Abstract：
UNLABELLED:This study analyzed the role of nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF) in gender differences in the renal vascular reactivity of rats. Renal responses to vasoconstrictors and vasodilators were studied in isolated kidneys from male and female rats under basal conditions, after NO and EDHF blockade or after endothelium removal. Female rat kidneys had reduced responsiveness to vasoconstrictors. The blockade of NO or of EDHF did not completely abolish the differences, but the simultaneous blockade of both factors or endothelium removal abolished gender differences. Male and female kidneys showed a similar responsiveness to endothelium-dependent and -independent vasodilators under basal conditions and after NO or EDHF blockade. IN CONCLUSION:(a) the attenuated response to vasoconstrictors in female kidneys is related to an increased production of NO and EDHF; and (b), the contributions of NO and EDHF to endothelium-dependent vasodilation are similar in the male and female renal vasculature.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Wangensteen R,Moreno JM,Sainz J,Rodríguez-Gómez I,Chamorro V,Luna Jde D,Osuna A,Vargas Fdoi
10.1016/j.ejphar.2003.12.036keywords:
subject
Has Abstractpub_date
2004-02-23 00:00:00pages
281-8issue
3eissn
0014-2999issn
1879-0712pii
S0014299903028383journal_volume
486pub_type
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