Affinity cross-linking of bradykinin B2 receptors in guinea pig ileum membranes.

abstract：:Intracellular recording was used to study the effect of uncouplers of oxidative phosphorylation on miniature endplate potentials (m.e.p.p.s) in skeletal muscles from dystrophic mice and their clinically normal littermates. Control m.e.p.p. frequency in muscles from dystrophic mice was not significantly different from ...

journal_title：European journal of pharmacology

authors： Kelly S,Morgan G,Smith J

更新日期：1988-02-16 00:00:00

abstract：:The maximal number of binding sites (Bmax) and the equilibrium dissociation constant (KD) values for [3H]PK 11195 binding were determined in the platelet membranes of epileptic patients before and after 4 weeks of carbamazepine (CBZ) treatment, as well as in healthy controls. There was a decrease of 17.1% in the Bmax ...

journal_title：European journal of pharmacology

authors： Weizman A,Tanne Z,Karp L,Martfeld Y,Tyano S,Gavish M

更新日期：1987-09-23 00:00:00

abstract：:Pristinamycin IA is a cyclo-peptidic macrolactone antibiotic belonging to the streptogramin family. In the present work, the interaction of pristinamycin IA with the multidrug transporter P-glycoprotein was investigated in the differentiated human intestinal epithelial cell line Caco-2. Pristinamycin IA specifically i...

journal_title：European journal of pharmacology

authors： Phung-Ba V,Warnery A,Scherman D,Wils P

更新日期：1995-01-16 00:00:00

abstract：:Analogues of the C-terminal octapeptide of cholecystokinin (CCK) modified in the Met28-Gly29 region, were tested for their ability to interact with peripheral cholecystokinin receptors on rat pancreatic acini and to stimulate amylase secretion. These analogues were further evaluated for their ability to recognize cent...

journal_title：European journal of pharmacology

authors： Mendre C,Rodriguez M,Lignon MF,Galas MC,Gueudet C,Worms P,Martinez J

更新日期：1990-09-21 00:00:00

abstract：:Changes in autonomic receptor systems (alpha- and beta-adrenoceptors and muscarinic receptors) were compared in the aging and failing human heart. In both settings responsiveness of beta-adrenoceptors and all other receptor systems that evoke their effects via cyclic AMP accumulation was diminished. Muscarinic recepto...

journal_title：European journal of pharmacology

authors： Brodde OE,Leineweber K

更新日期：2004-10-01 00:00:00

abstract：:In follicle-enclosed Xenopus oocytes, extracellular application of cromakalim (a K+ channel opener) or intracellular injection of cAMP induces the smooth outward K+ current which is inactivated by glibenclamide. We found that cromakalim- or cAMP-induced K+ currents in the oocytes were rapidly, reversibly and dose-depe...

journal_title：European journal of pharmacology

authors： Sakuta H,Sekiguchi M,Okamoto K,Sakai Y

更新日期：1992-07-01 00:00:00

abstract：:Polygonum tinctorium Lour. (P. tinctorium) is known to have the ability to suppress inflammation. We attempted to isolate the active compounds from P. tinctorium based on their inhibitory effects on the production of interferon-gamma, which is a well-known inflammatory cytokine. We thus isolated indirubin, an isomer o...

journal_title：European journal of pharmacology

authors： Kunikata T,Tatefuji T,Aga H,Iwaki K,Ikeda M,Kurimoto M

更新日期：2000-12-20 00:00:00

abstract：:SCH 23390 (R(+)-7-chloro-8-hydroxy-2,3,4,5-tetrahydro-3-methyl-1-phenyl-1H-3 -benzazepine) is a potent, relatively selective antagonist of the D-1 dopamine receptor ( Iorio et al., J. Pharmacol. Exp. Ther. 226, 462). Because SKF 75670, the 7-OH analogue of SCH 23390, is a partial D-1 agonist, we conclude that the 7-Cl...

journal_title：European journal of pharmacology

authors： Itoh Y,Beaulieu M,Kebabian JW

更新日期：1984-04-13 00:00:00

abstract：:Translational research for neurodegenerative disease depends intimately upon animal models. Unfortunately, promising therapies developed using mouse models mostly fail in clinical trials, highlighting uncertainty about how well mouse models mimic human neurodegenerative disease at the molecular level. We compared the ...

journal_title：European journal of pharmacology

authors： Burns TC,Li MD,Mehta S,Awad AJ,Morgan AA

更新日期：2015-07-15 00:00:00

abstract：:The aim of the present study was to investigate the contribution of extracellular signal regulated kinase-1/2 (ERK1/2) to pulmonary artery contraction in response to 4-aminopyridione (4-AP), an inhibitor of a voltage-gated K(+) channels that regulate pulmonary vascular tone. Pulmonary artery rings 1-1.5 mm in diameter...

journal_title：European journal of pharmacology

authors： Han W,Tang X,Wu H,Liu Y,Zhu D

更新日期：2007-08-13 00:00:00

abstract：:The administration of ethyl beta-carboline-3-carboxylate (beta-CCE), a ligand for benzodiazepine receptors, did not affect the cerebellar cyclic GMP level in mice, but giving beta-CCE together with diazepam significantly inhibited the diazepam-induced decrease in cyclic GMP. The fact that no antagonism was observed wh...

journal_title：European journal of pharmacology

authors： Fujimoto M,Kawasaki K,Matsushita A,Okabayashi T

更新日期：1982-05-21 00:00:00

abstract：:It has been reported that icariin protects neurons against ischemia/reperfusion injury. In this study, we found that icariin could enhance neuronal viability and suppress neuronal death after oxygen and glucose deprivation (OGD). Further study showed that neuroprotection by icariin was through the induction of Sirtuin...

journal_title：European journal of pharmacology

authors： Wang L,Zhang L,Chen ZB,Wu JY,Zhang X,Xu Y

更新日期：2009-05-01 00:00:00

abstract：:It has been shown that galanin plays a role in central cardiovascular regulation. Galanin administered centrally induces an increase of heart rate and a weak vasodepressor response, whereas the N-terminal galanin fragment (1-15) elicits vasopressor effects and tachycardia. Furthermore, it has been shown that galanin-(...

journal_title：European journal of pharmacology

authors： Narváez JA,Díaz-Cabiale Z,Hedlund PB,Aguirre JA,Coveñas R,González-Barón S,Fuxe K

更新日期：2000-07-07 00:00:00

abstract：:In guinea pig papillary muscle, the rate of electrical stimulation (0.1-2 Hz) strongly influenced the effects of the Anemonia sulcata toxin ATX II on action potential duration (APD) and contractile force. In the concentration range studied (10-8-10-7 M), ATX II always produced a larger prolongation in APD at low rates...

journal_title：European journal of pharmacology

authors： Beress L,Ritter R,Ravens U

更新日期：1982-04-23 00:00:00

abstract：:Extravasation elicited in rat skin by antidromic electrical stimulation of the saphenous nerve was dose dependently inhibited by the intravenous (i.v.) application of the mu-opioid receptor agonists, morphine and [D-Ala2,Me-Phe4,Gly-ol5]enkephalin (DAGO), and the kappa-opioid receptor agonists (-)-U 50488H, (-)-ICI 19...

journal_title：European journal of pharmacology

authors： Barber A

更新日期：1993-05-12 00:00:00

abstract：:We have examined the pharmacology of kainate receptors in cultured hippocampal neurons (6-8 days in vitro (DIV)) from embryonic rats (E17). Cultured neurons were pre-treated with concanavalin A to remove kainate receptor desensitization and whole-cell voltage clamp electrophysiology employed to record inward currents ...

journal_title：European journal of pharmacology

authors： Bleakman D,Ogden AM,Ornstein PL,Hoo K

更新日期：1999-08-13 00:00:00

abstract：:New, more effective pharmacologic treatments for epilepsy are needed, as a substantial portion of patients (>30%) are refractory to currently available anti-epileptic drugs. Cenobamate (YKP3089) is an investigational anti-epileptic drug in clinical development. Two completed adequate and well-controlled studies demons...

journal_title：European journal of pharmacology

authors： Nakamura M,Cho JH,Shin H,Jang IS

更新日期：2019-07-15 00:00:00

abstract：:In the sheep cerebral vasculature 5-hydroxytryptamine (5-HT) caused a contraction of which ketanserin was found to be an effective antagonist (Basilar artery, pA2 = 9.33 +/- 0.16; middle cerebral artery, pA2 = 9.19 +/- 0.16; pial artery, pA2 = 9.47 +/- 0.12). Sumatriptan (GR 43175), a selective 5-HT1-like receptor ago...

journal_title：European journal of pharmacology

authors： Gaw AJ,Wadsworth RM,Humphrey PP

更新日期：1990-04-10 00:00:00

abstract：:Leukotriene C4 binding to mouse brain membranes was readily displaced by S-alkylglutathione derivatives, with the affinity of the test compound increasing as the alkyl chain length increases. S-decylglutathione was as potent as leukotriene C4. These data suggest that brain membrane leukotriene C4 binding sites are S-a...

journal_title：European journal of pharmacology

authors： Goffinet AM,Nguyen A

更新日期：1989-02-14 00:00:00

abstract：:Rats isolated at 16--18 days of age showed after 10--12 months a complex behavioural syndrome in which locomotor activity was markedly increased when compared to that of group-housed controls. The hyperactivity of the socially deprived animals was selectively blocked by clinically effective antidepressants but not by ...

journal_title：European journal of pharmacology

authors： Garzón J,Fuentes JA,Del Rio J

更新日期：1979-11-16 00:00:00

abstract：:Not much has been reported about the effects of hyperthyroidism and its correction on resistance vessels, and just two inconsistent studies have investigated the impacts of restored euthyroidism on vascular reactivity. In this regard, we designed the current study to evaluate the vascular reactivity of the mesenteric ...

journal_title：European journal of pharmacology

authors： Khorshidi-Behzadi M,Alimoradi H,Haghjoo-Javanmard S,Reza Sharifi M,Rahimi N,Dehpour AR

更新日期：2013-02-15 00:00:00

abstract：:Our purpose was to verify if alcohol causes alterations on translocation of Ca(2+) and tension induced by KCl or noradrenaline in vas deferens of periadolescent Wistar rats. A single dose of alcohol (i.p. 3.0g/kg) or saline as control, was given 4h before sacrifice. Longitudinal strips of prostatic portion were mounte...

journal_title：European journal of pharmacology

authors： Ferreira Verde L,Silva Lopes G,Miki Ihara SS,Hyppolito Jurkiewicz N,Jurkiewicz A

更新日期：2014-07-15 00:00:00

abstract：:The alpha(2)-adrenoceptor agonist, clonidine, modulates colorectal sensorimotor functions in humans and, given intrathecally, has analgesic effects in the colorectal distension (CRD) model in rats. We tested the effects of systemic clonidine on the visceral pain-related viscerosomatic and autonomic cardiovascular resp...

journal_title：European journal of pharmacology

authors： Brusberg M,Ravnefjord A,Lindgreen M,Larsson H,Lindström E,Martinez V

更新日期：2008-09-04 00:00:00

abstract：:Vagal motor outflow from the dorsal vagal complex is important in the regulation of intestinal motility. The aim of our study was to test the hypothesis that within the dorsal vagal complex, tonic GABA(A)-receptor mediated neurotransmission modulates intestinal motility. The GABA(A) receptor antagonist, bicuculline (m...

journal_title：European journal of pharmacology

authors： Greenwood-Van Meerveld B,Barron KW

更新日期：1998-04-10 00:00:00

abstract：:Although the gastrointestinal tract is a rich source of melatonin and possesses numerous melatonin-binding sites, the role of melatonin in this tissue has not yet been fully elucidated. In this work we focused on the role of melatonin in the modulation of ion transport in rat distal colon. Whereas melatonin had no eff...

journal_title：European journal of pharmacology

authors： Mrnka L,Hock M,Rybová M,Pácha J

更新日期：2008-02-26 00:00:00

abstract：:Liver plays an important role in bile synthesis, metabolic function, degradation of toxins, new substances synthesis in body. However, hepatopathy morbidity and mortality are increasing year by year around the world, which become a major public health problem. Traditional Chinese medicine (TCM) has a prominent role in...

journal_title：European journal of pharmacology

authors： Zhou M,Deng Y,Liu M,Liao L,Dai X,Guo C,Zhao X,He L,Peng C,Li Y

更新日期：2021-01-05 00:00:00

abstract：:St. John's wort (Hypericum perforatum L.) is widely used for the treatment of mild to moderately severe depression. However, the nature of its active principles and the exact mode of antidepressant action are still unknown. It has been suggested repeatedly in preclinical and clinical studies that the content of the ac...

journal_title：European journal of pharmacology

authors： Simmen U,Bobirnac I,Ullmer C,Lübbert H,Berger Büter K,Schaffner W,Schoeffter P

更新日期：2003-01-05 00:00:00

abstract：:The actions of a purified Helicobacter pylori lipopolysaccharide (3 mg x kg(-1), i.v.) on rat gastric antral and duodenal microvascular integrity (determined as radiolabelled albumin leakage) and the expression of the inducible nitric oxide (NO) synthase (iNOS; assessed by the citrulline assay) were investigated 4 h a...

journal_title：European journal of pharmacology

authors： Kiss J,Lamarque D,Moran AP,Pozsár J,Morschl E,László F,Whittle BJ

更新日期：2001-05-25 00:00:00

abstract：:Failed medical therapy is a common problem in inflammatory bowel disease. P-glycoprotein (P-gp), an efflux pump encoded by MDR1 (ABCB1) gene can actively pump drugs out of cells conferring the phenotype of multidrug resistance. Various studies evoked that cyclooxygenase (COX) system may be involved in the regulation o...

journal_title：European journal of pharmacology

authors： Zrieki A,Farinotti R,Buyse M

更新日期：2010-06-25 00:00:00

abstract：:Cardiovascular and behavioral responses induced by intravenous administration of the serotonin (5-HT)1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), were studied in conscious normotensive rats either after a single administration, after repeated subcutaneous treatments (1 mg/kg daily for 3 day...

journal_title：European journal of pharmacology

authors： Kolbasa KP,McCall RB,Ludens JH

更新日期：1991-02-14 00:00:00