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Characterization of scratching behavior induced by intradermal administration of morphine and fentanyl in mice.

Abstract：

:Itching is known as a commonly side effect of opioid administration. However, the relationship of opioid receptors to itching is unclear. In this study, we examined the effect of intradermal injection of morphine and fentanyl on the itching sensation. When injected intradermally into the rostral back of mice, morphine and fentanyl elicited scratching behavior. In addition, an opioid receptor antagonist, naloxone, and a peripherally restricted opioid receptor antagonist, naloxone methiodide, significantly suppressed morphine- and fentanyl-induced scratching behavior. Moreover, the morphine-induced scratching behavior was suppressed by histamine H(1) receptor antagonists, such as diphenhydramine, chlorpheniramine, epinastine and cetirizine. On the other hand, fentanyl-induced scratching behavior was not suppressed by histamine H(1) receptor antagonists. Additionally, scratching behavior induced by morphine and fentanyl were not suppressed by glucocorticoids (predonisolone and dexamethasone). In conclusion, opioid-induced itching may involve in peripheral opioid receptors. Moreover, histamine and arachidonic acid metabolites played no main role in opioid-induced scratching behavior.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Yamamoto A,Kuyama S,Kamei C,Sugimoto Y

doi

10.1016/j.ejphar.2009.10.066

subject

Has Abstract

pub_date

2010-02-10 00:00:00

pages

162-6

issue

1-3

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(09)00992-3

journal_volume

627

pub_type

杂志文章

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