Diallyl disulfide ameliorates gentamicin-induced oxidative stress and nephropathy in rats.

abstract：:The aim of the present study was to investigate the contribution of extracellular signal regulated kinase-1/2 (ERK1/2) to pulmonary artery contraction in response to 4-aminopyridione (4-AP), an inhibitor of a voltage-gated K(+) channels that regulate pulmonary vascular tone. Pulmonary artery rings 1-1.5 mm in diameter...

journal_title：European journal of pharmacology

authors： Han W,Tang X,Wu H,Liu Y,Zhu D

更新日期：2007-08-13 00:00:00

abstract：:7-Nitroindazole (a selective neuronal nitric oxide (NO) synthase inhibitor) at 25 and 50 mg/kg, 30 min before the test, did not influence the electroconvulsive threshold. However, at 50 mg/kg, it enhanced the anticonvulsive activity of phenobarbital against maximal electroshock and did not affect that of carbamazepine...

journal_title：European journal of pharmacology

authors： Borowicz KK,Kleinrok Z,Czuczwar SJ

更新日期：1997-07-23 00:00:00

abstract：:The rapid breakout of the coronavirus disease of 2019 (COVID-19) has been declared pandemic with serious global concern due to high morbidity and mortality. As we enter the phase beyond limitations there is an urgent need for explicit treatment against COVID-19. To face this immediate global challenge, drug developmen...

journal_title：European journal of pharmacology

authors： Bibi N,Gul S,Ali J,Kamal MA

更新日期：2020-10-15 00:00:00

abstract：:There is now evidence from human studies to suggest that cardiac beta-adrenoceptor density and coupling to adenylate cyclase may be regulated in a subtype selective fashion. An animal model was used to investigate this further. Rats were infused for 6 days with the non-selective full agonist isoprenaline (n = 6) or th...

journal_title：European journal of pharmacology

authors： Arnold IR,Mistry R,Barnett DB

更新日期：1993-05-15 00:00:00

abstract：:The beta-carboline FG 7142 was studied alone and in combination with Ro 15-1788, CGS 8216 and lorazepam in squirrel monkeys trained to respond under a fixed-interval (FI) schedule of food presentation. FG 7142 (0.3-5.6 mg/kg i.v.) produced dose-related decreases in the rate of FI responding, effects opposite to those ...

journal_title：European journal of pharmacology

authors： Wettstein JG

更新日期：1989-04-25 00:00:00

abstract：:We have previously reported that subacute hypoxia activates lung 15-lipoxygenase (15-LOX), which catalyzes arachidonic acid to produce 15-HETE, leading to constriction of neonatal rabbit pulmonary arteries. Subacute hypoxia suppresses Kv3.4 channel expression and results in an inhibition of whole-cell K(+) currents (I...

journal_title：European journal of pharmacology

authors： Guo L,Tang X,Tian H,Liu Y,Wang Z,Wu H,Wang J,Guo S,Zhu D

更新日期：2008-06-10 00:00:00

abstract：:We assessed the intrinsic activity of the purported selective muscarinic M1 receptor agonist SR 95639A (morpholinoethylamino-3-benzocyclohepta-(5,6-c)-pyridazine) in inducing several receptor-mediated signals. Our results indicate that SR 95639A lacks the ability to activate phosphoinositide hydrolysis in rat cerebral...

journal_title：European journal of pharmacology

authors： Mohamed AS,Forray C,Aly MH,el-Fakahany EE

更新日期：1992-10-01 00:00:00

abstract：:The effect and role of nitric oxide (NO) in the regulation of ion transport in the mouse cecum were investigated. L-arginine, used to increase NO production, increased short-circuit current (Isc), a measure of ion transport, in a concentration-dependent manner with a maximal increase of 193.8+/-65.5 microA/cm2. This i...

journal_title：European journal of pharmacology

authors： Homaidan FR,Martello LA,Melson SJ,Burakoff R

更新日期：1998-05-29 00:00:00

abstract：:Sabiporide, a new benzoguanidine, was characterized on fibroblasts stably expressing the Na(+)/H(+) exchanger isoforms NHE-1, NHE-2 and NHE-3. 22Na(+) uptake experiments show that this compound possesses a K(i) of 5+/-1.2 x 10(-8) M for NHE-1, and discriminates efficiently between the NHE-1, -2 and -3 isoforms (K(i) f...

journal_title：European journal of pharmacology

authors： Touret N,Tanneur V,Godart H,Seidler R,Taki N,Bürger E,Dämmgen J,Counillon L

更新日期：2003-01-17 00:00:00

abstract：:The involvement of peptidoleukotrienes (LTs) in mediating the increase in microvascular permeability associated with experimental cutaneous immediate hypersensitivity was studied by examining the effect of SK&F 104353, a potent and selective LT-antagonist, on the response evoked by graded, intradermal injections of an...

journal_title：European journal of pharmacology

authors： Woodward DF,Nieves AL,Williams LS,Gary RK Jr,Wasserman MA,Gleason JG

更新日期：1989-05-19 00:00:00

abstract：:The effects of paeoniflorin, a glycoside isolated from the root of Paeonia lactiflora, on ion currents in a mouse neuroblastoma and rat glioma hybrid cell line, NG108-15 were investigated. Paeoniflorin (1-300 microM) reversibly produced an inhibition of L-type voltage-dependent Ca2+ current (I(Ca,L)) in a concentratio...

journal_title：European journal of pharmacology

authors： Tsai TY,Wu SN,Liu YC,Wu AZ,Tsai YC

更新日期：2005-10-31 00:00:00

abstract：:Kakkon-to is composed of seven medicinal herbs and exhibited novel antipyretic activity by suppressing interleukin-1alpha production responsive to interferon in a murine intranasal influenza virus infection model. Using this model, antipyretic compounds with such novel biological activities were characterized from the...

journal_title：European journal of pharmacology

authors： Kurokawa M,Kumeda CA,Yamamura J,Kamiyama T,Shiraki K

更新日期：1998-05-01 00:00:00

abstract：:Dopamine (DA) was injected in the third brain ventricle of goats and the thermoregulatory effects were studied under different ambient conditions. The effects depended on dose, ambient conditions and cannula used. In the cold, there was a drop in body temperature, sometimes accompanied by suppression of shivering and ...

journal_title：European journal of pharmacology

authors： De Roij TA,Frens J,Bakker J,Németh F

更新日期：1977-05-01 00:00:00

abstract：:Thirteen Ca2+ entry blockers were compared with respect to their inhibitory effects on the activity of smooth muscle myosin light-chain kinase and smooth muscle protein kinase C, and the Ca2+-induced contraction of basilar artery rings. Comparison of the IC50 values obtained for these compounds, suggests that with the...

journal_title：European journal of pharmacology

authors： Schächtele C,Wagner B,Rudolph C

更新日期：1989-04-12 00:00:00

abstract：:The intracerebral injection technique was used to apply dopamine directly into dopamine-containing areas of the mesolimbic system, the nucleus accumbens septi, tuberculum olfactorium and nucleus amygdaloideus centralis. 200 mug dopamine injected bilaterally into the nucleus accumbens septi caused a stereotyped sniffin...

journal_title：European journal of pharmacology

authors： Costall B,Naylor RJ

更新日期：1975-05-01 00:00:00

abstract：:The effect of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (NMPTP) on central monoamine neurons in mice was investigated using histo- and biochemical techniques. NMPTP (2 X 10 mg/kg i.v.) produced a rapid and long-lasting reduction (-30%) of striatal dopamine, while the dopamine levels were only transiently reduced in...

journal_title：European journal of pharmacology

authors： Hallman H,Olson L,Jonsson G

更新日期：1984-01-13 00:00:00

abstract：:The action of a new effective antiarrhythmic agent, encainide, was studied with respect to the mechanical performance of isolated cat papillary muscle. Encainide (0.1-10 micrograms/ml) did not alter the performance of cardiac muscle during either the contraction or relaxation phase. By contrast, lidocaine (1-5 microgr...

journal_title：European journal of pharmacology

authors： Brutsaert DL

更新日期：1981-12-03 00:00:00

abstract：:Recent reports of increased diabetes risk have raised concerns regarding the use of statins. The present study was therefore planned to clarify whether atorvastatin can prevent diabetes development in a rat model of type 2 diabetes mellitus. Eight week old male Wistar rats were randomized into three groups (n = 12 eac...

journal_title：European journal of pharmacology

authors： Madhu SV,Aslam M,Galav V,Bhattacharya SK,Jafri AA

更新日期：2014-04-05 00:00:00

abstract：:Carbocyclic thromboxane A2 (CTA2) constricted rabbit basilar and saphenous arteries. The contractions of the basilar artery, but not those of the saphenous artery, were potently inhibited by the calcium antagonist nimodipine. Selective inhibition of thromboxane-induced vasoconstriction of cerebral vessels may contribu...

journal_title：European journal of pharmacology

authors： Towart R,Perzborn E

更新日期：1981-01-16 00:00:00

abstract：:Electrically stimulated release of [3H]dopamine [( 3H]DA) in slices of rat striatum was dose dependently inhibited by apomorphine (67% maximal inhibition) with an EC50 of 17 nM. DA receptor inactivation with N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ; 0.5 and 2 mg/kg) dose dependently shifted the ED50 for ap...

journal_title：European journal of pharmacology

authors： Yokoo H,Goldstein M,Meller E

更新日期：1988-10-18 00:00:00

abstract：:It has been suggested that morphine-6-glucuronide, a major metabolite of the opioid analgesic morphine, is more potent as an analgesic than the parent drug. This finding appears not to be due to differences in affinity for opioid receptors. Therefore, in the present study the opioid receptor mediated effects of morphi...

journal_title：European journal of pharmacology

authors： Schmidt N,Brune K,Geisslinger G

更新日期：1994-04-01 00:00:00

abstract：:This study was designed to assess whether nitroglycerin would improve the relationship between O2 supply and O2 consumption in the reperfused ischemic dog myocardium. In 16 dogs the left anterior descending coronary artery was occluded for 2 h, followed by a 4 h period of reperfusion. In 8 of the 16 dogs, an infusion ...

journal_title：European journal of pharmacology

authors： Joselevitz-Goldman J,Acad BA,Weiss HR

更新日期：1989-07-18 00:00:00

abstract：:In view of the scarce information about the analgesic mechanism of kappa-opioid receptor agonists, the objective of the present study was to determine whether nitric oxide (NO) is involved in the peripheral antinociception of bremazocine, a kappa-opioid receptor agonist. Three drugs all interfering with the L-arginine...

journal_title：European journal of pharmacology

authors： Amarante LH,Duarte ID

更新日期：2002-11-01 00:00:00

abstract：:Clonidine and methysergide constrict the rabbit auricular artery by activating smooth muscle alpha-adrenoceptors. Clonidine inhibits and methysergide enhances responses to stimulation of the sympathetic nerves. Both drugs sensitise the artery to a variety of vasoconstrictor stimuli, although not to potassium chloride....

journal_title：European journal of pharmacology

authors： Fozard JR

更新日期：1976-03-01 00:00:00

abstract：:The analgesic effect of cyclazocine microinjected into the diencephalon of rats was studied by using the bradykinin-induced flexor reflex test. The dorsal portion of the medial hypothalamic area was sensitive to cyclazocine with respect to the production of analgesia (ED50 2.6 micrograms/rat). Microinjections of morph...

journal_title：European journal of pharmacology

authors： Kawajiri S,Satoh M

更新日期：1985-04-23 00:00:00

abstract：:Nicotine is one of the most representative components in cigarette smoke leading to gastric ulceration. Both ornithine decarboxylase and potassium ion (K(+)) channels are essential for cell growth and wound repair. The aim of the present study is to elucidate the causative relationship of these two factors during woun...

journal_title：European journal of pharmacology

authors： Shin VY,Liu ES,Koo MW,Luo JC,So WH,Cho CH

更新日期：2002-05-24 00:00:00

abstract：:One of the best known bioactive triterpenoids is oleanolic acid, a widespread 3-hydroxy-17-carboxy oleanane-type compound. In order to determine whether further oxidation of carbon 3 affects anti-inflammatory activity in mice, different tests were carried out on oleanolic acid and its 3-oxo-analogue oleanonic acid, wh...

journal_title：European journal of pharmacology

authors： Giner-Larza EM,Máñez S,Recio MC,Giner RM,Prieto JM,Cerdá-Nicolás M,Ríos JL

更新日期：2001-09-28 00:00:00

abstract：UNLABELLED:This study analyzed the role of nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF) in gender differences in the renal vascular reactivity of rats. Renal responses to vasoconstrictors and vasodilators were studied in isolated kidneys from male and female rats under basal conditions, after...

journal_title：European journal of pharmacology

authors： Wangensteen R,Moreno JM,Sainz J,Rodríguez-Gómez I,Chamorro V,Luna Jde D,Osuna A,Vargas F

更新日期：2004-02-23 00:00:00

abstract：:In the spinal cord of the pentobarbitone-anaesthetised cat, microelectrophoretic pitrazepin reduced the inhibitory effects on neuronal firing of both glycine and GABA. ...

journal_title：European journal of pharmacology

authors： Curtis DR,Gynther BD

更新日期：1986-11-19 00:00:00

abstract：:A 5-min period of cerebral ischemia induced in rats by the four-vessel occlusion method increased the number of errors (attempts to pass through two incorrect panels of the three panel-gates at four choice points) assessed by a working memory procedure applied in a three-panel runway task. The protein kinase C (PKC) i...

journal_title：European journal of pharmacology

authors： Ohno M,Yamamoto T,Watanabe S

更新日期：1991-10-29 00:00:00