Abstract:
:The effect of progesterone on isolated rabbit coronary arteries and its possible mechanism was investigated by measuring changes of isometric tension. Progesterone (1, 3, 10 and 30 microM) induced significant coronary relaxation in K+ (30 mM)-, prostaglandin F2 alpha (3 microM)- or Bay K 8644 (1 microM plus 15 mM K+)- precontracted arteries. There was no difference between endothelium-intact and -denuded coronary arteries from both male and female rabbits, precontracted with these three agents. Haemoglobin, indomethacin, methylene blue, glibenclamide or barium chloride did not affect the relaxation. In endothelium-denuded rabbit coronary arteries, progesterone shifted calcium concentration-dependent constrictor-response curves to the right, the maximal contraction was also reduced. The -log ED50s were 3.6 in control, and 3.3 and 2.9 after incubation with progesterone (3 and 30 microM), respectively. Similar results were obtained in rat aorta. We conclude that progesterone induces significant endothelium-independent relaxation in rabbit coronary arteries in vitro, possibly by affecting calcium influx.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Jiang CW,Sarrel PM,Lindsay DC,Poole-Wilson PA,Collins Pdoi
10.1016/0014-2999(92)90524-8keywords:
subject
Has Abstractpub_date
1992-02-11 00:00:00pages
163-7issue
2eissn
0014-2999issn
1879-0712pii
0014-2999(92)90524-8journal_volume
211pub_type
杂志文章abstract::Alzheimer's disease is associated with glial activation and increased levels of the cytokines as well as impaired forebrain cholinergic function. Current therapies focus on enhancing cholinergic function by administrating acetylcholinesterase inhibitors, such as galantamine. Epidemiological results also suggest that a...
journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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