Abstract:
:Three non-steroidal antiinflammatory agents were tested for their ability to antagonize bradykinin in the rabbit jugular vein, the dog carotid artery and the guinea pig trachea. The new agents were compared with indomethacin, as well as with [Thi5,8,D-Phe7] bradykinin and [Thi6,9,D-Phe8] kallidin, two B2 receptor antagonists. The antiinflammatory agents did not alter the effects of bradykinin in the two isolated vessels while they completely blocked (like indomethacin) the relaxation induced by bradykinin in guinea pig tracheae contracted with histamine or neurokinin A. The two bradykinin antagonists significantly reduced the contractions of the rabbit jugular vein and the relaxation of the dog carotid artery (with endothelium) in response to bradykinin: these antagonists were however inactive against bradykinin in the guinea pig trachea. The data now reported suggest that B2 receptors are involved in the opposite (stimulant or inhibitor) effects of the kinins in the two isolated vessels while the relaxation of the guinea pig trachea is a prostaglandin-dependent phenomenon which does not involve the activation of B1 or B2 receptors.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Rhaleb NE,Dion S,D'Orléans-Juste P,Drapeau G,Regoli D,Browne RGdoi
10.1016/0014-2999(88)90808-4subject
Has Abstractpub_date
1988-07-07 00:00:00pages
275-9issue
2eissn
0014-2999issn
1879-0712pii
0014-2999(88)90808-4journal_volume
151pub_type
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