Raloxifene promotes adipocyte differentiation of 3T3-L1 cells.

abstract：:The effect of ketanserin on alpha-adrenoceptors was studied in membrane preparations of the porcine aorta using [3H]prazosin and [3H]yohimbine binding assays to identify alpha 1- and alpha 2-adrenoceptors. Ketanserin bound to alpha-adrenoceptors and the Ki value of ketanserin for alpha 1-adrenoceptors was 8.3 nM, a va...

journal_title：European journal of pharmacology

authors： Nishimura J,Kanaide H,Shogakiuchi Y,Nakamura M

更新日期：1987-01-13 00:00:00

abstract：:Itching is known as a commonly side effect of opioid administration. However, the relationship of opioid receptors to itching is unclear. In this study, we examined the effect of intradermal injection of morphine and fentanyl on the itching sensation. When injected intradermally into the rostral back of mice, morphine...

journal_title：European journal of pharmacology

authors： Yamamoto A,Kuyama S,Kamei C,Sugimoto Y

更新日期：2010-02-10 00:00:00

abstract：:We investigated the effects of acute p.o. pretraining treatment with an indirect acetylcholinesterase inhibitor, metrifonate, on water maze spatial navigation and passive avoidance behavior. Metrifonate (10-100 mg/kg, orally, p.o.) did not improve the water maze or passive avoidance performance of young intact rats. H...

journal_title：European journal of pharmacology

authors： Riekkinen P Jr,Schmidt B,Stefanski R,Kuitunen J,Riekkinen M

更新日期：1996-08-08 00:00:00

abstract：:Venlafaxine is a dual serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline uptake inhibitor which has been claimed to have an onset of antidepressant action which is faster than for other comparable drugs. The effects of venlafaxine on brain 5-HT levels in vivo have not yet been examined. Acute administration of ve...

journal_title：European journal of pharmacology

authors： Gur E,Dremencov E,Lerer B,Newman ME

更新日期：1999-05-07 00:00:00

abstract：:Mitiglinide (KAD-1229), a new anti-diabetic drug, is thought to stimulate insulin secretion by closing the ATP-sensitive K+ (K(ATP)) channels in pancreatic beta-cells. However, its selectivity for the various K(ATP) channels is not known. In this study, we examined the effects of mitiglinide on various cloned K(ATP) c...

journal_title：European journal of pharmacology

authors： Sunaga Y,Gonoi T,Shibasaki T,Ichikawa K,Kusama H,Yano H,Seino S

更新日期：2001-11-09 00:00:00

abstract：:Ovarian cancer (OC) is a major cause of cancer-related deaths in women all over the world. The easy metastasis of OC and the problem of radioresistance are serious issues remaining to be overcome. Thus, research on molecular mechanisms underlying is in urgent demand. Long non-coding RNAs (lncRNAs) are a class of RNAs ...

journal_title：European journal of pharmacology

authors： Dou Q,Xu Y,Zhu Y,Hu Y,Yan Y,Yan H

更新日期：2019-06-05 00:00:00

abstract：:Increasing concentrations of the functional antagonist carbachol resulted in a shift to the right of the dose-response curves for (--)-isoproterenol-induced positive chronotropic and inotropic responses and a reduction of the maximum degree of response that could be produced relative to that produced by theophylline. ...

journal_title：European journal of pharmacology

authors： Buckner CK,Torphy T,Costa DJ

更新日期：1978-02-01 00:00:00

abstract：:The endogenous cannabinoid system has been noted for its therapeutic potential, as well as the psychoactivity of cannabinoids such as Δ9-tetrahydrocannabinol (THC). However, less is known about the psychoactivity of anandamide (AEA), an endocannabinoid ligand. Thus, the goals of this study were to establish AEA as a d...

journal_title：European journal of pharmacology

authors： Walentiny DM,Gamage TF,Warner JA,Nguyen TK,Grainger DB,Wiley JL,Vann RE

更新日期：2011-04-10 00:00:00

abstract：:Nociceptin (orphanin FQ) is an endogenous agonist for the opioid receptor-like1 (ORL1) receptor. We investigated the effects of nociceptin on mean circulatory filling pressure, an index of venous tone. The effects of nociceptin (10, 30 nmol/kg, i.v.) and the vehicle (0.9% NaCl) on mean arterial pressure, heart rate an...

journal_title：European journal of pharmacology

authors： Abdelrahman AM,Pang CC

更新日期：2002-11-29 00:00:00

abstract：:Paclitaxel, an antitumoral drug, was used in a single dose (29 mg/kg i.p.) as an injury agent for inducing transient suppression of hematopoiesis in a murine experimental model during 10days. The aim of this study focuses on erythropoietin (EPO) receptor, GATA binding protein 1 (globin transcription factor 1) (GATA-1)...

journal_title：European journal of pharmacology

authors： Aguirre MV,Todaro JS,Juaristi JA,Brandan NC

更新日期：2010-06-25 00:00:00

abstract：:It has been shown that G-protein coupled receptors have seven transmembrane alpha-helices, but the structural changes occurring in a G-protein coupled receptor as a response on agonist stimulus and the molecular events leading to blockade of the signal transduction by antagonists are not well understood. In the presen...

journal_title：European journal of pharmacology

authors： Sylte I,Bronowska A,Dahl SG

更新日期：2001-03-23 00:00:00

abstract：:In the present study, the possible role of nitric oxide on the conditioned place preference (CPP) induced by nicotine in mice was investigated. Intraperitoneal (i.p.) injections of nicotine (1 mg/kg) and the nitric oxide (NO) precursor, L-arginine (200 and 500 mg/kg), produced significant place preference. However, in...

journal_title：European journal of pharmacology

authors： Sahraei H,Falahi M,Zarrindast MR,Sabetkasaei M,Ghoshooni H,Khalili M

更新日期：2004-10-25 00:00:00

abstract：:Antidepressant drugs are currently one of the most prescribed medications. In addition to treatment resistance and side effects of antidepressants, their clinical use is further complicated by antidepressant discontinuation syndrome (ADS). ADS is a common problem in patients following the interruption, dose reduction,...

journal_title：European journal of pharmacology

authors： Zabegalov KN,Kolesnikova TO,Khatsko SL,Volgin AD,Yakovlev OA,Amstislavskaya TG,Alekseeva PA,Meshalkina DA,Friend AJ,Bao W,Demin KA,Gainetdinov RR,Kalueff AV

更新日期：2018-06-15 00:00:00

abstract：:The pharmacological mechanisms involved in the interactions between C-fibers, cholinergic fibers and mast cells were investigated in tracheally perfused rabbit lungs by measuring the simultaneous release of substance P and histamine in lung effluents. The amounts of substance P and histamine released in lung superfusa...

journal_title：European journal of pharmacology

authors： Nemmar A,Delaunois A,Beckers JF,Sulon J,Bloden S,Gustin P

更新日期：1999-04-23 00:00:00

abstract：:Inhibition of intrathecal substance P-elicited behavior by mu-, delta- and kappa-opioids was compared. In both the substance P behavioral test and the tail flick antinociceptive test, intrathecal [D-Ala2, Met5]enkephalinamide and [D-Ala2, D-Leu5]enkephalin (DADL) were equipotent, morphine and ethylketazocine were less...

journal_title：European journal of pharmacology

authors： Hylden JL,Wilcox GL

更新日期：1982-12-17 00:00:00

abstract：:Berend Olivier has had a long-standing interest in the utility of animal models for a wide variety of therapeutic indications. His work has spanned multiple types of models, blending ethological, or species typical and naturalistic behaviors, along with methodologies based on learned behavior. He has consistently done...

journal_title：European journal of pharmacology

authors： Barrett JE

更新日期：2015-04-15 00:00:00

abstract：:Endothelins, 21-amino acid peptides involved in the pathogenesis of various diseases, bind to endothelin ET(A) and ET(B) receptors to initiate their effects. Here, we characterize the pharmacology of A-216546 ([2S-(2,2-dimethylpentyl)-4S-(7-methoxy-1,3-benzodioxol-5-yl )-1-(N,N-di(n-butyl) aminocarbonylmethyl)-pyrroli...

journal_title：European journal of pharmacology

authors： Wu-Wong JR,Dixon DB,Chiou WJ,Dayton BD,Novosad EI,Adler AL,Wessale JL,Calzadilla SV,Hernandez L,Marsh KC,Liu G,Szczepankiewicz B,von Geldern TW,Opgenorth TJ

更新日期：1999-02-05 00:00:00

abstract：:The effects of histamine H1- and H2-receptor antagonists on histamine-stimulated renin secretion were examined in anesthetized dogs. Tripelennamine (H1 blocker) further enhanced renin secretion in the presence of exogenous histamine. Moreover, tripelennamine alone increased renin secretion. These effects are probably ...

journal_title：European journal of pharmacology

authors： Radke KJ,Willis LR,Zimmerman GW,Weinberger MH,Selkurt EE

更新日期：1986-04-29 00:00:00

abstract：:The antithrombotic effect of desethyl KBT-3022, which is the main active metabolite of the new antiplatelet agent, KBT-3022 (ethyl 2-[4,5-bis(4-methoxyphenyl)thiazol-2-yl] pyrrol-1-ylacetate; a cyclooxygenase inhibitor), was determined using a photochemically induced arterial thrombosis model in the rat femoral artery...

journal_title：European journal of pharmacology

authors： Shimazawa M,Takiguchi Y,Umemura K,Kondo K,Nakashima M

更新日期：1997-06-11 00:00:00

abstract：:Effects of N-ethylmaleimide or forskolin on electrically evoked dopamine release were investigated in striatal slices of rats pretreated with methamphetamine. N-Ethylmaleimide and forskolin both enhanced the evoked dopamine release in a concentration-dependent manner. The enhancement by N-ethylmaleimide of spontaneous...

journal_title：European journal of pharmacology

authors： Yamada S,Yokoo H,Nishi S

更新日期：1994-05-23 00:00:00

abstract：:When injected directly into the tail, U50,488H is a potent analgesic in the tailflick assay (ED50 3.1 micrograms). The analgesic activity is lost if the radiant heat is focused 1 cm away from the site of injection. The kappa 1-opioid receptor antagonist nor-binaltorphimine given systemically reverses the local analges...

journal_title：European journal of pharmacology

authors： Kolesnikov Y,Jain S,Wilson R,Pasternak GW

更新日期：1996-08-29 00:00:00

abstract：:We studied the effects of interleukin (IL)-1β on DNA synthesis and cell proliferation in primary cultures of adult rat hepatocytes in order to elucidate the mechanisms of its action. Hepatocyte parenchymal cells maintained in a serum-free, defined medium synthesized DNA and proliferated in the presence of IL-1β (3-30 ...

journal_title：European journal of pharmacology

authors： Kimura M,Moteki H,Ogihara M

更新日期：2014-12-15 00:00:00

abstract：:The effect of high helium pressure on inhibitory synaptic transmission was studied in rat hippocampal slices with extracellular recordings. Both feed-forward and recurrent GABAergic inhibition were tested in the CA1 region with paired-pulse stimulation paradigms. The efficiency of both types of inhibition decreased un...

journal_title：European journal of pharmacology

authors： Zinebi F,Fagni L,Hugon M

更新日期：1988-08-24 00:00:00

abstract：:The effect of GABA (gamma-aminobutyric acid system) receptor agonists and antagonists on naloxone-induced jumping in morphine-dependent mice was examined. Intraperitoneal (i.p.) or intracerebroventricular (i.c.v.) injection of different doses of the GABA(B) receptor agonist, baclofen (2.5, 5 and 10 mg/kg), reduced nal...

journal_title：European journal of pharmacology

authors： Zarrindast MR,Mousa-Ahmadi E

更新日期：1999-09-24 00:00:00

abstract：:Although cannabinoids are known to be more effective analgesics against chronic rather than acute pain, the mechanism underlying this phenomenon is still unclear. We report now that contralateral thalamic cannabinoid CB(1) receptors are upregulated after unilateral axotomy of the tibial branch of the sciatic nerve, a ...

journal_title：European journal of pharmacology

authors： Siegling A,Hofmann HA,Denzer D,Mauler F,De Vry J

更新日期：2001-03-09 00:00:00

abstract：:Unilateral ureteral obstruction (UUO) is a well-established method to study interstitial fibrosis of the kidney. In this study, we investigated the effects of a calcium channel blocker, amlodipine, on UUO-induced renal interstitial fibrosis in mice. UUO significantly increased the fibrotic area in the obstructed kidne...

journal_title：European journal of pharmacology

authors： Honma S,Nakamura K,Shinohara M,Mitazaki S,Abe S,Yoshida M

更新日期：2016-06-05 00:00:00

abstract：:It has been shown that galanin plays a role in central cardiovascular regulation. Galanin administered centrally induces an increase of heart rate and a weak vasodepressor response, whereas the N-terminal galanin fragment (1-15) elicits vasopressor effects and tachycardia. Furthermore, it has been shown that galanin-(...

journal_title：European journal of pharmacology

authors： Narváez JA,Díaz-Cabiale Z,Hedlund PB,Aguirre JA,Coveñas R,González-Barón S,Fuxe K

更新日期：2000-07-07 00:00:00

abstract：:A comparison was made in awake rats between the analgesic and the respiratory depressant actions induced by the mu-opiate agonists morphine and Tyr-D-Ala-Gly-N-Me-Phe-Met-(O)-ol (FK-33824), and the delta-agonists Tyr-D-Ala-Gly-Phe-D-Leu ( DADLE ) and Tyr-D-Ser-Gly-Phe-D-Leu-Thr (D-Ser2- Thr6 ), injected into the cereb...

journal_title：European journal of pharmacology

authors： Pazos A,Flórez J

更新日期：1984-03-16 00:00:00

abstract：:Overexpression of Cav3.2 T-type Ca2+ channels in L4 dorsal root ganglion (DRG) participates in neuropathic pain after L5 spinal nerve cutting (L5SNC) in rats. The L5SNC-induced neuropathic pain also involves high mobility group box 1 (HMGB1), a damage-associated molecular pattern protein, and its target, the receptor ...

journal_title：European journal of pharmacology

authors： Tomita S,Sekiguchi F,Kasanami Y,Naoe K,Tsubota M,Wake H,Nishibori M,Kawabata A

更新日期：2020-12-05 00:00:00

abstract：:St. John's wort (Hypericum perforatum L.) is widely used for the treatment of mild to moderately severe depression. However, the nature of its active principles and the exact mode of antidepressant action are still unknown. It has been suggested repeatedly in preclinical and clinical studies that the content of the ac...

journal_title：European journal of pharmacology

authors： Simmen U,Bobirnac I,Ullmer C,Lübbert H,Berger Büter K,Schaffner W,Schoeffter P

更新日期：2003-01-05 00:00:00