Abstract:
:In rats, tolerance to the analgesic effect of intraventricular substance P (SP) develops quickly. In rats made tolerant to [D-Ala2, D-Leu5]enkephalin the analgesic efficacy of SP is reduced significantly. The latter result suggests some overlap in the sites of action of SP and [D-Ala2,D-Leu5] enkephalin. Since SP seems to lack any direct effect on opiate receptors of the brain, the present data suggest that the analgesic effect of SP is mediated by enkephalin release at supraspinal levels which are related to pain control.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Naranjo JR,Fernandez-Tome MP,Del Rio Jdoi
10.1016/0014-2999(84)90119-5subject
Has Abstractpub_date
1984-02-10 00:00:00pages
133-6issue
1eissn
0014-2999issn
1879-0712pii
0014-2999(84)90119-5journal_volume
98pub_type
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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