Abstract:
:The targets which mediate the actions of the volatile general anaesthetic isoflurane are unknown. Based on pharmacological studies using GABA(A) receptor antagonists it has recently been suggested that GABA(A) receptors would not mediate the immobilizing action of isoflurane. Using the beta3(N265M) knock-in mouse model we found that the mutant mice were less sensitive to the immobilizing action of isoflurane, indicating a role of beta3-containing GABA(A) receptors in mediating immobility. At high concentrations isoflurane also immobilizes beta3(N265M) mice, indicating that other targets also mediate immobility. Thus, our findings support a multisite model for the immobilizing action of isoflurane.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Lambert S,Arras M,Vogt KE,Rudolph Udoi
10.1016/j.ejphar.2005.04.030keywords:
subject
Has Abstractpub_date
2005-05-23 00:00:00pages
23-7issue
1eissn
0014-2999issn
1879-0712pii
S0014-2999(05)00412-7journal_volume
516pub_type
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journal_title:European journal of pharmacology
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