Receptor reserve at striatal dopamine receptors modulating the release of [3H]dopamine.

abstract：:The polyphenolic flavonoid silymarin that is the milk thistle extract has been found to possess an anti-cancer effect against various human epithelial cancers. In this study, to explore the regulative effect of silymarin on human ovarian cancer line A2780s and PA-1 cells, 3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltet...

journal_title：European journal of pharmacology

authors： Fan L,Ma Y,Liu Y,Zheng D,Huang G

更新日期：2014-11-15 00:00:00

abstract：:A natural monoterpene alkaloid incarvillateine isolated from the plant Incarvillea sinensis is known to relieve inflammatory and neuropathic pain. However, the molecular target for the action of incarvillateine remains elusive. Here, we report that incarvillateine exacerbates epileptic seizures by inhibiting subtypes ...

journal_title：European journal of pharmacology

authors： Bian X,Zhang Y,Huang B,Wang X,Wang G,Zhu Y,Liu Y,Liang J,Jia Y,Wang K

更新日期：2019-09-05 00:00:00

abstract：:Excessive intracellular accumulation of zinc (Zn(2+)) is neurotoxic and contributes to a number of neuropathological conditions. Here, we investigated the protective effect of 3-morpholinosydnonimine (SIN-1) against Zn(2+)-induced neuronal cell death in differentiated PC12 cells. We found that Zn(2+)-induced PC12 cell...

journal_title：European journal of pharmacology

authors： An JM,Moon SA,Hong SY,Kang JW,Seo JT

更新日期：2015-02-05 00:00:00

abstract：:Endogenous opioid peptides have been demonstrated to regulate luteinizing hormone (LH) secretion in a variety of species. Studies in rodents suggest a role of opioid peptide systems in controlling the timing of the LH surge, which is entrained to the circadian rhythm. The current studies utilize clocinnamox, a novel l...

journal_title：European journal of pharmacology

authors： Lieberman PB,Woods JH,Young EA

更新日期：1998-07-03 00:00:00

abstract：:Increasing evidence demonstrates that oxidative stress plays an important role in brain injury in experimental models of brain ischemia. Thymoquinone, the main constituents of the volatile oil from Negella sativa seeds, is reported to possess strong antioxidant properties. Hence, the present study was undertaken to ev...

journal_title：European journal of pharmacology

authors： Al-Majed AA,Al-Omar FA,Nagi MN

更新日期：2006-08-14 00:00:00

abstract：:Pyrrolidine dithiocarbamate (PDTC) can form a complex with metal ions and then act as a proteasome inhibitor, which leads to tumor cell apoptosis, and could therefore be developed as an anticancer agent. In our efforts to find factors that induce PDTC-mediated apoptosis of tumor cells, the effect of serum concentratio...

journal_title：European journal of pharmacology

authors： Oh DH,Bang JS,Choi HM,Yang HI,Yoo MC,Kim KS

更新日期：2010-12-15 00:00:00

abstract：:Antipsychotic drugs are traditionally classified as typical or atypical on the basis of their property to cause or not to cause extrapyramidal side-effects. A widely accepted selectivity for the mesolimbic, vs. the nigrostriatal, dopaminergic system is postulated to underlie the existence of fewer or no extrapyramidal...

journal_title：European journal of pharmacology

authors： Melis M,Gessa GL,Diana M

更新日期：1998-12-18 00:00:00

abstract：:Three non-steroidal antiinflammatory agents were tested for their ability to antagonize bradykinin in the rabbit jugular vein, the dog carotid artery and the guinea pig trachea. The new agents were compared with indomethacin, as well as with [Thi5,8,D-Phe7] bradykinin and [Thi6,9,D-Phe8] kallidin, two B2 receptor anta...

journal_title：European journal of pharmacology

authors： Rhaleb NE,Dion S,D'Orléans-Juste P,Drapeau G,Regoli D,Browne RG

更新日期：1988-07-07 00:00:00

abstract：:We have previously shown that particular phenolic antidiarrheic ingredients, including 2-methoxy-4-methylphenol (2M4MP) and 2-methoxy-4-ethyphenol (2M4EP), but not 2-methoxyphenol (2MP), significantly inhibit cellular maturation and differentiation of the bone-resorbing osteoclasts with concomitant protection of the b...

journal_title：European journal of pharmacology

authors： Matsushima N,Nakamichi N,Kambe Y,Takano K,Moriguchi N,Yoneda Y

更新日期：2007-07-12 00:00:00

abstract：:In addition to its well-known interaction with ionotropic and metabotropic receptors, glutamate may, at high concentrations, interfere with a cystine-glutamate antiport designated as Xc- and lead to a significant decrease in cystine uptake and intracellular glutathione level. These effects, in turn, may induce death i...

journal_title：European journal of pharmacology

authors： Froissard P,Monrocq H,Duval D

更新日期：1997-05-12 00:00:00

abstract：:The effects of H 25 and H 74 on ouabain-resistant 86Rb+ influx were tested in beta-cell-rich mouse pancreatic islets. Both H 25, which is considered to be a specific inhibitor of Na+, K+, Cl- co-transport, and H 74, a specific inhibitor of K+, Cl- co-transport, reduced the ouabain-resistant 86Rb+ influx. The specific ...

journal_title：European journal of pharmacology

authors： Sandström PE,Sehlin J

更新日期：1993-07-20 00:00:00

abstract：:The actions of 5-hydroxytryptamine have been studied in the chick biventer cervicis nerve--muscle preparation. At concentrations between 2.5 X 10(-3) and 3.7 X 10(-3) M, 5HT produced a transient increase in responses to indirect stimulation, but not to direct stimulation. At higher concentrations, 5HT produced a rever...

journal_title：European journal of pharmacology

authors： Teerapong P,Harvey AL

更新日期：1977-07-15 00:00:00

abstract：:Estrogen-related receptor alpha (ERRα), one of orphan nuclear receptors, has been recently revealed as an oncogenic regulator in a variety of cancers. However, the linking gain of ERRα expression and cancer progression in cutaneous squamous cell carcinoma (cSCC) is largely unknown. Here, we showed that the mRNA and pr...

journal_title：European journal of pharmacology

authors： Chen H,Pan J,Zhang L,Chen L,Qi H,Zhong M,Shi X,Du J,Li Q

更新日期：2018-04-15 00:00:00

abstract：:Secondary hyperparathyroidism is a common complication in patients with chronic kidney disease and frequently persists after kidney transplantation. Paricalcitol, a selective vitamin D receptor activator, is indicated in the management of this disorder and recent evidences have suggested that this drug has other benef...

journal_title：European journal of pharmacology

authors： Pérez V,Sánchez-Escuredo A,Lauzurica R,Bayés B,Navarro-Muñoz M,Pastor MC,Cañas L,Bonet J,Romero R

更新日期：2013-06-05 00:00:00

abstract：:The effects of ketamine and barbiturates (pentobarbital, thiopental, methohexital) were studied in an isolated rabbit Langendorff preparation. All agents tested depressed contractility. Ketamine, as well as the lipophilic barbiturates (thiopental, methohexital), caused a relatively greater depression at higher pacing ...

journal_title：European journal of pharmacology

authors： Davies AE,McCans JL

更新日期：1979-10-26 00:00:00

abstract：:Chlorpropamide and phenformin inhibited (Na+ - K+)-ATPase and stimulated a high affinity cyclic AMP-phosphodiesterase of isolated liver plasma membrane when tested in vitro. In addition, the two drugs decreased the intracellular cyclic AMP content of isolated hepatocytes without being effective on plasma membrane-boun...

journal_title：European journal of pharmacology

authors： Luly P,Baldini P,Cocco C,Incerpi S,Tria E

更新日期：1977-11-15 00:00:00

abstract：:We have investigated the effect of 2(4-((2-carboxymethyl)phenyl)ethylamino)-5'-N-ethylcarboxamidoadenosine (CGS 21680), a potent and selective agonist at adenosine A2A receptors, on pulmonary inflammation induced by allergen challenge in the ovalbumin-sensitised, Brown Norway rat. Aerosol administration of ovalbumin (...

journal_title：European journal of pharmacology

authors： Fozard JR,Ellis KM,Villela Dantas MF,Tigani B,Mazzoni L

更新日期：2002-03-08 00:00:00

abstract：:The 5-lipoxygenase inhibitors WY-50,295 tromethamine, A-64,077, L-663,536 and ICI-207,968 were compared in a reverse passive Arthus reaction-induced pleurisy model of eicosanoid biosynthesis in the rat. When a 1 h pretreatment schedule was employed, all four inhibitors equivalently blocked leukotriene B4 (LTB4) produc...

journal_title：European journal of pharmacology

authors： Berkenkopf JW,Weichman BM

更新日期：1991-01-25 00:00:00

abstract：:KF17837 is a novel selective adenosine A2A receptor antagonist. Oral administration of KF17837 (2.5, 10.0 and 30.0 mg/kg) significantly ameliorated the cataleptic responses induced by intracerebroventricular administration of an adenosine A2A receptor agonist, CGS 21680 (10 micrograms), in a dose-dependent manner. KF1...

journal_title：European journal of pharmacology

authors： Kanda T,Shiozaki S,Shimada J,Suzuki F,Nakamura J

更新日期：1994-05-02 00:00:00

abstract：:Cisplatin is widely used chemotherapeutic drug and have some serious side effects as tissue toxicity and nausea and vomiting. Aprepitant is used in clinic as an anti-emetic drug for cisplatin treated patient to prevent nausea and vomiting. We aimed to investigate the protective effects of Aprepitant on cisplatin-induc...

journal_title：European journal of pharmacology

authors： Un H,Ugan RA,Kose D,Bayir Y,Cadirci E,Selli J,Halici Z

更新日期：2020-08-05 00:00:00

abstract：:Receptor for advanced glycation end-products (RAGE) is involved in the pathogenesis of diabetic nephropathy. FPS-ZM1, a selective RAGE inhibitor, in combination with valsartan were investigated for their protective potentials on the renal markers of tubular injury in streptozotocin-induced diabetic rats. Rats were ass...

journal_title：European journal of pharmacology

authors： Sanajou D,Ghorbani Haghjo A,Argani H,Roshangar L,Rashtchizadeh N,Ahmad SNS,Ashrafi-Jigheh Z,Bahrambeigi S,Asiaee F,Rashedi J,Aslani S

更新日期：2019-01-05 00:00:00

abstract：:Racemic baclofen, (-)-baclofen and muscimol depressed all spontaneously firing locus coeruleus neurons tested in a slice preparation. Racemic phaclofen (100 microM; 1 mM) moderately antagonized the effects of racemic baclofen without antagonizing those of muscimol. Bicuculline (10, 30, 100 microM) potently antagonized...

journal_title：European journal of pharmacology

authors： Olpe HR,Steinmann MW,Hall RG,Brugger F,Pozza MF

更新日期：1988-04-27 00:00:00

abstract：:In contrast to the pronounced fall in 5HT levels and synaptosomal uptake caused by p-chloroamphetamine, bilateral lesions of the B-9 cell group caused minimal regional changes, except for 35% decreases in the metathalamus-thalamus. We conclude therefore that the prolonged biochemical effects of p-chloroamphetamine are...

journal_title：European journal of pharmacology

authors： Massari VJ,Sanders-Bush E

更新日期：1975-09-01 00:00:00

abstract：:FR134043, disodium(Z,1S,15S,8S,24S,27R,29S,34S,37R)-29-ben zyl-21-ethylidene-27-hydroxy-15-isobutyrylamino-34-isopropyl-31,37 -dimethyl-10,16,19,22,30,32,35,38-octaoxo-36-oxa-9,11,17,20,23,28, 31,33-octaazatetracyclo[16.13.6.1(24),(28).0(3),(8)]octatricont a-3,5,7-trien-5,6-diyl disulfate, is a water-soluble inhibitor...

journal_title：European journal of pharmacology

authors： Shinguh Y,Yamazaki A,Inamura N,Fujie K,Okamoto M,Nakahara K,Notsu Y,Okuhara M,Ono T

更新日期：1998-03-26 00:00:00

abstract：:In this study the desensitizing power of increasing concentrations of resiniferatoxin applied topically to the bladder mucosa, and the irritating properties of the most effective desensitizing dose, were determined with the aid of the spinal expression of the proto-oncogene c-fos. Desensitization was assessed by the d...

journal_title：European journal of pharmacology

authors： Avelino A,Cruz F,Coimbra A

更新日期：1999-07-28 00:00:00

abstract：:Herein, we examined the direct coupling of human dopamine D1 receptors to G(s) proteins using an antibody capture assay together with a detection technique employing scintillation proximity assay beads. Using a specific antibody, dopamine (DA) and the selective dopamine D1 receptor agonists, 6-chloro-7,8-dihydroxy-1-p...

journal_title：European journal of pharmacology

authors： Cussac D,Pasteau V,Millan MJ

更新日期：2004-02-06 00:00:00

abstract：:Rats were given powdered diet containing L-DOPA (together with the peripheral decarboxylase inhibitor carbidopa) for a period of 6 months. The estimated daily intake was in the range 20-30 mg/kg. Initially, at 1 week and 1 month, L-DOPA-fed rats exhibited enhanced spontaneous locomotor activity, but this fell to withi...

journal_title：European journal of pharmacology

authors： Pycock C,Dawbarn D,O'Shaughnessy C

更新日期：1982-04-23 00:00:00

abstract：:The antifibrillatory and electrophysiologic actions of bepridil and butyl-methylenedioxyindene (BU-MDI), two intracellular calcium antagonists, were examined in anesthetized dogs. The administration of bepridil (1.0-10.0 mg/kg i.v.) significantly increased the electrical threshold for ventricular fibrillation determin...

journal_title：European journal of pharmacology

authors： Lynch JJ,Rahwan RG,Lucchesi BR

更新日期：1985-04-23 00:00:00

abstract：:An intricate surveillance network consisting of enteroendocrine cells, immune cells and sensory nerve fibres monitors the luminal and interstitial environment in the alimentary canal. Functional bowel disorders are characterized by persistent alterations in digestive regulation and gastrointestinal discomfort and pain...

journal_title：European journal of pharmacology

authors： Holzer P

更新日期：2001-10-19 00:00:00

abstract：:The effects of the two enantiomers of the antidepressant nomifensine on catecholamine uptake were investigated using rat brain synaptosomes. According to the results from in vitro and ex vivo/in vitro studies, the inhibitory activity on catecholamine uptake resides entirely in the (+)-form of nomifensine. Further stud...

journal_title：European journal of pharmacology

authors： Schacht U,Leven M

更新日期：1984-02-17 00:00:00