symptoms. Several reports have described the up-regulation of spinal cannabinoid CB(2) receptors in neuropathic settings together with the analgesic effects derived from their activation. Besi...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Curto-Reyes V,Boto T,Hidalgo A,Menéndez L,Baamonde A

    更新日期:2011-10-01 00:00:00

  • [3H]N-[4-(3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl)butyl]-2-methoxy-5-methylbenzamide: a novel sigma-2 receptor probe.

    abstract::N-[4-(3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl)butyl]-2-methoxy-5-methyl-benzamide (RHM-1) and N-[2-(3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl)ethyl]-2-methoxy-5-methylbenzamide (RHM-2), two conformationally flexible benzamide analogues, were radiolabeled with tritium (specific activity=80 Ci/mmol) and the bi...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Xu J,Tu Z,Jones LA,Vangveravong S,Wheeler KT,Mach RH

    更新日期:2005-11-21 00:00:00

  • Serotonin: a never-ending story.

    abstract::The neurotransmitter serotonin is an evolutionary ancient molecule that has remarkable modulatory effects in almost all central nervous system integrative functions, such as mood, anxiety, stress, aggression, feeding, cognition and sexual behavior. After giving a short outline of the serotonergic system (anatomy, rece...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章,评审


    authors: Olivier B

    更新日期:2015-04-15 00:00:00

  • Nitric oxide enhances prostaglandin production in ethanol-induced gastric mucosal injury in rats.

    abstract::The interaction between endogenous nitric oxide (NO), elicited by administration of Escherichia coli lipopolysaccharide, and cyclooxygenase system, in ethanol-induced injury in rat gastric mucosa, was investigated. Administration of graded doses of lipopolysaccharide reduced the gastric mucosal injury in response to e...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Franco L,Doria D

    更新日期:1998-05-08 00:00:00

  • Modulation of ischemia-evoked release of excitatory and inhibitory amino acids by adenosine A1 receptor agonist.

    abstract::Adenosine has been reported to have beneficial effects against ischemic brain damage, although the mechanisms are not fully clarified. To examine the role of adenosine on the ischemia-evoked release of neurotransmitters, we applied a highly selective agonist for adenosine A1 receptor, 2-chloro-N6-cyclopentyladenosine ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Goda H,Ooboshi H,Nakane H,Ibayashi S,Sadoshima S,Fujishima M

    更新日期:1998-09-18 00:00:00

  • The interleukin-8 receptor: a potential target for antipsoriatic therapy?

    abstract::Interleukin-8 is assumed to play a central role in the pathogenesis of psoriasis. Since an increased expression of the interleukin-8 receptor has been observed both in polymorphonuclear leukocytes and in affected psoriatic epidermis, we were interested in whether the interleukin-8 receptor could be a molecular target ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Kemény L,Kenderessy AS,Olasz E,Michel G,Ruzicka T,Farkas B,Dobozy A

    更新日期:1994-06-13 00:00:00

  • gp120 of HIV-1 induces apoptosis in rat cortical cell cultures: prevention by memantine.

    abstract::After incubation of rat cortical cell cultures with the human immunodeficiency virus type 1 (HIV-1) coat protein gp120 for 12 h, cells showed fragmentation of DNA at internucleosomal linkers, the characteristic feature of apoptosis. In a quantitative approach, it was determined that the percentage of DNA fragmentation...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Müller WE,Schröder HC,Ushijima H,Dapper J,Bormann J

    更新日期:1992-07-01 00:00:00

  • Quantitative autoradiography of beta-adrenoceptors in the cardiac vagus ganglia of the rat.

    abstract::We studied beta-adrenoceptors by quantitative autoradiography in the cardiac vagus ganglia of the rat, after incubation of tissue sections with [125I]iodocyanopindolol. The cardiac vagus ganglia presented a high concentration of a single population of high affinity binding sites (Bmax 109 +/- 10 fmol/mg protein; Kd 64...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Saito K,Potter WZ,Saavedra JM

    更新日期:1988-08-24 00:00:00

  • Effect of cardamonin on hepatic ischemia reperfusion induced in rats: Role of nitric oxide.

    abstract::Ischemia reperfusion (I/R) injury is a cellular damage in a hypoxic organ following the restoration of oxygen delivery. It may occur during organ transplantation, trauma and hepatectomies. Nitric oxide (NO) effects during hepatic I/R are complicated. The iNOS-derived NO has a deleterious effect, whereas eNOS-derived N...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Atef Y,El-Fayoumi HM,Abdel-Mottaleb Y,Mahmoud MF

    更新日期:2017-11-15 00:00:00

  • Enhancement by captopril of bradykinin-induced calcium transients in cultured endothelial cells of the bovine aorta.

    abstract::Using microscopic fluorometry and fura-2-loaded cultured bovine aortic endothelial cells, we determined the effects of captopril, an angiotensin converting enzyme (ACE) inhibitor, on bradykinin-induced Ca2+ transients in endothelial cells. In the presence of extracellular Ca2+, 10(-9) M bradykinin induced an early ris...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Hirano K,Hirano M,Kanaide H

    更新日期:1993-01-15 00:00:00

  • Drug-induced alterations in the efflux of 5-hydroxytryptamine and of 5-hydroxyindoleacetic acid into superfusates of the rat spinal cord.

    abstract::The effect of dl-p-chloroamphetamine, fluoxetine and probenecid on the efflux of endogenous 5-hydroxytryptamine (5HT) and 5-hydroxyindoleacetic acid (5HIAA) into superfusates of the spinal cord of anesthetized rats was examined. Mean basal efflux of 5HT and 5HIAA was 0.27 and 15.56 ng/ml superfusate, respectively. The...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Hammond DL,Tyce GM,Yaksh TL

    更新日期:1983-03-04 00:00:00

  • Termination of ouabain-induced ventricular tachycardia by flunarizine in conscious dogs.

    abstract::The ability of flunarizine to terminate ouabain-induced ventricular tachycardia was investigated in conscious dogs. These arrhythmias result from triggered activity based on delayed afterdepolarizations. Sustained ventricular tachycardia was induced by ouabain (48 +/- 6 micrograms/kg) and pacing in 13 animals with sur...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Vos MA,Gorgels AP,Drenth JP,Leunissen JD,Wellens HJ

    更新日期:1989-06-08 00:00:00

  • Nicotinamide prevents sweet beverage-induced hepatic steatosis in rats by regulating the G6PD, NADPH/NADP+ and GSH/GSSG ratios and reducing oxidative and inflammatory stress.

    abstract::The disruption of redox state homeostasis, the overexpression of lipogenic transcription factors and enzymes, and the increase in lipogenic precursors induced by sweetened beverages are determinants of the development of nonalcoholic fatty liver disease. This study evaluated the action of nicotinamide (NAM) on the exp...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Mejía SÁ,Gutman LAB,Camarillo CO,Navarro RM,Becerra MCS,Santana LD,Cruz M,Pérez EH,Flores MD

    更新日期:2018-01-05 00:00:00

  • Discovery of a novel neuroprotective compound, AS1219164, by high-throughput chemical screening of a newly identified apoptotic gene marker.

    abstract::We have reported that tacrolimus (FK506), an immunosuppressive drug, and diclofenac, a non-steroidal anti-inflammatory drug, possess different modes of neuroprotective action. FK506 suppresses only thapsigargin-induced apoptosis in neuroblastoma SH-SY5Y cells while diclofenac reverses tunicamycin-induced as well as th...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Yamazaki T,Muramoto M,Okitsu O,Morikawa N,Kita Y

    更新日期:2011-11-01 00:00:00

  • Linoleoyl ethanolamide reduces lipopolysaccharide-induced inflammation in macrophages and ameliorates 2,4-dinitrofluorobenzene-induced contact dermatitis in mice.

    abstract::In our previous study, it was found that linoleoyl ethanolamide (LE) is present in sake lees, which are produced as a byproduct during the making of Japanese sake. LE is a fatty acid ethanolamide, which have been demonstrated to exert a variety of biological functions, and in this study, the anti-inflammatory effects ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Ishida T,Nishiumi S,Tanahashi T,Yamasaki A,Yamazaki A,Akashi T,Miki I,Kondo Y,Inoue J,Kawauchi S,Azuma T,Yoshida M,Mizuno S

    更新日期:2013-01-15 00:00:00

  • Minor alkaloids of tobacco release [3H]dopamine from superfused rat striatal slices.

    abstract::In addition to S(-)-nicotine, several minor tobacco alkaloids ((+/-)-nornicotine, anabaseine, S(-)-anabasine, and S(-)-N-methylanabasine) are present in tobacco smoke. This study demonstrates that these alkaloids increase fractional 3H release in a concentration-dependent manner from rat striatal slices preloaded with...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Dwoskin LP,Teng L,Buxton ST,Ravard A,Deo N,Crooks PA

    更新日期:1995-03-24 00:00:00

  • Yawning produced by dopamine agonists in rhesus monkeys.

    abstract::Yawning was recorded from five rhesus monkeys restrained in a chair after i.m. injection of dopaminergic compounds: apomorphine (0.03 mg/kg), quinpirole (0.01 mg/kg), and (-)-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine (1 mg/kg). SKF 38393 or physostigmine produced no yawning. Yawning from apomorphine was blocked by ch...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Code RA,Tang AH

    更新日期:1991-08-29 00:00:00

  • Interaction of thyrotropin-releasing hormone (TRH) and serotonin in cardiovascular control.

    abstract::Intravenous injection of the synthetic TRH analog, MK-771, to anesthetised cats raised the blood pressure by a central mechanism, i.e. by activating the outflow of sympathetic stimuli from the CNS to the periphery and raising the plasma concentration of adrenaline and noradrenaline. In contrast, noradrenaline in the C...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Elam R,Bergmann F,Feuerstein G

    更新日期:1988-09-01 00:00:00

  • Autoradiographic comparison of in vitro binding characteristics of various tritiated adenosine A2A receptor ligands in rat, mouse and pig brain and first ex vivo results.

    abstract::The adenosine A(2A) receptor in the basal ganglia is involved in the control of movement and plays a role in movement disorders such as Parkinsonism. Developing ligands to evaluate that receptor by noninvasive methods such as positron emission tomography has a high priority. In vitro radioligand binding guides the sel...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Sihver W,Schulze A,Wutz W,Stüsgen S,Olsson RA,Bier D,Holschbach MH

    更新日期:2009-08-15 00:00:00

  • ETB receptor antagonist, IRL 1038, selectively inhibits the endothelin-induced endothelium-dependent vascular relaxation.

    abstract::In isolated rat aorta, endothelin-1 induced contractions at lower concentrations than endothelin-3. The contractile effects were augmented by removing the endothelium. In contrast, endothelium-1 and endothelin-3 at similar concentrations induced endothelium-dependent relaxation in norepinephrine-stimulated aorta. IRL ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Karaki H,Sudjarwo SA,Hori M,Sakata K,Urade Y,Takai M,Okada T

    更新日期:1993-02-16 00:00:00

  • (S)YS-51, a novel isoquinoline alkaloid, attenuates obesity-associated non-alcoholic fatty liver disease in mice by suppressing lipogenesis, inflammation and coagulation.

    abstract::Obesity-associated non-alcoholic fatty liver disease (NAFLD) increases coagulation and inflammation. We hypothesized that (S)YS-51, an agent found to be beneficial in animal models of sepsis, may reduce NAFLD in high-fat diet (HFD) mice by reducing coagulation and inflammation. C57BL/6 mice were fed either a chow diet...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Park EJ,Kim YM,Kim HJ,Jang SY,Oh MH,Lee DH,Chang KC

    更新日期:2016-10-05 00:00:00

  • Avarol and avarone, two new anti-inflammatory agents of marine origin.

    abstract::The anti-inflammatory activity of avarol and avarone, sesquiterpenoid derivatives from the Mediterranean sponge Dysidea avara, was investigated. Both compounds potently inhibited paw oedema induced by carrageenan (approximated ED50 = 9.2 and 4.6 mg/kg, p.o., respectively) as well as ear oedema induced by 12-O-tetradec...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Ferrándiz ML,Sanz MJ,Bustos G,Payá M,Alcaraz MJ,De Rosa S

    更新日期:1994-02-21 00:00:00

  • Cytoprotective properties of phenolic antidiarrheic ingredients in cultured astrocytes and neurons of rat brains.

    abstract::We have previously shown that particular phenolic antidiarrheic ingredients, including 2-methoxy-4-methylphenol (2M4MP) and 2-methoxy-4-ethyphenol (2M4EP), but not 2-methoxyphenol (2MP), significantly inhibit cellular maturation and differentiation of the bone-resorbing osteoclasts with concomitant protection of the b...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Matsushima N,Nakamichi N,Kambe Y,Takano K,Moriguchi N,Yoneda Y

    更新日期:2007-07-12 00:00:00

  • Pharmacology of muscarinic acetylcholine receptor subtypes (m1-m5): high throughput assays in mammalian cells.

    abstract::Based on the ability of many receptors to amplify NIH 3T3 cells, we developed a high throughput assay of cloned receptor pharmacology. In this assay, receptors are transiently co-expressed with the marker enzyme beta-galactosidase. Receptors that induce cellular proliferation select and amplify the cells that also exp...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Bräuner-Osborne H,Brann MR

    更新日期:1996-01-04 00:00:00

  • Stimulation of dopamine D-2 but not D-1 receptors reduces immobility time of rats in the forced swimming test: implication for antidepressant activity.

    abstract::The involvement of dopamine D-1 and D-2 receptor mechanisms was investigated in the forced swimming test with rats. d,1-Sulpiride, a D-2 receptor antagonist, reported to reduce desipramine-induced anti-immobility, did not alter the brain levels of desipramine. In addition, the anti-immobility effect of desipramine was...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Borsini F,Lecci A,Mancinelli A,D'Aranno V,Meli A

    更新日期:1988-04-13 00:00:00