Abstract:
:The maximal number of binding sites (Bmax) and the equilibrium dissociation constant (KD) values for [3H]PK 11195 binding were determined in the platelet membranes of epileptic patients before and after 4 weeks of carbamazepine (CBZ) treatment, as well as in healthy controls. There was a decrease of 17.1% in the Bmax value of patients before treatment as compared to the controls whereas an increase of 50.3% was observed in CBZ-treated patients as compared to their pretreatment values. The up-regulatory effect of CBZ on peripheral benzodiazepine receptors was not accompanied by alterations in KD values.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Weizman A,Tanne Z,Karp L,Martfeld Y,Tyano S,Gavish Mdoi
10.1016/0014-2999(87)90567-xsubject
Has Abstractpub_date
1987-09-23 00:00:00pages
471-4issue
3eissn
0014-2999issn
1879-0712pii
0014-2999(87)90567-Xjournal_volume
141pub_type
杂志文章abstract::In the rat distal colon, 5-hydroxytryptamine (5-HT)-induced Cl- secretion is seen as a rise in short circuit current (Isc). We investigated the 5-HT receptor mediating 5-HT-induced Cl- secretion in the rat distal colon. Rat distal colon was prepared either by stripping away the muscularis propria with the neural gangl...
journal_title:European journal of pharmacology
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abstract::Our aim was to investigate the role of oxidative stress and inflammation on the functional and biochemical changes caused by hyperglycemia in the aorta and corpus cavernosum tissues of streptozotozin diabetic rats and to determine if rosiglitazone and/or insulin treatment has any preventive effect on organ dysfunction...
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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abstract::We have shown previously in dogs with right heart failure that the reduction of myocardial beta-adrenoceptor density occurs only in the failing right ventricle, while cardiac inotropic responses to beta-adrenergic stimulation are reduced in both the right and left ventricles. The purpose of the present study was to de...
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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