Nicotine's opioid and anti-opioid interactions: proposed role in smoking behavior.

abstract：:The endogenous release of adenosine 5'-triphosphate (ATP) from strips of guinea-pig gallbladder during transmural stimulation (TS) was measured with a firefly luciferine-luciferase reaction. TS (15V, 1 ms, 0.5-5 Hz, for 1 min) caused a rapid and marked increase of ATP release in a frequency-dependent manner. Both ATP ...

journal_title：European journal of pharmacology

authors： Takahashi T,Kusunoki M,Ishikawa Y,Kantoh M,Yamamura T,Utsunomiya J

更新日期：1987-01-28 00:00:00

abstract：:The effects of propofol, pentobarbital, alphaxalone, etomidate and diazepam on t-[35S]butylbicyclophosphorothionate ([35S]TBPS) binding to membrane preparations from rat cerebral cortex were studied in the absence of gamma-aminobutyric acid (GABA). Addition of low concentrations (3-10 microM) of propofol to washed mem...

journal_title：European journal of pharmacology

authors： Concas A,Santoro G,Mascia MP,Maciocco E,Dazzi L,Biggio G

更新日期：1994-04-15 00:00:00

abstract：:The administration of radioactive angiotensin I to the retrogradely perfused feline adrenal gland caused a brisk discharge of catecholamines. Recovery of the labelled decapeptide and metabolites in the adrenal effluent fluid was complete in 5 min. Radioimmunoassay of this perfusate revealed that most of the peptide re...

journal_title：European journal of pharmacology

authors： Ackerly JA,Felger TS,Peach MJ

更新日期：1976-07-01 00:00:00

abstract：:The spasmolytic activity of synthetic alpha-human atrial natriuretic peptide (alpha-hANP) and its related peptides was determined in vitro using the chick rectum and the rat aorta. Natriuretic activity was also measured in the anesthetized rat, alpha-hANP-(7-28), with the NH2-terminal hexapeptide truncated, had greate...

journal_title：European journal of pharmacology

authors： Watanabe TX,Noda Y,Chino N,Nishiuchi Y,Kimura T,Sakakibara S,Imai M

更新日期：1988-02-16 00:00:00

abstract：:Transient activation of the outward K+ current caused by a rise in the cytosolic free Ca2+ concentration, [Ca2+]i was the predominant change in plasma membrane ion flux during the first phase of thyrotropin-releasing hormone (TRH) action on pituitary cells. Following the intracellular application of inhibitors of 1,2-...

journal_title：European journal of pharmacology

authors： Mollard P,Vacher P,Dufy B,Winiger BP,Schlegel W

更新日期：1989-03-07 00:00:00

abstract：:The effects of group 2- versus group 3-selective metabotropic glutamate (mGlu) receptor agonists were examined against forskolin (10 microM)-, vasoactive intestinal peptide (VIP; 1 microM)- and 5'-N-ethylcarboxamidoadenosine (NECA; 10 microM)-stimulated cAMP accumulations in adult rat hippocampal slices (in the presen...

journal_title：European journal of pharmacology

authors： Wright RA,Schoepp DD

更新日期：1996-02-22 00:00:00

abstract：:Docetaxel is a first line chemotherapy agent, which stabilizes microtubules in metastatic prostate cancer (PCa). Resistance to Docetaxel and its side effects remain as obstacle for its efficacy in monotherapy. Recently, combination with novel adjuvants have been emerged as a beneficial alternative strategy, which targ...

journal_title：European journal of pharmacology

authors： Eftekhari S,Montazeri H,Tarighi P

更新日期：2020-07-05 00:00:00

abstract：:Population spikes associated with the paired pulse ratio protocol were used to measure the presynaptic inhibition of corticostriatal transmission caused by mu-opioid receptor activation. A 1 microM of [D-Ala(2), N-MePhe(4), Gly-ol(5)]-enkephalin (DAMGO), a selective mu-opioid receptor agonist, enhanced paired pulse fa...

journal_title：European journal of pharmacology

authors： Barral J,Mendoza E,Galarraga E,Bargas J

更新日期：2003-02-21 00:00:00

abstract：:Single myocytes isolated from the guinea-pig ventricle were used under voltage-clamp conditions to study the activity of a newly developed drug, R56865, a benzothiazolamine derivative, against digitalis toxicity. Multicellular Purkinje preparations were used in some experiments. The drug blocked the transient inward c...

journal_title：European journal of pharmacology

authors： Leyssens A,Carmeliet E

更新日期：1991-04-10 00:00:00

abstract：:The effects of P2Y receptor agonists on smooth muscle membrane potential in isolated ring segments of rat mesenteric artery were examined by intracellular microelectrodes. In the presence of inhibitors of nitric oxide-synthase and cyclo-oxygenase, the selective P2Y1 receptor agonist adenosine 5'-O-thiodiphosphate (ADP...

journal_title：European journal of pharmacology

authors： Malmsjö M,Erlinge D,Högestätt ED,Zygmunt PM

更新日期：1999-01-08 00:00:00

abstract：:Endothelin produced a concentration-dependent (1 nM-0.3 microM) contraction of isolated guinea-pig airways (trachea and main bronchi). The response was unaffected by tetrodotoxin (1 microM) and slightly depressed by indomethacin (5 microM) but promptly abolished by isoprenaline (1 microM) or EDTA (3 mM). In the bronch...

journal_title：European journal of pharmacology

authors： Maggi CA,Patacchini R,Giuliani S,Meli A

更新日期：1989-01-24 00:00:00

abstract：:The Nuclear factor (erythroid 2-derived)-like 2 (Nrf2) plays a key role in inflammation which is implicated in the pathophysiology of depression. The Nrf2 activators have antidepressant effects in animal models of depression. The present study was undertaken to examine whether TBE-31 [(±)-(4bS,8aR,10aS)-10a-ethynyl-4b...

journal_title：European journal of pharmacology

authors： Yao W,Zhang JC,Ishima T,Ren Q,Yang C,Dong C,Ma M,Saito A,Honda T,Hashimoto K

更新日期：2016-12-15 00:00:00

abstract：:In rats adapted to a +30 degrees C temperature for one week, transfer to a temperature of +4 degrees C increased immunoassay-able serum TSH from 150-300 ng/ml to 800-2000 ng/ml in 30 min. Since this response, as well as the level of serum TSH without stimulation, were decreased by reserpine, phentolamine, phenoxybenza...

journal_title：European journal of pharmacology

authors： Tuomisto J,Ranta T,Männistö P,Saarinen A,Leppälioto J

更新日期：1975-02-01 00:00:00

abstract：:Cannabinoids have been widely reported to produce antinociception in models such as tail flick and hot plate. However, their role in modulating thermal hyperalgesia is unknown. The potency of some drugs, such as the opioids, increases during hyperalgesia. Thus, we evaluated whether there is a change in the effectivene...

journal_title：European journal of pharmacology

authors： Richardson JD,Aanonsen L,Hargreaves KM

更新日期：1998-03-19 00:00:00

abstract：:Our previous studies demonstrated that light-induced vascular relaxation (photorelaxation) was mediated by a tissue source of nitric oxide that was independent of endothelial nitric oxide synthase (eNOS), but sensitive to inhibitors of soluble guanylate cyclase, extracellular nitric oxide scavengers and possessed the ...

journal_title：European journal of pharmacology

authors： Ng ES,Cheng ZJ,Ellis A,Ding H,Jiang Y,Li Y,Hollenberg MD,Triggle CR

更新日期：2007-04-10 00:00:00

abstract：:Disturbances in myocyte calcium homeostasis are hypothesized to be one cause for cardiac arrhythmia. The full development of this hypothesis requires (i) the identification of all sources of arrhythmogenic calcium and (ii) an understanding of the mechanism(s) through which calcium initiates arrhythmia. To these ends w...

journal_title：European journal of pharmacology

authors： Wolkowicz P,Umeda PK,Sharifov OF,White CR,Huang J,Mahtani H,Urthaler F

更新日期：2014-02-05 00:00:00

abstract：:A series of tertiary amines structurally related to the potent muscarinic agent oxotremorine showed weak stimulant activity on the frog rectus abdominis preparation. The corresponding quaternary ammonium salts were more effective stimulants, the most potent being half as active as carbachol. The effects appeared to be...

journal_title：European journal of pharmacology

authors： Ringdahl B

更新日期：1984-03-23 00:00:00

abstract：:We investigated the involvement of p160ROCK (a Rho-associated coiled coil-forming protein kinase), one of Rho kinases on superoxide anion production (O(2)(-) production), aggregation and adhesion of human polymorphonuclear leukocytes under physiological condition, using a selective p160ROCK inhibitor, (+)-(R)-trans-4-...

journal_title：European journal of pharmacology

authors： Kawaguchi A,Ohmori M,Harada K,Tsuruoka S,Sugimoto K,Fujimura A

更新日期：2000-09-08 00:00:00

abstract：:We investigated the effects of ginsenosides, the active ingredient of ginseng, on neuronal or muscle-type nicotinic acetylcholine receptor channel activity expressed in Xenopus oocytes after injection of cRNA encoding bovine neuronal alpha3beta4, alpha7 or human muscle alphabetadeltavarepsilon subunits. Treatment with...

journal_title：European journal of pharmacology

authors： Choi S,Jung SY,Lee JH,Sala F,Criado M,Mulet J,Valor LM,Sala S,Engel AG,Nah SY

更新日期：2002-05-03 00:00:00

abstract：:Inhibition of the p38 mitogen-activated protein kinase (MAP Kinase) pathway reduces acute ischemic injury in vivo, suggesting a direct role for this signaling pathway in a number of neurodegenerative processes. The present study was designed to evaluate further the role of p38 MAP Kinase in acute excitotoxic neuronal ...

journal_title：European journal of pharmacology

authors： Legos JJ,McLaughlin B,Skaper SD,Strijbos PJ,Parsons AA,Aizenman E,Herin GA,Barone FC,Erhardt JA

更新日期：2002-06-28 00:00:00

abstract：:The persistence of neurogenesis raises the idea that neurons produced by the resident or transplanted neural stem cells could replace the neurons lost from brain injury or neurodegenerative disease. Therefore, compounds or methods for promoting neuronal differentiation become the focus of neurodegenerative disease the...

journal_title：European journal of pharmacology

authors： Huang JY,Ma YZ,Yuan YH,Zuo W,Chu SF,Liu H,Du GH,Zhang DM,Chen NH

更新日期：2016-09-05 00:00:00

abstract：:In this study we have investigated the functional activity of GR127935 (2-methyl-1,2,4 oxadiazol-3-yl)-biphenyl-[4-carboxylic acid 4-methoxy-3-(4-methyl-piperazine-1-yl]-amide) at human 5-HT1D alpha and 5-HT1D beta receptors which have been expressed in a Chinese Hamster Ovary (CHO) cell line. Using [35S] GTP gamma S ...

journal_title：European journal of pharmacology

authors： Watson JM,Burton MJ,Price GW,Jones BJ,Middlemiss DN

更新日期：1996-10-31 00:00:00

abstract：:The objective of the present studies was to investigate the effect of voluntary ethanol consumption for 21 days on the brain beta-endorphin system of C57BL/6 (alcohol-preferring) and DBA/2 (alcohol-avoiding) strains of mice. As expected, C57BL/6 mice consumed a significantly higher quantity of the 10% ethanol solution...

journal_title：European journal of pharmacology

authors： De Waele JP,Gianoulakis C

更新日期：1994-06-02 00:00:00

abstract：:Lycopene has attracted significant research interest due to its beneficial therapeutic effects, which include anti-oxidant, neuro-protective and anti-cancer effects, but the mechanisms of its beneficial action are not clear so far. The present study was carried out to elucidate the neuroprotective effect of lycopene a...

journal_title：European journal of pharmacology

authors： Prakash A,Kumar A

更新日期：2014-10-15 00:00:00

abstract：:An intricate surveillance network consisting of enteroendocrine cells, immune cells and sensory nerve fibres monitors the luminal and interstitial environment in the alimentary canal. Functional bowel disorders are characterized by persistent alterations in digestive regulation and gastrointestinal discomfort and pain...

journal_title：European journal of pharmacology

authors： Holzer P

更新日期：2001-10-19 00:00:00

abstract：:Nitric oxide (NO) is continuously produced in the lung and can be measured in exhaled gas of different species. To investigate a possible neuro-humoral regulation of pulmonary NO production in vivo we injected veratrine, an activator of Na(+) channels known to activate the sympathoadrenal system, in anaesthetized, mec...

journal_title：European journal of pharmacology

authors： Adding LC,Agvald P,Artlich A,Gustafsson LE

更新日期：2001-01-12 00:00:00

abstract：:The effect of two serotonin precursors, 5-hydroxytryptophan (5-OH-TRP) and indolepyruvic acid (IPA), a tryptophan ketoanalogue, on rat pineal indole metabolism during the light-dark cycle was investigated. 5-OH-TRP drastically increased the production of 5-hydroxyindoleacetic acid at a dose of only 10 mg/kg, whereas 5...

journal_title：European journal of pharmacology

authors： Ferretti C,Blengio M,Ghi P,Genazzani E

更新日期：1990-10-23 00:00:00

abstract：:GABAA receptors are pentameric chloride ion channels that are opened by GABA. We have screened a cell line derived from human glioblastoma, U3047MG, for expression of GABAA receptor subunit isoforms and formation of functional ion channels. We identified GABAA receptors subunit α2, α3, α5, β1, β2, β3, δ, γ3, π, and θ ...

journal_title：European journal of pharmacology

authors： Babateen O,Jin Z,Bhandage A,Korol SV,Westermark B,Forsberg Nilsson K,Uhrbom L,Smits A,Birnir B

更新日期：2015-02-05 00:00:00

abstract：:The in vivo bronchoconstrictor effect of tachykinins in Fisher 344 rats is accompanied by release into the airways of 5-hydroxytryptamine (5-HT). 5-HT is possibly derived from mast cells. In the present study the presumed mast cell-tachykinin interaction was studied in isolated trachea from Fisher 344 rats. Contractio...

journal_title：European journal of pharmacology

authors： Joos GF,Lefebvre RA,Bullock GR,Pauwels RA

更新日期：1997-11-12 00:00:00

abstract：:Pre- and postjunctional pA2 values of the muscarinic antagonist hexahydrosiladifenidol were determined with guinea-pig ileum and rat heart. Hexahydrosiladifenidol did not discriminate between pre- and postjunctional receptors within the same organ but was more potent on the ileum (20-80 times) than on the heart. It is...

journal_title：European journal of pharmacology

authors： Fuder H,Kilbinger H,Müller H

更新日期：1985-07-11 00:00:00