Potassium-induced release of enkephalins from rat striatal slices.

abstract：:Imipramine and mianserin are equipotent inhibitors of noradrenaline (NA) uptake in synaptosomes. However, after in vivo administration, NA uptake was inhibited only in synaptosomes from imipramine-treated rats, suggesting that imipramine, or its metabolite desipramine, binds to the NA carrier in a manner outlasting th...

journal_title：European journal of pharmacology

authors： Raiteri M,Del Carmine R,Cervoni AM,Levi G

更新日期：1979-08-15 00:00:00

abstract：:The kinetic and equilibrium binding properties of the 1,4-dihydropyridine activator [3H](-)-S-Bay K 8644 and the antagonist [3H](+)-PN 200-110 were determined in rat heart membrane particulate preparations at temperatures between 4 and 37 degrees C. The binding of [3H](-)-S-Bay K 8644 was temperature-dependent with a ...

journal_title：European journal of pharmacology

authors： Zheng W,Hawthorn M,Triggle DJ

更新日期：1991-10-14 00:00:00

abstract：:In the rat distal colon, 5-hydroxytryptamine (5-HT)-induced Cl- secretion is seen as a rise in short circuit current (Isc). We investigated the 5-HT receptor mediating 5-HT-induced Cl- secretion in the rat distal colon. Rat distal colon was prepared either by stripping away the muscularis propria with the neural gangl...

journal_title：European journal of pharmacology

authors： Budhoo MR,Harris RP,Kellum JM

更新日期：1996-03-07 00:00:00

abstract：:The present investigation was designed to study the cardioprotective effects of nicorandil and pioglitazone preconditioning in myocardial ischemia/reperfusion-induced hemodynamic, biochemical and histological changes in rats. Oral doses of nicorandil (3 or 6 mg/kg) and pioglitazone (10 or 20mg/kg) were administered on...

journal_title：European journal of pharmacology

authors： Ahmed LA,Salem HA,Attia AS,Agha AM

更新日期：2011-08-01 00:00:00

abstract：:[3H]MDL 105,519 (((E)-3-(2-phenyl-2-carboxyethenyl)-4,6-dichloro-1[3H]-indole-2-ca rboxylic acid) is a novel radioligand which binds with high affinity, Kd = 2.5 nM, to the glycine site of adult rodent forebrain, N-methyl-D-aspartate subtype of glutamate receptors. As with other glycine site antagonists, the major det...

journal_title：European journal of pharmacology

authors： Chazot PL,Reiss C,Chopra B,Stephenson FA

更新日期：1998-07-17 00:00:00

abstract：:The effects of escins Ib and IIb isolated from horse chestnuts on Mg(2+) absorption from the digestive tract and the role of endogenous nitric oxide (NO) were investigated in mice. Test samples were given orally to fasted mice 30, 120, 180, 240 and 300 min before administration of 0.5 M MgSO(4) (10 ml/kg, p.o.). The s...

journal_title：European journal of pharmacology

authors： Li Y,Matsuda H,Wen S,Yamahara J,Yoshikawa M

更新日期：2000-01-17 00:00:00

abstract：:Metabotropic glutamate mGlu(1) receptors play a modulatory role in the nervous system. They enhance cell excitability, modulate synaptic neurotransmission and are involved in synaptic plasticity. During the last 10 years, several selective metabotropic glutamate mGlu(1) receptor competitive antagonists and potentiator...

journal_title：European journal of pharmacology

authors： Lesage A,Steckler T

更新日期：2010-08-10 00:00:00

abstract：:Clearance of apoptotic cells, so-called efferocytosis, by alveolar macrophages (AMs) is important for lung homeostasis and is impaired in pulmonary inflammatory diseases, such as chronic obstructive pulmonary disease and asthma. Carbocisteine, a mucoregulatory drug, corrects the contents of fucose in airway mucus and ...

journal_title：European journal of pharmacology

authors： Inoue M,Ishibashi Y,Nogawa H,Yasue T

更新日期：2012-02-29 00:00:00

abstract：:The effects of the new 3,4-disubstituted furoxan, CHF 2206, on vascular tone, platelet aggregation and platelet cyclic 3',5'-guanosine monophosphate (cGMP) levels were investigated. The compound was a potent inhibitor of rabbit aortic ring contraction induced by norepinephrine, the stable prostaglandin F2 alpha analog...

journal_title：European journal of pharmacology

authors： Civelli M,Caruso P,Giossi M,Bergamaschi M,Razzetti R,Bongrani S,Gasco A

更新日期：1994-04-01 00:00:00

abstract：:Recently published studies have suggested that behavioral and neurochemical changes induced by selective serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitors are potentiated by coadministration of a 5-HT1A receptor antagonist. The potentiating effect is hypothesized to be due to antagonism of somatodendritic 5-HT...

journal_title：European journal of pharmacology

authors： Sànchez C

更新日期：1997-09-10 00:00:00

abstract：:Malfunction of the serotonergic system and dysregulation of the hypothalamo-pituitary-adrenocortical axis have been implicated in the pathophysiology of depression. Several studies provide evidence for reciprocal influences between glucocorticoids and 5-HT receptors. The effect of repeated treatment with a high dose o...

journal_title：European journal of pharmacology

authors： Berendsen HH,Kester RC,Peeters BW,Broekkamp CL

更新日期：1996-07-18 00:00:00

abstract：:In view of the scarce information about the analgesic mechanism of kappa-opioid receptor agonists, the objective of the present study was to determine whether nitric oxide (NO) is involved in the peripheral antinociception of bremazocine, a kappa-opioid receptor agonist. Three drugs all interfering with the L-arginine...

journal_title：European journal of pharmacology

authors： Amarante LH,Duarte ID

更新日期：2002-11-01 00:00:00

abstract：:C-type natriuretic peptide (CNP) is the major natriuretic peptide in the brain and its mRNA has been reported in the central nervous system, which supports local synthesis and its role as a neuromodulator. The aim of the present work was to study the effect of centrally applied CNP on pancreatic secretion. Rats were f...

journal_title：European journal of pharmacology

authors： Sabbatini ME,Rodríguez MR,Corbo NS,Vatta MS,Bianciotti LG

更新日期：2005-11-07 00:00:00

abstract：:The inhibition of the tail-flick response induced by beta-endorphin given i.c.v. has been demonstrated to be mediated by the stimulation of epsilon- but not mu-, delta- or kappa-opioid receptors. beta-Endorphin given i.t. also inhibited the tail-flick response. The present studies were designed to determine what types...

journal_title：European journal of pharmacology

authors： Tseng LF,Collins KA

更新日期：1992-04-07 00:00:00

abstract：:In the present study 12 of 13 untreated pigs died of ventricular fibrillation during three 10 min episodes of left anterior descending coronary artery occlusion interrupted by 20 min of reperfusion. The selective beta-adrenoceptor antagonist bevantolol in a dose of 1.5 mg X kg-1, but not 0.5 mg X kg-1, offered nearly ...

journal_title：European journal of pharmacology

authors： Verdouw PD,Van Bremen RH,Verkeste CM,Van der Giessen WJ

更新日期：1985-05-20 00:00:00

abstract：:Cholangiocarcinoma (CCA) is one of the most serious of all cancers and a major public health problem. CCA is an extremely invasive cancer, and the survival rate for CCA patients is only 24 months after diagnosis. Although surgery and chemotherapy can extend the survival rate to 5 years, < 20-40% of CCA patients will s...

journal_title：European journal of pharmacology

authors： Lee MY,Li YZ,Huang KJ,Huang HC,Lin CY,Lee YR

更新日期：2018-11-15 00:00:00

abstract：:Not much has been reported about the effects of hyperthyroidism and its correction on resistance vessels, and just two inconsistent studies have investigated the impacts of restored euthyroidism on vascular reactivity. In this regard, we designed the current study to evaluate the vascular reactivity of the mesenteric ...

journal_title：European journal of pharmacology

authors： Khorshidi-Behzadi M,Alimoradi H,Haghjoo-Javanmard S,Reza Sharifi M,Rahimi N,Dehpour AR

更新日期：2013-02-15 00:00:00

abstract：:The imidazopyridines EMD 35993 and EMD 41717 antagonized the anticonflict actions of diazepam and chlordiazepoxide in rodent models which are predictive for anxiolytic action in man. In contrast to other described benzodiazepine antagonists, these compounds did not antagonize either the anticonvulsant or muscle relaxa...

journal_title：European journal of pharmacology

authors： Skolnick P,Paul S,Crawley J,Lewin E,Lippa A,Clody D,Irmscher K,Saiko O,Minck KO

更新日期：1983-04-08 00:00:00

abstract：:Vagal motor outflow from the dorsal vagal complex is important in the regulation of intestinal motility. The aim of our study was to test the hypothesis that within the dorsal vagal complex, tonic GABA(A)-receptor mediated neurotransmission modulates intestinal motility. The GABA(A) receptor antagonist, bicuculline (m...

journal_title：European journal of pharmacology

authors： Greenwood-Van Meerveld B,Barron KW

更新日期：1998-04-10 00:00:00

abstract：:The action of 9(0)-thiaprostacyclin (PGI2-S) was compared with that of prostacyclin (PGI2) and papaverine in the femoral circulation of dogs. PGI2-S, injected into the dog femoral artery in a dose of 0.1 microgram or higher, produced marked vasodilation in the femoral artery without any change in blood pressure. The p...

journal_title：European journal of pharmacology

authors： Horii D,Kanayama T,Mori M,Shibasaki M,Ikegami S

更新日期：1978-10-01 00:00:00

abstract：:High affinity binding sites for [3H]leukotriene C4 ([3H]LTC4) have been identified and characterised in guinea-pig lung membranes. [3H]LTC4 bound to these membranes with a pharmacological specificity totally distinct to that previously observed for [3H]LTD4 binding in guinea-pig lung. Scatchard analysis of saturation ...

journal_title：European journal of pharmacology

authors： Norman P,Abram TS,Kluender HC,Gardiner PJ,Cuthbert NJ

更新日期：1987-11-17 00:00:00

abstract：:The family of facilitative glucose transporter (GLUT) proteins is responsible for the entry of glucose into cells throughout the periphery and the brain. The expression, regulation and activity of GLUTs play an essential role in neuronal homeostasis, since glucose represents the primary energy source for the brain. Br...

journal_title：European journal of pharmacology

authors： McEwen BS,Reagan LP

更新日期：2004-04-19 00:00:00

abstract：:The suppressing effect of acamprosate (calcium-acetyl homotaurinate) on alcohol drinking is well established; however, little is known about its effects upon the alcohol-induced withdrawal syndrome. Male Wistar rats received as a sole drinking fluid a 20% (v/v) alcohol solution for one week. Animals consumed on averag...

journal_title：European journal of pharmacology

authors： Spanagel R,Putzke J,Stefferl A,Schöbitz B,Zieglgänsberger W

更新日期：1996-06-03 00:00:00

abstract：:Salvianolic acid B (SalB) is a polyphenolic compound found in Salvia miltiorrhiza Bunge that has several anti-oxidative and anti-inflammatory effects. In the present study, we investigated whether SalB has neuroprotective effects in an amyloid β (Aβ) peptide-induced Alzheimer's disease mouse model. Mice were injected ...

journal_title：European journal of pharmacology

authors： Lee YW,Kim DH,Jeon SJ,Park SJ,Kim JM,Jung JM,Lee HE,Bae SG,Oh HK,Son KH,Ryu JH

更新日期：2013-03-15 00:00:00

abstract：:The melanocortin subtype 4 (MC4) receptor has been postulated to be involved in stress and stress-related behavior. We made use of melanocortin MC4 receptor agonists and antagonist to investigate the relationship between the melanocortin MC4 receptor and stress related disorders. The nonspecific melanocortin receptor ...

journal_title：European journal of pharmacology

authors： Chaki S,Ogawa S,Toda Y,Funakoshi T,Okuyama S

更新日期：2003-08-01 00:00:00

abstract：:Characteristics of [3H]flunitrazepam ([3H]FLU) binding to cortical and cerebellar membrane receptors were examined following chronic (six days) administration of phenobarbital (PB) to C57B1 mice. Following PB treatment, the number of [3H]FLU binding sites (Bmax) was significantly reduced in both cerebral cortex and in...

journal_title：European journal of pharmacology

authors： Liljequist S,Garrett KM,Tabakoff B

更新日期：1984-08-17 00:00:00

abstract：:The development of anticonvulsant tolerance with RO 16-6028, a benzodiazepine receptor partial agonist, was assessed in mice using an i.v. infusion of pentylenetetrazol as the convulsive stimulus. In contrast to other benzodiazepines tested previously in this seizure model the anticonvulsant protection afforded by RO ...

journal_title：European journal of pharmacology

authors： Haigh JR,Feely M

更新日期：1988-03-01 00:00:00

abstract：:High pressure liquid chromatography (HPLC) combined with radiochemical detection was used to show that [3H]noradrenaline (NA) and [14C]ATP were released concomitantly during field stimulation of the rat vas deferens. The release of radioactivity (3H and 14C) in response to three consecutive field stimulations was cons...

journal_title：European journal of pharmacology

authors： Vizi ES,Burnstock G

更新日期：1988-12-06 00:00:00

abstract：:The vascular effects of bradykinin were studied in rat perfused mesenteric vascular beds with active tone. Bolus injections of bradykinin (1-1000 pmol) but not des-Arg(9)-bradykinin (bradykinin B(1) receptor agonist) induced triphasic vascular responses: the initial sharp vasodilation followed by transient vasoconstri...

journal_title：European journal of pharmacology

authors： Nawa H,Kawasaki H,Nakatsuma A,Isobe S,Kurosaki Y

更新日期：2001-12-14 00:00:00

abstract：:The relationship between adipocytes and infiltrated macrophages in fat tissue is important for the pathogenesis of insulin resistance through the activation of cytokines. Peroxisome proliferator-activated receptors (PPARs) play a role in the regulation of cytokine secretion in these cells. We studied the effect of the...

journal_title：European journal of pharmacology

authors： Murakami K,Bujo H,Unoki H,Saito Y

更新日期：2007-04-30 00:00:00