Oleanonic acid, a 3-oxotriterpene from Pistacia, inhibits leukotriene synthesis and has anti-inflammatory activity.

abstract：:We discovered a novel compound, YM-126414 [1,3, 3-trimethyl-2-(2-phenylaminovinyl)-3H-indolium perchlorate], which stimulates glucose uptake in skeletal muscle cells in vitro. This compound increased the rate of consumption of glucose by C2C12 mouse myoblast cells in a dose-dependent manner (EC(50)=10 nM). To investig...

journal_title：European journal of pharmacology

authors： Shimokawa T,Kagami M,Kato M,Kurosaki E,Shibasaki M,Katoh M

更新日期：2000-12-20 00:00:00

abstract：:Intravenous administration of 0.3 mg/kg of quinpirole to conscious rabbits that had been pretreated with domperidone caused a marked increase in blood pressure and renal sympathetic nerve activity with a peak at 5-10 min after injection (25% and 3-fold increase, respectively). Spectral analysis of the blood pressure-r...

journal_title：European journal of pharmacology

authors： van den Buuse M,Head GA

更新日期：2000-01-24 00:00:00

abstract：:This study was designed to determine if the histamine H3 receptor agonist R-alpha-methylhistamine would play a role in modulation of sympathetically evoked mydriasis in anesthetized rats, and if so, to ascertain the specific receptor subtype(s) involved. Reproducible frequency-response curves of pupillary dilation wer...

journal_title：European journal of pharmacology

authors： Yu Y,Kawarai M,Koss MC

更新日期：2001-05-04 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) receptor system is thought to be underactive in schizophrenia which may contribute to attentional dysfunction in this disease. In a visual signal detection task that required discrimination of signaled-trials from trials with no signal, the NMDA receptor antagonist, dizocilpine (0.05 mg...

journal_title：European journal of pharmacology

authors： Howe WM,Burk JA

更新日期：2007-12-22 00:00:00

abstract：:The effect of moguisteine, a novel peripherally acting non-narcotic antitussive drug, on allergic coughs was examined in guinea pigs. Male Hartley guinea pigs were actively sensitized to ovalbumin. The number of coughs elicited over 5 min following a 2-min exposure to ovalbumin was counted. Exposure of sensitized guin...

journal_title：European journal of pharmacology

authors： Kamei J,Morita K,Kashiwazaki T,Ohsawa M

更新日期：1998-04-24 00:00:00

abstract：:Specific binding of [3H]imipramine to its recognition sites in frontal cortex and levels of serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and norepinephrine (NE) as well as uptake of serotonin by crude synaptosomal (P2) fraction were determined in a group of rats chronically (for 21 days) treated with differen...

journal_title：European journal of pharmacology

authors： Hrdina PD

更新日期：1987-06-19 00:00:00

abstract：:The neuroprotective effects of erythropoietin on 1-methyl-4-phenylpyridinium (MPP(+))-induced oxidative stress and apoptosis in cultured PC12 cells as well as the underlying mechanism were investigated. Treatment of PC12 cells with MPP(+) caused the loss of cell viability, which was associated with the elevation in ap...

journal_title：European journal of pharmacology

authors： Wu Y,Shang Y,Sun S,Liu R

更新日期：2007-06-14 00:00:00

abstract：:Recently, we reported that intracerebroventricularly (i.c.v.) administered (±)-epibatidine (a non-selective agonist of nicotinic acetylcholine receptors) elevates plasma noradrenaline and adrenaline through brain nicotinic acetylcholine receptor-mediated mechanisms in rats. In the present study, we characterized the r...

journal_title：European journal of pharmacology

authors： Shimizu T,Tanaka K,Hasegawa T,Yokotani K

更新日期：2011-03-11 00:00:00

abstract：:In rabbits, i.v. delta9-tetrahydrocannabinol (delta9-THC) at 0.5 mg/kg was challenged with i.v. arecoline (0.025 mg/kg), nicotine (0.02 mg/kg) or physostigmine (PHYSO, 0.05 mg/kg), and observations were made on quantified EEG and behavior. The cholinomimetics effectively reversed the cortical and hippocampal EEG alter...

journal_title：European journal of pharmacology

authors： Jones BC,Consroe PF,Laird HE 2nd

更新日期：1976-08-01 00:00:00

abstract：:Sabiporide, a new benzoguanidine, was characterized on fibroblasts stably expressing the Na(+)/H(+) exchanger isoforms NHE-1, NHE-2 and NHE-3. 22Na(+) uptake experiments show that this compound possesses a K(i) of 5+/-1.2 x 10(-8) M for NHE-1, and discriminates efficiently between the NHE-1, -2 and -3 isoforms (K(i) f...

journal_title：European journal of pharmacology

authors： Touret N,Tanneur V,Godart H,Seidler R,Taki N,Bürger E,Dämmgen J,Counillon L

更新日期：2003-01-17 00:00:00

abstract：:UP 269-6, 5-methyl-7-propyl-8(-)[2'-(1H-tetrazol-5-yl)biphenyl-4- yl)methyl]-1,2,4-triazolo]1,5-c]pyrimidin-2(3H)-one is a novel nonpeptide angiotensin II receptor antagonist. In vivo studies were performed to evaluate UP 269-6 for its angiotensin II antagonistic action. In pithed rats, i.v. administration of UP 269-6...

journal_title：European journal of pharmacology

authors： Cazes M,Provost D,Versigny A,Cloarec A

更新日期：1995-09-15 00:00:00

abstract：:The effect of a leukotriene D(4) receptor antagonist, (3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl(3-dimethyl amino-3-oxo propyl)thio)methyl)thio) propanoic acid (L-660,711; MK-571), was investigated on nociceptive responses in mice using three different assays: acetic-acid-induced abdominal constrictions, formalin ...

journal_title：European journal of pharmacology

authors： Gök S,Onal A,Cinar MG,Evinç A

更新日期：1999-12-15 00:00:00

abstract：:Disodium cromoglycate is an anti-asthmatic drug that has mast cell-stabilizing effects and other anti-inflammatory effects. However, the mechanisms of its anti-inflammatory effects are unclear. In this study, we evaluated effects of disodium cromoglycate on eosinophilia, early and late asthmatic responses, and product...

journal_title：European journal of pharmacology

authors： Nabe T,Yamamoto M,Suga M,Kohno S

更新日期：2004-08-16 00:00:00

abstract：:To shed light on the discrepancy between reported binding and functional affinity and selectivity at alpha(1b/B)-adrenoceptors, the antagonist (+)-cyclazosin was reinvestigated in rat and rabbit tissues. It displayed a competitive antagonism at alpha(1A) and alpha(1D)-adrenoceptors of rat prostatic vas deferens and ao...

journal_title：European journal of pharmacology

authors： Marucci G,Angeli P,Buccioni M,Gulini U,Melchiorre C,Sagratini G,Testa R,Giardinà D

更新日期：2005-10-17 00:00:00

abstract：:The effect of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (NMPTP) on central monoamine neurons in mice was investigated using histo- and biochemical techniques. NMPTP (2 X 10 mg/kg i.v.) produced a rapid and long-lasting reduction (-30%) of striatal dopamine, while the dopamine levels were only transiently reduced in...

journal_title：European journal of pharmacology

authors： Hallman H,Olson L,Jonsson G

更新日期：1984-01-13 00:00:00

abstract：:The pharmacological profile of the opioid antagonist norbinaltorphimine has been characterised in vitro and in vivo. In vitro, norbinaltorphimine reversibly antagonised the effects of kappa agonists with pA2 values of 10.2-10.4. Norbinaltorphimine was much less potent as an antagonist at mu and delta receptors, pA2 va...

journal_title：European journal of pharmacology

authors： Birch PJ,Hayes AG,Sheehan MJ,Tyers MB

更新日期：1987-12-15 00:00:00

abstract：:Gamma globin induction remains a promising pharmacological therapeutic treatment mode for sickle cell anemia and beta thalassemia, however Hydroxyurea remains the only FDA approved drug which works via this mechanism. In this regard, we assayed the γ-globin inducing capacity of Cis-vaccenic acid (CVA). CVA induced dif...

journal_title：European journal of pharmacology

authors： Aimola IA,Inuwa HM,Nok AJ,Mamman AI,Bieker JJ

更新日期：2016-04-05 00:00:00

abstract：:Rhesus monkeys were trained to discriminate saline from an injection of ketamine. In tests of stimulus generalization, phencyclidine (PCP) produced dose-related ketamine-appropriate responding in each monkey. Two monohydroxylated PCP metabolites also produced ketamine-like discriminative effects, although only at cons...

journal_title：European journal of pharmacology

authors： Solomon RE,Herling S,Woods JH

更新日期：1982-08-27 00:00:00

abstract：:Pristinamycin IA is a cyclo-peptidic macrolactone antibiotic belonging to the streptogramin family. In the present work, the interaction of pristinamycin IA with the multidrug transporter P-glycoprotein was investigated in the differentiated human intestinal epithelial cell line Caco-2. Pristinamycin IA specifically i...

journal_title：European journal of pharmacology

authors： Phung-Ba V,Warnery A,Scherman D,Wils P

更新日期：1995-01-16 00:00:00

abstract：:This study investigates the effect and the underlying mechanism of 2',3-dihydroxy-5-methoxybiphenyl (RIR-2), a lignan extracted from the roots of Rhaphiolepis indica (L.) Lindl. ex Ker var. tashiroi Hayata ex Matsum. & Hayata (Rosaceae), on N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced respiratory burst...

journal_title：European journal of pharmacology

authors： Liao HR,Chen IS,Liu FC,Lin SZ,Tseng CP

更新日期：2018-06-15 00:00:00

abstract：:Osteoporosis is a reduction in skeletal mass due to an imbalance between bone resorption and bone formation. Bone morphogenetic protein (BMP) plays important roles in osteoblastic differentiation and bone formation. Therefore, components involved in BMP activation are good targets for the development of anti-osteoporo...

journal_title：European journal of pharmacology

authors： Tang CH,Yang RS,Chien MY,Chen CC,Fu WM

更新日期：2008-01-28 00:00:00

abstract：:The sciatic nerve in the right thigh was divided in 40 rats and the nerve stumps then sewn together with two microsutures. The treated animals, 20 rats, had daily subcutaneous administration of a bovine cortex ganglioside mixture. The controls, 20 rats, received the solvent alone. At 21 days after nerve division it wa...

journal_title：European journal of pharmacology

authors： Kleinebeckel D

更新日期：1982-05-21 00:00:00

abstract：:Slices of rat kidney cortex were incubated in [3H]noradrenaline, then placed in a flow cell and subjected to electrical field stimulation. At a stimulation frequency of 5 Hz, both the alpha 2-adrenoceptor antagonist idazoxan (0.1 microM) and the alpha 1-adrenoceptor antagonist prazosin (0.1 microM) significantly enhan...

journal_title：European journal of pharmacology

authors： Murphy TV,Majewski H

更新日期：1989-10-10 00:00:00

abstract：:[3H]Idazoxan is a labelled ligand that is frequently used to study alpha 2-adrenoceptors in the central nervous system. In pig kidney membranes, [3H]idazoxan labelled high-affinity binding sites (Kd = 1.5 nM) that were not alpha 2-adrenoceptors and which recognized clonidine with low affinity. This new class of bindin...

journal_title：European journal of pharmacology

authors： Vigne P,Lazdunski M,Frelin C

更新日期：1989-01-31 00:00:00

abstract：:N-methyl-d-aspartate (NMDA) receptors are important in mediating excitatory neurotransmission in the nervous system. They are preferentially inhibited by some general anesthetics and have, therefore, been implied in the mediation of their effects. This review summarizes the main research findings available related to ...

journal_title：European journal of pharmacology

authors： Petrenko AB,Yamakura T,Sakimura K,Baba H

更新日期：2014-01-15 00:00:00

abstract：:Levetiracetam was initially developed as a nootropic drug, although since 2002 it has been used as anticonvulsant for the treatment of partial and generalized epilepsy syndromes. The purpose of the research was to investigate anti-paroxysmal activity of levetiracetam (LEV) on the model of cobalt-induced chronic epilep...

journal_title：European journal of pharmacology

authors： Litvinova Svetlana A,Voroninа Tatyana A,Nerobkova Lubov N,Kutepova Inga S,Avakyan Georgii G,Avakyan Gagik N

更新日期：2019-07-05 00:00:00

abstract：:Traditional methods of analyzing the binding of opiates do not accurately establish the affinities of the drugs for the agonist and antagonist states of the opioid receptor. The poor results obtained by the Scatchard procedure may be attributed to the presence of extraneous drug binding sites in the brain-homogenate m...

journal_title：European journal of pharmacology

authors： Cheney BV,Lahti RA,Barsuhn C

更新日期：1982-02-05 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs (NSAID) inhibit cyclooxygenase activity and cause gastrointestinal damage in part by promoting leukocyte accumulation in the mucosa. Our aim was to evaluate the effects of selective blockade of the isoenzymes cyclooxygenase-1 and cyclooxygenase-2 on leukocyte adhesion in vivo. Leuk...

journal_title：European journal of pharmacology

authors： Calatayud S,Mitchell JA,Perretti M,Giuliano F,Warner TD

更新日期：2002-04-05 00:00:00

abstract：:Mizoribine is a disease-modifying anti-rheumatic drug (DMARD) that is used in the treatment of rheumatoid arthritis. However, clinical use of the drug is restricted to a few Asian countries due to a lack of comprehensive evidence on its effectiveness. The inhibitory effect of the drug on human osteoclastogenesis was i...

journal_title：European journal of pharmacology

authors： Lee YA,Yang HI,Park EK,Bang JS,Choi HM,Oh DH,Lee SH,Hong SJ,Jo YJ,Yoo MC,Kim KS

更新日期：2009-03-01 00:00:00

abstract：:The effects of systemic administration of the full dopamine D1 receptor agonist A-77636 on acetylcholine release in rat frontal cortex and hippocampus were studied using in vivo microdialysis. Administration of A-77636 (4 mumol/kg s.c.) greatly (> 230%) increased both cortical and hippocampal acetylcholine release for...

journal_title：European journal of pharmacology

authors： Acquas E,Day JC,Fibiger HC

更新日期：1994-07-21 00:00:00