当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PHARMACOLOGY期刊下所有文献 > Mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease.

Mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease.

Abstract：

:The past decade has witnessed a number of exciting developments in the field of mitochondrial dynamics - a phenomenon in which changes in mitochondrial shape and movement impact on cellular physiology and pathology. By undergoing fusion and fission, mitochondria are able to change their morphology between elongated interconnected networks and discrete fragmented structures, respectively. The cardiac mitochondria, in particular, have garnered much interest due to their unique spatial arrangement in the adult cardiomyocyte, and the multiple roles they play in cell death and survival. In this article, we review the role of the mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Ong SB,Kalkhoran SB,Cabrera-Fuentes HA,Hausenloy DJ

doi

10.1016/j.ejphar.2015.04.056

subject

Has Abstract

pub_date

2015-09-15 00:00:00

pages

104-14

issue

Pt A

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(15)00451-3

journal_volume

763

pub_type

杂志文章,评审

相关文献

EUROPEAN JOURNAL OF PHARMACOLOGY文献大全
  • Regulation of blood pressure by L-arginine-nitric oxide pathway within the superior colliculus of rats.

    abstract：:Injection into the superior colliculus of anaesthetised rats of the nitric oxide (NO) synthase inhibitor N(omega)-nitro-L-arginine methyl ester (L-NAME; 1 micromol), but not its inactive enantiomer N(omega)-nitro-D-arginine methyl ester (D-NAME; 1 micromol), significantly (P < 0.01) increased the mean arterial blood p...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(97)83029-4

    authors： D'Amico M,Rossi F,Warner TD

    更新日期：1997-06-05 00:00:00

  • An examination of age-related changes in pre- and postsynaptic alpha-adrenoceptors in the rat isolated vas deferens.

    abstract：:Age-related changes in pre- and postsynaptic alpha-adrenoceptors were investigated in prostatic and epididymal portions of vasa deferentia from young adult (2-3 month) and 24 month old Sprague-Dawley rats, using the selective alpha 1-agonist amidephrine and the selective alpha 2-agonist xylazine. Effects of agonists w...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(83)90631-3

    authors： Docherty JR,O'Malley K

    更新日期：1983-11-25 00:00:00

  • Alpha-flupenthixol-induced hyperactivity by chronic dosing in rats.

    abstract：:Socially reared and isolation-reared rats treated chronically since weaning with alpha-flupenthixol showed elevated levels of spontaneous locomotor activity compared with control treated rats. However, chronic apomorphine treatment had no effect on spontaneous locomotor activity. Chronic alpha-flupenthixol treatment e...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(76)90019-4

    authors： Sahakian BJ,Robbins TW,Iversen SD

    更新日期：1976-05-01 00:00:00

  • Release of neuropeptide Y and noradrenaline during afferent nerve stimulation.

    abstract：:The present study was carried out to investigate the possibility that noradrenaline (NA) and neuropeptide Y (NPY) are co-released after afferent vagal or saphenous stimulation (1, 5, 10 and 20 Hz) in chloralose-anaesthetized dogs. Electrical stimulation of the vagus elicited an increase in plasma NA levels for the 5, ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(92)90249-4

    authors： Montastruc P,Damase-Michel C,Tavernier G,Tran MA,Montastruc JL

    更新日期：1992-03-17 00:00:00

  • Selegiline attenuates cardiac oxidative stress and apoptosis in heart failure: association with improvement of cardiac function.

    abstract：:We have shown recently that selegiline exerts a cardiac neuroprotective effect in chronic heart failure. Since selegiline has an antioxidant antiapoptotic effect, we proposed to determine whether selegiline attenuates cardiac oxidative stress and myocyte apoptosis in chronic heart failure by modulating Bcl-2 and Bax p...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(03)01306-2

    authors： Qin F,Shite J,Mao W,Liang CS

    更新日期：2003-02-14 00:00:00

  • Structure-activity relationships of enkephalin analogs at opiate and enkephalin receptors: correlation with analgesia.

    abstract：:We have investigated the influence of physico-chemical parameters (chemical structure and lipophilicity), biochemical properties (catabolism, affinity for 3H-etorphine binding sites and 3H-(D-Ala)2-Leu5-enkephalin amide binding sites) and biological activity in isolated organs (guinea-pig ileum and mouse vas deferens)...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(80)90114-4

    authors： Audigier Y,Mazarguil H,Gout R,Cros J

    更新日期：1980-04-11 00:00:00

  • WISP1 overexpression promotes proliferation and migration of human vascular smooth muscle cells via AKT signaling pathway.

    abstract：:Proliferation and migration of vascular smooth muscle cells (VSMCs) play crucial roles in the development of vascular restenosis. Our previous study showed that CCN4, namely Wnt1 inducible signaling pathway protein 1 (WISP1), significantly promotes proliferation and migration of rat VSMCs, but its mechanism remains un...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2016.06.027

    authors： Lu S,Liu H,Lu L,Wan H,Lin Z,Qian K,Yao X,Chen Q,Liu W,Yan J,Liu Z

    更新日期：2016-10-05 00:00:00

  • Nicotine's opioid and anti-opioid interactions: proposed role in smoking behavior.

    abstract：:Nicotine produced antinociception in mice which was antagonized noncompetitively by naloxone. In addition, at significantly lower doses, nicotine noncompetitively antagonized morphine-induced antinociception. A speculative suggestion regarding the opiatergic and anti-opiatergic actions of nicotine is that it significa...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0926-6917(93)90009-f

    authors： Aceto MD,Scates SM,Ji Z,Bowman ER

    更新日期：1993-12-01 00:00:00

  • The effects of nitroglycerin during cardiopulmonary resuscitation.

    abstract：:The outcome for both in-hospital and out-of hospital cardiac arrest remains dismal. Vasopressors are used to increase coronary perfusion pressure and thus facilitate return of spontaneous circulation during cardiopulmonary resuscitation. However, they are associated with a number of potential adverse effects and may d...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejphar.2014.04.002

    authors： Stefaniotou A,Varvarousi G,Varvarousis DP,Xanthos T

    更新日期：2014-07-05 00:00:00

  • [125I]iodoclonazepam, a specific high affinity radioligand for the identification of BZ1 and BZ2 sites in rat brain.

    abstract：:Binding of the radioligand [125I]iodoclonazepam to three different areas of rat brain (cerebellum, hippocampus and striatum) has been characterised. In all three regions binding is rapid, saturable and of high affinity (cerebellum Bmax = 1.49 +/- 0.3 pmol/mg of protein, Kd = 0.39 +/- 0.06 nM; hippocampus Bmax = 1.5 +/...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(91)90484-8

    authors： Gillard NP,Quirk K,Ragan CI,McKernan RM

    更新日期：1991-04-03 00:00:00

  • Differential effects of selective and non-selective inhibition of nitric oxide synthase on the expression and activity of cyclooxygenase-2 during gastric ulcer healing.

    abstract：:Nitric oxide synthases (NOS) and cyclooxygenase-2 (COX-2) are important enzymes involved in ulcer healing but interactions between them have not been clearly defined. The aim of this study was to investigate the effects of selective or non-selective inhibition of NOS on the expression and activity of COX-2 during heal...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2005.12.088

    authors： Guo JS,Cho CH,Wang JY,Koo MW

    更新日期：2006-05-01 00:00:00

  • Studies on the role of 5-HT2C and 5-HT2B receptors in regulating generalised seizure threshold in rodents.

    abstract：:The present studies were conducted to investigate the role of 5-HT2C and 5-HT2B receptors in the generation of pentylenetetrazol and electroshock-evoked seizures. The 5-HT2C/2B receptor-preferring agonist 1-(m-chlorophenyl)-piperazine (mCPP; 2.5-7 mg/kg i.p.) weakly elevated seizure threshold in the mouse (but not the...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(98)00621-9

    authors： Upton N,Stean T,Middlemiss D,Blackburn T,Kennett G

    更新日期：1998-10-16 00:00:00

  • Interaction between inhibitors of inducible nitric oxide synthase and cyclooxygenase in adjuvant-induced arthritis in female albino rats: an isobolographic study.

    abstract：:We studied the interaction of S-methylisothiourea (a selective inducible nitric oxide synthase inhibitor) with rofecoxib (a selective cyclooxygenase-2 inhibitor) and mefenamic acid (a non-selective cyclooxygenase inhibitor) in adjuvant-induced arthritis in female albino Wistar rats, applying the isobolographic analysi...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2006.10.047

    authors： Bhat AS,Tandan SK,Kumar D,Krishna V,Prakash VR

    更新日期：2007-02-05 00:00:00

  • A direct relationship between aggressive behavior in the resident/intruder test and cell oxidative status in adult male mice.

    abstract：:Disturbances in oxidative metabolism are involved in many acute and chronic diseases, as well as in several other conditions. The objective of the present study was to examine the relationship between the level of intracellular reactive oxygen species in the peripheral blood granulocytes of mice, as evaluated by 2',7'...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2009.11.001

    authors： Rammal H,Bouayed J,Soulimani R

    更新日期：2010-02-10 00:00:00

  • The phytoestrogen genistein enhances endothelium-independent relaxation in the porcine coronary artery.

    abstract：:Genistein, a phytoestrogen, possesses cardioprotective effects. Responses to genistein (0.1-100 microM) were assessed in 9,11-dideoxy-9 alpha, 11 alpha-methanoepoxy prostaglandin F(2 alpha) (U46619)-contracted porcine coronary arterial rings, with significant relaxations at high concentrations. At concentrations with ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2003.09.028

    authors： Lee MY,Man RY

    更新日期：2003-11-28 00:00:00

  • The novel monoamine reuptake inhibitor and potential antidepressant, S33005, induces Arc gene expression in cerebral cortex.

    abstract：:Recent data show that corticolimbic expression of the effector immediate early gene Arc is up-regulated by standard antidepressant drugs. Here, we tested the effect upon Arc expression of a novel antidepressant and selective 5-hydroxytryptamine/noradrenaline reuptake inhibitor (SNRI), (-)1-(1-dimethylaminomethyl) 5-me...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2004.03.002

    authors： Pei Q,Sprakes M,Millan MJ,Rochat C,Sharp T

    更新日期：2004-04-12 00:00:00

  • Ischemia-induced impairment of 2-deoxyglucose uptake and CA1 field potentials in rat hippocampal slices: protection by 5-HT1A receptor agonists and 5-HT2 receptor antagonists.

    abstract：:Various in vitro models have been developed to study ischemia and/or hypoxia. In the present experiment, we examined whether hypoxia/hypoglycemia (ischemia) in rat hippocampal slices reduced the 2-deoxyglucose (2-DG) uptake and CA1 field potentials evoked by stimulation of Schaffer collaterals. Autoradiograms revealed...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(92)90281-8

    authors： Shibata S,Kagami-Ishi Y,Tominaga K,Kodama K,Ueki S,Watanabe S

    更新日期：1992-12-08 00:00:00

  • Evidence for the presence of P1-purinoceptors on cholinergic nerve terminals in the guinea-pig ileum.

    abstract：:The inhibitory effects of adenosine, ATP, 5'-adenylyl methylene diphosphonate (beta, gamma-meATP) and adenosine 5'-alpha, beta-methylene triphosphonate (alpha, beta-meATP) were compared on the cholinergic twitch responses to transmural stimulation of the guinea-pig ileum. Adenosine, ATP and beta, gamma-meATP reduced t...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(82)90527-1

    authors： Moody CJ,Burnstock G

    更新日期：1982-01-08 00:00:00

  • CysLT2 receptor activation is involved in LTC4-induced lung air-trapping in guinea pigs.

    abstract：:CysLT1 receptors are known to be involved in the pathogenesis of asthma. However, the functional roles of CysLT2 receptors in this condition have not been determined. The purpose of this study is to develop an experimental model of CysLT2 receptor-mediated LTC4-induced lung air-trapping in guinea pigs and use this mod...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2016.11.036

    authors： Sekioka T,Kadode M,Yonetomi Y,Kamiya A,Fujita M,Nabe T,Kawabata K

    更新日期：2017-01-05 00:00:00

  • Comparative actions of insulin sensitizers on ion channels in vascular smooth muscle.

    abstract：:Thiazolidinedione and isoxazolidinedione insulin sensitizers activate peroxisome proliferator-activated receptor gamma (PPAR gamma). Some thiazolidinediones modify ion channels in smooth muscles; however, the mechanism by which their actions occur has not been clarified. We, thus, examined the effects of three thiazol...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(01)01047-0

    authors： Eto K,Ohya Y,Nakamura Y,Abe I,Fujishima M

    更新日期：2001-06-29 00:00:00

  • Determination of the target proteins in chemotherapy resistant breast cancer stem cell-like cells by protein array.

    abstract：:Breast cancer comes second among the causes of cancer deaths of women. Although new generation hormone therapy is a promising strategy, re-occurrence or emergence of drug resistance limits the success. According to the theory of cancer stem cells (CSCs); CSCs are immortal, tumor inducing and self renewing pluripotent ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2019.01.052

    authors： Kars MD,Yıldırım G

    更新日期：2019-04-05 00:00:00

  • Vasodilator effects of dopaminomimetics in the perfused rat kidney.

    abstract：:The renal vascular effects of dopaminomimetics were studied in the isolated perfused rat kidney after pretreatment with 10(-5) M phenoxybenzamine and 10(-5) M sotalol and after contraction of the vascular bed with prostaglandin F2 alpha (10(-7) to 3 x 10(-6) M). Under these conditions, our criterion for vascular dopam...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(82)90157-1

    authors： Schmidt M,Imbs JL,Giesen EM,Schwartz J

    更新日期：1982-10-15 00:00:00

  • Dopamine D1 receptor stimulation increases striatal acetylcholine release in the rat.

    abstract：:The effect of selective D1 receptor agonists on acetylcholine (ACh) release in the striatum was investigated using in vivo microdialysis. Administration of the reactive enantiomer, (+)-SKF 38393 (2, 10 mg/kg s.c.), doses which elevate grooming and sniffing behaviour, increased ACh release by 40 and 75%, respectively. ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(90)90456-g

    authors： Damsma G,Tham CS,Robertson GS,Fibiger HC

    更新日期：1990-09-21 00:00:00

  • Nocistatin reverses nociceptin inhibition of glutamate release from rat brain slices.

    abstract：:We have examined the effects of the recently described heptadecapeptide nocistatin on K+-evoked glutamate release from rat cerebrocortical slices in vitro. In vivo, nocistatin reverses the action of nociceptin. Nocistatin (100 nM, n = 7) did not inhibit K+-evoked glutamate release alone. Nociceptin (100 nM) inhibited ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(98)00545-7

    authors： Nicol B,Lambert DG,Rowbotham DJ,Okuda-Ashitaka E,Ito S,Smart D,McKnight AT

    更新日期：1998-09-04 00:00:00

  • Ca2+ channel blockade prevents lysergic acid diethylamide-induced changes in dopamine and serotonin metabolism.

    abstract：:To investigate the effect of a single and multiple administration of lysergic acid diethylamide (LSD) on cerebral metabolism of dopamine and serotonin, male Wistar rats were treated with low and high doses (0.1 and 2.0 mg/kg i.p.) of LSD and the levels of dopamine, 3,4-dihydroxyphenylacetic acid, homovanillic acid, 3-...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(97)01025-x

    authors： Antkiewicz-Michaluk L,Románska I,Vetulani J

    更新日期：1997-07-30 00:00:00

  • Persistence of the effects of ethanol in vitro on the lipid order and enzyme activities of chick-liver membranes.

    abstract：:Results demonstrate for the first time that ethanol exerts two different effects on the lipid order of chick-liver mitochondria and microsomes: a fluidizing effect both in the core and at the surface of the membrane, which depends on its physical presence, and a rigidization of the surface of these membranes which occ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0926-6917(95)90025-x

    authors： Sanchez-Amate MC,Carrasco MP,Zurera JM,Segovia JL,Marco C

    更新日期：1995-03-16 00:00:00

  • Epithelium-derived inhibitory factor in human bronchus.

    abstract：:The potencies of histamine and methacholine were significantly increased by approximately 2- and 5-fold respectively in human non-diseased isolated bronchi on removal of the epithelium. In contrast, no increases in spasmogen potency were observed following epithelium removal in bronchi obtained from a sample of asthma...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(90)90360-i

    authors： Fernandes LB,Preuss JM,Paterson JW,Goldie RG

    更新日期：1990-10-23 00:00:00

  • Inhibitory effect of 2-phenyl-4-quinolone on serotonin-mediated changes in the morphology and permeability of endothelial monolayers.

    abstract：:The integrity of endothelial cell monolayers, a critical requirement for barrier maintenance, is needed for the prevention of edema formation. To investigate the mechanisms by which 2-phenyl-4-quinolone (YT-1) provided protection against serotonin-induced exudation, rat heart endothelial cell cultures were used. In th...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(97)01203-x

    authors： Lee HZ

    更新日期：1997-09-24 00:00:00

  • Effects of adrenoceptor antagonists on the hyperthermia and hyperglycemia induced by prostaglandin F2 alpha in rats.

    abstract：:We investigated the effects of intraperitoneal administration of adrenoceptor antagonists to the hyperthermia and hyperglycemia induced by prostaglandin F2 alpha (50 micrograms) injected into the third cerebral ventricle in anesthetized rats. Phentolamine inhibited the hyperthermia and hyperglycemia induced by prostag...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(94)90043-4

    authors： Nonogaki K,Iguchi A,Sakamoto N

    更新日期：1994-09-01 00:00:00

  • Acute and chronic bupropion treatment does not prevent morphine-induced conditioned place preference in mice.

    abstract：:A substantial barrier to the treatment of Opioid Use Disorder (OUD) is the elevated relapse rates in affected patients, and a significant contributor to these events of relapse is exposure to cues and contexts that are intensely associated with prior drug abuse. The neurotransmitter dopamine plays a key role in reward...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2020.173638

    authors： McKendrick G,Sharma S,Sun D,Randall PA,Graziane NM

    更新日期：2020-12-15 00:00:00