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Adenosine 5'-triphosphate release evoked by electrical nerve stimulation from the guinea-pig gallbladder.

Abstract：

:The endogenous release of adenosine 5'-triphosphate (ATP) from strips of guinea-pig gallbladder during transmural stimulation (TS) was measured with a firefly luciferine-luciferase reaction. TS (15V, 1 ms, 0.5-5 Hz, for 1 min) caused a rapid and marked increase of ATP release in a frequency-dependent manner. Both ATP release and contractions evoked by TS (15 V, 5 Hz, 1 ms) were completely abolished in Ca-free medium. BaCl2 (3 X 10(-3) M), a direct muscle stimulant, produced almost the same degree of contractile tension as TS (15 V, 5 Hz, 1 ms) while the ATP release induced by BaCl2 was significantly reduced to about 60 percent of that induced by TS. Atropine (10(-6) M) significantly reduced TS-evoked contraction without affecting ATP release. It was suggested, therefore, that some of the ATP release induced by TS was of neural origin. Theophylline (a P1-purinoreceptor antagonist) 10(-6) M, quinidine (a non-specific P2-purinoreceptor antagonist) 10(-6) M and apamin (a potassium channel blocking agent) 10(-8) M had no effects on TS-evoked contraction and ATP release, suggesting the absence of a presynaptic autoregulatory mechanism of ATP release in the guinea-pig gallbladder.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Takahashi T,Kusunoki M,Ishikawa Y,Kantoh M,Yamamura T,Utsunomiya J

doi

10.1016/0014-2999(87)90133-6

subject

Has Abstract

pub_date

1987-01-28 00:00:00

pages

77-82

issue

1

eissn

0014-2999

issn

1879-0712

pii

0014-2999(87)90133-6

journal_volume

134

pub_type

杂志文章

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